LGI1_HUMAN
Evidence for PS localization
Functions
Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors . Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 26 | Leu | Arg | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 46 | Cys | Arg | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 383 | Glu | Ala | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 318 | Phe | Cys | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 42 | Cys | Gly | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 473 | Ser | Leu | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 42 | Cys | Arg | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 110 | Ala | Asp | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 122 | Ile | Lys | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 123 | Glu | Lys | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 136 | Arg | Trp | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 145 | Ser | Arg | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 154 | Leu | Pro | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 200 | Cys | Arg | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 232 | Leu | Pro | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 298 | Ile | Thr | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 432 | Val | Glu | Epilepsy,familialtemporallobe,1(ETL1) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LGI1_HUMAN |
|---|---|---|---|---|
| GO:0005524 | ATP binding | 26.0870 | 5 | no |
| GO:0017076 | purine nucleotide binding | 26.0870 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 26.0870 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 26.0870 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 26.0870 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.0870 | 4 | no |
| GO:0016301 | kinase activity | 26.0870 | 4 | no |
| GO:0019900 | kinase binding | 21.7391 | 4 | no |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 21.7391 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LGI1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.5217 | 4 | yes |
| GO:0010646 | regulation of cell communication | 47.8261 | 4 | yes |
| GO:0008104 | protein localization | 43.4783 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 43.4783 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 39.1304 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 34.7826 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 30.4348 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 30.4348 | 4 | yes |
| GO:0030030 | cell projection organization | 30.4348 | 4 | yes |
| GO:0050890 | cognition | 30.4348 | 4 | no |
| GO:0031175 | neuron projection development | 26.0870 | 6 | yes |
| GO:0033365 | protein localization to organelle | 26.0870 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 26.0870 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 26.0870 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.0870 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 26.0870 | 4 | no |
| GO:0051049 | regulation of transport | 26.0870 | 4 | no |
| GO:0007612 | learning | 26.0870 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 26.0870 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 26.0870 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 26.0870 | 4 | no |
| GO:1990778 | protein localization to cell periphery | 21.7391 | 5 | yes |
| GO:0006996 | organelle organization | 21.7391 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 21.7391 | 5 | no |
| GO:0022607 | cellular component assembly | 21.7391 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.7391 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.7391 | 5 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 21.7391 | 4 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 21.7391 | 5 | no |
| GO:0034765 | regulation of ion transmembrane transport | 21.7391 | 5 | no |
| GO:0043269 | regulation of ion transport | 21.7391 | 5 | no |
| GO:1904062 | regulation of cation transmembrane transport | 21.7391 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 21.7391 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 21.7391 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 21.7391 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 21.7391 | 4 | no |
| GO:0072657 | protein localization to membrane | 17.3913 | 4 | yes |
| GO:0007399 | nervous system development | 13.0435 | 4 | yes |
| GO:0007411 | axon guidance | 13.0435 | 8 | yes |
| GO:0035418 | protein localization to synapse | 13.0435 | 6 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 13.0435 | 5 | yes |
| GO:0062237 | protein localization to postsynapse | 13.0435 | 7 | yes |
| GO:0097485 | neuron projection guidance | 13.0435 | 7 | yes |
| GO:0099633 | protein localization to postsynaptic specialization membrane | 13.0435 | 6 | yes |
| GO:0099645 | neurotransmitter receptor localization to postsynaptic specialization membrane | 13.0435 | 4 | yes |
| GO:1902414 | protein localization to cell junction | 13.0435 | 5 | yes |
| GO:1903539 | protein localization to postsynaptic membrane | 13.0435 | 5 | yes |
| GO:0001558 | regulation of cell growth | 8.6957 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in LGI1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 13.0435 | 3 | yes |
| DOID:1289 | neurodegenerative disease | 8.6957 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ADA22_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUT11_HUMAN | [view interactions] | High throughput | no | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| STK39_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRP5_HUMAN | [view interactions] | High throughput | no | yes |
| DUS14_HUMAN | [view interactions] | High throughput | no | yes |
| ARSK_HUMAN | [view interactions] | High throughput | no | no |
| RAD17_HUMAN | [view interactions] | High throughput | no | yes |
| EOGT_HUMAN | [view interactions] | High throughput | no | yes |
| OXSR1_HUMAN | [view interactions] | High throughput | no | yes |
| BANP_HUMAN | [view interactions] | High throughput | no | yes |
| RGPD5_HUMAN | [view interactions] | High throughput | no | no |
| TRIPC_HUMAN | [view interactions] | High throughput | no | yes |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| EDEM3_HUMAN | [view interactions] | High throughput | no | yes |
| ANKL2_HUMAN | [view interactions] | High throughput | no | yes |
| I17RA_HUMAN | [view interactions] | High throughput | no | yes |
| TMED4_HUMAN | [view interactions] | High throughput | no | yes |
| BCD1_HUMAN | [view interactions] | High throughput | no | yes |
| ABCF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANAG_HUMAN | [view interactions] | High throughput | no | no |
| SKP2_HUMAN | [view interactions] | High throughput | no | yes |
| DYR_HUMAN | [view interactions] | High throughput | no | yes |
| MARE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUN2_HUMAN | [view interactions] | High throughput | no | yes |
| LRP1B_HUMAN | [view interactions] | High throughput | no | yes |
| STXB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGA_HUMAN | [view interactions] | High throughput | no | yes |
| TOR3A_HUMAN | [view interactions] | High throughput | no | no |
| PGLT1_HUMAN | [view interactions] | High throughput | no | no |
| CTF18_HUMAN | [view interactions] | High throughput | no | no |
| DYHC2_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7E_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP6_HUMAN | [view interactions] | High throughput | no | yes |
| METH_HUMAN | [view interactions] | High throughput | no | yes |
| ARP8_HUMAN | [view interactions] | High throughput | no | no |
| P3H3_HUMAN | [view interactions] | High throughput | no | yes |
| COASY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APAF_HUMAN | [view interactions] | High throughput | no | no |
| DCC1_HUMAN | [view interactions] | High throughput | no | yes |
| PMVK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HYAL2_HUMAN | [view interactions] | High throughput | no | no |
| CHSTC_HUMAN | [view interactions] | High throughput | no | yes |
| ATS2_HUMAN | [view interactions] | High throughput | no | yes |
| ELF2_HUMAN | [view interactions] | High throughput | no | yes |
| APOA1_HUMAN | [view interactions] | High throughput | no | no |
| ADA11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PNMA2_HUMAN | [view interactions] | Computational | no | yes |
| KCNA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DPYL5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KCAB1_HUMAN | [view interactions] | Computational | no | no |
| ADA23_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ADA28_HUMAN | [view interactions] | Computational | no | no |
| CNTP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CNTN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |