LGI1_HUMAN
Evidence for PS localization
Functions
Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors . Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 26 | Leu | Arg | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 46 | Cys | Arg | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 383 | Glu | Ala | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 318 | Phe | Cys | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 42 | Cys | Gly | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 473 | Ser | Leu | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 42 | Cys | Arg | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 110 | Ala | Asp | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 122 | Ile | Lys | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 123 | Glu | Lys | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 136 | Arg | Trp | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 145 | Ser | Arg | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 154 | Leu | Pro | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 200 | Cys | Arg | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 232 | Leu | Pro | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 298 | Ile | Thr | Epilepsy,familialtemporallobe,1(ETL1) | - |
| 432 | Val | Glu | Epilepsy,familialtemporallobe,1(ETL1) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LGI1_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 40.0000 | 4 | no |
| GO:0005524 | ATP binding | 40.0000 | 5 | no |
| GO:0016301 | kinase activity | 40.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 40.0000 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 40.0000 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 40.0000 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 40.0000 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.0000 | 4 | no |
| GO:0043168 | anion binding | 40.0000 | 4 | no |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 33.3333 | 4 | no |
| GO:0019900 | kinase binding | 26.6667 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LGI1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 53.3333 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 53.3333 | 4 | yes |
| GO:0010646 | regulation of cell communication | 46.6667 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 46.6667 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0008104 | protein localization | 33.3333 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | yes |
| GO:0033365 | protein localization to organelle | 33.3333 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0050890 | cognition | 33.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 33.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 33.3333 | 4 | no |
| GO:0016310 | phosphorylation | 33.3333 | 5 | no |
| GO:0030030 | cell projection organization | 26.6667 | 4 | yes |
| GO:1990778 | protein localization to cell periphery | 26.6667 | 5 | yes |
| GO:0006996 | organelle organization | 26.6667 | 4 | no |
| GO:0007612 | learning | 26.6667 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 26.6667 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.6667 | 6 | no |
| GO:0022607 | cellular component assembly | 26.6667 | 4 | no |
| GO:0031399 | regulation of protein modification process | 26.6667 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.6667 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.6667 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.6667 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 26.6667 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.6667 | 5 | no |
| GO:0031175 | neuron projection development | 20.0000 | 6 | yes |
| GO:0072657 | protein localization to membrane | 20.0000 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.0000 | 5 | yes |
| GO:0001558 | regulation of cell growth | 13.3333 | 4 | yes |
| GO:0007399 | nervous system development | 13.3333 | 4 | yes |
| GO:0035418 | protein localization to synapse | 13.3333 | 6 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 13.3333 | 5 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 13.3333 | 5 | yes |
| GO:0062237 | protein localization to postsynapse | 13.3333 | 7 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 13.3333 | 4 | yes |
| GO:0099633 | protein localization to postsynaptic specialization membrane | 13.3333 | 6 | yes |
| GO:0099645 | neurotransmitter receptor localization to postsynaptic specialization membrane | 13.3333 | 4 | yes |
| GO:1902414 | protein localization to cell junction | 13.3333 | 5 | yes |
| GO:1903539 | protein localization to postsynaptic membrane | 13.3333 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ADA22_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC6_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUT11_HUMAN | [view interactions] | High throughput | no | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| STK39_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRP5_HUMAN | [view interactions] | High throughput | no | yes |
| DUS14_HUMAN | [view interactions] | High throughput | no | yes |
| ARSK_HUMAN | [view interactions] | High throughput | no | no |
| RAD17_HUMAN | [view interactions] | High throughput | no | yes |
| EOGT_HUMAN | [view interactions] | High throughput | no | yes |
| OXSR1_HUMAN | [view interactions] | High throughput | no | yes |
| BANP_HUMAN | [view interactions] | High throughput | no | yes |
| RGPD5_HUMAN | [view interactions] | High throughput | no | no |
| TRIPC_HUMAN | [view interactions] | High throughput | no | yes |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| EDEM3_HUMAN | [view interactions] | High throughput | no | yes |
| ANKL2_HUMAN | [view interactions] | High throughput | no | yes |
| I17RA_HUMAN | [view interactions] | High throughput | no | yes |
| TMED4_HUMAN | [view interactions] | High throughput | no | yes |
| BCD1_HUMAN | [view interactions] | High throughput | no | yes |
| ABCF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANAG_HUMAN | [view interactions] | High throughput | no | no |
| SKP2_HUMAN | [view interactions] | High throughput | no | yes |
| DYR_HUMAN | [view interactions] | High throughput | no | yes |
| MARE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUN2_HUMAN | [view interactions] | High throughput | no | yes |
| LRP1B_HUMAN | [view interactions] | High throughput | no | yes |
| STXB4_HUMAN | [view interactions] | High throughput | no | yes |
| OGA_HUMAN | [view interactions] | High throughput | no | yes |
| TOR3A_HUMAN | [view interactions] | High throughput | no | no |
| PGLT1_HUMAN | [view interactions] | High throughput | no | no |
| CTF18_HUMAN | [view interactions] | High throughput | no | no |
| DYHC2_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7E_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP6_HUMAN | [view interactions] | High throughput | no | yes |
| METH_HUMAN | [view interactions] | High throughput | no | yes |
| ARP8_HUMAN | [view interactions] | High throughput | no | no |
| P3H3_HUMAN | [view interactions] | High throughput | no | yes |
| COASY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APAF_HUMAN | [view interactions] | High throughput | no | no |
| DCC1_HUMAN | [view interactions] | High throughput | no | yes |
| PMVK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HYAL2_HUMAN | [view interactions] | High throughput | no | no |
| CHSTC_HUMAN | [view interactions] | High throughput | no | yes |
| ATS2_HUMAN | [view interactions] | High throughput | no | yes |
| ELF2_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| APOA1_HUMAN | [view interactions] | High throughput | no | no |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |