KCC4_HUMAN
Evidence for PS localization
Functions
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on Ser-133 in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KCC4_HUMAN |
|---|---|---|---|---|
| GO:0005524 | ATP binding | 36.0000 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 36.0000 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 36.0000 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 36.0000 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 36.0000 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 36.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 36.0000 | 4 | no |
| GO:0019900 | kinase binding | 32.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 32.0000 | 5 | no |
| GO:0004674 | protein serine/threonine kinase activity | 28.0000 | 4 | yes |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 28.0000 | 4 | yes |
| GO:0016301 | kinase activity | 28.0000 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 28.0000 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 28.0000 | 4 | yes |
| GO:0005509 | calcium ion binding | 24.0000 | 5 | no |
| GO:0004683 | calmodulin-dependent protein kinase activity | 16.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KCC4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 76.0000 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 60.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 60.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 60.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 60.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 56.0000 | 4 | no |
| GO:0051049 | regulation of transport | 48.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 48.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 44.0000 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 44.0000 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 44.0000 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 44.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 44.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 44.0000 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 44.0000 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 40.0000 | 7 | no |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 40.0000 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 40.0000 | 6 | no |
| GO:0051338 | regulation of transferase activity | 40.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 40.0000 | 5 | yes |
| GO:0043412 | macromolecule modification | 36.0000 | 4 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 36.0000 | 8 | no |
| GO:0009892 | negative regulation of metabolic process | 36.0000 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 36.0000 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 36.0000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 36.0000 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 36.0000 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 36.0000 | 8 | no |
| GO:0043085 | positive regulation of catalytic activity | 36.0000 | 4 | no |
| GO:0043549 | regulation of kinase activity | 36.0000 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 36.0000 | 6 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 36.0000 | 7 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 36.0000 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 36.0000 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 36.0000 | 5 | yes |
| GO:0036211 | protein modification process | 36.0000 | 4 | yes |
| GO:0051347 | positive regulation of transferase activity | 32.0000 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 32.0000 | 5 | no |
| GO:0010468 | regulation of gene expression | 32.0000 | 5 | yes |
| GO:0043269 | regulation of ion transport | 28.0000 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.0000 | 4 | no |
| GO:0051050 | positive regulation of transport | 28.0000 | 4 | no |
| GO:0033674 | positive regulation of kinase activity | 28.0000 | 6 | no |
| GO:0045860 | positive regulation of protein kinase activity | 28.0000 | 7 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.0000 | 5 | no |
| GO:0008104 | protein localization | 28.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 28.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.0000 | 4 | no |
| GO:0006468 | protein phosphorylation | 28.0000 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 28.0000 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.0000 | 5 | yes |
| GO:0016310 | phosphorylation | 28.0000 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 28.0000 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 24.0000 | 4 | yes |
| GO:0046777 | protein autophosphorylation | 24.0000 | 6 | yes |
| GO:0010941 | regulation of cell death | 24.0000 | 4 | no |
| GO:0010959 | regulation of metal ion transport | 24.0000 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 24.0000 | 4 | no |
| GO:0030334 | regulation of cell migration | 24.0000 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 24.0000 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 24.0000 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 24.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 24.0000 | 5 | no |
| GO:1904062 | regulation of cation transmembrane transport | 24.0000 | 6 | no |
| GO:2000145 | regulation of cell motility | 24.0000 | 4 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 24.0000 | 6 | no |
| GO:0042326 | negative regulation of phosphorylation | 24.0000 | 8 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 24.0000 | 7 | no |
| GO:0051248 | negative regulation of protein metabolic process | 24.0000 | 6 | no |
| GO:0033043 | regulation of organelle organization | 24.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.0000 | 4 | no |
| GO:0006996 | organelle organization | 24.0000 | 4 | no |
| GO:0030030 | cell projection organization | 24.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 24.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 24.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 24.0000 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.0000 | 6 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 20.0000 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.0000 | 6 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.0000 | 6 | yes |
| GO:0050890 | cognition | 16.0000 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 16.0000 | 5 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 16.0000 | 7 | yes |
| GO:2000026 | regulation of multicellular organismal development | 16.0000 | 4 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 16.0000 | 6 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 16.0000 | 6 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 8.0000 | 7 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 8.0000 | 6 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 8.0000 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 8.0000 | 8 | yes |
| GO:0007613 | memory | 8.0000 | 4 | yes |
| GO:0018105 | peptidyl-serine phosphorylation | 8.0000 | 6 | yes |
| GO:0018193 | peptidyl-amino acid modification | 8.0000 | 5 | yes |
| GO:0018209 | peptidyl-serine modification | 8.0000 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in KCC4_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 8.0000 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 8.0000 | 5 | no |
| DOID:114 | heart disease | 8.0000 | 3 | no |
| DOID:2843 | long QT syndrome | 8.0000 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HDAC4_HUMAN | [view interactions] | Low throughput | no | yes |
| CABIN_HUMAN | [view interactions] | Low throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PPM1E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NOTC1_HUMAN | [view interactions] | Low throughput | no | yes |
| SUH_HUMAN | [view interactions] | Low throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LGI1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| TCPQM_HUMAN | [view interactions] | High throughput | no | no |
| HNRC2_HUMAN | [view interactions] | High throughput | no | no |
| TRI17_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| ANR52_HUMAN | [view interactions] | High throughput | no | yes |
| GIT2_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIPK2_HUMAN | [view interactions] | High throughput | no | yes |
| FRK_HUMAN | [view interactions] | High throughput | no | no |
| GIT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KKCC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CKAP2_HUMAN | [view interactions] | High throughput | no | yes |
| ABTB2_HUMAN | [view interactions] | High throughput | no | yes |
| CARM1_HUMAN | [view interactions] | High throughput | no | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| H90B3_HUMAN | [view interactions] | High throughput | no | no |
| F110C_HUMAN | [view interactions] | High throughput | no | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NU153_HUMAN | [view interactions] | High throughput | no | yes |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| MCM3_HUMAN | [view interactions] | High throughput | no | no |
| RU1C_HUMAN | [view interactions] | High throughput | no | yes |
| PSMG1_HUMAN | [view interactions] | High throughput | no | yes |
| UBR5_HUMAN | [view interactions] | High throughput | no | no |
| STK10_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT1_HUMAN | [view interactions] | High throughput | no | yes |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KKCC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP6R2_HUMAN | [view interactions] | High throughput | no | no |
| CUL9_HUMAN | [view interactions] | High throughput | no | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| STMN1_HUMAN | [view interactions] | Computational | no | yes |
| MEF2A_HUMAN | [view interactions] | Computational | no | yes |
| NOS3_HUMAN | [view interactions] | Computational | no | no |
| 1433T_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GPS2_HUMAN | [view interactions] | Computational | no | yes |
| CALL3_HUMAN | [view interactions] | Computational | no | yes |
| EP300_HUMAN | [view interactions] | Computational | no | yes |
| CALL5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| IMA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CBP_HUMAN | [view interactions] | Computational | no | yes |
| CREB1_HUMAN | [view interactions] | Computational | no | yes |
| TBL1R_HUMAN | [view interactions] | Computational | no | yes |
| NCOR2_HUMAN | [view interactions] | Computational | no | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NCOR1_HUMAN | [view interactions] | Computational | no | yes |
| MEF2C_HUMAN | [view interactions] | Computational | no | yes |
| CALL6_HUMAN | [view interactions] | Computational | no | no |
| SRF_HUMAN | [view interactions] | Computational | no | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCG2_HUMAN | [view interactions] | Computational | no | yes |
| MECP2_HUMAN | [view interactions] | Computational | no | yes |
| HDAC5_HUMAN | [view interactions] | Computational | no | yes |
| HDAC3_HUMAN | [view interactions] | Computational | no | yes |
| MEF2D_HUMAN | [view interactions] | Computational | no | yes |