Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCC4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on Ser-133 in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KCC4_HUMAN
GO:0000166 nucleotide binding 43.4783 4 yes
GO:0017076 purine nucleotide binding 43.4783 5 yes
GO:0032555 purine ribonucleotide binding 43.4783 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 43.4783 4 yes
GO:0043168 anion binding 43.4783 4 yes
GO:0005524 ATP binding 39.1304 5 yes
GO:0030554 adenyl nucleotide binding 39.1304 6 yes
GO:0032559 adenyl ribonucleotide binding 39.1304 5 yes
GO:0043169 cation binding 34.7826 4 no
GO:0046872 metal ion binding 34.7826 5 no
GO:0004674 protein serine/threonine kinase activity 30.4348 4 yes
GO:0016301 kinase activity 30.4348 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 30.4348 4 yes
GO:0106310 protein serine kinase activity 30.4348 4 yes
GO:0019900 kinase binding 30.4348 4 no
GO:0019901 protein kinase binding 30.4348 5 no
GO:0005509 calcium ion binding 21.7391 6 no
GO:0004683 calmodulin-dependent protein kinase activity 17.3913 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KCC4_HUMAN
GO:0048522 positive regulation of cellular process 73.9130 4 yes
GO:0051128 regulation of cellular component organization 60.8696 4 no
GO:0031323 regulation of cellular metabolic process 56.5217 4 yes
GO:0060255 regulation of macromolecule metabolic process 56.5217 4 yes
GO:0080090 regulation of primary metabolic process 56.5217 4 yes
GO:0048523 negative regulation of cellular process 52.1739 4 no
GO:0009893 positive regulation of metabolic process 47.8261 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 47.8261 5 yes
GO:0051049 regulation of transport 47.8261 4 no
GO:0010646 regulation of cell communication 47.8261 4 no
GO:0031325 positive regulation of cellular metabolic process 43.4783 5 yes
GO:0019220 regulation of phosphate metabolic process 43.4783 6 no
GO:0051174 regulation of phosphorus metabolic process 43.4783 5 no
GO:0051246 regulation of protein metabolic process 43.4783 5 no
GO:0009966 regulation of signal transduction 43.4783 4 no
GO:0001932 regulation of protein phosphorylation 39.1304 7 no
GO:0009892 negative regulation of metabolic process 39.1304 4 no
GO:0010605 negative regulation of macromolecule metabolic process 39.1304 5 no
GO:0031399 regulation of protein modification process 39.1304 6 no
GO:0042325 regulation of phosphorylation 39.1304 7 no
GO:0051338 regulation of transferase activity 39.1304 4 no
GO:0051247 positive regulation of protein metabolic process 39.1304 6 no
GO:0006796 phosphate-containing compound metabolic process 34.7826 4 yes
GO:0009889 regulation of biosynthetic process 34.7826 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 34.7826 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 34.7826 5 yes
GO:0031326 regulation of cellular biosynthetic process 34.7826 5 yes
GO:0031324 negative regulation of cellular metabolic process 34.7826 5 no
GO:0043549 regulation of kinase activity 34.7826 5 no
GO:0045859 regulation of protein kinase activity 34.7826 6 no
GO:0001934 positive regulation of protein phosphorylation 34.7826 8 no
GO:0010562 positive regulation of phosphorus metabolic process 34.7826 6 no
GO:0031401 positive regulation of protein modification process 34.7826 7 no
GO:0042327 positive regulation of phosphorylation 34.7826 8 no
GO:0043085 positive regulation of catalytic activity 34.7826 4 no
GO:0045937 positive regulation of phosphate metabolic process 34.7826 7 no
GO:0048584 positive regulation of response to stimulus 34.7826 4 no
GO:0141124 intracellular signaling cassette 34.7826 4 no
GO:0010647 positive regulation of cell communication 34.7826 5 no
GO:0023056 positive regulation of signaling 34.7826 4 no
GO:0016310 phosphorylation 30.4348 5 yes
GO:0036211 protein modification process 30.4348 4 yes
GO:0043412 macromolecule modification 30.4348 4 yes
GO:0044087 regulation of cellular component biogenesis 30.4348 4 no
GO:0051130 positive regulation of cellular component organization 30.4348 5 no
GO:0071310 cellular response to organic substance 30.4348 4 no
GO:0006996 organelle organization 30.4348 4 no
GO:0008104 protein localization 30.4348 4 no
GO:0044057 regulation of system process 30.4348 4 no
GO:0051347 positive regulation of transferase activity 30.4348 5 no
GO:1902531 regulation of intracellular signal transduction 30.4348 5 no
GO:0009891 positive regulation of biosynthetic process 26.0870 5 yes
GO:0010468 regulation of gene expression 26.0870 6 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 26.0870 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 26.0870 6 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 26.0870 5 yes
GO:0010563 negative regulation of phosphorus metabolic process 26.0870 6 no
GO:0033043 regulation of organelle organization 26.0870 5 no
GO:0045936 negative regulation of phosphate metabolic process 26.0870 7 no
GO:0051248 negative regulation of protein metabolic process 26.0870 6 no
GO:0031344 regulation of cell projection organization 26.0870 5 no
GO:0033674 positive regulation of kinase activity 26.0870 6 no
GO:0045860 positive regulation of protein kinase activity 26.0870 7 no
GO:0051050 positive regulation of transport 26.0870 4 no
GO:0090257 regulation of muscle system process 26.0870 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.0870 6 no
GO:0043269 regulation of monoatomic ion transport 26.0870 5 no
GO:0009967 positive regulation of signal transduction 26.0870 5 no
GO:0006468 protein phosphorylation 21.7391 5 yes
GO:0045595 regulation of cell differentiation 21.7391 4 yes
GO:0001933 negative regulation of protein phosphorylation 21.7391 8 no
GO:0031400 negative regulation of protein modification process 21.7391 7 no
GO:0042326 negative regulation of phosphorylation 21.7391 8 no
GO:0051493 regulation of cytoskeleton organization 21.7391 6 no
GO:1901701 cellular response to oxygen-containing compound 21.7391 4 no
GO:0009894 regulation of catabolic process 21.7391 4 no
GO:0015031 protein transport 21.7391 4 no
GO:0022607 cellular component assembly 21.7391 4 no
GO:0042981 regulation of apoptotic process 21.7391 5 no
GO:0043067 regulation of programmed cell death 21.7391 4 no
GO:0060341 regulation of cellular localization 21.7391 4 no
GO:0071702 organic substance transport 21.7391 4 no
GO:0071705 nitrogen compound transport 21.7391 4 no
GO:0022603 regulation of anatomical structure morphogenesis 21.7391 4 no
GO:0030030 cell projection organization 21.7391 4 no
GO:0030334 regulation of cell migration 21.7391 5 no
GO:0051336 regulation of hydrolase activity 21.7391 4 no
GO:0051345 positive regulation of hydrolase activity 21.7391 5 no
GO:0120036 plasma membrane bounded cell projection organization 21.7391 5 no
GO:2000145 regulation of cell motility 21.7391 4 no
GO:0010038 response to metal ion 21.7391 4 no
GO:0010959 regulation of metal ion transport 21.7391 6 no
GO:0022898 regulation of transmembrane transporter activity 21.7391 4 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 21.7391 5 no
GO:0034762 regulation of transmembrane transport 21.7391 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 21.7391 5 no
GO:0051051 negative regulation of transport 21.7391 4 no
GO:0051726 regulation of cell cycle 21.7391 4 no
GO:0006355 regulation of DNA-templated transcription 17.3913 7 yes
GO:0050890 cognition 17.3913 4 yes
GO:0051252 regulation of RNA metabolic process 17.3913 5 yes
GO:2001141 regulation of RNA biosynthetic process 17.3913 6 yes
GO:0045893 positive regulation of DNA-templated transcription 13.0435 8 yes
GO:0051254 positive regulation of RNA metabolic process 13.0435 6 yes
GO:0060284 regulation of cell development 13.0435 5 yes
GO:1902680 positive regulation of RNA biosynthetic process 13.0435 7 yes
GO:2000026 regulation of multicellular organismal development 13.0435 4 yes
GO:0006954 inflammatory response 8.6957 4 yes
GO:0007613 memory 8.6957 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
PPM1E_HUMAN [view entry] [view interactions] Low throughput yes yes
NOTC1_HUMAN [view entry] [view interactions] Low throughput yes yes
SUH_HUMAN [view interactions] Low throughput no yes
HDAC4_HUMAN [view interactions] Low throughput no yes
CABIN_HUMAN [view interactions] Low throughput no yes
ANR28_HUMAN [view interactions] High throughput no no
ARHG7_HUMAN [view entry] [view interactions] High throughput yes yes
GIT2_HUMAN [view interactions] High throughput no yes
ANR52_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
RIPK2_HUMAN [view interactions] High throughput no yes
FRK_HUMAN [view interactions] High throughput no no
CNOT1_HUMAN [view interactions] High throughput no yes
STK10_HUMAN [view interactions] High throughput no yes
UBR5_HUMAN [view interactions] High throughput no no
PSMG1_HUMAN [view interactions] High throughput no yes
RU1C_HUMAN [view interactions] High throughput no yes
MCM3_HUMAN [view interactions] High throughput no no
MCM5_HUMAN [view interactions] High throughput no no
NU153_HUMAN [view interactions] High throughput no yes
GBB1_HUMAN [view entry] [view interactions] High throughput yes yes
RACK1_HUMAN [view interactions] High throughput no yes
F110C_HUMAN [view interactions] High throughput no yes
H90B3_HUMAN [view interactions] High throughput no no
CE170_HUMAN [view interactions] High throughput no yes
CARM1_HUMAN [view interactions] High throughput no yes
ABTB2_HUMAN [view interactions] High throughput no yes
CKAP2_HUMAN [view interactions] High throughput no yes
KKCC2_HUMAN [view entry] [view interactions] High throughput yes yes
SLK_HUMAN [view entry] [view interactions] High throughput yes yes
GIT1_HUMAN [view entry] [view interactions] High throughput yes yes
AAK1_HUMAN [view entry] [view interactions] High throughput yes yes
KKCC1_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
PP6R2_HUMAN [view interactions] High throughput no no
CUL9_HUMAN [view interactions] High throughput no no
CUL7_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
LGI1_HUMAN [view entry] [view interactions] High throughput yes no
GLPA_HUMAN [view interactions] High throughput no no
TCPQM_HUMAN [view interactions] High throughput no no
HNRC2_HUMAN [view interactions] High throughput no no
TRI17_HUMAN [view interactions] High throughput no yes
EFMT3_HUMAN [view interactions] High throughput no no
UBXN6_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
DCAF6_HUMAN [view interactions] High throughput no no
KCC2G_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
NAA40_HUMAN [view interactions] High throughput no no
ARF5_HUMAN [view entry] [view interactions] High throughput yes no
SAR1B_HUMAN [view interactions] High throughput no yes