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ARHG7_HUMAN

Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions . May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ARHG7_HUMAN
GO:0019900 kinase binding 29.8507 4 yes
GO:0019901 protein kinase binding 29.8507 5 yes
GO:0043169 cation binding 28.3582 4 no
GO:0046872 metal ion binding 28.3582 5 no
GO:0043168 anion binding 25.3731 4 no
GO:0000166 nucleotide binding 23.8806 4 no
GO:0017076 purine nucleotide binding 22.3881 5 no
GO:0032555 purine ribonucleotide binding 22.3881 4 no
GO:0035639 purine ribonucleoside triphosphate binding 20.8955 4 no
GO:0030695 GTPase regulator activity 13.4328 4 yes
GO:0005085 guanyl-nucleotide exchange factor activity 8.9552 5 yes
GO:0015631 tubulin binding 8.9552 4 yes
GO:0043015 gamma-tubulin binding 5.9701 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ARHG7_HUMAN
GO:0048523 negative regulation of cellular process 61.1940 4 yes
GO:0048522 positive regulation of cellular process 59.7015 4 yes
GO:0010646 regulation of cell communication 59.7015 4 no
GO:0060255 regulation of macromolecule metabolic process 56.7164 4 no
GO:0080090 regulation of primary metabolic process 55.2239 4 no
GO:0031323 regulation of cellular metabolic process 55.2239 4 no
GO:0009966 regulation of signal transduction 52.2388 4 no
GO:0051128 regulation of cellular component organization 46.2687 4 yes
GO:0009893 positive regulation of metabolic process 43.2836 4 no
GO:0010604 positive regulation of macromolecule metabolic process 41.7910 5 no
GO:0009892 negative regulation of metabolic process 38.8060 4 no
GO:0051246 regulation of protein metabolic process 37.3134 5 no
GO:0031324 negative regulation of cellular metabolic process 37.3134 5 no
GO:0031399 regulation of protein modification process 35.8209 6 no
GO:1902531 regulation of intracellular signal transduction 35.8209 5 no
GO:0006996 organelle organization 35.8209 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 35.8209 5 no
GO:0031325 positive regulation of cellular metabolic process 35.8209 5 no
GO:0009889 regulation of biosynthetic process 34.3284 4 no
GO:0031326 regulation of cellular biosynthetic process 34.3284 5 no
GO:0022607 cellular component assembly 32.8358 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 32.8358 5 no
GO:0051174 regulation of phosphorus metabolic process 31.3433 5 no
GO:0044087 regulation of cellular component biogenesis 31.3433 4 yes
GO:0010468 regulation of gene expression 31.3433 6 no
GO:0019220 regulation of phosphate metabolic process 31.3433 6 no
GO:0048584 positive regulation of response to stimulus 29.8507 4 no
GO:0008104 protein localization 29.8507 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.8507 5 no
GO:0033043 regulation of organelle organization 28.3582 5 yes
GO:0051493 regulation of cytoskeleton organization 28.3582 6 yes
GO:0042325 regulation of phosphorylation 26.8657 7 no
GO:0048585 negative regulation of response to stimulus 26.8657 4 no
GO:0030030 cell projection organization 26.8657 4 yes
GO:1902903 regulation of supramolecular fiber organization 26.8657 5 yes
GO:0001932 regulation of protein phosphorylation 26.8657 7 no
GO:0051247 positive regulation of protein metabolic process 25.3731 6 no
GO:0051248 negative regulation of protein metabolic process 25.3731 6 no
GO:0051049 regulation of transport 25.3731 4 no
GO:0031344 regulation of cell projection organization 25.3731 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.3731 6 yes
GO:0080134 regulation of response to stress 23.8806 4 no
GO:0042981 regulation of apoptotic process 23.8806 5 yes
GO:0043067 regulation of programmed cell death 23.8806 4 yes
GO:0120036 plasma membrane bounded cell projection organization 23.8806 5 yes
GO:0010648 negative regulation of cell communication 23.8806 5 no
GO:0023056 positive regulation of signaling 23.8806 4 no
GO:0023057 negative regulation of signaling 23.8806 4 no
GO:0031400 negative regulation of protein modification process 22.3881 7 no
GO:0032956 regulation of actin cytoskeleton organization 22.3881 5 no
GO:0032970 regulation of actin filament-based process 22.3881 4 no
GO:0045936 negative regulation of phosphate metabolic process 22.3881 7 no
GO:0051252 regulation of RNA metabolic process 22.3881 5 no
GO:0031401 positive regulation of protein modification process 22.3881 7 no
GO:0071310 cellular response to organic substance 22.3881 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 22.3881 4 yes
GO:0009891 positive regulation of biosynthetic process 22.3881 5 no
GO:0009968 negative regulation of signal transduction 22.3881 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.3881 6 no
GO:0010563 negative regulation of phosphorus metabolic process 22.3881 6 no
GO:0010647 positive regulation of cell communication 22.3881 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.3881 6 no
GO:0110053 regulation of actin filament organization 20.8955 6 no
GO:0007010 cytoskeleton organization 20.8955 5 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 20.8955 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 20.8955 4 yes
GO:0030155 regulation of cell adhesion 20.8955 4 yes
GO:0051130 positive regulation of cellular component organization 20.8955 5 yes
GO:0141124 intracellular signaling cassette 20.8955 4 yes
GO:0030334 regulation of cell migration 17.9104 5 yes
GO:0043254 regulation of protein-containing complex assembly 17.9104 5 yes
GO:2000145 regulation of cell motility 17.9104 4 yes
GO:0032271 regulation of protein polymerization 16.4179 6 yes
GO:0034330 cell junction organization 16.4179 4 yes
GO:0043085 positive regulation of catalytic activity 16.4179 4 yes
GO:0051129 negative regulation of cellular component organization 16.4179 5 yes
GO:0030335 positive regulation of cell migration 14.9254 6 yes
GO:0040017 positive regulation of locomotion 14.9254 4 yes
GO:0051094 positive regulation of developmental process 14.9254 4 yes
GO:0051336 regulation of hydrolase activity 14.9254 4 yes
GO:2000147 positive regulation of cell motility 14.9254 5 yes
GO:0030031 cell projection assembly 13.4328 5 yes
GO:0010639 negative regulation of organelle organization 11.9403 6 yes
GO:0010810 regulation of cell-substrate adhesion 11.9403 5 yes
GO:0034329 cell junction assembly 11.9403 5 yes
GO:0043065 positive regulation of apoptotic process 11.9403 6 yes
GO:0043068 positive regulation of programmed cell death 11.9403 5 yes
GO:0045785 positive regulation of cell adhesion 11.9403 5 yes
GO:0051345 positive regulation of hydrolase activity 11.9403 5 yes
GO:0007264 small GTPase-mediated signal transduction 10.4478 5 yes
GO:0031346 positive regulation of cell projection organization 10.4478 6 yes
GO:0048013 ephrin receptor signaling pathway 10.4478 6 yes
GO:0051494 negative regulation of cytoskeleton organization 10.4478 7 yes
GO:0120031 plasma membrane bounded cell projection assembly 10.4478 6 yes
GO:1902904 negative regulation of supramolecular fiber organization 10.4478 6 yes
GO:0010811 positive regulation of cell-substrate adhesion 8.9552 6 yes
GO:0022604 regulation of cell morphogenesis 8.9552 5 yes
GO:0031110 regulation of microtubule polymerization or depolymerization 8.9552 6 yes
GO:0032886 regulation of microtubule-based process 8.9552 4 yes
GO:0070507 regulation of microtubule cytoskeleton organization 8.9552 5 yes
GO:1900024 regulation of substrate adhesion-dependent cell spreading 8.9552 6 yes
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 8.9552 7 yes
GO:1902743 regulation of lamellipodium organization 8.9552 7 yes
GO:1902745 positive regulation of lamellipodium organization 8.9552 7 yes
GO:0007030 Golgi organization 7.4627 5 yes
GO:0031113 regulation of microtubule polymerization 7.4627 6 yes
GO:0010968 regulation of microtubule nucleation 5.9701 7 yes
GO:0030032 lamellipodium assembly 5.9701 7 yes
GO:0043087 regulation of GTPase activity 5.9701 5 yes
GO:0097581 lamellipodium organization 5.9701 6 yes
GO:0150115 cell-substrate junction organization 5.9701 5 yes
GO:0007044 cell-substrate junction assembly 4.4776 6 yes
GO:0007266 Rho protein signal transduction 4.4776 6 yes
GO:0010762 regulation of fibroblast migration 4.4776 6 yes
GO:0031111 negative regulation of microtubule polymerization or depolymerization 4.4776 7 yes
GO:0031333 negative regulation of protein-containing complex assembly 4.4776 6 yes
GO:0043547 positive regulation of GTPase activity 4.4776 6 yes
GO:0048041 focal adhesion assembly 4.4776 7 yes
GO:0007399 nervous system development 2.9851 4 yes
GO:0010763 positive regulation of fibroblast migration 2.9851 7 yes
GO:0031115 negative regulation of microtubule polymerization 2.9851 7 yes
GO:0032272 negative regulation of protein polymerization 2.9851 7 yes
GO:1905833 negative regulation of microtubule nucleation 2.9851 8 yes
GO:2000392 regulation of lamellipodium morphogenesis 2.9851 6 yes
GO:2000394 positive regulation of lamellipodium morphogenesis 2.9851 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PAK2_HUMAN [view entry] [view interactions] Low throughput yes no
SCRIB_HUMAN [view entry] [view interactions] Low throughput yes no
CBLB_HUMAN [view entry] [view interactions] Low throughput yes yes
GIT2_HUMAN [view interactions] Low throughput no yes
PAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
SH21A_HUMAN [view interactions] Low throughput no no
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
CBL_HUMAN [view interactions] Low throughput no yes
NAA10_HUMAN [view interactions] Low throughput no yes
LRRK2_HUMAN [view interactions] Low throughput no yes
PARVB_HUMAN [view interactions] Low throughput no no
CD244_HUMAN [view interactions] Low throughput no no
SRGP1_HUMAN [view interactions] Low throughput no no
2AAA_HUMAN [view entry] [view interactions] Low throughput yes no
PAXI_HUMAN [view interactions] Low throughput no yes
ARHG6_HUMAN [view interactions] Low throughput no no
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
SL9A3_HUMAN [view interactions] Low throughput no yes
CSKP_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
SHAN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN2_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] Low throughput no no
PAK3_HUMAN [view entry] [view interactions] Low throughput yes no
ARHG7_HUMAN [view entry] [view interactions] Low throughput yes yes
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
ITCH_HUMAN [view interactions] Low throughput no yes
KLHL2_HUMAN [view interactions] Low throughput no no
IGBP1_HUMAN [view interactions] Low throughput no yes
LATS1_HUMAN [view entry] [view interactions] Low throughput yes yes
PPM1E_HUMAN [view entry] [view interactions] Low throughput yes yes
PPM1F_HUMAN [view interactions] Low throughput no yes
NOX1_HUMAN [view interactions] Low throughput no no
KPCG_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRB3_HUMAN [view entry] [view interactions] Low throughput yes no
TMG4_HUMAN [view interactions] High throughput no yes
ITPA_HUMAN [view interactions] High throughput no yes
TZAP_HUMAN [view interactions] High throughput no no
ACATN_HUMAN [view interactions] High throughput no yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
POTB3_HUMAN [view interactions] High throughput no no
ICAM1_HUMAN [view interactions] High throughput no no
INAVA_HUMAN [view interactions] High throughput no yes
FBX28_HUMAN [view interactions] High throughput no yes
KCC4_HUMAN [view entry] [view interactions] High throughput yes yes
LPXN_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CENPC_HUMAN [view interactions] High throughput no no
MED4_HUMAN [view interactions] High throughput no yes
MAST1_HUMAN [view interactions] High throughput no yes
ADA15_HUMAN [view interactions] High throughput no yes
MCM7_HUMAN [view interactions] High throughput no no
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC5_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
CK5P2_HUMAN [view interactions] High throughput no yes
MEOX2_HUMAN [view interactions] High throughput no no
TBB4A_HUMAN [view interactions] High throughput no yes
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
SMAD3_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
SKP1_HUMAN [view interactions] High throughput no yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
CERS2_HUMAN [view interactions] High throughput no no
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
SMAD2_HUMAN [view interactions] High throughput no yes
SMAD4_HUMAN [view interactions] High throughput no yes
SMUF1_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
SPN90_HUMAN [view entry] [view interactions] High throughput yes no
EXOC1_HUMAN [view entry] [view interactions] High throughput yes yes
SYNCI_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
MTOR_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
KPCD2_HUMAN [view interactions] High throughput no yes
HDAC2_HUMAN [view interactions] High throughput no yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
TIM13_HUMAN [view interactions] High throughput no yes
KAISO_HUMAN [view interactions] High throughput no yes
PSB6_HUMAN [view entry] [view interactions] High throughput yes yes
RUXF_HUMAN [view interactions] High throughput no no
ERLN1_HUMAN [view entry] [view interactions] High throughput yes yes
MYL6B_HUMAN [view entry] [view interactions] High throughput yes no
ZYX_HUMAN [view interactions] High throughput no no
TRIO_HUMAN [view entry] [view interactions] High throughput yes yes
AKT3_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
UBP1_HUMAN [view interactions] High throughput no yes
WDR48_HUMAN [view entry] [view interactions] High throughput yes yes
PHLP1_HUMAN [view interactions] High throughput no yes
FOXO3_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
IMA5_HUMAN [view entry] [view interactions] High throughput yes yes
PFD1_HUMAN [view interactions] High throughput no yes
TM154_HUMAN [view interactions] High throughput no no
NHRF2_HUMAN [view interactions] High throughput no no
ZNHI1_HUMAN [view interactions] High throughput no yes
TX1B3_HUMAN [view interactions] High throughput no no
KLHL1_HUMAN [view interactions] High throughput no no
CENPQ_HUMAN [view interactions] High throughput no yes
TPC2L_HUMAN [view interactions] High throughput no yes
ATIF1_HUMAN [view interactions] High throughput no yes
TPPC4_HUMAN [view entry] [view interactions] High throughput yes yes
TPP2_HUMAN [view interactions] High throughput no yes
PYGM_HUMAN [view entry] [view interactions] High throughput yes no
DNPEP_HUMAN [view interactions] High throughput no yes
RFX1_HUMAN [view interactions] High throughput no yes
ADSSP_HUMAN [view interactions] High throughput no yes
ACOX3_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOU_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
REPS1_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
SPRNG_HUMAN [view interactions] High throughput no yes
MBP_HUMAN [view entry] [view interactions] High throughput yes no
ERBIN_HUMAN [view entry] [view interactions] High throughput yes yes
KDM2A_HUMAN [view interactions] High throughput no yes
RHG15_HUMAN [view interactions] High throughput no no
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
CHIO_HUMAN [view interactions] High throughput no yes
FGD4_HUMAN [view entry] [view interactions] High throughput yes yes
GLI1_HUMAN [view interactions] High throughput no no
GLI2_HUMAN [view interactions] High throughput no yes
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
PREX1_HUMAN [view entry] [view interactions] High throughput yes no
PREX2_HUMAN [view interactions] High throughput no no
PRIC1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIC2_HUMAN [view entry] [view interactions] High throughput yes no
SRBS1_HUMAN [view entry] [view interactions] High throughput yes yes
SRBS2_HUMAN [view entry] [view interactions] High throughput yes no
TIM44_HUMAN [view interactions] High throughput no yes
VAV_HUMAN [view interactions] High throughput no no
VINEX_HUMAN [view interactions] High throughput no no
TPR_HUMAN [view interactions] High throughput no yes
BASP1_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
SMRC2_HUMAN [view interactions] High throughput no yes
SMRC1_HUMAN [view interactions] High throughput no yes
EMAL4_HUMAN [view interactions] High throughput no yes
BRSK2_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no