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ARHG7_HUMAN

Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions . May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ARHG7_HUMAN
GO:0019900 kinase binding 32.9268 4 yes
GO:0019901 protein kinase binding 32.9268 5 yes
GO:0046872 metal ion binding 25.6098 4 no
GO:0017076 purine nucleotide binding 25.6098 4 no
GO:0032555 purine ribonucleotide binding 25.6098 4 no
GO:0035639 purine ribonucleoside triphosphate binding 24.3902 4 no
GO:0030695 GTPase regulator activity 10.9756 4 yes
GO:0015631 tubulin binding 8.5366 4 yes
GO:0005085 guanyl-nucleotide exchange factor activity 7.3171 5 yes
GO:0043015 gamma-tubulin binding 4.8780 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ARHG7_HUMAN
GO:0048522 positive regulation of cellular process 67.0732 4 yes
GO:0048523 negative regulation of cellular process 56.0976 4 yes
GO:0010646 regulation of cell communication 54.8780 4 no
GO:0031323 regulation of cellular metabolic process 54.8780 4 no
GO:0060255 regulation of macromolecule metabolic process 52.4390 4 no
GO:0080090 regulation of primary metabolic process 51.2195 4 no
GO:0051171 regulation of nitrogen compound metabolic process 48.7805 4 no
GO:0051128 regulation of cellular component organization 47.5610 4 yes
GO:0009966 regulation of signal transduction 47.5610 4 no
GO:0009893 positive regulation of metabolic process 42.6829 4 no
GO:0010604 positive regulation of macromolecule metabolic process 41.4634 5 no
GO:0031325 positive regulation of cellular metabolic process 37.8049 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 36.5854 5 no
GO:0051246 regulation of protein metabolic process 36.5854 5 no
GO:1902531 regulation of intracellular signal transduction 36.5854 5 no
GO:0006996 organelle organization 32.9268 4 yes
GO:0031399 regulation of protein modification process 32.9268 6 no
GO:0051049 regulation of transport 32.9268 4 no
GO:0019220 regulation of phosphate metabolic process 31.7073 6 no
GO:0051174 regulation of phosphorus metabolic process 31.7073 5 no
GO:0048584 positive regulation of response to stimulus 31.7073 4 no
GO:0010941 regulation of cell death 30.4878 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 30.4878 4 yes
GO:0022607 cellular component assembly 30.4878 4 yes
GO:0009892 negative regulation of metabolic process 30.4878 4 no
GO:0042981 regulation of apoptotic process 29.2683 6 yes
GO:0043067 regulation of programmed cell death 29.2683 5 yes
GO:0042325 regulation of phosphorylation 29.2683 7 no
GO:0010468 regulation of gene expression 29.2683 5 no
GO:0008104 protein localization 29.2683 4 no
GO:0030030 cell projection organization 28.0488 4 yes
GO:0044087 regulation of cellular component biogenesis 28.0488 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 28.0488 5 no
GO:0051247 positive regulation of protein metabolic process 28.0488 6 no
GO:0030155 regulation of cell adhesion 26.8293 4 yes
GO:0033043 regulation of organelle organization 26.8293 5 yes
GO:0045595 regulation of cell differentiation 26.8293 4 yes
GO:0120036 plasma membrane bounded cell projection organization 26.8293 5 yes
GO:0001932 regulation of protein phosphorylation 26.8293 7 no
GO:0009889 regulation of biosynthetic process 26.8293 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.8293 5 no
GO:0031326 regulation of cellular biosynthetic process 26.8293 5 no
GO:0031344 regulation of cell projection organization 25.6098 5 yes
GO:0043085 positive regulation of catalytic activity 25.6098 4 yes
GO:0051130 positive regulation of cellular component organization 25.6098 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.6098 6 yes
GO:0031324 negative regulation of cellular metabolic process 25.6098 5 no
GO:0080134 regulation of response to stress 25.6098 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 24.3902 4 yes
GO:0051493 regulation of cytoskeleton organization 24.3902 6 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 24.3902 5 no
GO:0023056 positive regulation of signaling 24.3902 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 23.1707 5 yes
GO:0051094 positive regulation of developmental process 23.1707 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 23.1707 5 no
GO:0010647 positive regulation of cell communication 23.1707 5 no
GO:0036211 protein modification process 23.1707 4 no
GO:0043412 macromolecule modification 23.1707 4 no
GO:0071310 cellular response to organic substance 23.1707 4 no
GO:0010562 positive regulation of phosphorus metabolic process 21.9512 6 no
GO:0031401 positive regulation of protein modification process 21.9512 7 no
GO:0042327 positive regulation of phosphorylation 21.9512 8 no
GO:0045937 positive regulation of phosphate metabolic process 21.9512 7 no
GO:0051248 negative regulation of protein metabolic process 21.9512 6 no
GO:0048585 negative regulation of response to stimulus 21.9512 4 no
GO:0006796 phosphate-containing compound metabolic process 21.9512 4 no
GO:0007010 cytoskeleton organization 21.9512 5 no
GO:0051336 regulation of hydrolase activity 20.7317 4 yes
GO:0001934 positive regulation of protein phosphorylation 20.7317 8 no
GO:0051050 positive regulation of transport 20.7317 4 no
GO:0030334 regulation of cell migration 19.5122 5 yes
GO:1902903 regulation of supramolecular fiber organization 19.5122 5 yes
GO:2000145 regulation of cell motility 19.5122 4 yes
GO:0010942 positive regulation of cell death 18.2927 5 yes
GO:0034330 cell junction organization 17.0732 4 yes
GO:0043065 positive regulation of apoptotic process 17.0732 7 yes
GO:0043068 positive regulation of programmed cell death 17.0732 6 yes
GO:0045785 positive regulation of cell adhesion 17.0732 5 yes
GO:0022604 regulation of cell morphogenesis 15.8537 5 yes
GO:0030335 positive regulation of cell migration 15.8537 6 yes
GO:0040017 positive regulation of locomotion 15.8537 4 yes
GO:0045597 positive regulation of cell differentiation 15.8537 5 yes
GO:0051345 positive regulation of hydrolase activity 15.8537 5 yes
GO:0060284 regulation of cell development 15.8537 5 yes
GO:2000147 positive regulation of cell motility 15.8537 5 yes
GO:0010810 regulation of cell-substrate adhesion 14.6341 5 yes
GO:0031346 positive regulation of cell projection organization 14.6341 6 yes
GO:0043254 regulation of protein-containing complex assembly 14.6341 5 yes
GO:0051129 negative regulation of cellular component organization 14.6341 5 yes
GO:0010720 positive regulation of cell development 13.4146 6 yes
GO:0030031 cell projection assembly 13.4146 5 yes
GO:0048013 ephrin receptor signaling pathway 13.4146 6 yes
GO:0032271 regulation of protein polymerization 12.1951 6 yes
GO:0034329 cell junction assembly 12.1951 5 yes
GO:0043087 regulation of GTPase activity 10.9756 5 yes
GO:0120031 plasma membrane bounded cell projection assembly 10.9756 6 yes
GO:0010769 regulation of cell morphogenesis involved in differentiation 9.7561 6 yes
GO:0010811 positive regulation of cell-substrate adhesion 9.7561 6 yes
GO:0010639 negative regulation of organelle organization 8.5366 6 yes
GO:0010770 positive regulation of cell morphogenesis involved in differentiation 8.5366 7 yes
GO:0032886 regulation of microtubule-based process 8.5366 4 yes
GO:1900024 regulation of substrate adhesion-dependent cell spreading 8.5366 6 yes
GO:1902743 regulation of lamellipodium organization 8.5366 7 yes
GO:1902745 positive regulation of lamellipodium organization 8.5366 7 yes
GO:0010762 regulation of fibroblast migration 7.3171 6 yes
GO:0031110 regulation of microtubule polymerization or depolymerization 7.3171 6 yes
GO:0043547 positive regulation of GTPase activity 7.3171 6 yes
GO:0051494 negative regulation of cytoskeleton organization 7.3171 7 yes
GO:0070507 regulation of microtubule cytoskeleton organization 7.3171 5 yes
GO:0097581 lamellipodium organization 7.3171 6 yes
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 7.3171 7 yes
GO:1902904 negative regulation of supramolecular fiber organization 7.3171 6 yes
GO:0007030 Golgi organization 6.0976 5 yes
GO:0007044 cell-substrate junction assembly 6.0976 6 yes
GO:0010763 positive regulation of fibroblast migration 6.0976 7 yes
GO:0030032 lamellipodium assembly 6.0976 7 yes
GO:0031113 regulation of microtubule polymerization 6.0976 6 yes
GO:0048041 focal adhesion assembly 6.0976 7 yes
GO:0150115 cell-substrate junction organization 6.0976 5 yes
GO:0007399 nervous system development 4.8780 4 yes
GO:0010968 regulation of microtubule nucleation 4.8780 7 yes
GO:0031333 negative regulation of protein-containing complex assembly 4.8780 6 yes
GO:0031111 negative regulation of microtubule polymerization or depolymerization 3.6585 7 yes
GO:2000392 regulation of lamellipodium morphogenesis 3.6585 6 yes
GO:2000394 positive regulation of lamellipodium morphogenesis 3.6585 5 yes
GO:0031115 negative regulation of microtubule polymerization 2.4390 7 yes
GO:0032272 negative regulation of protein polymerization 2.4390 7 yes
GO:1904424 regulation of GTP binding 2.4390 4 yes
GO:1905833 negative regulation of microtubule nucleation 2.4390 8 yes

Disease

Term Name % Distance from top the of the tree Annotated in ARHG7_HUMAN
DOID:0060038 specific developmental disorder 3.6585 3 no
DOID:1059 intellectual disability 3.6585 4 no
DOID:440 neuromuscular disease 3.6585 5 no
DOID:574 peripheral nervous system disease 3.6585 3 no
DOID:870 neuropathy 3.6585 4 no
DOID:0050700 cardiomyopathy 2.4390 4 no
DOID:0060036 intrinsic cardiomyopathy 2.4390 5 no
DOID:114 heart disease 2.4390 3 no
DOID:2843 long QT syndrome 2.4390 6 no
DOID:0060307 autosomal dominant intellectual developmental disorder 2.4390 5 no
DOID:0111962 combined immunodeficiency 2.4390 4 no
DOID:612 primary immunodeficiency disease 2.4390 3 no
DOID:10595 Charcot-Marie-Tooth disease 2.4390 6 no
DOID:331 central nervous system disease 2.4390 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PAK2_HUMAN [view entry] [view interactions] Low throughput yes no
SCRIB_HUMAN [view entry] [view interactions] Low throughput yes no
CBLB_HUMAN [view interactions] Low throughput no yes
GIT2_HUMAN [view interactions] Low throughput no yes
PAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
SH21A_HUMAN [view interactions] Low throughput no no
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
CBL_HUMAN [view interactions] Low throughput no yes
NAA10_HUMAN [view interactions] Low throughput no yes
LRRK2_HUMAN [view interactions] Low throughput no yes
PARVB_HUMAN [view interactions] Low throughput no no
CD244_HUMAN [view interactions] Low throughput no no
SRGP1_HUMAN [view interactions] Low throughput no no
2AAA_HUMAN [view entry] [view interactions] Low throughput yes no
PAXI_HUMAN [view interactions] Low throughput no yes
ARHG6_HUMAN [view interactions] Low throughput no no
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
CSKP_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
SHAN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN2_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] Low throughput no no
PAK3_HUMAN [view entry] [view interactions] Low throughput yes no
ARHG7_HUMAN [view entry] [view interactions] Low throughput yes yes
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
ITCH_HUMAN [view interactions] Low throughput no yes
KLHL2_HUMAN [view interactions] Low throughput no no
IGBP1_HUMAN [view interactions] Low throughput no yes
LATS1_HUMAN [view interactions] Low throughput no yes
PPM1E_HUMAN [view entry] [view interactions] Low throughput yes yes
PPM1F_HUMAN [view interactions] Low throughput no yes
NOX1_HUMAN [view interactions] Low throughput no no
KPCG_HUMAN [view entry] [view interactions] Low throughput yes yes
GBRB3_HUMAN [view entry] [view interactions] Low throughput yes no
TMG4_HUMAN [view interactions] High throughput no yes
ITPA_HUMAN [view interactions] High throughput no yes
TZAP_HUMAN [view interactions] High throughput no no
ACATN_HUMAN [view interactions] High throughput no yes
NCK2_HUMAN [view entry] [view interactions] High throughput yes yes
POTB3_HUMAN [view interactions] High throughput no no
ICAM1_HUMAN [view interactions] High throughput no no
INAVA_HUMAN [view interactions] High throughput no yes
FBX28_HUMAN [view interactions] High throughput no yes
KCC4_HUMAN [view entry] [view interactions] High throughput yes yes
LPXN_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CENPC_HUMAN [view interactions] High throughput no no
MED4_HUMAN [view interactions] High throughput no yes
MAST1_HUMAN [view interactions] High throughput no yes
ADA15_HUMAN [view interactions] High throughput no yes
MCM7_HUMAN [view interactions] High throughput no no
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC5_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
MEOX2_HUMAN [view interactions] High throughput no no
TBB4A_HUMAN [view interactions] High throughput no yes
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
SMAD3_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
SKP1_HUMAN [view interactions] High throughput no yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
CERS2_HUMAN [view interactions] High throughput no no
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
SMAD2_HUMAN [view interactions] High throughput no yes
SMAD4_HUMAN [view interactions] High throughput no yes
SMUF1_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
SPN90_HUMAN [view entry] [view interactions] High throughput yes no
EXOC1_HUMAN [view entry] [view interactions] High throughput yes yes
SYNCI_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
MTOR_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
KPCD2_HUMAN [view interactions] High throughput no yes
HDAC2_HUMAN [view interactions] High throughput no yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
TIM13_HUMAN [view interactions] High throughput no yes
KAISO_HUMAN [view interactions] High throughput no yes
PSB6_HUMAN [view entry] [view interactions] High throughput yes yes
RUXF_HUMAN [view interactions] High throughput no no
ERLN1_HUMAN [view entry] [view interactions] High throughput yes yes
MYL6B_HUMAN [view entry] [view interactions] High throughput yes no
ZYX_HUMAN [view interactions] High throughput no no
TRIO_HUMAN [view entry] [view interactions] High throughput yes yes
AKT3_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
UBP1_HUMAN [view interactions] High throughput no yes
WDR48_HUMAN [view entry] [view interactions] High throughput yes yes
PHLP1_HUMAN [view interactions] High throughput no yes
FOXO3_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
IMA5_HUMAN [view entry] [view interactions] High throughput yes yes
PFD1_HUMAN [view interactions] High throughput no yes
TM154_HUMAN [view interactions] High throughput no no
NHRF2_HUMAN [view entry] [view interactions] High throughput yes no
ZNHI1_HUMAN [view interactions] High throughput no yes
TX1B3_HUMAN [view interactions] High throughput no no
KLHL1_HUMAN [view interactions] High throughput no no
CENPQ_HUMAN [view interactions] High throughput no yes
TPC2L_HUMAN [view interactions] High throughput no yes
ATIF1_HUMAN [view interactions] High throughput no yes
TPPC4_HUMAN [view entry] [view interactions] High throughput yes yes
TPP2_HUMAN [view interactions] High throughput no yes
PYGM_HUMAN [view entry] [view interactions] High throughput yes no
DNPEP_HUMAN [view interactions] High throughput no yes
RFX1_HUMAN [view interactions] High throughput no yes
CT027_HUMAN [view interactions] High throughput no yes
ACOX3_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOU_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
REPS1_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
SPRNG_HUMAN [view interactions] High throughput no yes
MBP_HUMAN [view entry] [view interactions] High throughput yes no
ERBIN_HUMAN [view entry] [view interactions] High throughput yes yes
KDM2A_HUMAN [view interactions] High throughput no yes
RHG15_HUMAN [view interactions] High throughput no no
RHG21_HUMAN [view entry] [view interactions] High throughput yes yes
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
CHIO_HUMAN [view interactions] High throughput no yes
FGD4_HUMAN [view entry] [view interactions] High throughput yes yes
GLI1_HUMAN [view interactions] High throughput no no
GLI2_HUMAN [view interactions] High throughput no yes
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
PREX1_HUMAN [view entry] [view interactions] High throughput yes no
PREX2_HUMAN [view interactions] High throughput no no
PRIC1_HUMAN [view interactions] High throughput no yes
PRIC2_HUMAN [view entry] [view interactions] High throughput yes no
SRBS1_HUMAN [view entry] [view interactions] High throughput yes yes
SRBS2_HUMAN [view entry] [view interactions] High throughput yes no
TIM44_HUMAN [view interactions] High throughput no yes
VAV_HUMAN [view interactions] High throughput no no
VINEX_HUMAN [view interactions] High throughput no no
LAMB2_HUMAN [view interactions] Computational no yes
S12A5_HUMAN [view entry] [view interactions] Computational yes yes
LAMC3_HUMAN [view interactions] Computational no no
LAMA1_HUMAN [view interactions] Computational no no
KCC1A_HUMAN [view entry] [view interactions] Computational yes yes
PAK4_HUMAN [view interactions] Computational no yes
ARHG1_HUMAN [view interactions] Computational no no
LAMA2_HUMAN [view interactions] Computational no no
LAMA3_HUMAN [view interactions] Computational no no
SRC_HUMAN [view entry] [view interactions] Computational yes no
ARHGC_HUMAN [view interactions] Computational no yes
YES_HUMAN [view entry] [view interactions] Computational yes yes
LAMB3_HUMAN [view interactions] Computational no yes
ACHA_HUMAN [view entry] [view interactions] Computational yes no
RAPSN_HUMAN [view entry] [view interactions] Computational yes no
LAMC1_HUMAN [view interactions] Computational no yes
DAG1_HUMAN [view entry] [view interactions] Computational yes no
ITB1_HUMAN [view entry] [view interactions] Computational yes no
UTRN_HUMAN [view entry] [view interactions] Computational yes yes
FAK1_HUMAN [view entry] [view interactions] Computational yes yes
ITA1_HUMAN [view interactions] Computational no yes
ML12A_HUMAN [view interactions] Computational no no
PLCG1_HUMAN [view entry] [view interactions] Computational yes yes
LAMB1_HUMAN [view interactions] Computational no yes
FYN_HUMAN [view entry] [view interactions] Computational yes no
LCK_HUMAN [view entry] [view interactions] Computational yes no
AGRIN_HUMAN [view entry] [view interactions] Computational yes yes
AURKA_HUMAN [view entry] [view interactions] Computational yes no
ACM1_HUMAN [view entry] [view interactions] Computational yes yes
SRC8_HUMAN [view entry] [view interactions] Computational yes yes
GDIR1_HUMAN [view entry] [view interactions] Computational yes yes
LAMC2_HUMAN [view interactions] Computational no no
TF65_HUMAN [view entry] [view interactions] Computational yes yes
LAMA5_HUMAN [view entry] [view interactions] Computational yes no
ILK_HUMAN [view interactions] Computational no no
PAK5_HUMAN [view interactions] Computational no yes
ACTS_HUMAN [view interactions] Computational no no