PYGM_HUMAN
Evidence for PS localization
Functions
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 205 | Gly | Ser | Glycogenstoragedisease5(GSD5) | - |
| 397 | Leu | Pro | Glycogenstoragedisease5(GSD5) | - |
| 543 | Lys | Thr | Glycogenstoragedisease5(GSD5) | - |
| 655 | Glu | Lys | Glycogenstoragedisease5(GSD5) | - |
| 116 | Leu | Pro | Glycogenstoragedisease5(GSD5) | - |
| 194 | Arg | Trp | Glycogenstoragedisease5(GSD5) | - |
| 292 | Leu | Pro | Glycogenstoragedisease5(GSD5) | - |
| 349 | Glu | Lys | Glycogenstoragedisease5(GSD5) | - |
| 488 | Thr | Asn | Glycogenstoragedisease5(GSD5) | - |
| 602 | Arg | Trp | Glycogenstoragedisease5(GSD5) | - |
| 660 | Ala | Asp | Glycogenstoragedisease5(GSD5) | - |
| 666 | Gln | Glu | Glycogenstoragedisease5(GSD5) | - |
| 685 | Asn | Tyr | Glycogenstoragedisease5(GSD5) | - |
| 686 | Gly | Arg | Glycogenstoragedisease5(GSD5) | - |
| 687 | Ala | Pro | Glycogenstoragedisease5(GSD5) | - |
| 704 | Ala | Val | Glycogenstoragedisease5(GSD5) | - |
| 798 | Trp | Arg | Glycogenstoragedisease5(GSD5) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PYGM_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 34.7826 | 4 | no |
| GO:0019900 | kinase binding | 30.4348 | 4 | no |
| GO:0019901 | protein kinase binding | 26.0870 | 5 | no |
| GO:0015631 | tubulin binding | 21.7391 | 4 | no |
| GO:0016758 | hexosyltransferase activity | 13.0435 | 4 | yes |
| GO:0004645 | 1,4-alpha-oligoglucan phosphorylase activity | 8.6957 | 5 | yes |
| GO:0008184 | glycogen phosphorylase activity | 8.6957 | 6 | yes |
| GO:0030170 | pyridoxal phosphate binding | 8.6957 | 4 | yes |
| GO:0102250 | linear malto-oligosaccharide phosphorylase activity | 8.6957 | 5 | yes |
| GO:0102499 | SHG alpha-glucan phosphorylase activity | 8.6957 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PYGM_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 52.1739 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.4783 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 39.1304 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 39.1304 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.1304 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.1304 | 4 | no |
| GO:0010468 | regulation of gene expression | 34.7826 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 34.7826 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 30.4348 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.4348 | 4 | no |
| GO:0009966 | regulation of signal transduction | 30.4348 | 4 | no |
| GO:0010646 | regulation of cell communication | 30.4348 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.4348 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 30.4348 | 5 | no |
| GO:0006996 | organelle organization | 30.4348 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.0870 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.0870 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.0870 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.0870 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.0870 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 26.0870 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.0870 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.0870 | 5 | no |
| GO:0007010 | cytoskeleton organization | 26.0870 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 26.0870 | 4 | no |
| GO:0005976 | polysaccharide metabolic process | 21.7391 | 4 | yes |
| GO:0005977 | glycogen metabolic process | 21.7391 | 6 | yes |
| GO:0006073 | cellular glucan metabolic process | 21.7391 | 5 | yes |
| GO:0006112 | energy reserve metabolic process | 21.7391 | 5 | yes |
| GO:0015980 | energy derivation by oxidation of organic compounds | 21.7391 | 4 | yes |
| GO:0016052 | carbohydrate catabolic process | 21.7391 | 4 | yes |
| GO:0044042 | glucan metabolic process | 21.7391 | 5 | yes |
| GO:0044264 | cellular polysaccharide metabolic process | 21.7391 | 4 | yes |
| GO:0001558 | regulation of cell growth | 21.7391 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.7391 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 21.7391 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.7391 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.7391 | 5 | no |
| GO:0031399 | regulation of protein modification process | 21.7391 | 6 | no |
| GO:0036211 | protein modification process | 21.7391 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.7391 | 4 | no |
| GO:0043412 | macromolecule modification | 21.7391 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.7391 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.7391 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 21.7391 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.7391 | 6 | no |
| GO:0010639 | negative regulation of organelle organization | 21.7391 | 6 | no |
| GO:0010941 | regulation of cell death | 21.7391 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.7391 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.7391 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.7391 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.7391 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 21.7391 | 4 | no |
| GO:0008104 | protein localization | 21.7391 | 4 | no |
| GO:0000272 | polysaccharide catabolic process | 13.0435 | 5 | yes |
| GO:0005980 | glycogen catabolic process | 13.0435 | 6 | yes |
| GO:0009057 | macromolecule catabolic process | 13.0435 | 4 | yes |
| GO:0009251 | glucan catabolic process | 13.0435 | 6 | yes |
| GO:0044247 | cellular polysaccharide catabolic process | 13.0435 | 5 | yes |
| GO:0044275 | cellular carbohydrate catabolic process | 13.0435 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TRI63_HUMAN | [view interactions] | Low throughput | no | no |
| S10A1_HUMAN | [view interactions] | Low throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SET_HUMAN | [view interactions] | Low throughput | no | yes |
| KS6A1_HUMAN | [view interactions] | Low throughput | no | yes |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| TLE3_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| BRCA2_HUMAN | [view interactions] | High throughput | no | no |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GASP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| ABTB2_HUMAN | [view interactions] | High throughput | no | yes |
| LZTR1_HUMAN | [view interactions] | High throughput | no | no |
| RSH6A_HUMAN | [view interactions] | High throughput | no | no |
| DNJC3_HUMAN | [view interactions] | High throughput | no | yes |
| GLO2_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP6_HUMAN | [view interactions] | High throughput | no | no |
| STBD1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| T4S18_HUMAN | [view interactions] | High throughput | no | no |
| SPIN1_HUMAN | [view interactions] | High throughput | no | no |
| TSN33_HUMAN | [view interactions] | High throughput | no | no |
| RDH11_HUMAN | [view interactions] | High throughput | no | no |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| MAGF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FPPS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| MYEOV_HUMAN | [view interactions] | High throughput | no | no |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| TSPO_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| DJC30_HUMAN | [view interactions] | High throughput | no | no |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| TAF6L_HUMAN | [view interactions] | High throughput | no | yes |
| E41L5_HUMAN | [view interactions] | High throughput | no | no |
| DSN1_HUMAN | [view interactions] | High throughput | no | yes |
| FA81B_HUMAN | [view interactions] | High throughput | no | no |
| RT31_HUMAN | [view interactions] | High throughput | no | yes |
| ARL16_HUMAN | [view interactions] | High throughput | no | no |
| LATS1_HUMAN | [view interactions] | High throughput | no | yes |
| DDHD1_HUMAN | [view interactions] | High throughput | no | no |
| TRI31_HUMAN | [view interactions] | High throughput | no | no |
| TAF1B_HUMAN | [view interactions] | High throughput | no | no |
| TOP1_HUMAN | [view interactions] | High throughput | no | yes |
| GLGB_HUMAN | [view interactions] | High throughput | no | yes |
| GYS1_HUMAN | [view interactions] | High throughput | no | yes |
| ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLRX2_HUMAN | [view interactions] | High throughput | no | yes |
| MPC2_HUMAN | [view interactions] | High throughput | no | yes |
| PGAM2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTS_HUMAN | [view interactions] | High throughput | no | no |
| KCRS_HUMAN | [view interactions] | High throughput | no | no |
| NDUA3_HUMAN | [view interactions] | High throughput | no | yes |
| 2A5A_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOST_HUMAN | [view interactions] | High throughput | no | no |
| HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PACN3_HUMAN | [view interactions] | High throughput | no | yes |
| DEGS1_HUMAN | [view interactions] | High throughput | no | no |
| INP5K_HUMAN | [view interactions] | High throughput | no | no |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| AAKB2_HUMAN | [view interactions] | High throughput | no | yes |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| PYGL_HUMAN | [view interactions] | High throughput | no | yes |
| PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| CCD15_HUMAN | [view interactions] | High throughput | no | no |
| AMY1B_HUMAN | [view interactions] | High throughput | no | no |
| AMY2B_HUMAN | [view interactions] | High throughput | no | no |
| AMYP_HUMAN | [view interactions] | High throughput | no | no |
| POMP_HUMAN | [view interactions] | High throughput | no | yes |
| CBPC1_HUMAN | [view interactions] | High throughput | no | yes |
| ARI1B_HUMAN | [view interactions] | High throughput | no | yes |
| MRCKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F110A_HUMAN | [view interactions] | High throughput | no | yes |
| NIPS2_HUMAN | [view interactions] | High throughput | no | yes |
| IGBP1_HUMAN | [view interactions] | High throughput | no | yes |
| INT4_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| PPR3B_HUMAN | [view interactions] | High throughput | no | yes |
| SRP72_HUMAN | [view interactions] | High throughput | no | yes |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| TITIN_HUMAN | [view interactions] | High throughput | no | no |
| WWP1_HUMAN | [view interactions] | High throughput | no | yes |
| SGCG_HUMAN | [view interactions] | High throughput | no | no |
| ENPP3_HUMAN | [view interactions] | Computational | no | no |
| AMY1C_HUMAN | [view interactions] | Computational | no | no |
| AMY1A_HUMAN | [view interactions] | Computational | no | no |
| PGM1_HUMAN | [view interactions] | Computational | no | no |
| GYS2_HUMAN | [view interactions] | Computational | no | no |
| GLYG_HUMAN | [view interactions] | Computational | no | yes |
| PGM2_HUMAN | [view interactions] | Computational | no | no |
| GDE_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KPBB_HUMAN | [view interactions] | Computational | no | no |
| MGAL_HUMAN | [view interactions] | Computational | no | no |
| KPB1_HUMAN | [view interactions] | Computational | no | yes |
| PHKG1_HUMAN | [view interactions] | Computational | no | no |
| MGA_HUMAN | [view interactions] | Computational | no | no |
| RIPK3_HUMAN | [view interactions] | Computational | no | no |
| UGPA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PGM2L_HUMAN | [view entry] [view interactions] | Computational | yes | yes |