PYGM_HUMAN
Evidence for PS localization
Functions
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 205 | Gly | Ser | Glycogenstoragedisease5(GSD5) | - |
| 397 | Leu | Pro | Glycogenstoragedisease5(GSD5) | - |
| 543 | Lys | Thr | Glycogenstoragedisease5(GSD5) | - |
| 655 | Glu | Lys | Glycogenstoragedisease5(GSD5) | - |
| 116 | Leu | Pro | Glycogenstoragedisease5(GSD5) | - |
| 194 | Arg | Trp | Glycogenstoragedisease5(GSD5) | - |
| 292 | Leu | Pro | Glycogenstoragedisease5(GSD5) | - |
| 349 | Glu | Lys | Glycogenstoragedisease5(GSD5) | - |
| 488 | Thr | Asn | Glycogenstoragedisease5(GSD5) | - |
| 602 | Arg | Trp | Glycogenstoragedisease5(GSD5) | - |
| 660 | Ala | Asp | Glycogenstoragedisease5(GSD5) | - |
| 666 | Gln | Glu | Glycogenstoragedisease5(GSD5) | - |
| 685 | Asn | Tyr | Glycogenstoragedisease5(GSD5) | - |
| 686 | Gly | Arg | Glycogenstoragedisease5(GSD5) | - |
| 687 | Ala | Pro | Glycogenstoragedisease5(GSD5) | - |
| 704 | Ala | Val | Glycogenstoragedisease5(GSD5) | - |
| 798 | Trp | Arg | Glycogenstoragedisease5(GSD5) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PYGM_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 40.0000 | 4 | no |
| GO:0046872 | metal ion binding | 40.0000 | 5 | no |
| GO:0043168 | anion binding | 36.0000 | 4 | yes |
| GO:0019900 | kinase binding | 36.0000 | 4 | no |
| GO:0000166 | nucleotide binding | 28.0000 | 4 | yes |
| GO:0019901 | protein kinase binding | 28.0000 | 5 | no |
| GO:0017076 | purine nucleotide binding | 24.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 24.0000 | 4 | no |
| GO:0015631 | tubulin binding | 24.0000 | 4 | no |
| GO:0004645 | 1,4-alpha-oligoglucan phosphorylase activity | 8.0000 | 5 | yes |
| GO:0008184 | glycogen phosphorylase activity | 8.0000 | 6 | yes |
| GO:0016758 | hexosyltransferase activity | 8.0000 | 4 | yes |
| GO:0030170 | pyridoxal phosphate binding | 8.0000 | 4 | yes |
| GO:0102250 | linear malto-oligosaccharide phosphorylase activity | 8.0000 | 5 | yes |
| GO:0102499 | SHG alpha-glucan phosphorylase activity | 8.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PYGM_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 56.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 52.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 52.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 44.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 40.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0006996 | organelle organization | 40.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 36.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 36.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.0000 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 32.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 32.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 32.0000 | 5 | no |
| GO:0036211 | protein modification process | 32.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 32.0000 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 32.0000 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 32.0000 | 4 | no |
| GO:0008104 | protein localization | 32.0000 | 4 | no |
| GO:0001558 | regulation of cell growth | 28.0000 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.0000 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 28.0000 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 28.0000 | 4 | no |
| GO:0009894 | regulation of catabolic process | 28.0000 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 28.0000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.0000 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 28.0000 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 28.0000 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 28.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 28.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.0000 | 5 | no |
| GO:0043933 | protein-containing complex organization | 28.0000 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 24.0000 | 7 | no |
| GO:0009968 | negative regulation of signal transduction | 24.0000 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 24.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 24.0000 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 24.0000 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.0000 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 24.0000 | 6 | no |
| GO:0048638 | regulation of developmental growth | 24.0000 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 24.0000 | 7 | no |
| GO:0007010 | cytoskeleton organization | 24.0000 | 5 | no |
| GO:0043549 | regulation of kinase activity | 24.0000 | 5 | no |
| GO:0051338 | regulation of transferase activity | 24.0000 | 4 | no |
| GO:0033043 | regulation of organelle organization | 24.0000 | 5 | no |
| GO:0010038 | response to metal ion | 24.0000 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.0000 | 6 | no |
| GO:0016052 | carbohydrate catabolic process | 16.0000 | 4 | yes |
| GO:0005976 | polysaccharide metabolic process | 12.0000 | 4 | yes |
| GO:0005977 | glycogen metabolic process | 12.0000 | 6 | yes |
| GO:0006112 | energy reserve metabolic process | 12.0000 | 5 | yes |
| GO:0009057 | macromolecule catabolic process | 12.0000 | 4 | yes |
| GO:0015980 | energy derivation by oxidation of organic compounds | 12.0000 | 4 | yes |
| GO:0044042 | glucan metabolic process | 12.0000 | 5 | yes |
| GO:0000272 | polysaccharide catabolic process | 8.0000 | 5 | yes |
| GO:0005980 | glycogen catabolic process | 8.0000 | 7 | yes |
| GO:0009251 | glucan catabolic process | 8.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SET_HUMAN | [view interactions] | Low throughput | no | yes |
| KS6A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRI63_HUMAN | [view interactions] | Low throughput | no | no |
| S10A1_HUMAN | [view interactions] | Low throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOST_HUMAN | [view interactions] | High throughput | no | no |
| HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PACN3_HUMAN | [view interactions] | High throughput | no | yes |
| DEGS1_HUMAN | [view interactions] | High throughput | no | no |
| INP5K_HUMAN | [view interactions] | High throughput | no | no |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKB2_HUMAN | [view interactions] | High throughput | no | yes |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| PYGL_HUMAN | [view interactions] | High throughput | no | yes |
| PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M3K3_HUMAN | [view interactions] | High throughput | no | no |
| CCD15_HUMAN | [view interactions] | High throughput | no | no |
| AMY1B_HUMAN | [view interactions] | High throughput | no | no |
| AMY2B_HUMAN | [view interactions] | High throughput | no | no |
| AMYP_HUMAN | [view interactions] | High throughput | no | no |
| POMP_HUMAN | [view interactions] | High throughput | no | yes |
| CBPC1_HUMAN | [view interactions] | High throughput | no | yes |
| ARI1B_HUMAN | [view interactions] | High throughput | no | yes |
| MRCKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F110A_HUMAN | [view interactions] | High throughput | no | yes |
| NIPS2_HUMAN | [view interactions] | High throughput | no | yes |
| IGBP1_HUMAN | [view interactions] | High throughput | no | yes |
| INT4_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| PPR3B_HUMAN | [view interactions] | High throughput | no | yes |
| SRP72_HUMAN | [view interactions] | High throughput | no | yes |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| TITIN_HUMAN | [view interactions] | High throughput | no | no |
| WWP1_HUMAN | [view interactions] | High throughput | no | yes |
| SGCG_HUMAN | [view interactions] | High throughput | no | no |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| TLE3_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| BRCA2_HUMAN | [view interactions] | High throughput | no | no |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GASP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| ABTB2_HUMAN | [view interactions] | High throughput | no | yes |
| LZTR1_HUMAN | [view interactions] | High throughput | no | no |
| RSH6A_HUMAN | [view interactions] | High throughput | no | no |
| DNJC3_HUMAN | [view interactions] | High throughput | no | yes |
| GLO2_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP6_HUMAN | [view interactions] | High throughput | no | no |
| STBD1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| T4S18_HUMAN | [view interactions] | High throughput | no | no |
| SPIN1_HUMAN | [view interactions] | High throughput | no | no |
| TSN33_HUMAN | [view interactions] | High throughput | no | no |
| RDH11_HUMAN | [view interactions] | High throughput | no | no |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| MAGF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FPPS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| MYEOV_HUMAN | [view interactions] | High throughput | no | no |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| TSPO_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| DJC30_HUMAN | [view interactions] | High throughput | no | no |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| TAF6L_HUMAN | [view interactions] | High throughput | no | yes |
| E41L5_HUMAN | [view interactions] | High throughput | no | no |
| DSN1_HUMAN | [view interactions] | High throughput | no | yes |
| FA81B_HUMAN | [view interactions] | High throughput | no | no |
| RT31_HUMAN | [view interactions] | High throughput | no | yes |
| ARL16_HUMAN | [view interactions] | High throughput | no | no |
| LATS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDHD1_HUMAN | [view interactions] | High throughput | no | no |
| TRI31_HUMAN | [view interactions] | High throughput | no | no |
| TAF1B_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPF3_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP1_HUMAN | [view interactions] | High throughput | no | yes |
| GLGB_HUMAN | [view interactions] | High throughput | no | yes |
| GYS1_HUMAN | [view interactions] | High throughput | no | yes |
| ENOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GLRX2_HUMAN | [view interactions] | High throughput | no | yes |
| MPC2_HUMAN | [view interactions] | High throughput | no | yes |
| PGAM2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTS_HUMAN | [view interactions] | High throughput | no | no |
| KCRS_HUMAN | [view interactions] | High throughput | no | no |
| NDUA3_HUMAN | [view interactions] | High throughput | no | yes |
| 2A5A_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |