DYN2_HUMAN
Evidence for PS localization
Functions
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones . Plays an important role in vesicular trafficking processes, in particular endocytosis (PubMed). Involved in cytokinesis (PubMed). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002131 | LIG_SH3_2 | LIG | 829 | 834 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DYN2_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 24.1071 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 23.2143 | 4 | yes |
| GO:0019901 | protein kinase binding | 23.2143 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 22.3214 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.3214 | 4 | yes |
| GO:0003723 | RNA binding | 20.5357 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 11.6071 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 11.6071 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 11.6071 | 6 | yes |
| GO:0017124 | SH3 domain binding | 11.6071 | 4 | yes |
| GO:0019001 | guanyl nucleotide binding | 10.7143 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 10.7143 | 5 | yes |
| GO:0005525 | GTP binding | 8.9286 | 5 | yes |
| GO:0003924 | GTPase activity | 8.0357 | 7 | yes |
| GO:0015631 | tubulin binding | 8.0357 | 4 | yes |
| GO:0001664 | G protein-coupled receptor binding | 7.1429 | 4 | yes |
| GO:0008017 | microtubule binding | 6.2500 | 5 | yes |
| GO:0050998 | nitric-oxide synthase binding | 3.5714 | 4 | yes |
| GO:0031749 | D2 dopamine receptor binding | 1.7857 | 6 | yes |
| GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding | 1.7857 | 4 | yes |
| GO:0050699 | WW domain binding | 1.7857 | 4 | yes |
| GO:0050780 | dopamine receptor binding | 1.7857 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DYN2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 69.6429 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 55.3571 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 55.3571 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 48.2143 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 47.3214 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 47.3214 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 43.7500 | 4 | yes |
| GO:0010646 | regulation of cell communication | 43.7500 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 42.8571 | 4 | yes |
| GO:0051049 | regulation of transport | 40.1786 | 4 | yes |
| GO:0022607 | cellular component assembly | 40.1786 | 4 | no |
| GO:0008104 | protein localization | 40.1786 | 4 | yes |
| GO:0006996 | organelle organization | 39.2857 | 4 | no |
| GO:0009966 | regulation of signal transduction | 39.2857 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.2857 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 38.3929 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 36.6071 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 36.6071 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 34.8214 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 34.8214 | 5 | no |
| GO:0010468 | regulation of gene expression | 34.8214 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.8214 | 5 | yes |
| GO:0010941 | regulation of cell death | 32.1429 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.1429 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 32.1429 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 32.1429 | 4 | no |
| GO:0006897 | endocytosis | 32.1429 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 31.2500 | 5 | yes |
| GO:0030030 | cell projection organization | 30.3571 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 30.3571 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 30.3571 | 5 | no |
| GO:0023056 | positive regulation of signaling | 30.3571 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.5714 | 5 | yes |
| GO:0071702 | organic substance transport | 28.5714 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 27.6786 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 27.6786 | 5 | yes |
| GO:0051050 | positive regulation of transport | 27.6786 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 27.6786 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 27.6786 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 26.7857 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 26.7857 | 6 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 26.7857 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.7857 | 6 | yes |
| GO:0015031 | protein transport | 25.8929 | 4 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.8929 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 25.8929 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.8929 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.8929 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.8929 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 25.0000 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 24.1071 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 24.1071 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 24.1071 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 24.1071 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.1071 | 6 | no |
| GO:0031399 | regulation of protein modification process | 24.1071 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.1071 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.1071 | 6 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 23.2143 | 4 | no |
| GO:0007010 | cytoskeleton organization | 23.2143 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 23.2143 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 22.3214 | 5 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.3214 | 6 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 22.3214 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.3214 | 6 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.3214 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.3214 | 5 | no |
| GO:0034330 | cell junction organization | 22.3214 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.3214 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.3214 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 22.3214 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 21.4286 | 7 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.5357 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 20.5357 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 20.5357 | 5 | yes |
| GO:0006886 | intracellular protein transport | 20.5357 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 20.5357 | 4 | no |
| GO:0060548 | negative regulation of cell death | 20.5357 | 5 | no |
| GO:0006898 | receptor-mediated endocytosis | 20.5357 | 6 | yes |
| GO:0030100 | regulation of endocytosis | 19.6429 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 19.6429 | 4 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 19.6429 | 6 | yes |
| GO:0045597 | positive regulation of cell differentiation | 18.7500 | 5 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 18.7500 | 7 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 18.7500 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 18.7500 | 8 | yes |
| GO:0010942 | positive regulation of cell death | 17.8571 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 17.8571 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 17.8571 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 17.8571 | 5 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 16.9643 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 16.9643 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 15.1786 | 4 | yes |
| GO:0043269 | regulation of ion transport | 15.1786 | 5 | yes |
| GO:0061024 | membrane organization | 15.1786 | 4 | yes |
| GO:0014070 | response to organic cyclic compound | 14.2857 | 4 | yes |
| GO:0032990 | cell part morphogenesis | 14.2857 | 4 | yes |
| GO:0043065 | positive regulation of apoptotic process | 14.2857 | 7 | yes |
| GO:0043068 | positive regulation of programmed cell death | 14.2857 | 6 | yes |
| GO:0048858 | cell projection morphogenesis | 13.3929 | 5 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 13.3929 | 4 | yes |
| GO:1901699 | cellular response to nitrogen compound | 13.3929 | 4 | yes |
| GO:0030155 | regulation of cell adhesion | 12.5000 | 4 | yes |
| GO:0031346 | positive regulation of cell projection organization | 12.5000 | 6 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 12.5000 | 6 | yes |
| GO:0048812 | neuron projection morphogenesis | 12.5000 | 7 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 12.5000 | 6 | yes |
| GO:0060284 | regulation of cell development | 11.6071 | 5 | yes |
| GO:0001558 | regulation of cell growth | 11.6071 | 4 | yes |
| GO:0022604 | regulation of cell morphogenesis | 10.7143 | 5 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 10.7143 | 5 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 10.7143 | 5 | yes |
| GO:0045785 | positive regulation of cell adhesion | 10.7143 | 5 | yes |
| GO:0048488 | synaptic vesicle endocytosis | 10.7143 | 5 | yes |
| GO:0060491 | regulation of cell projection assembly | 10.7143 | 5 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 10.7143 | 5 | yes |
| GO:0099003 | vesicle-mediated transport in synapse | 10.7143 | 5 | yes |
| GO:0140238 | presynaptic endocytosis | 10.7143 | 4 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 10.7143 | 6 | yes |
| GO:0010720 | positive regulation of cell development | 10.7143 | 6 | yes |
| GO:0031623 | receptor internalization | 9.8214 | 7 | yes |
| GO:0048638 | regulation of developmental growth | 9.8214 | 4 | yes |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 9.8214 | 6 | yes |
| GO:0010959 | regulation of metal ion transport | 8.9286 | 6 | yes |
| GO:0043270 | positive regulation of ion transport | 8.9286 | 5 | yes |
| GO:1902115 | regulation of organelle assembly | 8.9286 | 5 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 8.0357 | 4 | yes |
| GO:0045807 | positive regulation of endocytosis | 8.0357 | 5 | yes |
| GO:0010639 | negative regulation of organelle organization | 8.0357 | 6 | yes |
| GO:0010810 | regulation of cell-substrate adhesion | 8.0357 | 5 | yes |
| GO:0031345 | negative regulation of cell projection organization | 7.1429 | 6 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 7.1429 | 5 | yes |
| GO:0034767 | positive regulation of ion transmembrane transport | 7.1429 | 6 | yes |
| GO:0048193 | Golgi vesicle transport | 7.1429 | 5 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 7.1429 | 6 | yes |
| GO:0051650 | establishment of vesicle localization | 7.1429 | 4 | yes |
| GO:0071241 | cellular response to inorganic substance | 7.1429 | 4 | yes |
| GO:0090287 | regulation of cellular response to growth factor stimulus | 7.1429 | 4 | yes |
| GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 7.1429 | 6 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 7.1429 | 7 | yes |
| GO:0006811 | ion transport | 7.1429 | 4 | yes |
| GO:0030001 | metal ion transport | 6.2500 | 6 | yes |
| GO:0030516 | regulation of axon extension | 6.2500 | 5 | yes |
| GO:0061387 | regulation of extent of cell growth | 6.2500 | 5 | yes |
| GO:0006812 | cation transport | 6.2500 | 5 | yes |
| GO:0046578 | regulation of Ras protein signal transduction | 5.3571 | 7 | yes |
| GO:0048260 | positive regulation of receptor-mediated endocytosis | 5.3571 | 6 | yes |
| GO:2000369 | regulation of clathrin-dependent endocytosis | 5.3571 | 7 | yes |
| GO:0009416 | response to light stimulus | 5.3571 | 4 | yes |
| GO:0010811 | positive regulation of cell-substrate adhesion | 5.3571 | 6 | yes |
| GO:0032411 | positive regulation of transporter activity | 4.4643 | 4 | yes |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 4.4643 | 5 | yes |
| GO:0071478 | cellular response to radiation | 4.4643 | 4 | yes |
| GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 4.4643 | 5 | yes |
| GO:1900024 | regulation of substrate adhesion-dependent cell spreading | 4.4643 | 6 | yes |
| GO:1902743 | regulation of lamellipodium organization | 4.4643 | 7 | yes |
| GO:1902745 | positive regulation of lamellipodium organization | 4.4643 | 7 | yes |
| GO:0006892 | post-Golgi vesicle-mediated transport | 4.4643 | 6 | yes |
| GO:0010212 | response to ionizing radiation | 4.4643 | 4 | yes |
| GO:0010769 | regulation of cell morphogenesis involved in differentiation | 4.4643 | 6 | yes |
| GO:0035020 | regulation of Rac protein signal transduction | 3.5714 | 8 | yes |
| GO:0043266 | regulation of potassium ion transport | 3.5714 | 7 | yes |
| GO:0050764 | regulation of phagocytosis | 3.5714 | 5 | yes |
| GO:0071479 | cellular response to ionizing radiation | 3.5714 | 5 | yes |
| GO:0071731 | response to nitric oxide | 3.5714 | 4 | yes |
| GO:0071732 | cellular response to nitric oxide | 3.5714 | 5 | yes |
| GO:0071867 | response to monoamine | 3.5714 | 5 | yes |
| GO:0071868 | cellular response to monoamine stimulus | 3.5714 | 5 | yes |
| GO:0071869 | response to catecholamine | 3.5714 | 4 | yes |
| GO:0071870 | cellular response to catecholamine stimulus | 3.5714 | 5 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 3.5714 | 4 | yes |
| GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | 3.5714 | 7 | yes |
| GO:1902170 | cellular response to reactive nitrogen species | 3.5714 | 5 | yes |
| GO:1903525 | regulation of membrane tubulation | 3.5714 | 6 | yes |
| GO:1903729 | regulation of plasma membrane organization | 3.5714 | 5 | yes |
| GO:0006909 | phagocytosis | 3.5714 | 5 | yes |
| GO:0010591 | regulation of lamellipodium assembly | 3.5714 | 7 | yes |
| GO:0010592 | positive regulation of lamellipodium assembly | 3.5714 | 7 | yes |
| GO:0010770 | positive regulation of cell morphogenesis involved in differentiation | 3.5714 | 7 | yes |
| GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 2.6786 | 6 | yes |
| GO:0033572 | transferrin transport | 2.6786 | 5 | yes |
| GO:0042220 | response to cocaine | 2.6786 | 4 | yes |
| GO:0043279 | response to alkaloid | 2.6786 | 5 | yes |
| GO:0045428 | regulation of nitric oxide biosynthetic process | 2.6786 | 6 | yes |
| GO:0045429 | positive regulation of nitric oxide biosynthetic process | 2.6786 | 7 | yes |
| GO:0048489 | synaptic vesicle transport | 2.6786 | 4 | yes |
| GO:0080164 | regulation of nitric oxide metabolic process | 2.6786 | 5 | yes |
| GO:0090101 | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 2.6786 | 6 | yes |
| GO:0097479 | synaptic vesicle localization | 2.6786 | 4 | yes |
| GO:1901379 | regulation of potassium ion transmembrane transport | 2.6786 | 7 | yes |
| GO:1902017 | regulation of cilium assembly | 2.6786 | 6 | yes |
| GO:1903350 | response to dopamine | 2.6786 | 5 | yes |
| GO:1903351 | cellular response to dopamine | 2.6786 | 6 | yes |
| GO:1903526 | negative regulation of membrane tubulation | 2.6786 | 6 | yes |
| GO:1903844 | regulation of cellular response to transforming growth factor beta stimulus | 2.6786 | 5 | yes |
| GO:1904407 | positive regulation of nitric oxide metabolic process | 2.6786 | 6 | yes |
| GO:2000370 | positive regulation of clathrin-dependent endocytosis | 2.6786 | 7 | yes |
| GO:0000041 | transition metal ion transport | 2.6786 | 7 | yes |
| GO:0002028 | regulation of sodium ion transport | 2.6786 | 7 | yes |
| GO:0002031 | G protein-coupled receptor internalization | 2.6786 | 8 | yes |
| GO:0006826 | iron ion transport | 2.6786 | 8 | yes |
| GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | 1.7857 | 5 | yes |
| GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 1.7857 | 7 | yes |
| GO:0032781 | positive regulation of ATP-dependent activity | 1.7857 | 4 | yes |
| GO:0034465 | response to carbon monoxide | 1.7857 | 4 | yes |
| GO:0043268 | positive regulation of potassium ion transport | 1.7857 | 6 | yes |
| GO:0044351 | macropinocytosis | 1.7857 | 7 | yes |
| GO:0044772 | mitotic cell cycle phase transition | 1.7857 | 4 | yes |
| GO:0044839 | cell cycle G2/M phase transition | 1.7857 | 4 | yes |
| GO:0048232 | male gamete generation | 1.7857 | 4 | yes |
| GO:0050766 | positive regulation of phagocytosis | 1.7857 | 5 | yes |
| GO:0071245 | cellular response to carbon monoxide | 1.7857 | 5 | yes |
| GO:0071481 | cellular response to X-ray | 1.7857 | 6 | yes |
| GO:0120033 | negative regulation of plasma membrane bounded cell projection assembly | 1.7857 | 7 | yes |
| GO:1901016 | regulation of potassium ion transmembrane transporter activity | 1.7857 | 6 | yes |
| GO:1901018 | positive regulation of potassium ion transmembrane transporter activity | 1.7857 | 6 | yes |
| GO:1901381 | positive regulation of potassium ion transmembrane transport | 1.7857 | 7 | yes |
| GO:1902018 | negative regulation of cilium assembly | 1.7857 | 7 | yes |
| GO:1902116 | negative regulation of organelle assembly | 1.7857 | 6 | yes |
| GO:1902305 | regulation of sodium ion transmembrane transport | 1.7857 | 7 | yes |
| GO:1902307 | positive regulation of sodium ion transmembrane transport | 1.7857 | 7 | yes |
| GO:1902855 | regulation of non-motile cilium assembly | 1.7857 | 7 | yes |
| GO:1902856 | negative regulation of non-motile cilium assembly | 1.7857 | 8 | yes |
| GO:1903358 | regulation of Golgi organization | 1.7857 | 6 | yes |
| GO:1903406 | regulation of P-type sodium:potassium-exchanging transporter activity | 1.7857 | 4 | yes |
| GO:1903408 | positive regulation of P-type sodium:potassium-exchanging transporter activity | 1.7857 | 5 | yes |
| GO:2000649 | regulation of sodium ion transmembrane transporter activity | 1.7857 | 6 | yes |
| GO:2000651 | positive regulation of sodium ion transmembrane transporter activity | 1.7857 | 6 | yes |
| GO:0000086 | G2/M transition of mitotic cell cycle | 1.7857 | 5 | yes |
| GO:0002478 | antigen processing and presentation of exogenous peptide antigen | 1.7857 | 4 | yes |
| GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II | 1.7857 | 4 | yes |
| GO:0006893 | Golgi to plasma membrane transport | 1.7857 | 5 | yes |
| GO:0006907 | pinocytosis | 1.7857 | 6 | yes |
| GO:0010165 | response to X-ray | 1.7857 | 5 | yes |
| GO:0010765 | positive regulation of sodium ion transport | 1.7857 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in DYN2_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 1.7857 | 3 | no |
| DOID:0080000 | muscular disease | 1.7857 | 3 | no |
| DOID:423 | myopathy | 1.7857 | 5 | no |
| DOID:66 | muscle tissue disease | 1.7857 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MYOF_HUMAN | [view interactions] | Low throughput | no | yes |
| MANEA_HUMAN | [view interactions] | Low throughput | no | yes |
| FBP1L_HUMAN | [view interactions] | Low throughput | no | yes |
| FER_HUMAN | [view interactions] | Low throughput | no | yes |
| AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNX9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRBS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3B4_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AHI1_HUMAN | [view interactions] | Low throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| GAK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRBS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FNBP1_HUMAN | [view interactions] | Low throughput | no | yes |
| MYO1E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3G2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PACN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SRC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNX33_HUMAN | [view interactions] | Low throughput | no | yes |
| GRAP2_HUMAN | [view interactions] | Low throughput | no | no |
| NDKB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDKA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CIP4_HUMAN | [view interactions] | Low throughput | no | no |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DRD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PACN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHAN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PACN3_HUMAN | [view interactions] | Low throughput | no | yes |
| PPIP1_HUMAN | [view interactions] | Low throughput | no | no |
| CD2AP_HUMAN | [view interactions] | Low throughput | no | no |
| KCNN3_HUMAN | [view interactions] | Low throughput | no | no |
| CNCG_HUMAN | [view interactions] | Low throughput | no | no |
| CNRG_HUMAN | [view interactions] | Low throughput | no | no |
| PTN11_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| PGFRA_HUMAN | [view interactions] | Low throughput | no | no |
| SNX18_HUMAN | [view interactions] | Low throughput | no | no |
| VGFR2_HUMAN | [view interactions] | Low throughput | no | no |
| ARC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| IKIP_HUMAN | [view interactions] | High throughput | no | no |
| AMGO1_HUMAN | [view interactions] | High throughput | no | yes |
| HCST_HUMAN | [view interactions] | High throughput | no | no |
| TMEM9_HUMAN | [view interactions] | High throughput | no | no |
| SH319_HUMAN | [view interactions] | High throughput | no | no |
| MAVS_HUMAN | [view interactions] | High throughput | no | yes |
| EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
| NKG2A_HUMAN | [view interactions] | High throughput | no | no |
| TYOBP_HUMAN | [view interactions] | High throughput | no | no |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| ACTS_HUMAN | [view interactions] | High throughput | no | no |
| EFNA4_HUMAN | [view interactions] | High throughput | no | no |
| CDKAL_HUMAN | [view interactions] | High throughput | no | no |
| PCDGE_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
| CD70_HUMAN | [view interactions] | High throughput | no | no |
| MND1_HUMAN | [view interactions] | High throughput | no | no |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| CR021_HUMAN | [view interactions] | High throughput | no | no |
| ASCL4_HUMAN | [view interactions] | High throughput | no | no |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| IGSF8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPC10_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| SYT6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZER1_HUMAN | [view interactions] | High throughput | no | no |
| FCN3_HUMAN | [view interactions] | High throughput | no | no |
| RT18C_HUMAN | [view interactions] | High throughput | no | yes |
| SGCA_HUMAN | [view interactions] | High throughput | no | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMC2_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H1X_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| H2A2A_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| WBP4_HUMAN | [view interactions] | High throughput | no | yes |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBMS1_HUMAN | [view interactions] | High throughput | no | no |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZNT5_HUMAN | [view interactions] | High throughput | no | yes |
| GLGB_HUMAN | [view interactions] | High throughput | no | yes |
| MPH6_HUMAN | [view interactions] | High throughput | no | yes |
| GGA1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN13_HUMAN | [view interactions] | High throughput | no | yes |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| RPE_HUMAN | [view interactions] | High throughput | no | yes |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| RTCB_HUMAN | [view interactions] | High throughput | no | yes |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BABA2_HUMAN | [view interactions] | High throughput | no | yes |
| GDF9_HUMAN | [view interactions] | High throughput | no | no |
| GAB1_HUMAN | [view interactions] | High throughput | no | yes |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| MA1B1_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RWD2B_HUMAN | [view interactions] | High throughput | no | no |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| TIAM2_HUMAN | [view interactions] | High throughput | no | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TYK2_HUMAN | [view interactions] | High throughput | no | no |
| RPB3_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT16_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| SPY2_HUMAN | [view interactions] | High throughput | no | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MED19_HUMAN | [view interactions] | High throughput | no | yes |
| MED29_HUMAN | [view interactions] | High throughput | no | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| PAK4_HUMAN | [view interactions] | High throughput | no | yes |
| DNMBP_HUMAN | [view interactions] | High throughput | no | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| HCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| LASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SET_HUMAN | [view interactions] | High throughput | no | yes |
| LAT_HUMAN | [view interactions] | High throughput | no | no |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IMB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF8_HUMAN | [view interactions] | High throughput | no | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRAF4_HUMAN | [view interactions] | High throughput | no | yes |
| SYQ_HUMAN | [view interactions] | High throughput | no | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| ZFAN6_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3L_HUMAN | [view interactions] | High throughput | no | yes |
| PEF1_HUMAN | [view interactions] | High throughput | no | no |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARX_HUMAN | [view interactions] | High throughput | no | no |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDLC_HUMAN | [view interactions] | High throughput | no | no |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYGM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| FBF1_HUMAN | [view interactions] | High throughput | no | no |
| CEP43_HUMAN | [view interactions] | High throughput | no | no |
| TECT1_HUMAN | [view interactions] | High throughput | no | yes |
| RPGR_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XIAP_HUMAN | [view interactions] | High throughput | no | yes |
| DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PALS2_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3R1_HUMAN | [view interactions] | High throughput | no | yes |
| UBS3A_HUMAN | [view interactions] | High throughput | no | no |
| FAD1_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| RPAP2_HUMAN | [view interactions] | High throughput | no | yes |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| FCSD1_HUMAN | [view interactions] | High throughput | no | yes |
| WIPI2_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| FOXP3_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| DYN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCN2B_HUMAN | [view interactions] | High throughput | no | no |
| LYPD6_HUMAN | [view interactions] | High throughput | no | no |
| 5HT6R_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| BUB3_HUMAN | [view interactions] | High throughput | no | yes |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA10_HUMAN | [view interactions] | High throughput | no | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOIP1_HUMAN | [view interactions] | High throughput | no | yes |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF19_HUMAN | [view interactions] | High throughput | no | yes |
| ABCG1_HUMAN | [view interactions] | High throughput | no | yes |
| GLPB_HUMAN | [view interactions] | High throughput | no | no |
| TMM9B_HUMAN | [view interactions] | High throughput | no | yes |
| TBC15_HUMAN | [view interactions] | High throughput | no | yes |
| ZBBX_HUMAN | [view interactions] | High throughput | no | no |
| RBM3_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ARNT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2L6_HUMAN | [view interactions] | High throughput | no | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| AGO2_HUMAN | [view interactions] | High throughput | no | yes |
| WDR76_HUMAN | [view interactions] | High throughput | no | no |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT7A_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| SMC1A_HUMAN | [view interactions] | High throughput | no | yes |
| STAG2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| PAR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MTMRE_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LY96_HUMAN | [view interactions] | Computational | no | no |
| AP2A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FIS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AUXI_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CBL_HUMAN | [view interactions] | Computational | no | yes |
| DOCK4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| VAV_HUMAN | [view interactions] | Computational | no | no |
| AP1B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HCLS1_HUMAN | [view interactions] | Computational | no | no |
| CD14_HUMAN | [view interactions] | Computational | no | no |
| TLR4_HUMAN | [view interactions] | Computational | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAV1_HUMAN | [view interactions] | Computational | no | no |
| AP2M1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NGF_HUMAN | [view interactions] | Computational | no | no |
| SDC4_HUMAN | [view interactions] | Computational | no | yes |
| NOS3_HUMAN | [view interactions] | Computational | no | no |
| CLCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| L1CAM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CTND1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| WASL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CLH2_HUMAN | [view interactions] | Computational | no | no |
| PDGFB_HUMAN | [view interactions] | Computational | no | yes |
| CTNA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PGFRB_HUMAN | [view interactions] | Computational | no | yes |