Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ARC_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory . Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 . In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ARC_HUMAN
GO:0043168 anion binding 30.7692 4 no
GO:0044389 ubiquitin-like protein ligase binding 23.0769 4 no
GO:0000166 nucleotide binding 23.0769 4 no
GO:0017076 purine nucleotide binding 23.0769 5 no
GO:0032555 purine ribonucleotide binding 23.0769 4 no
GO:0035639 purine ribonucleoside triphosphate binding 23.0769 4 no
GO:0043169 cation binding 23.0769 4 no
GO:0046872 metal ion binding 23.0769 5 no
GO:0003723 RNA binding 19.2308 4 yes
GO:0003729 mRNA binding 7.6923 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ARC_HUMAN
GO:0048522 positive regulation of cellular process 73.0769 4 yes
GO:0010646 regulation of cell communication 65.3846 4 yes
GO:0051128 regulation of cellular component organization 61.5385 4 yes
GO:0060255 regulation of macromolecule metabolic process 61.5385 4 no
GO:0050804 modulation of chemical synaptic transmission 57.6923 5 yes
GO:0099177 regulation of trans-synaptic signaling 57.6923 4 yes
GO:0031323 regulation of cellular metabolic process 57.6923 4 no
GO:0080090 regulation of primary metabolic process 57.6923 4 no
GO:0051049 regulation of transport 50.0000 4 yes
GO:0036211 protein modification process 50.0000 4 no
GO:0043412 macromolecule modification 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0023056 positive regulation of signaling 46.1538 4 yes
GO:0051246 regulation of protein metabolic process 46.1538 5 no
GO:0010647 positive regulation of cell communication 42.3077 5 yes
GO:0031344 regulation of cell projection organization 42.3077 5 yes
GO:0048168 regulation of neuronal synaptic plasticity 42.3077 4 yes
GO:0051247 positive regulation of protein metabolic process 42.3077 6 no
GO:0009889 regulation of biosynthetic process 42.3077 4 no
GO:0010468 regulation of gene expression 42.3077 6 no
GO:0010556 regulation of macromolecule biosynthetic process 42.3077 5 no
GO:0031326 regulation of cellular biosynthetic process 42.3077 5 no
GO:0022603 regulation of anatomical structure morphogenesis 38.4615 4 yes
GO:0030030 cell projection organization 38.4615 4 yes
GO:0050890 cognition 38.4615 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 38.4615 6 yes
GO:0031325 positive regulation of cellular metabolic process 38.4615 5 no
GO:0048584 positive regulation of response to stimulus 38.4615 4 no
GO:0006996 organelle organization 38.4615 4 yes
GO:0010975 regulation of neuron projection development 34.6154 7 yes
GO:0022607 cellular component assembly 34.6154 4 yes
GO:0031399 regulation of protein modification process 34.6154 6 no
GO:0007612 learning 30.7692 4 yes
GO:0048812 neuron projection morphogenesis 30.7692 5 yes
GO:0050807 regulation of synapse organization 30.7692 5 yes
GO:0120036 plasma membrane bounded cell projection organization 30.7692 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 30.7692 4 yes
GO:0008104 protein localization 30.7692 4 no
GO:0009967 positive regulation of signal transduction 30.7692 5 no
GO:0031401 positive regulation of protein modification process 30.7692 7 no
GO:0009891 positive regulation of biosynthetic process 30.7692 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 30.7692 6 no
GO:0031328 positive regulation of cellular biosynthetic process 30.7692 6 no
GO:0051129 negative regulation of cellular component organization 30.7692 5 no
GO:0051130 positive regulation of cellular component organization 30.7692 5 no
GO:0006355 regulation of DNA-templated transcription 30.7692 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.7692 5 no
GO:0051252 regulation of RNA metabolic process 30.7692 5 no
GO:2001141 regulation of RNA biosynthetic process 30.7692 6 no
GO:0043933 protein-containing complex organization 26.9231 4 yes
GO:0050806 positive regulation of synaptic transmission 26.9231 5 yes
GO:0098657 import into cell 26.9231 4 yes
GO:0099175 regulation of postsynapse organization 26.9231 6 yes
GO:0032446 protein modification by small protein conjugation 26.9231 7 no
GO:0043687 post-translational protein modification 26.9231 5 no
GO:0070647 protein modification by small protein conjugation or removal 26.9231 6 no
GO:0019220 regulation of phosphate metabolic process 26.9231 6 no
GO:0051174 regulation of phosphorus metabolic process 26.9231 5 no
GO:0009894 regulation of catabolic process 26.9231 4 no
GO:0030162 regulation of proteolysis 26.9231 6 no
GO:0045595 regulation of cell differentiation 26.9231 4 no
GO:0051094 positive regulation of developmental process 26.9231 4 no
GO:0034762 regulation of transmembrane transport 26.9231 4 no
GO:0031175 neuron projection development 23.0769 6 yes
GO:0065003 protein-containing complex assembly 23.0769 5 yes
GO:0106027 neuron projection organization 23.0769 6 yes
GO:0018193 peptidyl-amino acid modification 23.0769 5 no
GO:0060341 regulation of cellular localization 23.0769 4 no
GO:0001932 regulation of protein phosphorylation 23.0769 7 no
GO:0010243 response to organonitrogen compound 23.0769 4 no
GO:0042325 regulation of phosphorylation 23.0769 7 no
GO:1902531 regulation of intracellular signal transduction 23.0769 5 no
GO:0006508 proteolysis 23.0769 4 no
GO:0009057 macromolecule catabolic process 23.0769 4 no
GO:0009896 positive regulation of catabolic process 23.0769 5 no
GO:0042981 regulation of apoptotic process 23.0769 5 no
GO:0043067 regulation of programmed cell death 23.0769 4 no
GO:0045862 positive regulation of proteolysis 23.0769 7 no
GO:0051093 negative regulation of developmental process 23.0769 4 no
GO:0060284 regulation of cell development 23.0769 5 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 23.0769 7 no
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 23.0769 5 no
GO:0045893 positive regulation of DNA-templated transcription 23.0769 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0051254 positive regulation of RNA metabolic process 23.0769 6 no
GO:1902680 positive regulation of RNA biosynthetic process 23.0769 7 no
GO:0043269 regulation of monoatomic ion transport 23.0769 5 no
GO:0044057 regulation of system process 23.0769 4 no
GO:0051240 positive regulation of multicellular organismal process 23.0769 4 no
GO:0007010 cytoskeleton organization 19.2308 5 yes
GO:0022604 regulation of cell morphogenesis 19.2308 5 yes
GO:0061001 regulation of dendritic spine morphogenesis 19.2308 5 yes
GO:0071702 organic substance transport 19.2308 4 yes
GO:0071705 nitrogen compound transport 19.2308 4 yes
GO:0051259 protein complex oligomerization 15.3846 6 yes
GO:0060627 regulation of vesicle-mediated transport 15.3846 4 yes
GO:1900271 regulation of long-term synaptic potentiation 15.3846 4 yes
GO:0007613 memory 11.5385 4 yes
GO:0009952 anterior/posterior pattern specification 11.5385 4 yes
GO:0030100 regulation of endocytosis 11.5385 5 yes
GO:0048259 regulation of receptor-mediated endocytosis 11.5385 6 yes
GO:0060291 long-term synaptic potentiation 11.5385 4 yes
GO:0060997 dendritic spine morphogenesis 11.5385 6 yes
GO:0097061 dendritic spine organization 11.5385 5 yes
GO:0099173 postsynapse organization 11.5385 4 yes
GO:0002090 regulation of receptor internalization 11.5385 7 yes
GO:0007492 endoderm development 7.6923 4 yes
GO:0007616 long-term memory 7.6923 5 yes
GO:0015931 nucleobase-containing compound transport 7.6923 5 yes
GO:0050657 nucleic acid transport 7.6923 6 yes
GO:0050658 RNA transport 7.6923 4 yes
GO:0051028 mRNA transport 7.6923 5 yes
GO:0051260 protein homooligomerization 7.6923 7 yes
GO:1900452 regulation of long-term synaptic depression 7.6923 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KCC2B_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
NICA_HUMAN [view interactions] Low throughput no yes
DLGP1_HUMAN [view entry] [view interactions] Low throughput yes no
PSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
TFPT_HUMAN [view interactions] Low throughput no yes
RN216_HUMAN [view entry] [view interactions] Low throughput yes yes
DYN2_HUMAN [view entry] [view interactions] Low throughput yes yes
UBE3A_HUMAN [view entry] [view interactions] Low throughput yes yes
SPTN4_HUMAN [view entry] [view interactions] Low throughput yes no
CCG2_HUMAN [view entry] [view interactions] Low throughput yes no
ARC_HUMAN [view entry] [view interactions] Low throughput yes no
FER_HUMAN [view interactions] High throughput no yes
ITPI2_HUMAN [view interactions] High throughput no yes
FA83B_HUMAN [view interactions] High throughput no no
PP4P2_HUMAN [view interactions] High throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
CSRP2_HUMAN [view interactions] High throughput no yes
S100P_HUMAN [view interactions] High throughput no no
SH24A_HUMAN [view interactions] High throughput no no
TBX18_HUMAN [view interactions] High throughput no no
K1C15_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
NDE1_HUMAN [view interactions] High throughput no yes
SUMO1_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO2_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO3_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
RIN2_HUMAN [view interactions] High throughput no yes
INSY1_HUMAN [view entry] [view interactions] High throughput yes yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
TOP3B_HUMAN [view interactions] High throughput no no
RET_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no