ARC_HUMAN
Evidence for PS localization
Functions
Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory . Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 . In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation . [View more on UniProt]
Protein features
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Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
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Network
ARC_HUMAN has binary interactions with 25 proteins
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ARC_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 30.7692 | 4 | no |
GO:0044389 | ubiquitin-like protein ligase binding | 23.0769 | 4 | no |
GO:0000166 | nucleotide binding | 23.0769 | 4 | no |
GO:0017076 | purine nucleotide binding | 23.0769 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 23.0769 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 23.0769 | 4 | no |
GO:0043169 | cation binding | 23.0769 | 4 | no |
GO:0046872 | metal ion binding | 23.0769 | 5 | no |
GO:0003723 | RNA binding | 19.2308 | 4 | yes |
GO:0003729 | mRNA binding | 7.6923 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ARC_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 73.0769 | 4 | yes |
GO:0010646 | regulation of cell communication | 65.3846 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 61.5385 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 61.5385 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 57.6923 | 5 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 57.6923 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 57.6923 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 57.6923 | 4 | no |
GO:0051049 | regulation of transport | 50.0000 | 4 | yes |
GO:0036211 | protein modification process | 50.0000 | 4 | no |
GO:0043412 | macromolecule modification | 50.0000 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | no |
GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 50.0000 | 5 | no |
GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
GO:0023056 | positive regulation of signaling | 46.1538 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 46.1538 | 5 | no |
GO:0010647 | positive regulation of cell communication | 42.3077 | 5 | yes |
GO:0031344 | regulation of cell projection organization | 42.3077 | 5 | yes |
GO:0048168 | regulation of neuronal synaptic plasticity | 42.3077 | 4 | yes |
GO:0051247 | positive regulation of protein metabolic process | 42.3077 | 6 | no |
GO:0009889 | regulation of biosynthetic process | 42.3077 | 4 | no |
GO:0010468 | regulation of gene expression | 42.3077 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 42.3077 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 42.3077 | 5 | no |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CCG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSRP2_HUMAN | [view interactions] | High throughput | no | yes |
DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DLGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DX39A_HUMAN | [view interactions] | High throughput | no | yes |
DYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
FA83B_HUMAN | [view interactions] | High throughput | no | no |
FER_HUMAN | [view interactions] | High throughput | no | yes |
GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITPI2_HUMAN | [view interactions] | High throughput | no | yes |
K1C15_HUMAN | [view interactions] | High throughput | no | no |
KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KCC2B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NDE1_HUMAN | [view interactions] | High throughput | no | yes |
NICA_HUMAN | [view interactions] | Low throughput | no | yes |
NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PP4P2_HUMAN | [view interactions] | High throughput | no | yes |
PSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |