Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ARC_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory . Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 . In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ARC_HUMAN
GO:0017076 purine nucleotide binding 25.0000 4 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0046872 metal ion binding 20.8333 4 no
GO:0003723 RNA binding 12.5000 4 yes
GO:0003729 mRNA binding 8.3333 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ARC_HUMAN
GO:0010646 regulation of cell communication 75.0000 4 yes
GO:0048522 positive regulation of cellular process 70.8333 4 yes
GO:0009966 regulation of signal transduction 62.5000 4 yes
GO:0050804 modulation of chemical synaptic transmission 62.5000 5 yes
GO:0051128 regulation of cellular component organization 62.5000 4 yes
GO:0099177 regulation of trans-synaptic signaling 62.5000 4 yes
GO:0051049 regulation of transport 54.1667 4 yes
GO:0060255 regulation of macromolecule metabolic process 54.1667 4 no
GO:0031344 regulation of cell projection organization 50.0000 5 yes
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0006996 organelle organization 45.8333 4 yes
GO:0030030 cell projection organization 45.8333 4 yes
GO:0043269 regulation of ion transport 45.8333 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 45.8333 6 yes
GO:0031323 regulation of cellular metabolic process 45.8333 4 no
GO:0048523 negative regulation of cellular process 45.8333 4 no
GO:0010647 positive regulation of cell communication 41.6667 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 41.6667 4 yes
GO:0023056 positive regulation of signaling 41.6667 4 yes
GO:0009893 positive regulation of metabolic process 41.6667 4 no
GO:0010604 positive regulation of macromolecule metabolic process 41.6667 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 41.6667 5 no
GO:0051246 regulation of protein metabolic process 41.6667 5 no
GO:0043933 protein-containing complex organization 37.5000 4 yes
GO:0048168 regulation of neuronal synaptic plasticity 37.5000 4 yes
GO:0050890 cognition 37.5000 4 yes
GO:0051050 positive regulation of transport 37.5000 4 yes
GO:0031325 positive regulation of cellular metabolic process 37.5000 5 no
GO:0051247 positive regulation of protein metabolic process 37.5000 6 no
GO:0036211 protein modification process 37.5000 4 no
GO:0043412 macromolecule modification 37.5000 4 no
GO:0051129 negative regulation of cellular component organization 37.5000 5 no
GO:0045595 regulation of cell differentiation 37.5000 4 no
GO:0051094 positive regulation of developmental process 37.5000 4 no
GO:0010975 regulation of neuron projection development 33.3333 7 yes
GO:0022607 cellular component assembly 33.3333 4 yes
GO:0032990 cell part morphogenesis 33.3333 4 yes
GO:0034762 regulation of transmembrane transport 33.3333 4 yes
GO:0034765 regulation of ion transmembrane transport 33.3333 5 yes
GO:0048812 neuron projection morphogenesis 33.3333 7 yes
GO:0048858 cell projection morphogenesis 33.3333 5 yes
GO:0120036 plasma membrane bounded cell projection organization 33.3333 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 33.3333 6 yes
GO:0010468 regulation of gene expression 33.3333 5 no
GO:0010941 regulation of cell death 33.3333 4 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0007612 learning 29.1667 4 yes
GO:0043270 positive regulation of ion transport 29.1667 5 yes
GO:0060627 regulation of vesicle-mediated transport 29.1667 4 yes
GO:1904062 regulation of cation transmembrane transport 29.1667 6 yes
GO:0043085 positive regulation of catalytic activity 29.1667 4 no
GO:0008104 protein localization 29.1667 4 no
GO:0042981 regulation of apoptotic process 29.1667 6 no
GO:0043067 regulation of programmed cell death 29.1667 5 no
GO:1902531 regulation of intracellular signal transduction 29.1667 5 no
GO:0019220 regulation of phosphate metabolic process 29.1667 6 no
GO:0051174 regulation of phosphorus metabolic process 29.1667 5 no
GO:0007010 cytoskeleton organization 25.0000 5 yes
GO:0016192 vesicle-mediated transport 25.0000 4 yes
GO:0022604 regulation of cell morphogenesis 25.0000 5 yes
GO:0022898 regulation of transmembrane transporter activity 25.0000 4 yes
GO:0030100 regulation of endocytosis 25.0000 5 yes
GO:0031175 neuron projection development 25.0000 6 yes
GO:0032412 regulation of ion transmembrane transporter activity 25.0000 5 yes
GO:0034764 positive regulation of transmembrane transport 25.0000 5 yes
GO:0034767 positive regulation of ion transmembrane transport 25.0000 6 yes
GO:0048259 regulation of receptor-mediated endocytosis 25.0000 6 yes
GO:0050806 positive regulation of synaptic transmission 25.0000 5 yes
GO:0050807 regulation of synapse organization 25.0000 5 yes
GO:0065003 protein-containing complex assembly 25.0000 5 yes
GO:0099175 regulation of postsynapse organization 25.0000 6 yes
GO:0099601 regulation of neurotransmitter receptor activity 25.0000 4 yes
GO:0106027 neuron projection organization 25.0000 6 yes
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0030162 regulation of proteolysis 25.0000 6 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0045862 positive regulation of proteolysis 25.0000 7 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0010942 positive regulation of cell death 25.0000 5 no
GO:1901214 regulation of neuron death 25.0000 5 no
GO:0045597 positive regulation of cell differentiation 25.0000 5 no
GO:0060284 regulation of cell development 25.0000 5 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 no
GO:0006897 endocytosis 20.8333 5 yes
GO:0051259 protein complex oligomerization 20.8333 6 yes
GO:0071702 organic substance transport 20.8333 4 yes
GO:0071705 nitrogen compound transport 20.8333 4 yes
GO:1904064 positive regulation of cation transmembrane transport 20.8333 7 yes
GO:2001257 regulation of cation channel activity 20.8333 6 yes
GO:0006355 regulation of DNA-templated transcription 20.8333 6 no
GO:0006811 ion transport 20.8333 4 no
GO:0006812 cation transport 20.8333 5 no
GO:0009416 response to light stimulus 20.8333 4 no
GO:0010959 regulation of metal ion transport 20.8333 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.8333 5 no
GO:0030001 metal ion transport 20.8333 6 no
GO:0051252 regulation of RNA metabolic process 20.8333 5 no
GO:1903506 regulation of nucleic acid-templated transcription 20.8333 7 no
GO:2001141 regulation of RNA biosynthetic process 20.8333 6 no
GO:0031345 negative regulation of cell projection organization 20.8333 6 no
GO:0006468 protein phosphorylation 20.8333 5 no
GO:0006796 phosphate-containing compound metabolic process 20.8333 4 no
GO:0016310 phosphorylation 20.8333 5 no
GO:0031346 positive regulation of cell projection organization 20.8333 6 no
GO:0048169 regulation of long-term neuronal synaptic plasticity 20.8333 5 no
GO:0051240 positive regulation of multicellular organismal process 20.8333 4 no
GO:0033043 regulation of organelle organization 20.8333 5 no
GO:0048638 regulation of developmental growth 20.8333 4 no
GO:0071310 cellular response to organic substance 20.8333 4 no
GO:0001934 positive regulation of protein phosphorylation 20.8333 8 no
GO:0010562 positive regulation of phosphorus metabolic process 20.8333 6 no
GO:0032880 regulation of protein localization 20.8333 5 no
GO:0042327 positive regulation of phosphorylation 20.8333 8 no
GO:0045596 negative regulation of cell differentiation 20.8333 5 no
GO:0045937 positive regulation of phosphate metabolic process 20.8333 7 no
GO:0051093 negative regulation of developmental process 20.8333 4 no
GO:0051338 regulation of transferase activity 20.8333 4 no
GO:0060548 negative regulation of cell death 20.8333 5 no
GO:1901215 negative regulation of neuron death 20.8333 6 no
GO:1903829 positive regulation of protein localization 20.8333 5 no
GO:0072657 protein localization to membrane 20.8333 4 no
GO:0002090 regulation of receptor internalization 16.6667 7 yes
GO:0007613 memory 16.6667 4 yes
GO:0032411 positive regulation of transporter activity 16.6667 4 yes
GO:0032414 positive regulation of ion transmembrane transporter activity 16.6667 5 yes
GO:0061001 regulation of dendritic spine morphogenesis 16.6667 5 yes
GO:1900271 regulation of long-term synaptic potentiation 16.6667 4 yes
GO:0009952 anterior/posterior pattern specification 12.5000 4 yes
GO:0051260 protein homooligomerization 12.5000 7 yes
GO:0060291 long-term synaptic potentiation 12.5000 4 yes
GO:0060997 dendritic spine morphogenesis 12.5000 6 yes
GO:0097061 dendritic spine organization 12.5000 5 yes
GO:0099173 postsynapse organization 12.5000 4 yes
GO:1900452 regulation of long-term synaptic depression 12.5000 4 yes
GO:2000273 positive regulation of signaling receptor activity 12.5000 4 yes
GO:2000311 regulation of AMPA receptor activity 12.5000 5 yes
GO:2000969 positive regulation of AMPA receptor activity 12.5000 5 yes
GO:2001259 positive regulation of cation channel activity 12.5000 6 yes
GO:0007492 endoderm development 8.3333 4 yes
GO:0007616 long-term memory 8.3333 5 yes
GO:0015931 nucleobase-containing compound transport 8.3333 5 yes
GO:0050657 nucleic acid transport 8.3333 6 yes
GO:0050658 RNA transport 8.3333 4 yes
GO:0051028 mRNA transport 8.3333 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KCC2B_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
NICA_HUMAN [view interactions] Low throughput no yes
DLGP1_HUMAN [view entry] [view interactions] Low throughput yes no
PSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
TFPT_HUMAN [view interactions] Low throughput no yes
RN216_HUMAN [view entry] [view interactions] Low throughput yes yes
DYN2_HUMAN [view entry] [view interactions] Low throughput yes yes
UBE3A_HUMAN [view interactions] Low throughput no yes
SPTN4_HUMAN [view entry] [view interactions] Low throughput yes no
CCG2_HUMAN [view entry] [view interactions] Low throughput yes no
ARC_HUMAN [view entry] [view interactions] Low throughput yes no
PP4P2_HUMAN [view interactions] High throughput no yes
FA83B_HUMAN [view interactions] High throughput no no
ITPI2_HUMAN [view interactions] High throughput no yes
FER_HUMAN [view interactions] High throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
CSRP2_HUMAN [view interactions] High throughput no yes
S100P_HUMAN [view interactions] High throughput no no
SH24A_HUMAN [view interactions] High throughput no no
TBX18_HUMAN [view interactions] High throughput no no
K1C15_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
NDE1_HUMAN [view interactions] High throughput no yes
SUMO1_HUMAN [view interactions] High throughput no yes
SUMO2_HUMAN [view interactions] High throughput no yes
SUMO3_HUMAN [view interactions] High throughput no yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
RIN2_HUMAN [view interactions] High throughput no yes
INSY1_HUMAN [view entry] [view interactions] High throughput yes yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
RET_HUMAN [view interactions] High throughput no yes
EGR1_HUMAN [view interactions] Computational no yes
EGR3_HUMAN [view interactions] Computational no yes
CREB1_HUMAN [view interactions] Computational no yes
MEF2D_HUMAN [view interactions] Computational no yes
SH3G3_HUMAN [view entry] [view interactions] Computational yes no
EGR2_HUMAN [view interactions] Computational no no
JUND_HUMAN [view interactions] Computational no yes
FOSB_HUMAN [view interactions] Computational no no
SH3G1_HUMAN [view entry] [view interactions] Computational yes no
FOS_HUMAN [view interactions] Computational no yes
SRF_HUMAN [view interactions] Computational no yes
JUNB_HUMAN [view interactions] Computational no yes
FOSL1_HUMAN [view interactions] Computational no yes