Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CCG2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CCG2_HUMAN
GO:0005216 ion channel activity 45.8333 4 yes
GO:0015267 channel activity 45.8333 4 yes
GO:0022836 gated channel activity 45.8333 5 yes
GO:0005261 cation channel activity 43.7500 5 yes
GO:0008324 cation transmembrane transporter activity 43.7500 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 43.7500 4 yes
GO:0046873 metal ion transmembrane transporter activity 35.4167 5 yes
GO:0005262 calcium channel activity 33.3333 6 yes
GO:0015085 calcium ion transmembrane transporter activity 33.3333 6 yes
GO:0005244 voltage-gated ion channel activity 31.2500 4 yes
GO:0022832 voltage-gated channel activity 31.2500 6 yes
GO:0022843 voltage-gated cation channel activity 31.2500 5 yes
GO:0004970 ionotropic glutamate receptor activity 27.0833 5 no
GO:0005230 extracellular ligand-gated ion channel activity 27.0833 6 no
GO:0008066 glutamate receptor activity 27.0833 4 no
GO:0015276 ligand-gated ion channel activity 27.0833 5 no
GO:0022824 transmitter-gated ion channel activity 27.0833 5 no
GO:0022834 ligand-gated channel activity 27.0833 6 no
GO:0022835 transmitter-gated channel activity 27.0833 4 no
GO:0099094 ligand-gated cation channel activity 22.9167 6 no
GO:0005245 voltage-gated calcium channel activity 18.7500 6 yes
GO:0035254 glutamate receptor binding 10.4167 4 yes
GO:0035255 ionotropic glutamate receptor binding 8.3333 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CCG2_HUMAN
GO:0048522 positive regulation of cellular process 68.7500 4 yes
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0051049 regulation of transport 54.1667 4 yes
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 yes
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 yes
GO:0043269 regulation of ion transport 45.8333 5 yes
GO:0008104 protein localization 45.8333 4 yes
GO:0009966 regulation of signal transduction 43.7500 4 yes
GO:0034765 regulation of ion transmembrane transport 41.6667 5 yes
GO:0034762 regulation of transmembrane transport 41.6667 4 yes
GO:0010647 positive regulation of cell communication 39.5833 5 yes
GO:0023056 positive regulation of signaling 39.5833 4 yes
GO:1904062 regulation of cation transmembrane transport 37.5000 6 yes
GO:0051171 regulation of nitrogen compound metabolic process 35.4167 4 no
GO:0060255 regulation of macromolecule metabolic process 35.4167 4 no
GO:0080090 regulation of primary metabolic process 35.4167 4 no
GO:0048523 negative regulation of cellular process 35.4167 4 no
GO:0022898 regulation of transmembrane transporter activity 35.4167 4 yes
GO:0032412 regulation of ion transmembrane transporter activity 35.4167 5 yes
GO:2001257 regulation of cation channel activity 33.3333 6 yes
GO:0007268 chemical synaptic transmission 33.3333 6 no
GO:0098916 anterograde trans-synaptic signaling 33.3333 5 no
GO:0099537 trans-synaptic signaling 33.3333 4 no
GO:0050806 positive regulation of synaptic transmission 31.2500 5 yes
GO:0051246 regulation of protein metabolic process 31.2500 5 no
GO:0072657 protein localization to membrane 29.1667 4 yes
GO:0009893 positive regulation of metabolic process 29.1667 4 no
GO:0010604 positive regulation of macromolecule metabolic process 29.1667 5 no
GO:0031323 regulation of cellular metabolic process 29.1667 4 no
GO:0051128 regulation of cellular component organization 29.1667 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 27.0833 5 no
GO:0051050 positive regulation of transport 25.0000 4 yes
GO:0060341 regulation of cellular localization 25.0000 4 yes
GO:0007215 glutamate receptor signaling pathway 25.0000 4 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0016192 vesicle-mediated transport 25.0000 4 yes
GO:0006811 ion transport 22.9167 4 no
GO:0006812 cation transport 22.9167 5 no
GO:0006816 calcium ion transport 22.9167 7 no
GO:0030001 metal ion transport 22.9167 6 no
GO:0031325 positive regulation of cellular metabolic process 22.9167 5 no
GO:0043085 positive regulation of catalytic activity 22.9167 4 no
GO:0044057 regulation of system process 22.9167 4 no
GO:0010941 regulation of cell death 22.9167 4 no
GO:0099601 regulation of neurotransmitter receptor activity 20.8333 4 yes
GO:0022607 cellular component assembly 20.8333 4 no
GO:0042981 regulation of apoptotic process 20.8333 6 no
GO:0043067 regulation of programmed cell death 20.8333 5 no
GO:0033365 protein localization to organelle 20.8333 5 yes
GO:0035418 protein localization to synapse 18.7500 6 yes
GO:0071702 organic substance transport 18.7500 4 yes
GO:0071705 nitrogen compound transport 18.7500 4 yes
GO:1902414 protein localization to cell junction 18.7500 5 yes
GO:1990778 protein localization to cell periphery 18.7500 5 yes
GO:0006897 endocytosis 18.7500 5 yes
GO:0032880 regulation of protein localization 18.7500 5 yes
GO:0034330 cell junction organization 18.7500 4 yes
GO:0043270 positive regulation of ion transport 16.6667 5 yes
GO:0050808 synapse organization 16.6667 5 yes
GO:0062237 protein localization to postsynapse 16.6667 7 yes
GO:1903539 protein localization to postsynaptic membrane 16.6667 5 yes
GO:2000311 regulation of AMPA receptor activity 16.6667 5 yes
GO:0015031 protein transport 16.6667 4 yes
GO:0034764 positive regulation of transmembrane transport 14.5833 5 yes
GO:0034767 positive regulation of ion transmembrane transport 14.5833 6 yes
GO:1903829 positive regulation of protein localization 14.5833 5 yes
GO:1904064 positive regulation of cation transmembrane transport 14.5833 7 yes
GO:0006886 intracellular protein transport 14.5833 4 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 12.5000 6 yes
GO:0099633 protein localization to postsynaptic specialization membrane 12.5000 6 yes
GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 12.5000 4 yes
GO:1905475 regulation of protein localization to membrane 12.5000 6 yes
GO:2001259 positive regulation of cation channel activity 12.5000 6 yes
GO:0007528 neuromuscular junction development 12.5000 6 yes
GO:0010038 response to metal ion 12.5000 4 yes
GO:0032411 positive regulation of transporter activity 12.5000 4 yes
GO:0032414 positive regulation of ion transmembrane transporter activity 12.5000 5 yes
GO:0051968 positive regulation of synaptic transmission, glutamatergic 10.4167 6 yes
GO:0072594 establishment of protein localization to organelle 10.4167 4 yes
GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping 10.4167 4 yes
GO:0099628 neurotransmitter receptor diffusion trapping 10.4167 4 yes
GO:1904375 regulation of protein localization to cell periphery 10.4167 6 yes
GO:1905477 positive regulation of protein localization to membrane 10.4167 6 yes
GO:0006898 receptor-mediated endocytosis 10.4167 6 yes
GO:0031623 receptor internalization 10.4167 7 yes
GO:0051899 membrane depolarization 8.3333 4 yes
GO:0061462 protein localization to lysosome 8.3333 7 yes
GO:0072665 protein localization to vacuole 8.3333 6 yes
GO:0072666 establishment of protein localization to vacuole 8.3333 5 yes
GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome 8.3333 4 yes
GO:1904377 positive regulation of protein localization to cell periphery 8.3333 6 yes
GO:2000273 positive regulation of signaling receptor activity 8.3333 4 yes
GO:2000969 positive regulation of AMPA receptor activity 8.3333 5 yes
GO:0007034 vacuolar transport 8.3333 4 yes
GO:0007041 lysosomal transport 8.3333 5 yes
GO:0008333 endosome to lysosome transport 8.3333 5 yes
GO:0051592 response to calcium ion 6.2500 5 yes
GO:0090150 establishment of protein localization to membrane 6.2500 4 yes
GO:0006605 protein targeting 6.2500 5 yes
GO:0060081 membrane hyperpolarization 4.1667 4 yes
GO:0060082 eye blink reflex 4.1667 4 yes
GO:1904508 regulation of protein localization to basolateral plasma membrane 4.1667 7 yes
GO:1904510 positive regulation of protein localization to basolateral plasma membrane 4.1667 7 yes
GO:0006612 protein targeting to membrane 4.1667 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in CCG2_HUMAN
DOID:331 central nervous system disease 4.1667 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA2_HUMAN [view entry] [view interactions] Low throughput yes yes
CNIH2_HUMAN [view entry] [view interactions] Low throughput yes no
GRIA4_HUMAN [view entry] [view interactions] Low throughput yes no
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
GOPC_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
MAP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI3_HUMAN [view interactions] Low throughput no no
MPP2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA3_HUMAN [view entry] [view interactions] Low throughput yes yes
ARC_HUMAN [view entry] [view interactions] Low throughput yes no
CCG2_HUMAN [view entry] [view interactions] Low throughput yes no
ITPR2_HUMAN [view interactions] High throughput no yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
ATF1_HUMAN [view interactions] High throughput no yes
CCNT1_HUMAN [view interactions] High throughput no yes
PAL4G_HUMAN [view interactions] High throughput no no
HMGN1_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
WIPF1_HUMAN [view interactions] High throughput no no
HBS1L_HUMAN [view interactions] High throughput no yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
KC1D_HUMAN [view entry] [view interactions] High throughput yes yes
STAT3_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
MSTO1_HUMAN [view interactions] High throughput no yes
PAL4C_HUMAN [view interactions] High throughput no no
CHK2_HUMAN [view interactions] High throughput no yes
MRP2_HUMAN [view interactions] High throughput no no
LRRC1_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CA2D1_HUMAN [view entry] [view interactions] Computational yes yes
CCG8_HUMAN [view entry] [view interactions] Computational yes no
KCC2D_HUMAN [view entry] [view interactions] Computational yes yes
ADA22_HUMAN [view entry] [view interactions] Computational yes no
CAC1A_HUMAN [view interactions] Computational no no
MYO6_HUMAN [view entry] [view interactions] Computational yes no
CAC1B_HUMAN [view interactions] Computational no yes
AKAP5_HUMAN [view entry] [view interactions] Computational yes yes
E41L1_HUMAN [view entry] [view interactions] Computational yes yes
CNIH3_HUMAN [view entry] [view interactions] Computational yes no
NMD3A_HUMAN [view entry] [view interactions] Computational yes no
CAC1H_HUMAN [view entry] [view interactions] Computational yes yes
LGI1_HUMAN [view entry] [view interactions] Computational yes no
GRID2_HUMAN [view entry] [view interactions] Computational yes no
KCC2B_HUMAN [view entry] [view interactions] Computational yes yes
NMDE2_HUMAN [view entry] [view interactions] Computational yes no
CCG1_HUMAN [view interactions] Computational no no
GRIK2_HUMAN [view entry] [view interactions] Computational yes yes
CCG3_HUMAN [view entry] [view interactions] Computational yes no
CAC1D_HUMAN [view interactions] Computational no yes
NMD3B_HUMAN [view entry] [view interactions] Computational yes no
CACB4_HUMAN [view entry] [view interactions] Computational yes yes
CACB3_HUMAN [view entry] [view interactions] Computational yes no
CACB1_HUMAN [view entry] [view interactions] Computational yes yes
NMDE4_HUMAN [view entry] [view interactions] Computational yes yes
NMDE1_HUMAN [view entry] [view interactions] Computational yes yes
SHSA9_HUMAN [view entry] [view interactions] Computational yes no
NMDE3_HUMAN [view entry] [view interactions] Computational yes no