Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CCG2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004544 LIG_Arc_Nlobe_1 LIG 226 230 -
ELMI004544 LIG_Arc_Nlobe_1 LIG 226 230 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CCG2_HUMAN
GO:0022836 gated channel activity 29.1667 5 yes
GO:0022890 inorganic cation transmembrane transporter activity 29.1667 4 yes
GO:0005216 monoatomic ion channel activity 29.1667 4 yes
GO:0015267 channel activity 29.1667 4 yes
GO:0019900 kinase binding 20.8333 4 no
GO:0019902 phosphatase binding 20.8333 4 no
GO:0016301 kinase activity 20.8333 4 no
GO:0043168 anion binding 20.8333 4 no
GO:0004970 glutamate-gated receptor activity 20.8333 4 no
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 20.8333 6 no
GO:0008066 glutamate receptor activity 20.8333 4 no
GO:0015276 ligand-gated monoatomic ion channel activity 20.8333 5 no
GO:0022824 transmitter-gated monoatomic ion channel activity 20.8333 5 no
GO:0022834 ligand-gated channel activity 20.8333 6 no
GO:0022835 transmitter-gated channel activity 20.8333 4 no
GO:0046943 carboxylic acid transmembrane transporter activity 20.8333 4 no
GO:0035254 glutamate receptor binding 16.6667 4 yes
GO:0035255 ionotropic glutamate receptor binding 12.5000 5 yes
GO:0046873 metal ion transmembrane transporter activity 12.5000 5 yes
GO:0005244 voltage-gated monoatomic ion channel activity 12.5000 5 yes
GO:0005261 monoatomic cation channel activity 12.5000 5 yes
GO:0005262 calcium channel activity 12.5000 6 yes
GO:0008324 monoatomic cation transmembrane transporter activity 12.5000 4 yes
GO:0015085 calcium ion transmembrane transporter activity 12.5000 6 yes
GO:0022832 voltage-gated channel activity 12.5000 6 yes
GO:0022843 voltage-gated monoatomic cation channel activity 8.3333 6 yes
GO:0005245 voltage-gated calcium channel activity 8.3333 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CCG2_HUMAN
GO:0010646 regulation of cell communication 83.3333 4 yes
GO:0048522 positive regulation of cellular process 75.0000 4 yes
GO:0050804 modulation of chemical synaptic transmission 58.3333 5 yes
GO:0099177 regulation of trans-synaptic signaling 58.3333 4 yes
GO:0008104 protein localization 54.1667 4 yes
GO:0009966 regulation of signal transduction 54.1667 4 yes
GO:0048523 negative regulation of cellular process 54.1667 4 no
GO:0060255 regulation of macromolecule metabolic process 54.1667 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0010647 positive regulation of cell communication 45.8333 5 yes
GO:0023056 positive regulation of signaling 45.8333 4 yes
GO:0009893 positive regulation of metabolic process 45.8333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 45.8333 5 no
GO:0051049 regulation of transport 41.6667 4 yes
GO:0031325 positive regulation of cellular metabolic process 41.6667 5 no
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0051128 regulation of cellular component organization 37.5000 4 no
GO:0022607 cellular component assembly 37.5000 4 no
GO:0034762 regulation of transmembrane transport 33.3333 4 yes
GO:0050806 positive regulation of synaptic transmission 33.3333 5 yes
GO:0072657 protein localization to membrane 33.3333 4 yes
GO:0098657 import into cell 33.3333 4 yes
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0007268 chemical synaptic transmission 33.3333 7 no
GO:0098916 anterograde trans-synaptic signaling 33.3333 6 no
GO:0099536 synaptic signaling 33.3333 4 no
GO:0099537 trans-synaptic signaling 33.3333 5 no
GO:0006996 organelle organization 33.3333 4 no
GO:0022898 regulation of transmembrane transporter activity 29.1667 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 29.1667 5 yes
GO:0033365 protein localization to organelle 29.1667 5 yes
GO:0060341 regulation of cellular localization 29.1667 4 yes
GO:0071702 organic substance transport 29.1667 4 yes
GO:0071705 nitrogen compound transport 29.1667 4 yes
GO:0019220 regulation of phosphate metabolic process 29.1667 6 no
GO:0022603 regulation of anatomical structure morphogenesis 29.1667 4 no
GO:0051174 regulation of phosphorus metabolic process 29.1667 5 no
GO:0030030 cell projection organization 29.1667 4 no
GO:0050890 cognition 29.1667 4 no
GO:0120036 plasma membrane bounded cell projection organization 29.1667 5 no
GO:0043933 protein-containing complex organization 29.1667 4 no
GO:0065003 protein-containing complex assembly 29.1667 5 no
GO:0015031 protein transport 25.0000 4 yes
GO:0032880 regulation of protein localization 25.0000 5 yes
GO:0034330 cell junction organization 25.0000 4 yes
GO:0006796 phosphate-containing compound metabolic process 25.0000 4 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0016310 phosphorylation 25.0000 5 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0007612 learning 25.0000 4 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0006886 intracellular protein transport 20.8333 4 yes
GO:0035418 protein localization to synapse 20.8333 6 yes
GO:0050808 synapse organization 20.8333 5 yes
GO:0099601 regulation of neurotransmitter receptor activity 20.8333 4 yes
GO:1902414 protein localization to cell junction 20.8333 5 yes
GO:0008285 negative regulation of cell population proliferation 20.8333 5 no
GO:0009891 positive regulation of biosynthetic process 20.8333 5 no
GO:0009894 regulation of catabolic process 20.8333 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 20.8333 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.8333 5 no
GO:0030162 regulation of proteolysis 20.8333 6 no
GO:0031328 positive regulation of cellular biosynthetic process 20.8333 6 no
GO:0045595 regulation of cell differentiation 20.8333 4 no
GO:0048585 negative regulation of response to stimulus 20.8333 4 no
GO:0051252 regulation of RNA metabolic process 20.8333 5 no
GO:0001932 regulation of protein phosphorylation 20.8333 7 no
GO:0001934 positive regulation of protein phosphorylation 20.8333 8 no
GO:0042325 regulation of phosphorylation 20.8333 7 no
GO:0042327 positive regulation of phosphorylation 20.8333 8 no
GO:0043113 receptor clustering 20.8333 5 no
GO:0010648 negative regulation of cell communication 20.8333 5 no
GO:0023057 negative regulation of signaling 20.8333 4 no
GO:0031344 regulation of cell projection organization 20.8333 5 no
GO:0042981 regulation of apoptotic process 20.8333 5 no
GO:0043067 regulation of programmed cell death 20.8333 4 no
GO:0048168 regulation of neuronal synaptic plasticity 20.8333 4 no
GO:0048812 neuron projection morphogenesis 20.8333 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 20.8333 4 no
GO:1902531 regulation of intracellular signal transduction 20.8333 5 no
GO:0007215 glutamate receptor signaling pathway 20.8333 4 no
GO:0006898 receptor-mediated endocytosis 16.6667 4 yes
GO:0010038 response to metal ion 16.6667 4 yes
GO:0062237 protein localization to postsynapse 16.6667 7 yes
GO:0072594 establishment of protein localization to organelle 16.6667 4 yes
GO:0099633 protein localization to postsynaptic specialization membrane 16.6667 6 yes
GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane 16.6667 4 yes
GO:1903539 protein localization to postsynaptic membrane 16.6667 5 yes
GO:1903829 positive regulation of protein localization 16.6667 5 yes
GO:1990778 protein localization to cell periphery 16.6667 5 yes
GO:0007528 neuromuscular junction development 12.5000 6 yes
GO:0031623 receptor internalization 12.5000 5 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 12.5000 6 yes
GO:0051968 positive regulation of synaptic transmission, glutamatergic 12.5000 6 yes
GO:0090150 establishment of protein localization to membrane 12.5000 4 yes
GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping 12.5000 4 yes
GO:0099628 neurotransmitter receptor diffusion trapping 12.5000 4 yes
GO:1904375 regulation of protein localization to cell periphery 12.5000 6 yes
GO:1904377 positive regulation of protein localization to cell periphery 12.5000 6 yes
GO:1905475 regulation of protein localization to membrane 12.5000 6 yes
GO:1905477 positive regulation of protein localization to membrane 12.5000 6 yes
GO:2000311 regulation of AMPA receptor activity 12.5000 5 yes
GO:0006605 protein targeting 8.3333 4 yes
GO:0006612 protein targeting to membrane 8.3333 5 yes
GO:0007034 vacuolar transport 8.3333 4 yes
GO:0007041 lysosomal transport 8.3333 5 yes
GO:0019226 transmission of nerve impulse 8.3333 4 yes
GO:0051592 response to calcium ion 8.3333 5 yes
GO:0051899 membrane depolarization 8.3333 4 yes
GO:0060081 membrane hyperpolarization 8.3333 4 yes
GO:0060082 eye blink reflex 8.3333 4 yes
GO:0061462 protein localization to lysosome 8.3333 7 yes
GO:0072665 protein localization to vacuole 8.3333 6 yes
GO:0072666 establishment of protein localization to vacuole 8.3333 5 yes
GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome 8.3333 4 yes
GO:1904508 regulation of protein localization to basolateral plasma membrane 8.3333 7 yes
GO:1904510 positive regulation of protein localization to basolateral plasma membrane 8.3333 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA2_HUMAN [view entry] [view interactions] Low throughput yes yes
CNIH2_HUMAN [view entry] [view interactions] Low throughput yes no
GRIA4_HUMAN [view entry] [view interactions] Low throughput yes no
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
GOPC_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG3_HUMAN [view entry] [view interactions] Low throughput yes yes
MAP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI3_HUMAN [view interactions] Low throughput no no
MPP2_HUMAN [view entry] [view interactions] Low throughput yes yes
ARC_HUMAN [view entry] [view interactions] Low throughput yes no
CCG2_HUMAN [view entry] [view interactions] Low throughput yes no
GRIA3_HUMAN [view entry] [view interactions] Low throughput yes yes
PAL4G_HUMAN [view interactions] High throughput no no
CCNT1_HUMAN [view interactions] High throughput no yes
ATF1_HUMAN [view interactions] High throughput no yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
ITPR2_HUMAN [view interactions] High throughput no yes
HMGN1_HUMAN [view interactions] High throughput no yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
SRPK2_HUMAN [view entry] [view interactions] High throughput yes yes
WIPF1_HUMAN [view interactions] High throughput no no
HBS1L_HUMAN [view interactions] High throughput no yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
KC1D_HUMAN [view entry] [view interactions] High throughput yes yes
STAT3_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
MSTO1_HUMAN [view interactions] High throughput no yes
PAL4C_HUMAN [view interactions] High throughput no no
CHK2_HUMAN [view interactions] High throughput no yes
MRP2_HUMAN [view interactions] High throughput no no
LRRC1_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes