Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CNIH2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CNIH2_HUMAN
GO:0005216 monoatomic ion channel activity 66.6667 4 no
GO:0015267 channel activity 66.6667 4 no
GO:0022836 gated channel activity 66.6667 5 no
GO:0022890 inorganic cation transmembrane transporter activity 66.6667 4 no
GO:0004970 glutamate-gated receptor activity 33.3333 4 no
GO:0004971 AMPA glutamate receptor activity 33.3333 5 no
GO:0005230 extracellular ligand-gated monoatomic ion channel activity 33.3333 6 no
GO:0008066 glutamate receptor activity 33.3333 4 no
GO:0015276 ligand-gated monoatomic ion channel activity 33.3333 5 no
GO:0022824 transmitter-gated monoatomic ion channel activity 33.3333 5 no
GO:0022834 ligand-gated channel activity 33.3333 6 no
GO:0022835 transmitter-gated channel activity 33.3333 4 no
GO:0046943 carboxylic acid transmembrane transporter activity 33.3333 4 no
GO:0098960 postsynaptic neurotransmitter receptor activity 33.3333 4 no
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 33.3333 5 no
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 33.3333 6 no
GO:0005244 voltage-gated monoatomic ion channel activity 33.3333 5 no
GO:0005245 voltage-gated calcium channel activity 33.3333 7 no
GO:0005261 monoatomic cation channel activity 33.3333 5 no
GO:0005262 calcium channel activity 33.3333 6 no
GO:0008324 monoatomic cation transmembrane transporter activity 33.3333 4 no
GO:0015085 calcium ion transmembrane transporter activity 33.3333 6 no
GO:0022832 voltage-gated channel activity 33.3333 6 no
GO:0022843 voltage-gated monoatomic cation channel activity 33.3333 6 no
GO:0035254 glutamate receptor binding 33.3333 4 no
GO:0046873 metal ion transmembrane transporter activity 33.3333 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in CNIH2_HUMAN
GO:0010646 regulation of cell communication 100.0000 4 yes
GO:0009966 regulation of signal transduction 66.6667 4 yes
GO:0022898 regulation of transmembrane transporter activity 66.6667 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 66.6667 5 yes
GO:0034762 regulation of transmembrane transport 66.6667 4 yes
GO:0051049 regulation of transport 66.6667 4 yes
GO:0099601 regulation of neurotransmitter receptor activity 66.6667 4 yes
GO:2000311 regulation of AMPA receptor activity 66.6667 5 yes
GO:0050804 modulation of chemical synaptic transmission 66.6667 5 no
GO:0099177 regulation of trans-synaptic signaling 66.6667 4 no
GO:0006898 receptor-mediated endocytosis 50.0000 4 no
GO:0010647 positive regulation of cell communication 50.0000 5 no
GO:0023056 positive regulation of signaling 50.0000 4 no
GO:0031623 receptor internalization 50.0000 5 no
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0050806 positive regulation of synaptic transmission 50.0000 5 no
GO:0098657 import into cell 50.0000 4 no
GO:0007268 chemical synaptic transmission 33.3333 7 no
GO:0035249 synaptic transmission, glutamatergic 33.3333 8 no
GO:0098916 anterograde trans-synaptic signaling 33.3333 6 no
GO:0099536 synaptic signaling 33.3333 4 no
GO:0099537 trans-synaptic signaling 33.3333 5 no
GO:0006886 intracellular protein transport 33.3333 4 no
GO:0007034 vacuolar transport 33.3333 4 no
GO:0007041 lysosomal transport 33.3333 5 no
GO:0008104 protein localization 33.3333 4 no
GO:0010038 response to metal ion 33.3333 4 no
GO:0015031 protein transport 33.3333 4 no
GO:0019226 transmission of nerve impulse 33.3333 4 no
GO:0033365 protein localization to organelle 33.3333 5 no
GO:0034330 cell junction organization 33.3333 4 no
GO:0050808 synapse organization 33.3333 5 no
GO:0051966 regulation of synaptic transmission, glutamatergic 33.3333 6 no
GO:0051968 positive regulation of synaptic transmission, glutamatergic 33.3333 6 no
GO:0061462 protein localization to lysosome 33.3333 7 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0071705 nitrogen compound transport 33.3333 4 no
GO:0072594 establishment of protein localization to organelle 33.3333 4 no
GO:0072665 protein localization to vacuole 33.3333 6 no
GO:0072666 establishment of protein localization to vacuole 33.3333 5 no
GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome 33.3333 4 no
GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping 33.3333 4 no
GO:0099628 neurotransmitter receptor diffusion trapping 33.3333 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
CCG2_HUMAN [view entry] [view interactions] Low throughput yes no
CCG8_HUMAN [view entry] [view interactions] Low throughput yes no
GRIA2_HUMAN [view entry] [view interactions] Low throughput yes yes
CNIH2_HUMAN [view entry] [view interactions] Low throughput yes no
CR3L1_HUMAN [view interactions] High throughput no yes
CD53_HUMAN [view interactions] High throughput no yes
3HIDH_HUMAN [view interactions] High throughput no yes
TM14B_HUMAN [view interactions] High throughput no no
GORAB_HUMAN [view interactions] High throughput no yes
TMPS2_HUMAN [view interactions] High throughput no no