CNIH2_HUMAN
Evidence for PS localization
Functions
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CNIH2_HUMAN |
|---|---|---|---|---|
| GO:0005216 | ion channel activity | 66.6667 | 4 | no |
| GO:0005261 | cation channel activity | 66.6667 | 5 | no |
| GO:0008324 | cation transmembrane transporter activity | 66.6667 | 4 | no |
| GO:0015267 | channel activity | 66.6667 | 4 | no |
| GO:0022836 | gated channel activity | 66.6667 | 5 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 66.6667 | 4 | no |
| GO:0001540 | amyloid-beta binding | 40.0000 | 4 | no |
| GO:0004970 | ionotropic glutamate receptor activity | 40.0000 | 5 | no |
| GO:0005230 | extracellular ligand-gated ion channel activity | 40.0000 | 6 | no |
| GO:0005244 | voltage-gated ion channel activity | 40.0000 | 4 | no |
| GO:0005262 | calcium channel activity | 40.0000 | 6 | no |
| GO:0008066 | glutamate receptor activity | 40.0000 | 4 | no |
| GO:0015085 | calcium ion transmembrane transporter activity | 40.0000 | 6 | no |
| GO:0015276 | ligand-gated ion channel activity | 40.0000 | 5 | no |
| GO:0022824 | transmitter-gated ion channel activity | 40.0000 | 5 | no |
| GO:0022832 | voltage-gated channel activity | 40.0000 | 6 | no |
| GO:0022834 | ligand-gated channel activity | 40.0000 | 6 | no |
| GO:0022835 | transmitter-gated channel activity | 40.0000 | 4 | no |
| GO:0022843 | voltage-gated cation channel activity | 40.0000 | 5 | no |
| GO:0046873 | metal ion transmembrane transporter activity | 40.0000 | 5 | no |
| GO:0099094 | ligand-gated cation channel activity | 40.0000 | 6 | no |
| GO:0004971 | AMPA glutamate receptor activity | 26.6667 | 6 | no |
| GO:0005245 | voltage-gated calcium channel activity | 26.6667 | 6 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CNIH2_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 66.6667 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 66.6667 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 66.6667 | 4 | yes |
| GO:0051049 | regulation of transport | 60.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 53.3333 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 53.3333 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 53.3333 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 53.3333 | 5 | yes |
| GO:0043269 | regulation of ion transport | 53.3333 | 5 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 53.3333 | 6 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 46.6667 | 4 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 46.6667 | 5 | yes |
| GO:0099601 | regulation of neurotransmitter receptor activity | 46.6667 | 4 | yes |
| GO:2000311 | regulation of AMPA receptor activity | 46.6667 | 5 | yes |
| GO:2001257 | regulation of cation channel activity | 46.6667 | 6 | yes |
| GO:0048522 | positive regulation of cellular process | 46.6667 | 4 | no |
| GO:0008104 | protein localization | 46.6667 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 40.0000 | 6 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 40.0000 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 40.0000 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 40.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 40.0000 | 4 | no |
| GO:0015031 | protein transport | 40.0000 | 4 | no |
| GO:0071702 | organic substance transport | 40.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 40.0000 | 4 | no |
| GO:0031644 | regulation of nervous system process | 33.3333 | 5 | yes |
| GO:0044057 | regulation of system process | 33.3333 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 33.3333 | 4 | yes |
| GO:0007215 | glutamate receptor signaling pathway | 33.3333 | 4 | no |
| GO:0006886 | intracellular protein transport | 33.3333 | 4 | no |
| GO:0006897 | endocytosis | 33.3333 | 5 | no |
| GO:0006898 | receptor-mediated endocytosis | 33.3333 | 6 | no |
| GO:0031623 | receptor internalization | 33.3333 | 7 | no |
| GO:0050806 | positive regulation of synaptic transmission | 33.3333 | 5 | no |
| GO:0098962 | regulation of postsynaptic neurotransmitter receptor activity | 26.6667 | 5 | yes |
| GO:0006811 | ion transport | 26.6667 | 4 | no |
| GO:0006812 | cation transport | 26.6667 | 5 | no |
| GO:0006816 | calcium ion transport | 26.6667 | 7 | no |
| GO:0030001 | metal ion transport | 26.6667 | 6 | no |
| GO:0007034 | vacuolar transport | 26.6667 | 4 | no |
| GO:0007041 | lysosomal transport | 26.6667 | 5 | no |
| GO:0008333 | endosome to lysosome transport | 26.6667 | 5 | no |
| GO:0033365 | protein localization to organelle | 26.6667 | 5 | no |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 26.6667 | 6 | no |
| GO:0051968 | positive regulation of synaptic transmission, glutamatergic | 26.6667 | 6 | no |
| GO:0061462 | protein localization to lysosome | 26.6667 | 7 | no |
| GO:0072594 | establishment of protein localization to organelle | 26.6667 | 4 | no |
| GO:0072665 | protein localization to vacuole | 26.6667 | 6 | no |
| GO:0072666 | establishment of protein localization to vacuole | 26.6667 | 5 | no |
| GO:0098943 | neurotransmitter receptor transport, postsynaptic endosome to lysosome | 26.6667 | 4 | no |
| GO:0098970 | postsynaptic neurotransmitter receptor diffusion trapping | 26.6667 | 4 | no |
| GO:0099628 | neurotransmitter receptor diffusion trapping | 26.6667 | 4 | no |
| GO:0032386 | regulation of intracellular transport | 20.0000 | 5 | yes |
| GO:0035249 | synaptic transmission, glutamatergic | 20.0000 | 7 | yes |
| GO:0032387 | negative regulation of intracellular transport | 13.3333 | 5 | yes |
| GO:0032886 | regulation of microtubule-based process | 13.3333 | 4 | yes |
| GO:0051051 | negative regulation of transport | 13.3333 | 4 | yes |
| GO:0060632 | regulation of microtubule-based movement | 13.3333 | 5 | yes |
| GO:1901608 | regulation of vesicle transport along microtubule | 13.3333 | 7 | yes |
| GO:1901609 | negative regulation of vesicle transport along microtubule | 13.3333 | 6 | yes |
| GO:1902513 | regulation of organelle transport along microtubule | 13.3333 | 6 | yes |
| GO:1902683 | regulation of receptor localization to synapse | 13.3333 | 4 | yes |
| GO:1902684 | negative regulation of receptor localization to synapse | 13.3333 | 4 | yes |
| GO:1902803 | regulation of synaptic vesicle transport | 13.3333 | 5 | yes |
| GO:1902804 | negative regulation of synaptic vesicle transport | 13.3333 | 5 | yes |
| GO:1903742 | regulation of anterograde synaptic vesicle transport | 13.3333 | 6 | yes |
| GO:1903743 | negative regulation of anterograde synaptic vesicle transport | 13.3333 | 6 | yes |
| GO:2000310 | regulation of NMDA receptor activity | 13.3333 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CCG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CCG8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CNIH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CR3L1_HUMAN | [view interactions] | High throughput | no | yes |
| CD53_HUMAN | [view interactions] | High throughput | no | yes |
| 3HIDH_HUMAN | [view interactions] | High throughput | no | yes |
| TM14B_HUMAN | [view interactions] | High throughput | no | no |
| GORAB_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| NMDE1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SHSA9_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCG7_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SCFD1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NOE2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| 5NT1A_HUMAN | [view interactions] | Computational | no | yes |
| CCG4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| BET1_HUMAN | [view interactions] | Computational | no | no |
| NMDZ1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GRIA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| STX17_HUMAN | [view interactions] | Computational | no | yes |