GRIA1_HUMAN
Evidence for PS localization
Functions
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GRIA1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 23.8532 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 23.8532 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.9358 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 21.1009 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.1009 | 5 | no |
| GO:0005524 | ATP binding | 20.1835 | 5 | no |
| GO:0046872 | metal ion binding | 20.1835 | 4 | no |
| GO:0005216 | ion channel activity | 19.2661 | 4 | yes |
| GO:0008324 | cation transmembrane transporter activity | 19.2661 | 4 | yes |
| GO:0015267 | channel activity | 19.2661 | 4 | yes |
| GO:0022836 | gated channel activity | 19.2661 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 19.2661 | 4 | yes |
| GO:0005261 | cation channel activity | 17.4312 | 5 | yes |
| GO:0008066 | glutamate receptor activity | 14.6789 | 4 | yes |
| GO:0005230 | extracellular ligand-gated ion channel activity | 13.7615 | 6 | yes |
| GO:0015276 | ligand-gated ion channel activity | 13.7615 | 5 | yes |
| GO:0022824 | transmitter-gated ion channel activity | 13.7615 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 13.7615 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 13.7615 | 4 | yes |
| GO:0004970 | ionotropic glutamate receptor activity | 12.8440 | 5 | yes |
| GO:0099094 | ligand-gated cation channel activity | 11.9266 | 6 | yes |
| GO:0030165 | PDZ domain binding | 10.0917 | 4 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 10.0917 | 4 | yes |
| GO:0001540 | amyloid-beta binding | 9.1743 | 4 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 8.2569 | 5 | yes |
| GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 8.2569 | 6 | yes |
| GO:0004971 | AMPA glutamate receptor activity | 4.5872 | 6 | yes |
| GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration | 2.7523 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GRIA1_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 55.0459 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 55.0459 | 4 | no |
| GO:0051049 | regulation of transport | 51.3761 | 4 | no |
| GO:0008104 | protein localization | 49.5413 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 42.2018 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 40.3670 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 40.3670 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 39.4495 | 4 | no |
| GO:0071702 | organic substance transport | 38.5321 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 37.6147 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 36.6972 | 4 | no |
| GO:0015031 | protein transport | 33.9450 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 33.9450 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 33.9450 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.9450 | 4 | no |
| GO:0043269 | regulation of ion transport | 33.0275 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 33.0275 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 31.1927 | 4 | no |
| GO:0023056 | positive regulation of signaling | 28.4404 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 27.5229 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 27.5229 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 25.6881 | 6 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 25.6881 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 25.6881 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 25.6881 | 5 | no |
| GO:0034765 | regulation of ion transmembrane transport | 25.6881 | 5 | no |
| GO:0022607 | cellular component assembly | 24.7706 | 4 | no |
| GO:1904062 | regulation of cation transmembrane transport | 24.7706 | 6 | no |
| GO:0006886 | intracellular protein transport | 23.8532 | 4 | no |
| GO:0006996 | organelle organization | 22.9358 | 4 | no |
| GO:0051050 | positive regulation of transport | 22.9358 | 4 | no |
| GO:0060341 | regulation of cellular localization | 22.9358 | 4 | no |
| GO:0072657 | protein localization to membrane | 22.9358 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 22.0183 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.0183 | 5 | no |
| GO:0010468 | regulation of gene expression | 22.0183 | 5 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 22.0183 | 4 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 22.0183 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.1009 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 21.1009 | 4 | no |
| GO:0006897 | endocytosis | 20.1835 | 5 | yes |
| GO:0044057 | regulation of system process | 20.1835 | 4 | no |
| GO:2001257 | regulation of cation channel activity | 20.1835 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.1835 | 5 | no |
| GO:0010941 | regulation of cell death | 20.1835 | 4 | no |
| GO:0006898 | receptor-mediated endocytosis | 17.4312 | 6 | yes |
| GO:0010648 | negative regulation of cell communication | 16.5138 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 16.5138 | 4 | yes |
| GO:0050890 | cognition | 15.5963 | 4 | yes |
| GO:0031623 | receptor internalization | 12.8440 | 7 | yes |
| GO:1901699 | cellular response to nitrogen compound | 10.0917 | 4 | yes |
| GO:0007613 | memory | 8.2569 | 4 | yes |
| GO:0050805 | negative regulation of synaptic transmission | 5.5046 | 5 | yes |
| GO:0007616 | long-term memory | 4.5872 | 5 | yes |
| GO:0060292 | long-term synaptic depression | 2.7523 | 4 | yes |
| GO:0060359 | response to ammonium ion | 1.8349 | 4 | yes |
| GO:0071242 | cellular response to ammonium ion | 1.8349 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in GRIA1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 4.5872 | 3 | no |
| DOID:936 | brain disease | 1.8349 | 4 | no |
| DOID:2476 | hereditary spastic paraplegia | 1.8349 | 5 | no |
| DOID:607 | paraplegia | 1.8349 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PIAS3_HUMAN | [view interactions] | Low throughput | no | yes |
| CXCR2_HUMAN | [view interactions] | Low throughput | no | no |
| E41L1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CCG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARHG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CNIH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MYO5B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCI_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
| CCG8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KLC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PCLO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| E41L2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRID2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRIK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AKAP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANC2_HUMAN | [view interactions] | Low throughput | no | no |
| FZR1_HUMAN | [view interactions] | Low throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MYO5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TANC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPS8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DRD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FRS1L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KINH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CXCR1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBP46_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NED4L_HUMAN | [view interactions] | Low throughput | no | yes |
| KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KS6B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRRT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSKP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CNTP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AFAD_HUMAN | [view interactions] | Low throughput | no | yes |
| SHSA6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SHSA7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| IQEC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRRT4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GNB5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ASCL4_HUMAN | [view interactions] | High throughput | no | no |
| KLF15_HUMAN | [view interactions] | High throughput | no | yes |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BECN1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN232_HUMAN | [view interactions] | High throughput | no | no |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRID1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UN45B_HUMAN | [view interactions] | High throughput | no | no |
| G3PT_HUMAN | [view interactions] | High throughput | no | no |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SCFD1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SHSA9_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KAPCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 5HT3A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KIF5C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MDM2_HUMAN | [view interactions] | Computational | no | yes |
| EPS15_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| HOME1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TSN7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DLG3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NMD3A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| STX17_HUMAN | [view interactions] | Computational | no | yes |
| KPCG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AP2B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MYO6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NMDE4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYEM_HUMAN | [view interactions] | Computational | no | yes |
| KIF5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CNIH1_HUMAN | [view interactions] | Computational | no | yes |
| CCG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DLG2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NSF_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KAPCG_HUMAN | [view interactions] | Computational | no | no |
| RAB4A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CPT1C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| BET1_HUMAN | [view interactions] | Computational | no | no |
| GRM2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CNIH3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LYN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AP2S1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NMDE2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KCC2D_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GRM5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NFL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG7_HUMAN | [view entry] [view interactions] | Computational | yes | no |