GRIA1_HUMAN
Evidence for PS localization
Functions
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 636 | Ala | Thr | Intellectualdevelopmentaldisorder,autosomaldominant67(MRD67) | - |
| 627 | Ile | Thr | Intellectualdevelopmentaldisorder,autosomaldominant67(MRD67) | - |
| 745 | Gly | Asp | Intellectualdevelopmentaldisorder,autosomaldominant67(MRD67) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GRIA1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 25.0000 | 4 | no |
| GO:0043168 | anion binding | 22.8261 | 4 | no |
| GO:0046872 | metal ion binding | 22.8261 | 5 | no |
| GO:0005216 | monoatomic ion channel activity | 16.3043 | 4 | yes |
| GO:0015267 | channel activity | 16.3043 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 16.3043 | 4 | yes |
| GO:0019900 | kinase binding | 15.2174 | 4 | yes |
| GO:0022836 | gated channel activity | 15.2174 | 5 | yes |
| GO:0035254 | glutamate receptor binding | 13.0435 | 4 | yes |
| GO:0004970 | glutamate-gated receptor activity | 11.9565 | 4 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 11.9565 | 6 | yes |
| GO:0008066 | glutamate receptor activity | 11.9565 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 11.9565 | 5 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 11.9565 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 11.9565 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 11.9565 | 4 | yes |
| GO:0030165 | PDZ domain binding | 11.9565 | 4 | yes |
| GO:0046943 | carboxylic acid transmembrane transporter activity | 11.9565 | 4 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 11.9565 | 4 | yes |
| GO:0019901 | protein kinase binding | 10.8696 | 5 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 10.8696 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 10.8696 | 6 | yes |
| GO:0001664 | G protein-coupled receptor binding | 9.7826 | 4 | yes |
| GO:0051020 | GTPase binding | 8.6957 | 4 | yes |
| GO:0031267 | small GTPase binding | 7.6087 | 5 | yes |
| GO:0004971 | AMPA glutamate receptor activity | 5.4348 | 5 | yes |
| GO:0031690 | adrenergic receptor binding | 5.4348 | 5 | yes |
| GO:0099507 | ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential | 5.4348 | 6 | yes |
| GO:0008179 | adenylate cyclase binding | 4.3478 | 4 | yes |
| GO:0017022 | myosin binding | 4.3478 | 4 | yes |
| GO:0031489 | myosin V binding | 4.3478 | 5 | yes |
| GO:0031698 | beta-2 adrenergic receptor binding | 4.3478 | 6 | yes |
| GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration | 2.1739 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GRIA1_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 58.6957 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 56.5217 | 4 | yes |
| GO:0008104 | protein localization | 45.6522 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 44.5652 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 43.4783 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 43.4783 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 41.3043 | 4 | no |
| GO:0051049 | regulation of transport | 39.1304 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 39.1304 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 39.1304 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 35.8696 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 33.6957 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 33.6957 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 33.6957 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 31.5217 | 4 | yes |
| GO:0071702 | organic substance transport | 30.4348 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.4348 | 5 | yes |
| GO:0071705 | nitrogen compound transport | 29.3478 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.3478 | 5 | yes |
| GO:0010468 | regulation of gene expression | 28.2609 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 27.1739 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0015031 | protein transport | 25.0000 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 25.0000 | 7 | yes |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 25.0000 | 6 | yes |
| GO:0099536 | synaptic signaling | 25.0000 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 25.0000 | 5 | yes |
| GO:0072657 | protein localization to membrane | 23.9130 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.9130 | 5 | yes |
| GO:0006996 | organelle organization | 23.9130 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 22.8261 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.8261 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 22.8261 | 5 | no |
| GO:0032880 | regulation of protein localization | 22.8261 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 22.8261 | 4 | no |
| GO:0051050 | positive regulation of transport | 21.7391 | 4 | no |
| GO:0043269 | regulation of monoatomic ion transport | 20.6522 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 20.6522 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 20.6522 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 20.6522 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 19.5652 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 19.5652 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 18.4783 | 4 | yes |
| GO:0098657 | import into cell | 18.4783 | 4 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 17.3913 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 16.3043 | 4 | yes |
| GO:0034330 | cell junction organization | 16.3043 | 4 | yes |
| GO:0050890 | cognition | 16.3043 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 15.2174 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 14.1304 | 6 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 13.0435 | 6 | yes |
| GO:0006898 | receptor-mediated endocytosis | 11.9565 | 4 | yes |
| GO:0035249 | synaptic transmission, glutamatergic | 11.9565 | 8 | yes |
| GO:0050808 | synapse organization | 11.9565 | 5 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 11.9565 | 4 | yes |
| GO:1901699 | cellular response to nitrogen compound | 11.9565 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 11.9565 | 4 | yes |
| GO:0031623 | receptor internalization | 10.8696 | 5 | yes |
| GO:0007613 | memory | 9.7826 | 4 | yes |
| GO:0010038 | response to metal ion | 9.7826 | 4 | yes |
| GO:0010628 | positive regulation of gene expression | 9.7826 | 7 | yes |
| GO:0034329 | cell junction assembly | 8.6957 | 5 | yes |
| GO:0014070 | response to organic cyclic compound | 7.6087 | 4 | yes |
| GO:0032870 | cellular response to hormone stimulus | 7.6087 | 4 | yes |
| GO:0050805 | negative regulation of synaptic transmission | 7.6087 | 5 | yes |
| GO:0043434 | response to peptide hormone | 6.5217 | 4 | yes |
| GO:0071375 | cellular response to peptide hormone stimulus | 6.5217 | 5 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 6.5217 | 5 | yes |
| GO:0001508 | action potential | 5.4348 | 4 | yes |
| GO:0007416 | synapse assembly | 5.4348 | 6 | yes |
| GO:0007616 | long-term memory | 5.4348 | 5 | yes |
| GO:0033993 | response to lipid | 5.4348 | 4 | yes |
| GO:0014075 | response to amine | 4.3478 | 5 | yes |
| GO:0043200 | response to amino acid | 4.3478 | 4 | yes |
| GO:0060292 | long-term synaptic depression | 4.3478 | 4 | yes |
| GO:0019228 | neuronal action potential | 3.2609 | 5 | yes |
| GO:0032355 | response to estradiol | 3.2609 | 4 | yes |
| GO:0042220 | response to cocaine | 3.2609 | 4 | yes |
| GO:0043279 | response to alkaloid | 3.2609 | 5 | yes |
| GO:0071363 | cellular response to growth factor stimulus | 3.2609 | 4 | yes |
| GO:0001919 | regulation of receptor recycling | 2.1739 | 4 | yes |
| GO:0010226 | response to lithium ion | 2.1739 | 5 | yes |
| GO:0043331 | response to dsRNA | 2.1739 | 4 | yes |
| GO:0045838 | positive regulation of membrane potential | 2.1739 | 4 | yes |
| GO:0060359 | response to ammonium ion | 2.1739 | 4 | yes |
| GO:0060992 | response to fungicide | 2.1739 | 4 | yes |
| GO:0071229 | cellular response to acid chemical | 2.1739 | 4 | yes |
| GO:0071230 | cellular response to amino acid stimulus | 2.1739 | 5 | yes |
| GO:0071242 | cellular response to ammonium ion | 2.1739 | 5 | yes |
| GO:0071359 | cellular response to dsRNA | 2.1739 | 5 | yes |
| GO:0071418 | cellular response to amine stimulus | 2.1739 | 5 | yes |
| GO:1990089 | response to nerve growth factor | 2.1739 | 4 | yes |
| GO:1990090 | cellular response to nerve growth factor stimulus | 2.1739 | 5 | yes |
| GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus | 2.1739 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| E41L2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AKAP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANC2_HUMAN | [view interactions] | Low throughput | no | no |
| FZR1_HUMAN | [view interactions] | Low throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MYO5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TANC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPS8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DRD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FRS1L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KINH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CXCR1_HUMAN | [view interactions] | Low throughput | no | yes |
| RN220_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CYLD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBP46_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NED4L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KS6B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CCG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SHSA7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PRRT2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSKP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CNTP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AFAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHSA6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| IQEC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRRT4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PIAS3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CXCR2_HUMAN | [view interactions] | Low throughput | no | no |
| E41L1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CCG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARHG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CNIH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MYO5B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
| KPCI_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CCG8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRID2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PCLO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRID1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UN45B_HUMAN | [view interactions] | High throughput | no | no |
| G3PT_HUMAN | [view interactions] | High throughput | no | no |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF6_HUMAN | [view interactions] | High throughput | no | no |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABD12_HUMAN | [view interactions] | High throughput | no | no |
| ABHD6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANKL2_HUMAN | [view interactions] | High throughput | no | yes |
| PRAF3_HUMAN | [view interactions] | High throughput | no | yes |
| AT131_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CPT1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| SAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHSA9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STT3B_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC4C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNB5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ZN232_HUMAN | [view interactions] | High throughput | no | no |
| BECN1_HUMAN | [view interactions] | High throughput | no | yes |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLF15_HUMAN | [view interactions] | High throughput | no | yes |
| ASCL4_HUMAN | [view interactions] | High throughput | no | no |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |