GRID1_HUMAN
Evidence for PS localization
Functions
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GRID1_HUMAN |
|---|---|---|---|---|
| GO:0005216 | monoatomic ion channel activity | 58.3333 | 4 | yes |
| GO:0015267 | channel activity | 58.3333 | 4 | yes |
| GO:0022836 | gated channel activity | 58.3333 | 5 | yes |
| GO:0005230 | extracellular ligand-gated monoatomic ion channel activity | 50.0000 | 6 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 50.0000 | 5 | yes |
| GO:0022824 | transmitter-gated monoatomic ion channel activity | 50.0000 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 50.0000 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 50.0000 | 4 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 50.0000 | 4 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 50.0000 | 5 | yes |
| GO:1904315 | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | 50.0000 | 6 | yes |
| GO:0004970 | glutamate-gated receptor activity | 41.6667 | 4 | yes |
| GO:0008066 | glutamate receptor activity | 41.6667 | 4 | yes |
| GO:0046943 | carboxylic acid transmembrane transporter activity | 41.6667 | 4 | yes |
| GO:0005261 | monoatomic cation channel activity | 25.0000 | 5 | no |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0043169 | cation binding | 25.0000 | 4 | no |
| GO:0099507 | ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential | 25.0000 | 6 | no |
| GO:0001664 | G protein-coupled receptor binding | 25.0000 | 4 | no |
| GO:0019900 | kinase binding | 25.0000 | 4 | no |
| GO:0030165 | PDZ domain binding | 25.0000 | 4 | no |
| GO:0031690 | adrenergic receptor binding | 25.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GRID1_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 66.6667 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 58.3333 | 7 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 58.3333 | 6 | yes |
| GO:0099536 | synaptic signaling | 58.3333 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 58.3333 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 50.0000 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 50.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.6667 | 4 | no |
| GO:0008104 | protein localization | 41.6667 | 4 | no |
| GO:0035249 | synaptic transmission, glutamatergic | 41.6667 | 8 | yes |
| GO:0051049 | regulation of transport | 41.6667 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 41.6667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0050807 | regulation of synapse organization | 33.3333 | 5 | yes |
| GO:0099175 | regulation of postsynapse organization | 33.3333 | 6 | yes |
| GO:0034762 | regulation of transmembrane transport | 33.3333 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 33.3333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 33.3333 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
| GO:0010038 | response to metal ion | 25.0000 | 4 | no |
| GO:0043113 | receptor clustering | 25.0000 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 25.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0072657 | protein localization to membrane | 25.0000 | 4 | no |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 25.0000 | 5 | no |
| GO:0043269 | regulation of monoatomic ion transport | 25.0000 | 5 | no |
| GO:0044057 | regulation of system process | 25.0000 | 4 | no |
| GO:0098657 | import into cell | 25.0000 | 4 | no |
| GO:0098662 | inorganic cation transmembrane transport | 25.0000 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0050806 | positive regulation of synaptic transmission | 25.0000 | 5 | no |
| GO:0050890 | cognition | 25.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GOPC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAGI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRID1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DEFI6_HUMAN | [view interactions] | High throughput | no | no |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| HBB_HUMAN | [view interactions] | High throughput | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIRA6_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| 5HT3A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NKG2A_HUMAN | [view interactions] | High throughput | no | no |
| GRIA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CL12B_HUMAN | [view interactions] | High throughput | no | no |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRID2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |