GRID1_HUMAN
Evidence for PS localization
Functions
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GRID1_HUMAN |
|---|---|---|---|---|
| GO:0005216 | ion channel activity | 60.0000 | 4 | yes |
| GO:0005230 | extracellular ligand-gated ion channel activity | 60.0000 | 6 | yes |
| GO:0015267 | channel activity | 60.0000 | 4 | yes |
| GO:0015276 | ligand-gated ion channel activity | 60.0000 | 5 | yes |
| GO:0022824 | transmitter-gated ion channel activity | 60.0000 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 60.0000 | 6 | yes |
| GO:0022835 | transmitter-gated channel activity | 60.0000 | 4 | yes |
| GO:0022836 | gated channel activity | 60.0000 | 5 | yes |
| GO:0004970 | ionotropic glutamate receptor activity | 50.0000 | 5 | yes |
| GO:0008066 | glutamate receptor activity | 50.0000 | 4 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 40.0000 | 4 | yes |
| GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | 40.0000 | 5 | yes |
| GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | 40.0000 | 6 | yes |
| GO:0005261 | cation channel activity | 30.0000 | 5 | no |
| GO:0008324 | cation transmembrane transporter activity | 30.0000 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 30.0000 | 4 | no |
| GO:0099094 | ligand-gated cation channel activity | 30.0000 | 6 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GRID1_HUMAN |
|---|---|---|---|---|
| GO:0007268 | chemical synaptic transmission | 70.0000 | 6 | yes |
| GO:0010646 | regulation of cell communication | 70.0000 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 70.0000 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 70.0000 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 50.0000 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 50.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0008104 | protein localization | 40.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | no |
| GO:0035249 | synaptic transmission, glutamatergic | 30.0000 | 7 | yes |
| GO:0010941 | regulation of cell death | 30.0000 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 30.0000 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 30.0000 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.0000 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 30.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 30.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.0000 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GOPC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAGI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRID1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DEFI6_HUMAN | [view interactions] | High throughput | no | no |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| HBB_HUMAN | [view interactions] | High throughput | no | no |
| LIRA6_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| 5HT3A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NKG2A_HUMAN | [view interactions] | High throughput | no | no |
| GRIA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CL12B_HUMAN | [view interactions] | High throughput | no | no |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRID2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |