DLG2_HUMAN
Evidence for PS localization
Functions
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DLG2_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 29.2308 | 4 | no |
| GO:0046872 | metal ion binding | 29.2308 | 5 | no |
| GO:0043168 | anion binding | 23.0769 | 4 | no |
| GO:0019900 | kinase binding | 16.9231 | 4 | yes |
| GO:0016301 | kinase activity | 15.3846 | 4 | yes |
| GO:0004385 | guanylate kinase activity | 3.0769 | 6 | yes |
| GO:0016776 | phosphotransferase activity, phosphate group as acceptor | 3.0769 | 4 | yes |
| GO:0019205 | nucleobase-containing compound kinase activity | 3.0769 | 5 | yes |
| GO:0050145 | nucleoside monophosphate kinase activity | 3.0769 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DLG2_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 69.2308 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 61.5385 | 4 | no |
| GO:0009966 | regulation of signal transduction | 49.2308 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 46.1538 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 46.1538 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 43.0769 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 43.0769 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 40.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 40.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.9231 | 4 | no |
| GO:0051049 | regulation of transport | 36.9231 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.3846 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 33.8462 | 5 | no |
| GO:0008104 | protein localization | 30.7692 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 30.7692 | 5 | no |
| GO:0022607 | cellular component assembly | 30.7692 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.7692 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 30.7692 | 4 | no |
| GO:0050890 | cognition | 30.7692 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 29.2308 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.2308 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 29.2308 | 5 | no |
| GO:0030030 | cell projection organization | 27.6923 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 27.6923 | 6 | no |
| GO:0044057 | regulation of system process | 26.1538 | 4 | no |
| GO:0099536 | synaptic signaling | 24.6154 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 24.6154 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 24.6154 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.6154 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 24.6154 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 24.6154 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 24.6154 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 24.6154 | 4 | no |
| GO:0043269 | regulation of monoatomic ion transport | 24.6154 | 5 | no |
| GO:0050807 | regulation of synapse organization | 24.6154 | 5 | no |
| GO:0007268 | chemical synaptic transmission | 23.0769 | 7 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 23.0769 | 6 | yes |
| GO:0006996 | organelle organization | 23.0769 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.0769 | 6 | no |
| GO:0031399 | regulation of protein modification process | 23.0769 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 23.0769 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.0769 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.0769 | 5 | no |
| GO:0010468 | regulation of gene expression | 23.0769 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.0769 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.0769 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.0769 | 4 | no |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 23.0769 | 5 | no |
| GO:0072657 | protein localization to membrane | 21.5385 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 21.5385 | 7 | no |
| GO:0010975 | regulation of neuron projection development | 21.5385 | 7 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.5385 | 4 | no |
| GO:0007612 | learning | 21.5385 | 4 | no |
| GO:0051960 | regulation of nervous system development | 21.5385 | 5 | no |
| GO:0035418 | protein localization to synapse | 16.9231 | 6 | yes |
| GO:1902414 | protein localization to cell junction | 16.9231 | 5 | yes |
| GO:0071702 | organic substance transport | 13.8462 | 4 | yes |
| GO:0043113 | receptor clustering | 12.3077 | 5 | yes |
| GO:0071705 | nitrogen compound transport | 12.3077 | 4 | yes |
| GO:0010038 | response to metal ion | 10.7692 | 4 | yes |
| GO:0015031 | protein transport | 7.6923 | 4 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 7.6923 | 4 | yes |
| GO:0006886 | intracellular protein transport | 6.1538 | 4 | yes |
| GO:0010970 | transport along microtubule | 6.1538 | 4 | yes |
| GO:0035088 | establishment or maintenance of apical/basal cell polarity | 6.1538 | 4 | yes |
| GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 6.1538 | 5 | yes |
| GO:0071241 | cellular response to inorganic substance | 6.1538 | 4 | yes |
| GO:0071248 | cellular response to metal ion | 6.1538 | 5 | yes |
| GO:0099111 | microtubule-based transport | 6.1538 | 4 | yes |
| GO:0008088 | axo-dendritic transport | 4.6154 | 5 | yes |
| GO:0008089 | anterograde axonal transport | 4.6154 | 7 | yes |
| GO:0098840 | protein transport along microtubule | 4.6154 | 4 | yes |
| GO:0098930 | axonal transport | 4.6154 | 6 | yes |
| GO:0099640 | axo-dendritic protein transport | 4.6154 | 5 | yes |
| GO:0099641 | anterograde axonal protein transport | 4.6154 | 6 | yes |
| GO:1905383 | protein localization to presynapse | 4.6154 | 7 | yes |
| GO:0008090 | retrograde axonal transport | 3.0769 | 7 | yes |
| GO:0035864 | response to potassium ion | 3.0769 | 5 | yes |
| GO:0035865 | cellular response to potassium ion | 3.0769 | 6 | yes |
| GO:0099642 | retrograde axonal protein transport | 3.0769 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ABCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| ERBB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCNA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DGKZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NETO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DSCAM_HUMAN | [view interactions] | Low throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CRFR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRID2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GCYA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AT2B2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DGKI_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRID1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRP2_HUMAN | [view interactions] | Low throughput | no | no |
| SEM4C_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCNJ4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AT2B4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MDM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHSA9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SLIK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CSMD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TANC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TANC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CCG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| IQEC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TNFL6_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCJ12_HUMAN | [view interactions] | High throughput | no | no |
| SSR1_HUMAN | [view interactions] | High throughput | no | no |
| SSR4_HUMAN | [view interactions] | High throughput | no | no |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAP1_HUMAN | [view interactions] | High throughput | no | no |
| MEMO1_HUMAN | [view interactions] | High throughput | no | yes |
| AMZ2_HUMAN | [view interactions] | High throughput | no | yes |
| PTHD1_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| FZD4_HUMAN | [view interactions] | High throughput | no | yes |
| FZD1_HUMAN | [view interactions] | High throughput | no | yes |
| FZD7_HUMAN | [view interactions] | High throughput | no | yes |
| SPB13_HUMAN | [view interactions] | High throughput | no | no |
| RS8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLGP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIL4_HUMAN | [view interactions] | High throughput | no | yes |
| RPF2_HUMAN | [view interactions] | High throughput | no | yes |
| FA2H_HUMAN | [view interactions] | High throughput | no | yes |
| RNAS2_HUMAN | [view interactions] | High throughput | no | no |
| PKHA2_HUMAN | [view interactions] | High throughput | no | no |
| ERD21_HUMAN | [view interactions] | High throughput | no | yes |
| AOAH_HUMAN | [view interactions] | High throughput | no | yes |
| VTNC_HUMAN | [view interactions] | High throughput | no | no |
| KCNJ6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NLGN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NLGN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OTU7A_HUMAN | [view interactions] | High throughput | no | no |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNOT3_HUMAN | [view interactions] | High throughput | no | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC4C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |