Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DLG2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DLG2_HUMAN
GO:0046872 metal ion binding 26.5823 4 no
GO:0019900 kinase binding 16.4557 4 yes
GO:0016301 kinase activity 12.6582 4 yes
GO:0004385 guanylate kinase activity 2.5316 6 yes
GO:0016776 phosphotransferase activity, phosphate group as acceptor 2.5316 4 yes
GO:0019205 nucleobase-containing compound kinase activity 2.5316 5 yes
GO:0050145 nucleoside monophosphate kinase activity 2.5316 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DLG2_HUMAN
GO:0010646 regulation of cell communication 64.5570 4 no
GO:0048522 positive regulation of cellular process 56.9620 4 no
GO:0009966 regulation of signal transduction 51.8987 4 no
GO:0050804 modulation of chemical synaptic transmission 50.6329 5 no
GO:0099177 regulation of trans-synaptic signaling 50.6329 4 no
GO:0048523 negative regulation of cellular process 41.7722 4 no
GO:0023056 positive regulation of signaling 37.9747 4 no
GO:0010647 positive regulation of cell communication 36.7089 5 no
GO:0060255 regulation of macromolecule metabolic process 36.7089 4 no
GO:0080090 regulation of primary metabolic process 35.4430 4 no
GO:0051128 regulation of cellular component organization 35.4430 4 no
GO:0051171 regulation of nitrogen compound metabolic process 34.1772 4 no
GO:0051246 regulation of protein metabolic process 34.1772 5 no
GO:0051049 regulation of transport 34.1772 4 no
GO:0031323 regulation of cellular metabolic process 31.6456 4 no
GO:0022607 cellular component assembly 31.6456 4 no
GO:0050890 cognition 31.6456 4 no
GO:0048584 positive regulation of response to stimulus 29.1139 4 no
GO:0009893 positive regulation of metabolic process 29.1139 4 no
GO:0030030 cell projection organization 29.1139 4 no
GO:0008104 protein localization 27.8481 4 yes
GO:0009967 positive regulation of signal transduction 27.8481 5 no
GO:0010604 positive regulation of macromolecule metabolic process 27.8481 5 no
GO:0044057 regulation of system process 27.8481 4 no
GO:0099537 trans-synaptic signaling 26.5823 4 yes
GO:0043269 regulation of ion transport 26.5823 5 no
GO:0007268 chemical synaptic transmission 25.3165 6 yes
GO:0098916 anterograde trans-synaptic signaling 25.3165 5 yes
GO:0019220 regulation of phosphate metabolic process 25.3165 6 no
GO:0042325 regulation of phosphorylation 25.3165 7 no
GO:0051173 positive regulation of nitrogen compound metabolic process 25.3165 5 no
GO:0051174 regulation of phosphorus metabolic process 25.3165 5 no
GO:0051247 positive regulation of protein metabolic process 25.3165 6 no
GO:0120036 plasma membrane bounded cell projection organization 25.3165 5 no
GO:0034762 regulation of transmembrane transport 25.3165 4 no
GO:0034765 regulation of ion transmembrane transport 25.3165 5 no
GO:0031325 positive regulation of cellular metabolic process 24.0506 5 no
GO:0031399 regulation of protein modification process 24.0506 6 no
GO:0043085 positive regulation of catalytic activity 24.0506 4 no
GO:0007612 learning 24.0506 4 no
GO:1902531 regulation of intracellular signal transduction 22.7848 5 no
GO:0001932 regulation of protein phosphorylation 22.7848 7 no
GO:0031344 regulation of cell projection organization 22.7848 5 no
GO:0031644 regulation of nervous system process 22.7848 5 no
GO:0010468 regulation of gene expression 22.7848 5 no
GO:0060341 regulation of cellular localization 22.7848 4 no
GO:0010562 positive regulation of phosphorus metabolic process 21.5190 6 no
GO:0031401 positive regulation of protein modification process 21.5190 7 no
GO:0042327 positive regulation of phosphorylation 21.5190 8 no
GO:0045937 positive regulation of phosphate metabolic process 21.5190 7 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.5190 6 no
GO:0006996 organelle organization 21.5190 4 no
GO:1904062 regulation of cation transmembrane transport 21.5190 6 no
GO:0072657 protein localization to membrane 20.2532 4 yes
GO:0001934 positive regulation of protein phosphorylation 20.2532 8 no
GO:0009892 negative regulation of metabolic process 20.2532 4 no
GO:2000026 regulation of multicellular organismal development 20.2532 4 no
GO:0034330 cell junction organization 20.2532 4 no
GO:0051094 positive regulation of developmental process 20.2532 4 no
GO:0099601 regulation of neurotransmitter receptor activity 20.2532 4 no
GO:0032880 regulation of protein localization 20.2532 5 no
GO:0035418 protein localization to synapse 17.7215 6 yes
GO:1902414 protein localization to cell junction 17.7215 5 yes
GO:0043113 receptor clustering 13.9241 5 yes
GO:0071702 organic substance transport 11.3924 4 yes
GO:0071705 nitrogen compound transport 11.3924 4 yes
GO:0015031 protein transport 8.8608 4 yes
GO:0010038 response to metal ion 7.5949 4 yes
GO:0006886 intracellular protein transport 6.3291 4 yes
GO:0035088 establishment or maintenance of apical/basal cell polarity 6.3291 4 yes
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 6.3291 5 yes
GO:0071241 cellular response to inorganic substance 6.3291 4 yes
GO:0071248 cellular response to metal ion 5.0633 5 yes
GO:0030705 cytoskeleton-dependent intracellular transport 3.7975 4 yes
GO:0008088 axo-dendritic transport 2.5316 5 yes
GO:0008089 anterograde axonal transport 2.5316 7 yes
GO:0008090 retrograde axonal transport 2.5316 7 yes
GO:0010970 transport along microtubule 2.5316 4 yes
GO:0035864 response to potassium ion 2.5316 5 yes
GO:0035865 cellular response to potassium ion 2.5316 6 yes
GO:0098840 protein transport along microtubule 2.5316 4 yes
GO:0098930 axonal transport 2.5316 6 yes
GO:0099111 microtubule-based transport 2.5316 4 yes
GO:0099640 axo-dendritic protein transport 2.5316 5 yes
GO:0099641 anterograde axonal protein transport 2.5316 6 yes
GO:0099642 retrograde axonal protein transport 2.5316 6 yes
GO:1905383 protein localization to presynapse 2.5316 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in DLG2_HUMAN
DOID:1289 neurodegenerative disease 2.5316 4 no
DOID:331 central nervous system disease 2.5316 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ABCA1_HUMAN [view interactions] Low throughput no yes
ERBB4_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
KCNA4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] Low throughput yes no
DGKZ_HUMAN [view entry] [view interactions] Low throughput yes yes
NETO1_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
CRFR1_HUMAN [view interactions] Low throughput no yes
MAP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
GRID2_HUMAN [view entry] [view interactions] Low throughput yes no
GCYA2_HUMAN [view entry] [view interactions] Low throughput yes yes
AT2B2_HUMAN [view entry] [view interactions] Low throughput yes yes
DGKI_HUMAN [view entry] [view interactions] Low throughput yes no
GRID1_HUMAN [view entry] [view interactions] Low throughput yes no
LRP2_HUMAN [view interactions] Low throughput no no
SEM4C_HUMAN [view entry] [view interactions] Low throughput yes no
NOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNJ4_HUMAN [view entry] [view interactions] Low throughput yes no
AT2B4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRZ_HUMAN [view entry] [view interactions] Low throughput yes yes
MDM2_HUMAN [view interactions] Low throughput no yes
SHSA9_HUMAN [view entry] [view interactions] Low throughput yes no
SLIK2_HUMAN [view entry] [view interactions] Low throughput yes no
CSMD2_HUMAN [view interactions] Low throughput no no
TANC1_HUMAN [view entry] [view interactions] Low throughput yes yes
TANC2_HUMAN [view entry] [view interactions] Low throughput yes yes
CCG3_HUMAN [view entry] [view interactions] Low throughput yes no
IQEC2_HUMAN [view entry] [view interactions] Low throughput yes no
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
TNFL6_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
KCJ12_HUMAN [view interactions] High throughput no no
SSR1_HUMAN [view interactions] High throughput no no
SSR4_HUMAN [view interactions] High throughput no no
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
AMZ2_HUMAN [view interactions] High throughput no yes
MEMO1_HUMAN [view interactions] High throughput no yes
STAP1_HUMAN [view interactions] High throughput no no
PTHD1_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN1_HUMAN [view entry] [view interactions] High throughput yes yes
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
MYCB2_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
FZD4_HUMAN [view interactions] High throughput no yes
FZD1_HUMAN [view interactions] High throughput no yes
FZD7_HUMAN [view interactions] High throughput no yes
SPB13_HUMAN [view interactions] High throughput no no
RS8_HUMAN [view entry] [view interactions] High throughput yes no
DLGP3_HUMAN [view entry] [view interactions] High throughput yes yes
PPIL4_HUMAN [view interactions] High throughput no yes
RPF2_HUMAN [view interactions] High throughput no yes
FA2H_HUMAN [view interactions] High throughput no yes
RNAS2_HUMAN [view interactions] High throughput no no
PKHA2_HUMAN [view interactions] High throughput no no
ERD21_HUMAN [view interactions] High throughput no yes
AOAH_HUMAN [view interactions] High throughput no yes
VTNC_HUMAN [view interactions] High throughput no no
NLGN2_HUMAN [view entry] [view interactions] High throughput yes yes
NLGN1_HUMAN [view entry] [view interactions] High throughput yes yes
NLGN3_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP2_HUMAN [view entry] [view interactions] High throughput yes no
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
DYL2_HUMAN [view entry] [view interactions] High throughput yes no
DLG3_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CSK_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
OTUD4_HUMAN [view interactions] High throughput no yes
KHDR1_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
L2GL1_HUMAN [view entry] [view interactions] Computational yes yes
L2GL2_HUMAN [view interactions] Computational no yes
NMDE3_HUMAN [view entry] [view interactions] Computational yes no
GRM5_HUMAN [view entry] [view interactions] Computational yes no
NRX1A_HUMAN [view entry] [view interactions] Computational yes no
RASN_HUMAN [view entry] [view interactions] Computational yes no
RASH_HUMAN [view entry] [view interactions] Computational yes no
BEGIN_HUMAN [view entry] [view interactions] Computational yes no
ADA22_HUMAN [view entry] [view interactions] Computational yes no
DLGP4_HUMAN [view entry] [view interactions] Computational yes yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
GRIA1_HUMAN [view entry] [view interactions] Computational yes yes
LIN7A_HUMAN [view entry] [view interactions] Computational yes yes
GRIA3_HUMAN [view entry] [view interactions] Computational yes yes
HOME1_HUMAN [view entry] [view interactions] Computational yes yes
SCRIB_HUMAN [view entry] [view interactions] Computational yes no
TJAP1_HUMAN [view entry] [view interactions] Computational yes yes
GRIA4_HUMAN [view entry] [view interactions] Computational yes no
GRIA2_HUMAN [view entry] [view interactions] Computational yes yes
NRX3A_HUMAN [view entry] [view interactions] Computational yes yes
SHAN2_HUMAN [view entry] [view interactions] Computational yes yes
NRX2A_HUMAN [view entry] [view interactions] Computational yes no