TANC2_HUMAN
Evidence for PS localization
Functions
Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 760 | Arg | Cys | Intellectualdevelopmentaldisorderwithautisticfeaturesandlanguagedelay,withorwithoutseizures(IDDALDS) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TANC2_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 39.3939 | 4 | no |
| GO:0019901 | protein kinase binding | 33.3333 | 5 | no |
| GO:0003723 | RNA binding | 24.2424 | 4 | no |
| GO:0045296 | cadherin binding | 24.2424 | 4 | no |
| GO:0019902 | phosphatase binding | 21.2121 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TANC2_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 54.5455 | 4 | no |
| GO:0008104 | protein localization | 54.5455 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 51.5152 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 51.5152 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 51.5152 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.4848 | 4 | no |
| GO:0010646 | regulation of cell communication | 48.4848 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 45.4545 | 4 | no |
| GO:0009966 | regulation of signal transduction | 45.4545 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 39.3939 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 39.3939 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 33.3333 | 4 | yes |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0060341 | regulation of cellular localization | 30.3030 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.3030 | 6 | no |
| GO:0031399 | regulation of protein modification process | 30.3030 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 30.3030 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.3030 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 30.3030 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.3030 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.3030 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 30.3030 | 5 | no |
| GO:0071702 | organic substance transport | 30.3030 | 4 | no |
| GO:0071705 | nitrogen compound transport | 30.3030 | 4 | no |
| GO:0010468 | regulation of gene expression | 27.2727 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 27.2727 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.2727 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.2727 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.2727 | 5 | no |
| GO:0015031 | protein transport | 27.2727 | 4 | no |
| GO:0007010 | cytoskeleton organization | 27.2727 | 5 | no |
| GO:0022607 | cellular component assembly | 27.2727 | 4 | no |
| GO:0032880 | regulation of protein localization | 27.2727 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 24.2424 | 5 | yes |
| GO:0042325 | regulation of phosphorylation | 24.2424 | 7 | no |
| GO:0051338 | regulation of transferase activity | 24.2424 | 4 | no |
| GO:0006886 | intracellular protein transport | 24.2424 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.2121 | 6 | yes |
| GO:0036211 | protein modification process | 21.2121 | 4 | no |
| GO:0043412 | macromolecule modification | 21.2121 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 21.2121 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 21.2121 | 7 | no |
| GO:0043549 | regulation of kinase activity | 21.2121 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.2121 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 21.2121 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 21.2121 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.2121 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.2121 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.2121 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.2121 | 4 | no |
| GO:0030030 | cell projection organization | 21.2121 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.2121 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.2121 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.2121 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 18.1818 | 7 | yes |
| GO:0050807 | regulation of synapse organization | 15.1515 | 5 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 9.0909 | 4 | yes |
| GO:0061001 | regulation of dendritic spine morphogenesis | 9.0909 | 5 | yes |
| GO:0099175 | regulation of postsynapse organization | 9.0909 | 6 | yes |
| GO:0016482 | cytosolic transport | 6.0606 | 4 | yes |
| GO:0051650 | establishment of vesicle localization | 6.0606 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in TANC2_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 6.0606 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BRAP_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE120_HUMAN | [view interactions] | High throughput | no | no |
| CENPQ_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| SPIR2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAST3_HUMAN | [view interactions] | High throughput | no | yes |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GGYF2_HUMAN | [view interactions] | High throughput | no | yes |
| RGPS2_HUMAN | [view interactions] | High throughput | no | yes |
| LPIN3_HUMAN | [view interactions] | High throughput | no | yes |
| DEN1A_HUMAN | [view interactions] | High throughput | no | no |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| DEN4C_HUMAN | [view interactions] | High throughput | no | yes |
| SPD2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN13_HUMAN | [view interactions] | High throughput | no | yes |
| MPIP3_HUMAN | [view interactions] | High throughput | no | yes |
| IF4E2_HUMAN | [view interactions] | High throughput | no | no |
| SH3R3_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
| INP5E_HUMAN | [view interactions] | High throughput | no | yes |
| RTKN_HUMAN | [view interactions] | High throughput | no | yes |
| KI13B_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CING_HUMAN | [view interactions] | High throughput | no | no |
| ZBT21_HUMAN | [view interactions] | High throughput | no | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| PAK5_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| SNIP1_HUMAN | [view interactions] | High throughput | no | no |
| RHG39_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| M4K4_HUMAN | [view interactions] | High throughput | no | yes |
| IASPP_HUMAN | [view interactions] | High throughput | no | yes |
| TRI11_HUMAN | [view interactions] | High throughput | no | yes |
| TX1B3_HUMAN | [view interactions] | High throughput | no | no |
| REL_HUMAN | [view interactions] | High throughput | no | yes |
| RBM45_HUMAN | [view interactions] | High throughput | no | yes |
| FOXK1_HUMAN | [view interactions] | High throughput | no | yes |
| TYSY_HUMAN | [view interactions] | High throughput | no | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| C10_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| FLNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FOXK2_HUMAN | [view interactions] | High throughput | no | yes |
| LIMD1_HUMAN | [view interactions] | High throughput | no | yes |
| RFLB_HUMAN | [view interactions] | High throughput | no | yes |
| MOCOS_HUMAN | [view interactions] | High throughput | no | no |
| FHL3_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| CE295_HUMAN | [view interactions] | High throughput | no | yes |
| KIRR3_HUMAN | [view interactions] | High throughput | no | yes |
| TANC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |