LRFN1_HUMAN
Evidence for PS localization
Functions
Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LRFN1_HUMAN |
|---|---|---|---|---|
| GO:0030695 | GTPase regulator activity | 25.0000 | 4 | no |
| GO:0019900 | kinase binding | 20.8333 | 4 | no |
| GO:0005096 | GTPase activator activity | 20.8333 | 4 | no |
| GO:0043168 | anion binding | 20.8333 | 4 | no |
| GO:0045296 | cadherin binding | 20.8333 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LRFN1_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 45.8333 | 4 | yes |
| GO:0008104 | protein localization | 45.8333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 41.6667 | 4 | no |
| GO:0009966 | regulation of signal transduction | 37.5000 | 4 | no |
| GO:0010646 | regulation of cell communication | 37.5000 | 4 | no |
| GO:0050807 | regulation of synapse organization | 33.3333 | 5 | yes |
| GO:0099175 | regulation of postsynapse organization | 33.3333 | 6 | yes |
| GO:0048522 | positive regulation of cellular process | 29.1667 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 29.1667 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 29.1667 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 29.1667 | 4 | no |
| GO:0022607 | cellular component assembly | 29.1667 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 29.1667 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:0043547 | positive regulation of GTPase activity | 20.8333 | 6 | no |
| GO:0051336 | regulation of hydrolase activity | 20.8333 | 4 | no |
| GO:0051345 | positive regulation of hydrolase activity | 20.8333 | 5 | no |
| GO:0071702 | organic substance transport | 20.8333 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.8333 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 20.8333 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.8333 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 20.8333 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 20.8333 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.8333 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.8333 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 20.8333 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 20.8333 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 20.8333 | 4 | no |
| GO:0006996 | organelle organization | 20.8333 | 4 | no |
| GO:0043087 | regulation of GTPase activity | 20.8333 | 5 | no |
| GO:0051963 | regulation of synapse assembly | 16.6667 | 6 | yes |
| GO:0099150 | regulation of postsynaptic specialization assembly | 16.6667 | 6 | yes |
| GO:0099151 | regulation of postsynaptic density assembly | 16.6667 | 7 | yes |
| GO:1901888 | regulation of cell junction assembly | 16.6667 | 5 | yes |
| GO:1902115 | regulation of organelle assembly | 16.6667 | 5 | yes |
| GO:1904889 | regulation of excitatory synapse assembly | 16.6667 | 7 | yes |
| GO:1905874 | regulation of postsynaptic density organization | 16.6667 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| LRFN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTPRD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| M3K21_HUMAN | [view interactions] | High throughput | no | yes |
| MAST3_HUMAN | [view interactions] | High throughput | no | yes |
| SPD2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AN34A_HUMAN | [view interactions] | High throughput | no | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| LARP1_HUMAN | [view interactions] | High throughput | no | yes |
| RFIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCPP_HUMAN | [view interactions] | High throughput | no | no |
| PHLB2_HUMAN | [view interactions] | High throughput | no | yes |
| RGPS2_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| DEN1A_HUMAN | [view interactions] | High throughput | no | no |
| SH3R3_HUMAN | [view interactions] | High throughput | no | yes |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| EDC3_HUMAN | [view interactions] | High throughput | no | yes |
| SIN1_HUMAN | [view interactions] | High throughput | no | yes |
| LPIN3_HUMAN | [view interactions] | High throughput | no | yes |
| RTKN_HUMAN | [view interactions] | High throughput | no | yes |
| OSBL6_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TANC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INP5E_HUMAN | [view interactions] | High throughput | no | yes |
| FA53C_HUMAN | [view interactions] | High throughput | no | yes |
| DEN4C_HUMAN | [view interactions] | High throughput | no | yes |
| UBP21_HUMAN | [view interactions] | High throughput | no | no |
| ZBT21_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GAB2_HUMAN | [view interactions] | High throughput | no | yes |
| STA13_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
| CING_HUMAN | [view interactions] | High throughput | no | no |
| NGAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| DPA1_HUMAN | [view interactions] | High throughput | no | yes |
| ICAM2_HUMAN | [view interactions] | High throughput | no | no |
| RCN1_HUMAN | [view interactions] | High throughput | no | yes |
| CAB45_HUMAN | [view interactions] | High throughput | no | no |
| PCDGD_HUMAN | [view interactions] | High throughput | no | no |
| CDCP1_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP5_HUMAN | [view interactions] | High throughput | no | no |
| SPXN_HUMAN | [view interactions] | High throughput | no | no |
| SAA1_HUMAN | [view interactions] | High throughput | no | no |
| TMM59_HUMAN | [view interactions] | High throughput | no | yes |
| CLRN2_HUMAN | [view interactions] | High throughput | no | no |
| 4F2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NKG2A_HUMAN | [view interactions] | High throughput | no | no |
| BRID5_HUMAN | [view interactions] | High throughput | no | no |
| F234A_HUMAN | [view interactions] | High throughput | no | yes |
| B4GA1_HUMAN | [view interactions] | High throughput | no | yes |
| PCDA9_HUMAN | [view interactions] | High throughput | no | no |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| KLRG2_HUMAN | [view interactions] | High throughput | no | no |
| T106A_HUMAN | [view interactions] | High throughput | no | no |
| LRN4L_HUMAN | [view interactions] | High throughput | no | yes |
| PSPC_HUMAN | [view interactions] | High throughput | no | no |
| SGCA_HUMAN | [view interactions] | High throughput | no | yes |
| TNF18_HUMAN | [view interactions] | High throughput | no | no |
| CD70_HUMAN | [view interactions] | High throughput | no | no |
| SLAF8_HUMAN | [view interactions] | High throughput | no | no |
| TNFL8_HUMAN | [view interactions] | High throughput | no | no |
| MICA_HUMAN | [view interactions] | High throughput | no | no |
| CD3E_HUMAN | [view interactions] | High throughput | no | no |
| CLC4A_HUMAN | [view interactions] | High throughput | no | no |
| PCDG4_HUMAN | [view interactions] | High throughput | no | no |
| CEA21_HUMAN | [view interactions] | High throughput | no | yes |
| SIGL1_HUMAN | [view interactions] | High throughput | no | no |
| CAH10_HUMAN | [view interactions] | High throughput | no | yes |
| I27RA_HUMAN | [view interactions] | High throughput | no | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| RGS2_HUMAN | [view interactions] | High throughput | no | no |
| S39A5_HUMAN | [view interactions] | High throughput | no | no |
| CC50B_HUMAN | [view interactions] | High throughput | no | yes |
| ANM2_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| I13R2_HUMAN | [view interactions] | High throughput | no | no |
| CADH5_HUMAN | [view interactions] | High throughput | no | yes |
| SACA1_HUMAN | [view interactions] | High throughput | no | no |
| TMX1_HUMAN | [view interactions] | High throughput | no | no |
| IFN21_HUMAN | [view interactions] | High throughput | no | no |
| SCN3B_HUMAN | [view interactions] | High throughput | no | no |
| CCL14_HUMAN | [view interactions] | High throughput | no | no |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| CRTC2_HUMAN | [view interactions] | High throughput | no | yes |
| REEP3_HUMAN | [view interactions] | High throughput | no | no |
| GGYF2_HUMAN | [view interactions] | High throughput | no | yes |
| SYDE1_HUMAN | [view interactions] | High throughput | no | yes |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| NAV1_HUMAN | [view interactions] | High throughput | no | yes |
| F110B_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC7_HUMAN | [view interactions] | High throughput | no | no |
| SRS12_HUMAN | [view interactions] | High throughput | no | no |
| MAGI1_HUMAN | [view interactions] | High throughput | no | no |
| TESK2_HUMAN | [view interactions] | High throughput | no | yes |
| F110A_HUMAN | [view interactions] | High throughput | no | yes |
| PANK2_HUMAN | [view interactions] | High throughput | no | yes |
| KI13B_HUMAN | [view interactions] | High throughput | no | yes |
| SH3B4_HUMAN | [view interactions] | High throughput | no | yes |
| CHK1_HUMAN | [view interactions] | High throughput | no | no |
| IF4E2_HUMAN | [view interactions] | High throughput | no | no |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NADK_HUMAN | [view interactions] | High throughput | no | yes |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MPIP2_HUMAN | [view interactions] | High throughput | no | no |
| MPIP3_HUMAN | [view interactions] | High throughput | no | yes |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK16_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| PTN13_HUMAN | [view interactions] | High throughput | no | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MELK_HUMAN | [view interactions] | High throughput | no | yes |
| ZN638_HUMAN | [view interactions] | High throughput | no | yes |
| PTN14_HUMAN | [view interactions] | High throughput | no | yes |
| TBC25_HUMAN | [view interactions] | High throughput | no | yes |