LRFN1_HUMAN
Evidence for PS localization
Functions
Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LRFN1_HUMAN |
|---|---|---|---|---|
| GO:0030695 | GTPase regulator activity | 27.2727 | 4 | no |
| GO:0019900 | kinase binding | 22.7273 | 4 | no |
| GO:0005096 | GTPase activator activity | 22.7273 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LRFN1_HUMAN |
|---|---|---|---|---|
| GO:0009966 | regulation of signal transduction | 40.9091 | 4 | no |
| GO:0010646 | regulation of cell communication | 40.9091 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.9091 | 4 | no |
| GO:0071702 | organic substance transport | 36.3636 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 36.3636 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 36.3636 | 4 | no |
| GO:0008104 | protein localization | 31.8182 | 4 | no |
| GO:0071705 | nitrogen compound transport | 31.8182 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 31.8182 | 4 | no |
| GO:0043087 | regulation of GTPase activity | 27.2727 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 27.2727 | 4 | no |
| GO:0022607 | cellular component assembly | 27.2727 | 4 | no |
| GO:0015031 | protein transport | 22.7273 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.7273 | 6 | no |
| GO:0031323 | regulation of cellular metabolic process | 22.7273 | 4 | no |
| GO:0031399 | regulation of protein modification process | 22.7273 | 6 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 22.7273 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 22.7273 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.7273 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 22.7273 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 22.7273 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 22.7273 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 22.7273 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 22.7273 | 5 | no |
| GO:0006996 | organelle organization | 22.7273 | 4 | no |
| GO:0043547 | positive regulation of GTPase activity | 22.7273 | 6 | no |
| GO:0048522 | positive regulation of cellular process | 22.7273 | 4 | no |
| GO:0051345 | positive regulation of hydrolase activity | 22.7273 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.7273 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PTPRD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRFN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RTKN_HUMAN | [view interactions] | High throughput | no | yes |
| LPIN3_HUMAN | [view interactions] | High throughput | no | yes |
| SIN1_HUMAN | [view interactions] | High throughput | no | yes |
| EDC3_HUMAN | [view interactions] | High throughput | no | yes |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| SH3R3_HUMAN | [view interactions] | High throughput | no | yes |
| DEN1A_HUMAN | [view interactions] | High throughput | no | no |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| RGPS2_HUMAN | [view interactions] | High throughput | no | yes |
| PHLB2_HUMAN | [view interactions] | High throughput | no | yes |
| MYCPP_HUMAN | [view interactions] | High throughput | no | no |
| RFIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LARP1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| AN34A_HUMAN | [view interactions] | High throughput | no | no |
| DEN4C_HUMAN | [view interactions] | High throughput | no | yes |
| FA53C_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
| STA13_HUMAN | [view interactions] | High throughput | no | yes |
| GAB2_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT21_HUMAN | [view interactions] | High throughput | no | yes |
| UBP21_HUMAN | [view interactions] | High throughput | no | no |
| CING_HUMAN | [view interactions] | High throughput | no | no |
| NGAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| DPA1_HUMAN | [view interactions] | High throughput | no | yes |
| ICAM2_HUMAN | [view interactions] | High throughput | no | no |
| RCN1_HUMAN | [view interactions] | High throughput | no | yes |
| CAB45_HUMAN | [view interactions] | High throughput | no | yes |
| PCDGD_HUMAN | [view interactions] | High throughput | no | no |
| CDCP1_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP5_HUMAN | [view interactions] | High throughput | no | no |
| SPXN_HUMAN | [view interactions] | High throughput | no | no |
| SAA1_HUMAN | [view interactions] | High throughput | no | no |
| TMM59_HUMAN | [view interactions] | High throughput | no | yes |
| CLRN2_HUMAN | [view interactions] | High throughput | no | no |
| 4F2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NKG2A_HUMAN | [view interactions] | High throughput | no | no |
| BRID5_HUMAN | [view interactions] | High throughput | no | no |
| F234A_HUMAN | [view interactions] | High throughput | no | yes |
| B4GA1_HUMAN | [view interactions] | High throughput | no | yes |
| PCDA9_HUMAN | [view interactions] | High throughput | no | no |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| KLRG2_HUMAN | [view interactions] | High throughput | no | no |
| T106A_HUMAN | [view interactions] | High throughput | no | no |
| LRN4L_HUMAN | [view interactions] | High throughput | no | yes |
| PSPC_HUMAN | [view interactions] | High throughput | no | no |
| SGCA_HUMAN | [view interactions] | High throughput | no | yes |
| TNF18_HUMAN | [view interactions] | High throughput | no | no |
| CD70_HUMAN | [view interactions] | High throughput | no | no |
| SLAF8_HUMAN | [view interactions] | High throughput | no | no |
| TNFL8_HUMAN | [view interactions] | High throughput | no | no |
| MICA_HUMAN | [view interactions] | High throughput | no | no |
| CD3E_HUMAN | [view interactions] | High throughput | no | no |
| CLC4A_HUMAN | [view interactions] | High throughput | no | no |
| PCDG4_HUMAN | [view interactions] | High throughput | no | no |
| CEA21_HUMAN | [view interactions] | High throughput | no | yes |
| SIGL1_HUMAN | [view interactions] | High throughput | no | no |
| CAH10_HUMAN | [view interactions] | High throughput | no | yes |
| I27RA_HUMAN | [view interactions] | High throughput | no | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RGS2_HUMAN | [view interactions] | High throughput | no | no |
| S39A5_HUMAN | [view interactions] | High throughput | no | no |
| CC50B_HUMAN | [view interactions] | High throughput | no | yes |
| ANM2_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| I13R2_HUMAN | [view interactions] | High throughput | no | no |
| CADH5_HUMAN | [view interactions] | High throughput | no | yes |
| SACA1_HUMAN | [view interactions] | High throughput | no | no |
| TMX1_HUMAN | [view interactions] | High throughput | no | no |
| IFN21_HUMAN | [view interactions] | High throughput | no | no |
| SCN3B_HUMAN | [view interactions] | High throughput | no | no |
| CCL14_HUMAN | [view interactions] | High throughput | no | no |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| CRTC2_HUMAN | [view interactions] | High throughput | no | yes |
| REEP3_HUMAN | [view interactions] | High throughput | no | no |
| GGYF2_HUMAN | [view interactions] | High throughput | no | yes |
| SYDE1_HUMAN | [view interactions] | High throughput | no | yes |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| NAV1_HUMAN | [view interactions] | High throughput | no | yes |
| F110B_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC7_HUMAN | [view interactions] | High throughput | no | no |
| SRS12_HUMAN | [view interactions] | High throughput | no | no |
| MAGI1_HUMAN | [view interactions] | High throughput | no | no |
| TESK2_HUMAN | [view interactions] | High throughput | no | yes |
| F110A_HUMAN | [view interactions] | High throughput | no | yes |
| PANK2_HUMAN | [view interactions] | High throughput | no | yes |
| KI13B_HUMAN | [view interactions] | High throughput | no | yes |
| SH3B4_HUMAN | [view interactions] | High throughput | no | yes |
| M3K21_HUMAN | [view interactions] | High throughput | no | yes |
| PTN14_HUMAN | [view interactions] | High throughput | no | yes |
| ZN638_HUMAN | [view interactions] | High throughput | no | yes |
| MELK_HUMAN | [view interactions] | High throughput | no | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN13_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| CDK16_HUMAN | [view interactions] | High throughput | no | yes |
| AFAD_HUMAN | [view interactions] | High throughput | no | yes |
| MPIP3_HUMAN | [view interactions] | High throughput | no | yes |
| MPIP2_HUMAN | [view interactions] | High throughput | no | no |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NADK_HUMAN | [view interactions] | High throughput | no | yes |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IF4E2_HUMAN | [view interactions] | High throughput | no | no |
| MAST3_HUMAN | [view interactions] | High throughput | no | yes |
| CHK1_HUMAN | [view interactions] | High throughput | no | no |
| TBC25_HUMAN | [view interactions] | High throughput | no | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPD2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INP5E_HUMAN | [view interactions] | High throughput | no | yes |
| TANC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSBL6_HUMAN | [view interactions] | High throughput | no | yes |