Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NF1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
629 Gly Arg Neurofibromatosis1(NF1) -
844 Leu Arg Neurofibromatosis1(NF1) -
898 Leu Pro Neurofibromatosis1(NF1) -
1035 Met Arg Neurofibromatosis1(NF1) -
1440 Lys Arg Neurofibromatosis1(NF1) -
1444 Lys Glu Neurofibromatosis1(NF1) -
1444 Lys Glu Neurofibromatosis-Noonansyndrome(NFNS) -
1611 Arg Trp Neurofibromatosis1(NF1) -
1952 Trp Arg Neurofibromatosis1(NF1) -
1953 Leu Pro Neurofibromatosis1(NF1) -
2164 Leu Met Neurofibromatosis1(NF1) -
2192 Tyr Asn Neurofibromatosis1(NF1) -
2631 Thr Ala Neurofibromatosis1(NF1) -
1446 Leu Pro Neurofibromatosis1(NF1) -
117 Ile Ser Neurofibromatosis1(NF1) -
338 Asp Gly Neurofibromatosis1(NF1) -
508 Leu Pro Neurofibromatosis1(NF1) -
844 Leu Phe Neurofibromatosis1(NF1) -
1166 Gly Asp Neurofibromatosis1(NF1) -
1204 Arg Trp Neurofibromatosis1(NF1) -
1276 Arg Pro Neurofibromatosis1(NF1) -
1412 Arg Ser Neurofibromatosis1(NF1) -
1440 Lys Gln Neurofibromatosis1(NF1) -
1489 Ser Gly Neurofibromatosis1(NF1) -
93 Cys Tyr Neurofibromatosis1(NF1) -
604 Leu Val Neurofibromatosis1(NF1) -
1276 Arg Gln Neurofibromatosis1(NF1) -
2088 Leu Pro Familialspinalneurofibromatosis(FSNF) -
82 Ser Phe Neurofibromatosis1(NF1) -
157 Ile Asn Neurofibromatosis1(NF1) -
216 Leu Pro Neurofibromatosis1(NF1) -
357 Leu Pro Neurofibromatosis1(NF1) -
491 Tyr Cys Neurofibromatosis1(NF1) -
549 Leu Pro Neurofibromatosis1(NF1) -
578 Leu Arg Neurofibromatosis1(NF1) -
581 Ile Thr Neurofibromatosis1(NF1) -
583 Lys Arg Neurofibromatosis1(NF1) -
695 Leu Pro Neurofibromatosis1(NF1) -
763 Leu Pro Neurofibromatosis1(NF1) -
777 Trp Ser Neurofibromatosis1(NF1) -
780 Thr Lys Neurofibromatosis1(NF1) -
781 His Pro Neurofibromatosis1(NF1) -
784 Trp Cys Neurofibromatosis1(NF1) -
784 Trp Arg Neurofibromatosis1(NF1) -
847 Leu Pro Neurofibromatosis1(NF1) -
848 Gly Glu Neurofibromatosis1(NF1) -
920 Leu Pro Neurofibromatosis1(NF1) -
968 Met Arg Neurofibromatosis1(NF1) -
1147 Leu Pro Neurofibromatosis1(NF1) -
1156 Asn Ser Neurofibromatosis1(NF1) -
1193 Phe Cys Neurofibromatosis1(NF1) -
1204 Arg Gly Neurofibromatosis1(NF1) -
1250 Arg Pro Neurofibromatosis1(NF1) -
1444 Lys Asn Neurofibromatosis1(NF1) -
1444 Lys Arg Neurofibromatosis1(NF1) -
1605 Ile Val Neurofibromatosis1(NF1) -
1785 Ala Ser Neurofibromatosis1(NF1) -
2001 Gly Arg Neurofibromatosis1(NF1) -
2012 Asp Asn Neurofibromatosis1(NF1) -
2221 Pro Ala Neurofibromatosis1(NF1) -
2357 Glu Lys Neurofibromatosis1(NF1) -
2507 Thr Ile Neurofibromatosis1(NF1) -
31 His Arg Neurofibromatosis1(NF1) -
145 Leu Pro Neurofibromatosis1(NF1) -
186 Asp Val Neurofibromatosis1(NF1) -
194 Leu Arg Neurofibromatosis-Noonansyndrome(NFNS) -
324 Cys Arg Neurofibromatosis1(NF1) -
337 Glu Val Neurofibromatosis1(NF1) -
489 Tyr Cys Neurofibromatosis1(NF1) -
532 Leu Pro Neurofibromatosis1(NF1) -
574 Ser Arg Neurofibromatosis1(NF1) -
844 Leu Pro Neurofibromatosis1(NF1) -
1073 Met Val Neurofibromatosis1(NF1) -
1196 Leu Arg Neurofibromatosis1(NF1) -
1243 Leu Pro Neurofibromatosis1(NF1) -
1276 Arg Gly Neurofibromatosis1(NF1) -
1430 Lys Glu Neurofibromatosis1(NF1) -
1451 Asn Thr Neurofibromatosis-Noonansyndrome(NFNS) -
1453 Val Leu Neurofibromatosis-Noonansyndrome(NFNS) -
1411 Leu Phe Neurofibromatosis-Noonansyndrome(NFNS) -
160 Arg Thr Neurofibromatosis1(NF1) -
93 Cys Trp Neurofibromatosis1(NF1) -
1048 Trp Arg Neurofibromatosis1(NF1) -
1189 Gln Arg Neurofibromatosis1(NF1) -
2125 Leu Pro Neurofibromatosis1(NF1) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NF1_HUMAN
GO:0043168 anion binding 38.4615 4 no
GO:0000166 nucleotide binding 33.3333 4 no
GO:0017076 purine nucleotide binding 33.3333 5 no
GO:0032555 purine ribonucleotide binding 33.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 32.0513 4 no
GO:0019900 kinase binding 26.9231 4 no
GO:0019901 protein kinase binding 25.6410 5 no
GO:0043169 cation binding 23.0769 4 yes
GO:0030554 adenyl nucleotide binding 21.7949 6 no
GO:0032559 adenyl ribonucleotide binding 21.7949 5 no
GO:0005524 ATP binding 20.5128 5 no
GO:0046872 metal ion binding 20.5128 5 no
GO:0030695 GTPase regulator activity 11.5385 4 yes
GO:0005096 GTPase activator activity 10.2564 4 yes
GO:0008429 phosphatidylethanolamine binding 2.5641 4 yes
GO:0031210 phosphatidylcholine binding 2.5641 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NF1_HUMAN
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0048523 negative regulation of cellular process 62.8205 4 yes
GO:0010646 regulation of cell communication 58.9744 4 yes
GO:0060255 regulation of macromolecule metabolic process 56.4103 4 yes
GO:0080090 regulation of primary metabolic process 55.1282 4 yes
GO:0031323 regulation of cellular metabolic process 52.5641 4 yes
GO:0009966 regulation of signal transduction 51.2821 4 yes
GO:0051128 regulation of cellular component organization 50.0000 4 yes
GO:0009893 positive regulation of metabolic process 42.3077 4 no
GO:0009889 regulation of biosynthetic process 41.0256 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 41.0256 5 no
GO:0051049 regulation of transport 41.0256 4 yes
GO:0010468 regulation of gene expression 39.7436 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 39.7436 5 yes
GO:0031326 regulation of cellular biosynthetic process 39.7436 5 yes
GO:0051246 regulation of protein metabolic process 39.7436 5 yes
GO:1902531 regulation of intracellular signal transduction 38.4615 5 yes
GO:0048584 positive regulation of response to stimulus 35.8974 4 yes
GO:0031399 regulation of protein modification process 34.6154 6 yes
GO:0009892 negative regulation of metabolic process 33.3333 4 yes
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 yes
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 yes
GO:0006996 organelle organization 32.0513 4 yes
GO:0009967 positive regulation of signal transduction 32.0513 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 32.0513 5 yes
GO:0010647 positive regulation of cell communication 32.0513 5 yes
GO:0022607 cellular component assembly 32.0513 4 no
GO:0023056 positive regulation of signaling 32.0513 4 yes
GO:0008104 protein localization 30.7692 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.7692 5 no
GO:0051247 positive regulation of protein metabolic process 30.7692 6 no
GO:0031324 negative regulation of cellular metabolic process 30.7692 5 yes
GO:0042127 regulation of cell population proliferation 30.7692 4 yes
GO:0043085 positive regulation of catalytic activity 30.7692 4 yes
GO:0141124 intracellular signaling cassette 30.7692 4 yes
GO:0042325 regulation of phosphorylation 29.4872 7 yes
GO:0042981 regulation of apoptotic process 29.4872 5 yes
GO:0043067 regulation of programmed cell death 29.4872 4 yes
GO:0001932 regulation of protein phosphorylation 29.4872 7 yes
GO:2000145 regulation of cell motility 28.2051 4 yes
GO:0051252 regulation of RNA metabolic process 28.2051 5 no
GO:0006355 regulation of DNA-templated transcription 26.9231 7 no
GO:0031401 positive regulation of protein modification process 26.9231 7 no
GO:2001141 regulation of RNA biosynthetic process 26.9231 6 no
GO:0030334 regulation of cell migration 26.9231 5 yes
GO:0045595 regulation of cell differentiation 26.9231 4 yes
GO:0048585 negative regulation of response to stimulus 26.9231 4 yes
GO:0031344 regulation of cell projection organization 25.6410 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.6410 6 no
GO:0007010 cytoskeleton organization 24.3590 5 yes
GO:0010648 negative regulation of cell communication 24.3590 5 yes
GO:0006796 phosphate-containing compound metabolic process 24.3590 4 no
GO:0010562 positive regulation of phosphorus metabolic process 24.3590 6 no
GO:0045937 positive regulation of phosphate metabolic process 24.3590 7 no
GO:0051130 positive regulation of cellular component organization 24.3590 5 no
GO:0023057 negative regulation of signaling 24.3590 4 yes
GO:0060341 regulation of cellular localization 24.3590 4 yes
GO:0009968 negative regulation of signal transduction 23.0769 5 yes
GO:0001934 positive regulation of protein phosphorylation 23.0769 8 no
GO:0009891 positive regulation of biosynthetic process 23.0769 5 no
GO:0036211 protein modification process 23.0769 4 no
GO:0042327 positive regulation of phosphorylation 23.0769 8 no
GO:0043412 macromolecule modification 23.0769 4 no
GO:0044087 regulation of cellular component biogenesis 23.0769 4 no
GO:0071310 cellular response to organic substance 23.0769 4 no
GO:0051726 regulation of cell cycle 23.0769 4 no
GO:0030030 cell projection organization 23.0769 4 no
GO:0051240 positive regulation of multicellular organismal process 23.0769 4 no
GO:0050804 modulation of chemical synaptic transmission 23.0769 5 yes
GO:0050807 regulation of synapse organization 23.0769 5 yes
GO:0051336 regulation of hydrolase activity 23.0769 4 yes
GO:0051338 regulation of transferase activity 23.0769 4 yes
GO:0099177 regulation of trans-synaptic signaling 23.0769 4 yes
GO:0008284 positive regulation of cell population proliferation 21.7949 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 21.7949 6 no
GO:0031328 positive regulation of cellular biosynthetic process 21.7949 6 no
GO:1902533 positive regulation of intracellular signal transduction 21.7949 6 no
GO:0032101 regulation of response to external stimulus 21.7949 4 no
GO:0043269 regulation of monoatomic ion transport 21.7949 5 no
GO:0022603 regulation of anatomical structure morphogenesis 21.7949 4 yes
GO:0080134 regulation of response to stress 21.7949 4 no
GO:0043549 regulation of kinase activity 21.7949 5 yes
GO:0045859 regulation of protein kinase activity 21.7949 6 yes
GO:2000026 regulation of multicellular organismal development 20.5128 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 20.5128 8 no
GO:0016310 phosphorylation 20.5128 5 no
GO:0051248 negative regulation of protein metabolic process 20.5128 6 yes
GO:0051345 positive regulation of hydrolase activity 20.5128 5 yes
GO:0032880 regulation of protein localization 19.2308 5 yes
GO:0043408 regulation of MAPK cascade 19.2308 6 yes
GO:0060284 regulation of cell development 19.2308 5 yes
GO:0071702 organic substance transport 19.2308 4 yes
GO:0002684 positive regulation of immune system process 19.2308 4 yes
GO:0030155 regulation of cell adhesion 17.9487 4 yes
GO:0071705 nitrogen compound transport 17.9487 4 yes
GO:0006915 apoptotic process 16.6667 4 yes
GO:0008285 negative regulation of cell population proliferation 16.6667 5 yes
GO:0007264 small GTPase-mediated signal transduction 15.3846 5 yes
GO:0010563 negative regulation of phosphorus metabolic process 15.3846 6 yes
GO:0031400 negative regulation of protein modification process 15.3846 7 yes
GO:0045936 negative regulation of phosphate metabolic process 15.3846 7 yes
GO:0051051 negative regulation of transport 15.3846 4 yes
GO:0099175 regulation of postsynapse organization 15.3846 6 yes
GO:1902532 negative regulation of intracellular signal transduction 14.1026 6 yes
GO:0015031 protein transport 14.1026 4 yes
GO:0051960 regulation of nervous system development 14.1026 5 yes
GO:0071900 regulation of protein serine/threonine kinase activity 14.1026 7 yes
GO:0040013 negative regulation of locomotion 12.8205 4 yes
GO:0042326 negative regulation of phosphorylation 12.8205 8 yes
GO:0045596 negative regulation of cell differentiation 12.8205 5 yes
GO:0050678 regulation of epithelial cell proliferation 12.8205 5 yes
GO:0050767 regulation of neurogenesis 12.8205 6 yes
GO:0050890 cognition 12.8205 4 yes
GO:0051093 negative regulation of developmental process 12.8205 4 yes
GO:0051241 negative regulation of multicellular organismal process 12.8205 4 yes
GO:0000165 MAPK cascade 12.8205 5 yes
GO:0001933 negative regulation of protein phosphorylation 12.8205 8 yes
GO:0002685 regulation of leukocyte migration 12.8205 4 yes
GO:0097435 supramolecular fiber organization 12.8205 4 yes
GO:2000146 negative regulation of cell motility 11.5385 5 yes
GO:0010632 regulation of epithelial cell migration 11.5385 4 yes
GO:0030336 negative regulation of cell migration 11.5385 6 yes
GO:0043065 positive regulation of apoptotic process 11.5385 6 yes
GO:0043068 positive regulation of programmed cell death 11.5385 5 yes
GO:0043086 negative regulation of catalytic activity 11.5385 4 yes
GO:0048168 regulation of neuronal synaptic plasticity 11.5385 4 yes
GO:0051056 regulation of small GTPase mediated signal transduction 11.5385 6 yes
GO:0070201 regulation of establishment of protein localization 11.5385 6 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 11.5385 7 yes
GO:1903530 regulation of secretion by cell 10.2564 4 yes
GO:1903828 negative regulation of protein localization 10.2564 5 yes
GO:2001233 regulation of apoptotic signaling pathway 10.2564 5 yes
GO:0010810 regulation of cell-substrate adhesion 10.2564 5 yes
GO:0021782 glial cell development 10.2564 4 yes
GO:0032386 regulation of intracellular transport 10.2564 5 yes
GO:0043523 regulation of neuron apoptotic process 10.2564 6 yes
GO:0051046 regulation of secretion 10.2564 5 yes
GO:0051223 regulation of protein transport 10.2564 5 yes
GO:0002521 leukocyte differentiation 10.2564 4 yes
GO:0006886 intracellular protein transport 8.9744 4 yes
GO:0007612 learning 8.9744 4 yes
GO:0010594 regulation of endothelial cell migration 8.9744 5 yes
GO:0030099 myeloid cell differentiation 8.9744 4 yes
GO:0033673 negative regulation of kinase activity 8.9744 6 yes
GO:0034605 cellular response to heat 8.9744 4 yes
GO:0046903 secretion 8.9744 4 yes
GO:0048169 regulation of long-term neuronal synaptic plasticity 8.9744 5 yes
GO:0050806 positive regulation of synaptic transmission 8.9744 5 yes
GO:0051348 negative regulation of transferase activity 8.9744 5 yes
GO:0002573 myeloid leukocyte differentiation 8.9744 5 yes
GO:0006469 negative regulation of protein kinase activity 8.9744 7 yes
GO:0007162 negative regulation of cell adhesion 7.6923 5 yes
GO:1903706 regulation of hemopoiesis 7.6923 4 yes
GO:0009416 response to light stimulus 7.6923 4 yes
GO:0010721 negative regulation of cell development 7.6923 6 yes
GO:0016601 Rac protein signal transduction 7.6923 6 yes
GO:0033157 regulation of intracellular protein transport 7.6923 6 yes
GO:0033365 protein localization to organelle 7.6923 5 yes
GO:0043087 regulation of GTPase activity 7.6923 5 yes
GO:0043547 positive regulation of GTPase activity 7.6923 6 yes
GO:0048732 gland development 7.6923 4 yes
GO:0050679 positive regulation of epithelial cell proliferation 7.6923 6 yes
GO:0050680 negative regulation of epithelial cell proliferation 7.6923 6 yes
GO:0051402 neuron apoptotic process 7.6923 5 yes
GO:0070663 regulation of leukocyte proliferation 7.6923 5 yes
GO:0001952 regulation of cell-matrix adhesion 7.6923 6 yes
GO:0002683 negative regulation of immune system process 7.6923 4 yes
GO:1900180 regulation of protein localization to nucleus 7.6923 6 yes
GO:1900181 negative regulation of protein localization to nucleus 6.4103 6 yes
GO:1902105 regulation of leukocyte differentiation 6.4103 5 yes
GO:0007265 Ras protein signal transduction 6.4103 6 yes
GO:0007420 brain development 6.4103 4 yes
GO:0008306 associative learning 6.4103 5 yes
GO:0008542 visual learning 6.4103 4 yes
GO:2000177 regulation of neural precursor cell proliferation 6.4103 5 yes
GO:0010001 glial cell differentiation 6.4103 4 yes
GO:2001236 regulation of extrinsic apoptotic signaling pathway 6.4103 6 yes
GO:0010812 negative regulation of cell-substrate adhesion 6.4103 6 yes
GO:0014044 Schwann cell development 6.4103 5 yes
GO:0023061 signal release 6.4103 4 yes
GO:0034504 protein localization to nucleus 6.4103 6 yes
GO:0036293 response to decreased oxygen levels 6.4103 4 yes
GO:0042552 myelination 6.4103 4 yes
GO:0043405 regulation of MAP kinase activity 6.4103 8 yes
GO:0043535 regulation of blood vessel endothelial cell migration 6.4103 6 yes
GO:0045637 regulation of myeloid cell differentiation 6.4103 5 yes
GO:0046822 regulation of nucleocytoplasmic transport 6.4103 6 yes
GO:0048660 regulation of smooth muscle cell proliferation 6.4103 5 yes
GO:0050768 negative regulation of neurogenesis 6.4103 6 yes
GO:0051588 regulation of neurotransmitter transport 6.4103 5 yes
GO:0051961 negative regulation of nervous system development 6.4103 5 yes
GO:0060429 epithelium development 6.4103 4 yes
GO:0001936 regulation of endothelial cell proliferation 6.4103 6 yes
GO:0071901 negative regulation of protein serine/threonine kinase activity 6.4103 8 yes
GO:0006913 nucleocytoplasmic transport 5.1282 5 yes
GO:1900271 regulation of long-term synaptic potentiation 5.1282 4 yes
GO:1901342 regulation of vasculature development 5.1282 5 yes
GO:0007507 heart development 5.1282 4 yes
GO:2000106 regulation of leukocyte apoptotic process 5.1282 6 yes
GO:2001235 positive regulation of apoptotic signaling pathway 5.1282 6 yes
GO:0014013 regulation of gliogenesis 5.1282 7 yes
GO:0030198 extracellular matrix organization 5.1282 5 yes
GO:0031279 regulation of cyclase activity 5.1282 4 yes
GO:0031281 positive regulation of cyclase activity 5.1282 5 yes
GO:0043062 extracellular structure organization 5.1282 4 yes
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction 5.1282 5 yes
GO:0043525 positive regulation of neuron apoptotic process 5.1282 7 yes
GO:0045229 external encapsulating structure organization 5.1282 4 yes
GO:0045765 regulation of angiogenesis 5.1282 5 yes
GO:0048145 regulation of fibroblast proliferation 5.1282 5 yes
GO:0048661 positive regulation of smooth muscle cell proliferation 5.1282 6 yes
GO:0051169 nuclear transport 5.1282 4 yes
GO:0060251 regulation of glial cell proliferation 5.1282 5 yes
GO:0060537 muscle tissue development 5.1282 4 yes
GO:0001649 osteoblast differentiation 5.1282 4 yes
GO:0001938 positive regulation of endothelial cell proliferation 5.1282 7 yes
GO:0001953 negative regulation of cell-matrix adhesion 5.1282 7 yes
GO:0002686 negative regulation of leukocyte migration 5.1282 5 yes
GO:0098597 observational learning 5.1282 5 yes
GO:0002761 regulation of myeloid leukocyte differentiation 5.1282 6 yes
GO:1901343 negative regulation of vasculature development 3.8462 5 yes
GO:1902106 negative regulation of leukocyte differentiation 3.8462 6 yes
GO:1903707 negative regulation of hemopoiesis 3.8462 5 yes
GO:0007519 skeletal muscle tissue development 3.8462 5 yes
GO:1903975 regulation of glial cell migration 3.8462 6 yes
GO:1904705 regulation of vascular associated smooth muscle cell proliferation 3.8462 6 yes
GO:1904950 negative regulation of establishment of protein localization 3.8462 6 yes
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 3.8462 5 yes
GO:2000108 positive regulation of leukocyte apoptotic process 3.8462 7 yes
GO:2000178 negative regulation of neural precursor cell proliferation 3.8462 6 yes
GO:2000181 negative regulation of blood vessel morphogenesis 3.8462 5 yes
GO:2000647 negative regulation of stem cell proliferation 3.8462 6 yes
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand 3.8462 7 yes
GO:0014002 astrocyte development 3.8462 5 yes
GO:0015711 organic anion transport 3.8462 5 yes
GO:0016525 negative regulation of angiogenesis 3.8462 6 yes
GO:0021897 forebrain astrocyte development 3.8462 6 yes
GO:0030316 osteoclast differentiation 3.8462 6 yes
GO:0030325 adrenal gland development 3.8462 5 yes
GO:0032228 regulation of synaptic transmission, GABAergic 3.8462 6 yes
GO:0032387 negative regulation of intracellular transport 3.8462 5 yes
GO:0033032 regulation of myeloid cell apoptotic process 3.8462 6 yes
GO:0035020 regulation of Rac protein signal transduction 3.8462 7 yes
GO:0042060 wound healing 3.8462 4 yes
GO:0042306 regulation of protein import into nucleus 3.8462 7 yes
GO:0042308 negative regulation of protein import into nucleus 3.8462 7 yes
GO:0043407 negative regulation of MAP kinase activity 3.8462 8 yes
GO:0043409 negative regulation of MAPK cascade 3.8462 7 yes
GO:0045638 negative regulation of myeloid cell differentiation 3.8462 6 yes
GO:0045670 regulation of osteoclast differentiation 3.8462 7 yes
GO:0045761 regulation of adenylate cyclase activity 3.8462 5 yes
GO:0045762 positive regulation of adenylate cyclase activity 3.8462 6 yes
GO:0046823 negative regulation of nucleocytoplasmic transport 3.8462 6 yes
GO:0046928 regulation of neurotransmitter secretion 3.8462 5 yes
GO:0048514 blood vessel morphogenesis 3.8462 4 yes
GO:0051170 import into nucleus 3.8462 6 yes
GO:0051224 negative regulation of protein transport 3.8462 5 yes
GO:0051339 regulation of lyase activity 3.8462 4 yes
GO:0051349 positive regulation of lyase activity 3.8462 5 yes
GO:0060291 long-term synaptic potentiation 3.8462 4 yes
GO:0070664 negative regulation of leukocyte proliferation 3.8462 6 yes
GO:0001822 kidney development 3.8462 4 yes
GO:0070666 regulation of mast cell proliferation 3.8462 6 yes
GO:0070667 negative regulation of mast cell proliferation 3.8462 7 yes
GO:0071887 leukocyte apoptotic process 3.8462 5 yes
GO:0001937 negative regulation of endothelial cell proliferation 3.8462 7 yes
GO:0072091 regulation of stem cell proliferation 3.8462 5 yes
GO:0072594 establishment of protein localization to organelle 3.8462 4 yes
GO:0090317 negative regulation of intracellular protein transport 3.8462 6 yes
GO:0097191 extrinsic apoptotic signaling pathway 3.8462 4 yes
GO:0002762 negative regulation of myeloid leukocyte differentiation 3.8462 7 yes
GO:0006606 protein import into nucleus 3.8462 5 yes
GO:1900147 regulation of Schwann cell migration 3.8462 7 yes
GO:0006836 neurotransmitter transport 3.8462 4 yes
GO:0007269 neurotransmitter secretion 2.5641 4 yes
GO:1902692 regulation of neuroblast proliferation 2.5641 6 yes
GO:0007405 neuroblast proliferation 2.5641 4 yes
GO:0007406 negative regulation of neuroblast proliferation 2.5641 7 yes
GO:1903531 negative regulation of secretion by cell 2.5641 5 yes
GO:0007422 peripheral nervous system development 2.5641 4 yes
GO:1903976 negative regulation of glial cell migration 2.5641 7 yes
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 2.5641 7 yes
GO:1904738 vascular associated smooth muscle cell migration 2.5641 6 yes
GO:1904752 regulation of vascular associated smooth muscle cell migration 2.5641 7 yes
GO:0008347 glial cell migration 2.5641 4 yes
GO:1904753 negative regulation of vascular associated smooth muscle cell migration 2.5641 8 yes
GO:1990874 vascular associated smooth muscle cell proliferation 2.5641 5 yes
GO:0010624 regulation of Schwann cell proliferation 2.5641 6 yes
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 2.5641 7 yes
GO:0010626 negative regulation of Schwann cell proliferation 2.5641 7 yes
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand 2.5641 8 yes
GO:0014010 Schwann cell proliferation 2.5641 4 yes
GO:0014014 negative regulation of gliogenesis 2.5641 7 yes
GO:0014047 glutamate secretion 2.5641 4 yes
GO:0014051 gamma-aminobutyric acid secretion 2.5641 6 yes
GO:0014812 muscle cell migration 2.5641 4 yes
GO:0014909 smooth muscle cell migration 2.5641 5 yes
GO:0014910 regulation of smooth muscle cell migration 2.5641 6 yes
GO:0014912 negative regulation of smooth muscle cell migration 2.5641 7 yes
GO:0015800 acidic amino acid transport 2.5641 6 yes
GO:0015807 L-amino acid transport 2.5641 5 yes
GO:0015812 gamma-aminobutyric acid transport 2.5641 5 yes
GO:0015849 organic acid transport 2.5641 5 yes
GO:0021915 neural tube development 2.5641 4 yes
GO:0022011 myelination in peripheral nervous system 2.5641 5 yes
GO:0030199 collagen fibril organization 2.5641 5 yes
GO:0032292 peripheral nervous system axon ensheathment 2.5641 4 yes
GO:0033024 mast cell apoptotic process 2.5641 6 yes
GO:0033025 regulation of mast cell apoptotic process 2.5641 4 yes
GO:0033027 positive regulation of mast cell apoptotic process 2.5641 5 yes
GO:0033028 myeloid cell apoptotic process 2.5641 5 yes
GO:0033034 positive regulation of myeloid cell apoptotic process 2.5641 7 yes
GO:0034103 regulation of tissue remodeling 2.5641 4 yes
GO:0035021 negative regulation of Rac protein signal transduction 2.5641 8 yes
GO:0036135 Schwann cell migration 2.5641 5 yes
GO:0045124 regulation of bone resorption 2.5641 6 yes
GO:0045671 negative regulation of osteoclast differentiation 2.5641 8 yes
GO:0045685 regulation of glial cell differentiation 2.5641 5 yes
GO:0045686 negative regulation of glial cell differentiation 2.5641 6 yes
GO:0046717 acid secretion 2.5641 5 yes
GO:0046850 regulation of bone remodeling 2.5641 5 yes
GO:0046929 negative regulation of neurotransmitter secretion 2.5641 6 yes
GO:0046942 carboxylic acid transport 2.5641 6 yes
GO:0048147 negative regulation of fibroblast proliferation 2.5641 6 yes
GO:0048485 sympathetic nervous system development 2.5641 4 yes
GO:0048592 eye morphogenesis 2.5641 5 yes
GO:0048593 camera-type eye morphogenesis 2.5641 6 yes
GO:0048659 smooth muscle cell proliferation 2.5641 4 yes
GO:0048709 oligodendrocyte differentiation 2.5641 5 yes
GO:0048710 regulation of astrocyte differentiation 2.5641 6 yes
GO:0048712 negative regulation of astrocyte differentiation 2.5641 7 yes
GO:0048713 regulation of oligodendrocyte differentiation 2.5641 6 yes
GO:0048715 negative regulation of oligodendrocyte differentiation 2.5641 7 yes
GO:0048745 smooth muscle tissue development 2.5641 5 yes
GO:0048820 hair follicle maturation 2.5641 4 yes
GO:0048844 artery morphogenesis 2.5641 5 yes
GO:0051048 negative regulation of secretion 2.5641 5 yes
GO:0051058 negative regulation of small GTPase mediated signal transduction 2.5641 7 yes
GO:0051589 negative regulation of neurotransmitter transport 2.5641 5 yes
GO:0051938 L-glutamate import 2.5641 6 yes
GO:0060253 negative regulation of glial cell proliferation 2.5641 6 yes
GO:0061534 gamma-aminobutyric acid secretion, neurotransmission 2.5641 5 yes
GO:0061535 glutamate secretion, neurotransmission 2.5641 5 yes
GO:0070662 mast cell proliferation 2.5641 4 yes
GO:0001656 metanephros development 2.5641 5 yes
GO:0001889 liver development 2.5641 5 yes
GO:0001935 endothelial cell proliferation 2.5641 4 yes
GO:0090596 sensory organ morphogenesis 2.5641 4 yes
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 2.5641 4 yes
GO:0099643 signal release from synapse 2.5641 5 yes
GO:0006835 dicarboxylic acid transport 2.5641 7 yes
GO:1900148 negative regulation of Schwann cell migration 2.5641 8 yes
GO:0006865 amino acid transport 2.5641 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PO2F1_HUMAN [view interactions] Low throughput no yes
BRCA1_HUMAN [view interactions] Low throughput no yes
NF1_HUMAN [view entry] [view interactions] Low throughput yes no
SDC2_HUMAN [view entry] [view interactions] Low throughput yes yes
SDC3_HUMAN [view interactions] Low throughput no yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
SPRE1_HUMAN [view interactions] Low throughput no yes
SPRE2_HUMAN [view interactions] Low throughput no yes
SPRE3_HUMAN [view interactions] Low throughput no no
SUMO1_HUMAN [view entry] [view interactions] Low throughput yes yes
1433F_HUMAN [view entry] [view interactions] Low throughput yes yes
RASH_HUMAN [view entry] [view interactions] Low throughput yes no
PML_HUMAN [view interactions] Low throughput no yes
CSKP_HUMAN [view entry] [view interactions] Low throughput yes yes
STAT1_HUMAN [view entry] [view interactions] Low throughput yes no
DYHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
RASK_HUMAN [view entry] [view interactions] Low throughput yes no
RASN_HUMAN [view entry] [view interactions] Low throughput yes no
LIMK2_HUMAN [view interactions] Low throughput no yes
FAF2_HUMAN [view interactions] Low throughput no yes
TERA_HUMAN [view entry] [view interactions] Low throughput yes yes
NSF1C_HUMAN [view entry] [view interactions] Low throughput yes yes
CAV1_HUMAN [view interactions] Low throughput no no
ATF2_HUMAN [view interactions] Low throughput no yes
5HT6R_HUMAN [view interactions] Low throughput no yes
LZTR1_HUMAN [view interactions] Low throughput no no
FA12_HUMAN [view interactions] Low throughput no no
L2GL1_HUMAN [view entry] [view interactions] High throughput yes yes
E2AK3_HUMAN [view interactions] High throughput no yes
CT173_HUMAN [view interactions] High throughput no no
ECHD2_HUMAN [view interactions] High throughput no no
CATK_HUMAN [view interactions] High throughput no no
SYT12_HUMAN [view interactions] High throughput no yes
CAVN1_HUMAN [view interactions] High throughput no no
SUZ12_HUMAN [view interactions] High throughput no no
MARK2_HUMAN [view entry] [view interactions] High throughput yes yes
CAH4_HUMAN [view entry] [view interactions] High throughput yes yes
BFAR_HUMAN [view interactions] High throughput no no
HOP2_HUMAN [view interactions] High throughput no no
JTB_HUMAN [view interactions] High throughput no yes
G6PC1_HUMAN [view interactions] High throughput no no
PRDX1_HUMAN [view entry] [view interactions] High throughput yes yes
PRKRA_HUMAN [view entry] [view interactions] High throughput yes yes
USH1G_HUMAN [view interactions] High throughput no no
ATG9A_HUMAN [view interactions] High throughput no yes
HAPR1_HUMAN [view interactions] High throughput no yes
SHBG_HUMAN [view interactions] High throughput no no
DMAC1_HUMAN [view interactions] High throughput no no
NDUB6_HUMAN [view entry] [view interactions] High throughput yes yes
FBW1B_HUMAN [view interactions] High throughput no yes
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
UBP48_HUMAN [view interactions] High throughput no yes
PMVK_HUMAN [view entry] [view interactions] High throughput yes yes
EBP2_HUMAN [view interactions] High throughput no yes
TCAB1_HUMAN [view interactions] High throughput no yes
UIMC1_HUMAN [view interactions] High throughput no no
CIP2A_HUMAN [view interactions] High throughput no yes
RPR1B_HUMAN [view interactions] High throughput no yes
FANCJ_HUMAN [view interactions] High throughput no yes
TOR4A_HUMAN [view interactions] High throughput no yes
UBE2T_HUMAN [view interactions] High throughput no no
TYSY_HUMAN [view interactions] High throughput no yes
NDUC1_HUMAN [view interactions] High throughput no yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
CLK1_HUMAN [view interactions] High throughput no yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA2_HUMAN [view interactions] High throughput no no
MP2K3_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
SOX4_HUMAN [view interactions] High throughput no yes
NOSIP_HUMAN [view interactions] High throughput no yes
BIRC6_HUMAN [view entry] [view interactions] High throughput yes yes
VP13B_HUMAN [view interactions] High throughput no no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
CNTP2_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
MUC18_HUMAN [view interactions] High throughput no yes
SDC1_HUMAN [view interactions] High throughput no no
SDC4_HUMAN [view interactions] High throughput no yes
TIRAP_HUMAN [view interactions] High throughput no no
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
KI67_HUMAN [view interactions] High throughput no no
LCK_HUMAN [view entry] [view interactions] High throughput yes no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
NOLC1_HUMAN [view interactions] High throughput no yes
KS6A6_HUMAN [view interactions] High throughput no yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
CDC5L_HUMAN [view interactions] High throughput no yes
ABCF1_HUMAN [view interactions] High throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
HDAC4_HUMAN [view interactions] High throughput no yes
EFS_HUMAN [view interactions] High throughput no no
CTDP1_HUMAN [view interactions] High throughput no yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
DCLK1_HUMAN [view entry] [view interactions] High throughput yes yes
SI1L1_HUMAN [view entry] [view interactions] High throughput yes yes
KIF1C_HUMAN [view interactions] High throughput no yes
SRGP2_HUMAN [view entry] [view interactions] High throughput yes no
GGYF1_HUMAN [view interactions] High throughput no yes
NADK_HUMAN [view interactions] High throughput no yes
MAST3_HUMAN [view interactions] High throughput no yes
IF4E2_HUMAN [view interactions] High throughput no no
MPIP2_HUMAN [view interactions] High throughput no no
MPIP3_HUMAN [view interactions] High throughput no yes
CDK16_HUMAN [view interactions] High throughput no yes
CAMP2_HUMAN [view interactions] High throughput no yes
PTN13_HUMAN [view interactions] High throughput no yes
TIAM1_HUMAN [view entry] [view interactions] High throughput yes yes
ZN638_HUMAN [view interactions] High throughput no yes
PTN14_HUMAN [view interactions] High throughput no yes
M3K21_HUMAN [view interactions] High throughput no yes
SPD2A_HUMAN [view entry] [view interactions] High throughput yes yes
DEN4C_HUMAN [view interactions] High throughput no yes
AN34A_HUMAN [view interactions] High throughput no no
MYCPP_HUMAN [view interactions] High throughput no no
PHLB2_HUMAN [view interactions] High throughput no yes
KSR1_HUMAN [view interactions] High throughput no yes
DEN1A_HUMAN [view interactions] High throughput no no
SH3R3_HUMAN [view interactions] High throughput no yes
SIN1_HUMAN [view interactions] High throughput no yes
LPIN3_HUMAN [view interactions] High throughput no yes
RTKN_HUMAN [view interactions] High throughput no yes
OSBL6_HUMAN [view interactions] High throughput no yes
TANC2_HUMAN [view entry] [view interactions] High throughput yes yes
INP5E_HUMAN [view interactions] High throughput no yes
FA53C_HUMAN [view interactions] High throughput no yes
PPM1H_HUMAN [view interactions] High throughput no yes
GAB2_HUMAN [view interactions] High throughput no yes
KCTD3_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
GGYF2_HUMAN [view interactions] High throughput no yes
SYDE1_HUMAN [view interactions] High throughput no yes
RGPS2_HUMAN [view interactions] High throughput no yes
NAV1_HUMAN [view interactions] High throughput no yes
F110B_HUMAN [view interactions] High throughput no yes
SRS12_HUMAN [view interactions] High throughput no no
MAGI1_HUMAN [view interactions] High throughput no no
TESK2_HUMAN [view interactions] High throughput no yes
KI13B_HUMAN [view interactions] High throughput no yes
LRFN1_HUMAN [view entry] [view interactions] High throughput yes no
CING_HUMAN [view interactions] High throughput no no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
NGAP_HUMAN [view entry] [view interactions] High throughput yes yes
UBP21_HUMAN [view interactions] High throughput no no
ZBT21_HUMAN [view interactions] High throughput no yes
AGAP1_HUMAN [view entry] [view interactions] High throughput yes no
CBY1_HUMAN [view interactions] High throughput no no
STA13_HUMAN [view interactions] High throughput no yes
SMCA4_HUMAN [view interactions] High throughput no yes
RPB1_HUMAN [view interactions] High throughput no no
SIR7_HUMAN [view interactions] High throughput no yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
NXF1_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
DPA1_HUMAN [view interactions] High throughput no yes
EFNB2_HUMAN [view entry] [view interactions] High throughput yes yes
PD1L1_HUMAN [view interactions] High throughput no no
TN13B_HUMAN [view interactions] High throughput no no
CAH14_HUMAN [view interactions] High throughput no yes
SLAF1_HUMAN [view interactions] High throughput no no
VSIG4_HUMAN [view interactions] High throughput no no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
CD79B_HUMAN [view interactions] High throughput no no
P4HA3_HUMAN [view interactions] High throughput no no
SCN3B_HUMAN [view interactions] High throughput no no
VSIG1_HUMAN [view interactions] High throughput no no
SIGL1_HUMAN [view interactions] High throughput no no
EPHA1_HUMAN [view interactions] High throughput no yes
F174A_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ZUP1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
PRC1_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
HIDE1_HUMAN [view interactions] High throughput no no
CDHR2_HUMAN [view interactions] High throughput no yes
F234A_HUMAN [view interactions] High throughput no yes
CD80_HUMAN [view interactions] High throughput no no
SEM4C_HUMAN [view entry] [view interactions] High throughput yes no
IDD_HUMAN [view interactions] High throughput no no
EFNA4_HUMAN [view interactions] High throughput no no
PGES2_HUMAN [view interactions] High throughput no yes
LRC25_HUMAN [view interactions] High throughput no yes
EVI2A_HUMAN [view interactions] High throughput no no
EFNB1_HUMAN [view interactions] High throughput no yes
TPST2_HUMAN [view interactions] High throughput no yes
CC018_HUMAN [view interactions] High throughput no yes
GLPA_HUMAN [view interactions] High throughput no no
HCST_HUMAN [view interactions] High throughput no no
TACD2_HUMAN [view interactions] High throughput no no
OPALI_HUMAN [view interactions] High throughput no yes
IL2RA_HUMAN [view interactions] High throughput no no
CD226_HUMAN [view interactions] High throughput no yes
SIR6_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
MIF_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2B_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2D_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2G_HUMAN [view entry] [view interactions] High throughput yes yes
EZH2_HUMAN [view interactions] High throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
TOP1_HUMAN [view interactions] High throughput no yes
TOP2A_HUMAN [view interactions] High throughput no no
TOP3A_HUMAN [view interactions] High throughput no yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
ATG7_HUMAN [view interactions] High throughput no yes
SNG3_HUMAN [view entry] [view interactions] High throughput yes no
CDK10_HUMAN [view interactions] High throughput no no
C144A_HUMAN [view interactions] High throughput no no
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
COPG1_HUMAN [view interactions] High throughput no yes
SRSF6_HUMAN [view interactions] High throughput no yes
KAT5_HUMAN [view interactions] High throughput no yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
MOGS_HUMAN [view interactions] High throughput no yes