NF1_HUMAN
Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in NF1_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 36.4865 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 35.1351 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 33.7838 | 4 | no |
GO:0046872 | metal ion binding | 22.9730 | 4 | no |
GO:0019900 | kinase binding | 22.9730 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 22.9730 | 5 | no |
GO:0019901 | protein kinase binding | 21.6216 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 21.6216 | 5 | no |
GO:0005524 | ATP binding | 20.2703 | 5 | no |
GO:0030695 | GTPase regulator activity | 10.8108 | 4 | yes |
GO:0005096 | GTPase activator activity | 9.4595 | 4 | yes |
GO:0008429 | phosphatidylethanolamine binding | 2.7027 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in NF1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 66.2162 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 62.1622 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 59.4595 | 4 | yes |
GO:0010646 | regulation of cell communication | 58.1081 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 58.1081 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 58.1081 | 4 | yes |
GO:0009966 | regulation of signal transduction | 51.3514 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 47.2973 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 47.2973 | 5 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 44.5946 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 43.2432 | 5 | no |
GO:0051128 | regulation of cellular component organization | 43.2432 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 40.5405 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 39.1892 | 5 | no |
GO:0010468 | regulation of gene expression | 39.1892 | 5 | yes |
GO:0043085 | positive regulation of catalytic activity | 37.8378 | 4 | yes |
GO:0051247 | positive regulation of protein metabolic process | 36.4865 | 6 | no |
GO:0010941 | regulation of cell death | 36.4865 | 4 | yes |
GO:0031399 | regulation of protein modification process | 36.4865 | 6 | yes |
GO:0006996 | organelle organization | 35.1351 | 4 | yes |
GO:0019220 | regulation of phosphate metabolic process | 35.1351 | 6 | yes |
GO:0051049 | regulation of transport | 35.1351 | 4 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 35.1351 | 5 | yes |
GO:0022607 | cellular component assembly | 33.7838 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 32.4324 | 4 | yes |
GO:0042981 | regulation of apoptotic process | 32.4324 | 6 | yes |
GO:0043067 | regulation of programmed cell death | 32.4324 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 31.0811 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.0811 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 31.0811 | 5 | no |
GO:0031401 | positive regulation of protein modification process | 31.0811 | 7 | no |
GO:0036211 | protein modification process | 31.0811 | 4 | no |
GO:0043412 | macromolecule modification | 31.0811 | 4 | no |
GO:0010647 | positive regulation of cell communication | 31.0811 | 5 | yes |
GO:0023056 | positive regulation of signaling | 31.0811 | 4 | yes |
GO:0042127 | regulation of cell population proliferation | 31.0811 | 4 | yes |
GO:0042325 | regulation of phosphorylation | 31.0811 | 7 | yes |
GO:0009967 | positive regulation of signal transduction | 29.7297 | 5 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 29.7297 | 5 | yes |
GO:0045595 | regulation of cell differentiation | 29.7297 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 29.7297 | 4 | yes |
GO:0006355 | regulation of DNA-templated transcription | 28.3784 | 6 | no |
GO:0001932 | regulation of protein phosphorylation | 28.3784 | 7 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 28.3784 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 28.3784 | 5 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 28.3784 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 28.3784 | 6 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 28.3784 | 6 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 28.3784 | 7 | no |
GO:0010648 | negative regulation of cell communication | 28.3784 | 5 | yes |
GO:0023057 | negative regulation of signaling | 28.3784 | 4 | yes |
GO:0048585 | negative regulation of response to stimulus | 28.3784 | 4 | yes |
GO:0042327 | positive regulation of phosphorylation | 27.0270 | 8 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.0270 | 5 | yes |
GO:0051336 | regulation of hydrolase activity | 27.0270 | 4 | yes |
GO:2000145 | regulation of cell motility | 25.6757 | 4 | yes |
GO:0007010 | cytoskeleton organization | 25.6757 | 5 | yes |
GO:0051726 | regulation of cell cycle | 25.6757 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 25.6757 | 5 | yes |
GO:0001934 | positive regulation of protein phosphorylation | 24.3243 | 8 | no |
GO:0031344 | regulation of cell projection organization | 24.3243 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.3243 | 6 | no |
GO:0030334 | regulation of cell migration | 24.3243 | 5 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 24.3243 | 5 | yes |
GO:0051338 | regulation of transferase activity | 24.3243 | 4 | yes |
GO:0051345 | positive regulation of hydrolase activity | 24.3243 | 5 | yes |
GO:0030162 | regulation of proteolysis | 22.9730 | 6 | no |
GO:0008104 | protein localization | 22.9730 | 4 | no |
GO:0009057 | macromolecule catabolic process | 22.9730 | 4 | no |
GO:0008284 | positive regulation of cell population proliferation | 22.9730 | 5 | yes |
GO:0030030 | cell projection organization | 22.9730 | 4 | no |
GO:0043549 | regulation of kinase activity | 22.9730 | 5 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 22.9730 | 5 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 22.9730 | 4 | yes |
GO:0006357 | regulation of transcription by RNA polymerase II | 21.6216 | 7 | no |
GO:0043269 | regulation of ion transport | 21.6216 | 5 | no |
GO:0051050 | positive regulation of transport | 21.6216 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 21.6216 | 4 | no |
GO:0009894 | regulation of catabolic process | 21.6216 | 4 | no |
GO:0051347 | positive regulation of transferase activity | 21.6216 | 5 | no |
GO:0071310 | cellular response to organic substance | 21.6216 | 4 | no |
GO:0006508 | proteolysis | 21.6216 | 4 | no |
GO:0051603 | proteolysis involved in protein catabolic process | 21.6216 | 5 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 21.6216 | 6 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 21.6216 | 4 | yes |
GO:0071702 | organic substance transport | 21.6216 | 4 | yes |
GO:0009891 | positive regulation of biosynthetic process | 20.2703 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 20.2703 | 6 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.2703 | 6 | no |
GO:0033043 | regulation of organelle organization | 20.2703 | 5 | no |
GO:0051129 | negative regulation of cellular component organization | 20.2703 | 5 | no |
GO:0019941 | modification-dependent protein catabolic process | 20.2703 | 6 | no |
GO:0043632 | modification-dependent macromolecule catabolic process | 20.2703 | 5 | no |
GO:0044265 | cellular macromolecule catabolic process | 20.2703 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 20.2703 | 5 | no |
GO:0043408 | regulation of MAPK cascade | 20.2703 | 6 | yes |
GO:0045859 | regulation of protein kinase activity | 20.2703 | 6 | yes |
GO:0060341 | regulation of cellular localization | 20.2703 | 4 | yes |
GO:0071705 | nitrogen compound transport | 20.2703 | 4 | yes |
GO:0051248 | negative regulation of protein metabolic process | 18.9189 | 6 | yes |
GO:0010942 | positive regulation of cell death | 17.5676 | 5 | yes |
GO:0030155 | regulation of cell adhesion | 17.5676 | 4 | yes |
GO:0071900 | regulation of protein serine/threonine kinase activity | 17.5676 | 7 | yes |
GO:1901214 | regulation of neuron death | 17.5676 | 5 | yes |
GO:2000026 | regulation of multicellular organismal development | 16.2162 | 4 | yes |
GO:0000165 | MAPK cascade | 16.2162 | 4 | yes |
GO:0007264 | small GTPase mediated signal transduction | 16.2162 | 4 | yes |
GO:0008285 | negative regulation of cell population proliferation | 16.2162 | 5 | yes |
GO:0032880 | regulation of protein localization | 16.2162 | 5 | yes |
GO:0060284 | regulation of cell development | 16.2162 | 5 | yes |
GO:0007265 | Ras protein signal transduction | 14.8649 | 5 | yes |
GO:0043065 | positive regulation of apoptotic process | 14.8649 | 7 | yes |
GO:0043068 | positive regulation of programmed cell death | 14.8649 | 6 | yes |
GO:0045596 | negative regulation of cell differentiation | 14.8649 | 5 | yes |
GO:0051093 | negative regulation of developmental process | 14.8649 | 4 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 14.8649 | 4 | yes |
GO:0097435 | supramolecular fiber organization | 14.8649 | 4 | yes |
GO:1902532 | negative regulation of intracellular signal transduction | 14.8649 | 6 | yes |
GO:2001233 | regulation of apoptotic signaling pathway | 13.5135 | 5 | yes |
GO:0006811 | ion transport | 13.5135 | 4 | yes |
GO:0010563 | negative regulation of phosphorus metabolic process | 13.5135 | 6 | yes |
GO:0031400 | negative regulation of protein modification process | 13.5135 | 7 | yes |
GO:0040013 | negative regulation of locomotion | 13.5135 | 4 | yes |
GO:0045936 | negative regulation of phosphate metabolic process | 13.5135 | 7 | yes |
GO:0050678 | regulation of epithelial cell proliferation | 13.5135 | 5 | yes |
GO:0051056 | regulation of small GTPase mediated signal transduction | 13.5135 | 6 | yes |
GO:2000146 | negative regulation of cell motility | 12.1622 | 5 | yes |
GO:0010632 | regulation of epithelial cell migration | 12.1622 | 4 | yes |
GO:0030336 | negative regulation of cell migration | 12.1622 | 6 | yes |
GO:0050890 | cognition | 12.1622 | 4 | yes |
GO:0051051 | negative regulation of transport | 12.1622 | 4 | yes |
GO:0051960 | regulation of nervous system development | 12.1622 | 5 | yes |
GO:0001933 | negative regulation of protein phosphorylation | 10.8108 | 8 | yes |
GO:0010810 | regulation of cell-substrate adhesion | 10.8108 | 5 | yes |
GO:0032386 | regulation of intracellular transport | 10.8108 | 5 | yes |
GO:0042326 | negative regulation of phosphorylation | 10.8108 | 8 | yes |
GO:0043523 | regulation of neuron apoptotic process | 10.8108 | 6 | yes |
GO:0050767 | regulation of neurogenesis | 10.8108 | 6 | yes |
GO:0010594 | regulation of endothelial cell migration | 9.4595 | 5 | yes |
GO:0043086 | negative regulation of catalytic activity | 9.4595 | 4 | yes |
GO:0043087 | regulation of GTPase activity | 9.4595 | 5 | yes |
GO:0046578 | regulation of Ras protein signal transduction | 9.4595 | 7 | yes |
GO:0051046 | regulation of secretion | 9.4595 | 5 | yes |
GO:0051223 | regulation of protein transport | 9.4595 | 5 | yes |
GO:0070201 | regulation of establishment of protein localization | 9.4595 | 6 | yes |
GO:1901216 | positive regulation of neuron death | 9.4595 | 6 | yes |
GO:1903530 | regulation of secretion by cell | 9.4595 | 4 | yes |
GO:2001236 | regulation of extrinsic apoptotic signaling pathway | 8.1081 | 6 | yes |
GO:0001952 | regulation of cell-matrix adhesion | 8.1081 | 6 | yes |
GO:0007162 | negative regulation of cell adhesion | 8.1081 | 5 | yes |
GO:0007612 | learning | 8.1081 | 4 | yes |
GO:0009416 | response to light stimulus | 8.1081 | 4 | yes |
GO:0033157 | regulation of intracellular protein transport | 8.1081 | 6 | yes |
GO:0034605 | cellular response to heat | 8.1081 | 4 | yes |
GO:0036293 | response to decreased oxygen levels | 8.1081 | 4 | yes |
GO:0043405 | regulation of MAP kinase activity | 8.1081 | 8 | yes |
GO:0043547 | positive regulation of GTPase activity | 8.1081 | 6 | yes |
GO:0048168 | regulation of neuronal synaptic plasticity | 8.1081 | 4 | yes |
GO:0048169 | regulation of long-term neuronal synaptic plasticity | 8.1081 | 5 | yes |
GO:0050679 | positive regulation of epithelial cell proliferation | 8.1081 | 6 | yes |
GO:0050680 | negative regulation of epithelial cell proliferation | 8.1081 | 6 | yes |
GO:2000177 | regulation of neural precursor cell proliferation | 6.7568 | 5 | yes |
GO:2001235 | positive regulation of apoptotic signaling pathway | 6.7568 | 6 | yes |
GO:0001936 | regulation of endothelial cell proliferation | 6.7568 | 6 | yes |
GO:0002683 | negative regulation of immune system process | 6.7568 | 4 | yes |
GO:0006469 | negative regulation of protein kinase activity | 6.7568 | 7 | yes |
GO:0007420 | brain development | 6.7568 | 4 | yes |
GO:0008306 | associative learning | 6.7568 | 5 | yes |
GO:0008542 | visual learning | 6.7568 | 4 | yes |
GO:0010721 | negative regulation of cell development | 6.7568 | 6 | yes |
GO:0010812 | negative regulation of cell-substrate adhesion | 6.7568 | 6 | yes |
GO:0021782 | glial cell development | 6.7568 | 4 | yes |
GO:0031279 | regulation of cyclase activity | 6.7568 | 4 | yes |
GO:0031281 | positive regulation of cyclase activity | 6.7568 | 5 | yes |
GO:0033673 | negative regulation of kinase activity | 6.7568 | 6 | yes |
GO:0043409 | negative regulation of MAPK cascade | 6.7568 | 7 | yes |
GO:0043525 | positive regulation of neuron apoptotic process | 6.7568 | 7 | yes |
GO:0043535 | regulation of blood vessel endothelial cell migration | 6.7568 | 6 | yes |
GO:0048732 | gland development | 6.7568 | 4 | yes |
GO:0050768 | negative regulation of neurogenesis | 6.7568 | 6 | yes |
GO:0050805 | negative regulation of synaptic transmission | 6.7568 | 5 | yes |
GO:0051348 | negative regulation of transferase activity | 6.7568 | 5 | yes |
GO:0051588 | regulation of neurotransmitter transport | 6.7568 | 5 | yes |
GO:0051961 | negative regulation of nervous system development | 6.7568 | 5 | yes |
GO:0060537 | muscle tissue development | 6.7568 | 4 | yes |
GO:0071901 | negative regulation of protein serine/threonine kinase activity | 6.7568 | 8 | yes |
GO:1900180 | regulation of protein localization to nucleus | 6.7568 | 6 | yes |
GO:1903706 | regulation of hemopoiesis | 6.7568 | 4 | yes |
GO:1903828 | negative regulation of protein localization | 6.7568 | 5 | yes |
GO:0001649 | osteoblast differentiation | 5.4054 | 4 | yes |
GO:0001938 | positive regulation of endothelial cell proliferation | 5.4054 | 7 | yes |
GO:0001953 | negative regulation of cell-matrix adhesion | 5.4054 | 7 | yes |
GO:0007507 | heart development | 5.4054 | 4 | yes |
GO:0014065 | phosphatidylinositol 3-kinase signaling | 5.4054 | 6 | yes |
GO:0023061 | signal release | 5.4054 | 4 | yes |
GO:0030198 | extracellular matrix organization | 5.4054 | 5 | yes |
GO:0032228 | regulation of synaptic transmission, GABAergic | 5.4054 | 6 | yes |
GO:0043062 | extracellular structure organization | 5.4054 | 4 | yes |
GO:0045229 | external encapsulating structure organization | 5.4054 | 4 | yes |
GO:0045637 | regulation of myeloid cell differentiation | 5.4054 | 5 | yes |
GO:0045761 | regulation of adenylate cyclase activity | 5.4054 | 5 | yes |
GO:0045762 | positive regulation of adenylate cyclase activity | 5.4054 | 6 | yes |
GO:0045765 | regulation of angiogenesis | 5.4054 | 5 | yes |
GO:0046822 | regulation of nucleocytoplasmic transport | 5.4054 | 6 | yes |
GO:0046903 | secretion | 5.4054 | 4 | yes |
GO:0046928 | regulation of neurotransmitter secretion | 5.4054 | 4 | yes |
GO:0048015 | phosphatidylinositol-mediated signaling | 5.4054 | 5 | yes |
GO:0048017 | inositol lipid-mediated signaling | 5.4054 | 4 | yes |
GO:0051339 | regulation of lyase activity | 5.4054 | 4 | yes |
GO:0051349 | positive regulation of lyase activity | 5.4054 | 5 | yes |
GO:0060429 | epithelium development | 5.4054 | 4 | yes |
GO:1900181 | negative regulation of protein localization to nucleus | 5.4054 | 6 | yes |
GO:1900271 | regulation of long-term synaptic potentiation | 5.4054 | 4 | yes |
GO:1901342 | regulation of vasculature development | 5.4054 | 5 | yes |
GO:1902105 | regulation of leukocyte differentiation | 5.4054 | 5 | yes |
GO:2000178 | negative regulation of neural precursor cell proliferation | 4.0541 | 6 | yes |
GO:2000181 | negative regulation of blood vessel morphogenesis | 4.0541 | 5 | yes |
GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway | 4.0541 | 7 | yes |
GO:2001239 | regulation of extrinsic apoptotic signaling pathway in absence of ligand | 4.0541 | 7 | yes |
GO:0001822 | kidney development | 4.0541 | 4 | yes |
GO:0001937 | negative regulation of endothelial cell proliferation | 4.0541 | 7 | yes |
GO:0002761 | regulation of myeloid leukocyte differentiation | 4.0541 | 6 | yes |
GO:0002762 | negative regulation of myeloid leukocyte differentiation | 4.0541 | 7 | yes |
GO:0006836 | neurotransmitter transport | 4.0541 | 4 | yes |
GO:0007519 | skeletal muscle tissue development | 4.0541 | 5 | yes |
GO:0014002 | astrocyte development | 4.0541 | 5 | yes |
GO:0014013 | regulation of gliogenesis | 4.0541 | 7 | yes |
GO:0016525 | negative regulation of angiogenesis | 4.0541 | 6 | yes |
GO:0021897 | forebrain astrocyte development | 4.0541 | 6 | yes |
GO:0035020 | regulation of Rac protein signal transduction | 4.0541 | 8 | yes |
GO:0042060 | wound healing | 4.0541 | 4 | yes |
GO:0043407 | negative regulation of MAP kinase activity | 4.0541 | 8 | yes |
GO:0045638 | negative regulation of myeloid cell differentiation | 4.0541 | 6 | yes |
GO:0046580 | negative regulation of Ras protein signal transduction | 4.0541 | 8 | yes |
GO:0048145 | regulation of fibroblast proliferation | 4.0541 | 5 | yes |
GO:0048514 | blood vessel morphogenesis | 4.0541 | 4 | yes |
GO:0051058 | negative regulation of small GTPase mediated signal transduction | 4.0541 | 7 | yes |
GO:0098597 | observational learning | 4.0541 | 5 | yes |
GO:1901343 | negative regulation of vasculature development | 4.0541 | 5 | yes |
GO:1902106 | negative regulation of leukocyte differentiation | 4.0541 | 6 | yes |
GO:1903707 | negative regulation of hemopoiesis | 4.0541 | 5 | yes |
GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand | 2.7027 | 8 | yes |
GO:0001656 | metanephros development | 2.7027 | 5 | yes |
GO:0001889 | liver development | 2.7027 | 5 | yes |
GO:0006820 | anion transport | 2.7027 | 5 | yes |
GO:0006835 | dicarboxylic acid transport | 2.7027 | 7 | yes |
GO:0006865 | amino acid transport | 2.7027 | 5 | yes |
GO:0007269 | neurotransmitter secretion | 2.7027 | 4 | yes |
GO:0007406 | negative regulation of neuroblast proliferation | 2.7027 | 7 | yes |
GO:0007422 | peripheral nervous system development | 2.7027 | 4 | yes |
GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors | 2.7027 | 5 | yes |
GO:0014014 | negative regulation of gliogenesis | 2.7027 | 7 | yes |
GO:0014044 | Schwann cell development | 2.7027 | 5 | yes |
GO:0014047 | glutamate secretion | 2.7027 | 4 | yes |
GO:0014051 | gamma-aminobutyric acid secretion | 2.7027 | 6 | yes |
GO:0015711 | organic anion transport | 2.7027 | 5 | yes |
GO:0015800 | acidic amino acid transport | 2.7027 | 6 | yes |
GO:0015812 | gamma-aminobutyric acid transport | 2.7027 | 6 | yes |
GO:0015849 | organic acid transport | 2.7027 | 5 | yes |
GO:0021510 | spinal cord development | 2.7027 | 4 | yes |
GO:0021915 | neural tube development | 2.7027 | 4 | yes |
GO:0022011 | myelination in peripheral nervous system | 2.7027 | 5 | yes |
GO:0030199 | collagen fibril organization | 2.7027 | 5 | yes |
GO:0030325 | adrenal gland development | 2.7027 | 5 | yes |
GO:0032292 | peripheral nervous system axon ensheathment | 2.7027 | 4 | yes |
GO:0032387 | negative regulation of intracellular transport | 2.7027 | 5 | yes |
GO:0034103 | regulation of tissue remodeling | 2.7027 | 4 | yes |
GO:0035021 | negative regulation of Rac protein signal transduction | 2.7027 | 9 | yes |
GO:0042306 | regulation of protein import into nucleus | 2.7027 | 7 | yes |
GO:0042308 | negative regulation of protein import into nucleus | 2.7027 | 7 | yes |
GO:0042552 | myelination | 2.7027 | 4 | yes |
GO:0045670 | regulation of osteoclast differentiation | 2.7027 | 7 | yes |
GO:0045671 | negative regulation of osteoclast differentiation | 2.7027 | 8 | yes |
GO:0045685 | regulation of glial cell differentiation | 2.7027 | 5 | yes |
GO:0045686 | negative regulation of glial cell differentiation | 2.7027 | 6 | yes |
GO:0046717 | acid secretion | 2.7027 | 5 | yes |
GO:0046823 | negative regulation of nucleocytoplasmic transport | 2.7027 | 6 | yes |
GO:0046850 | regulation of bone remodeling | 2.7027 | 5 | yes |
GO:0046929 | negative regulation of neurotransmitter secretion | 2.7027 | 5 | yes |
GO:0046942 | carboxylic acid transport | 2.7027 | 6 | yes |
GO:0048147 | negative regulation of fibroblast proliferation | 2.7027 | 6 | yes |
GO:0048485 | sympathetic nervous system development | 2.7027 | 4 | yes |
GO:0048592 | eye morphogenesis | 2.7027 | 5 | yes |
GO:0048593 | camera-type eye morphogenesis | 2.7027 | 6 | yes |
GO:0048710 | regulation of astrocyte differentiation | 2.7027 | 6 | yes |
GO:0048712 | negative regulation of astrocyte differentiation | 2.7027 | 7 | yes |
GO:0048713 | regulation of oligodendrocyte differentiation | 2.7027 | 6 | yes |
GO:0048715 | negative regulation of oligodendrocyte differentiation | 2.7027 | 7 | yes |
GO:0048745 | smooth muscle tissue development | 2.7027 | 5 | yes |
GO:0048820 | hair follicle maturation | 2.7027 | 4 | yes |
GO:0048844 | artery morphogenesis | 2.7027 | 5 | yes |
GO:0051048 | negative regulation of secretion | 2.7027 | 5 | yes |
GO:0051224 | negative regulation of protein transport | 2.7027 | 5 | yes |
GO:0051589 | negative regulation of neurotransmitter transport | 2.7027 | 5 | yes |
GO:0061534 | gamma-aminobutyric acid secretion, neurotransmission | 2.7027 | 5 | yes |
GO:0061535 | glutamate secretion, neurotransmission | 2.7027 | 5 | yes |
GO:0090317 | negative regulation of intracellular protein transport | 2.7027 | 6 | yes |
GO:0090596 | sensory organ morphogenesis | 2.7027 | 4 | yes |
GO:0097191 | extrinsic apoptotic signaling pathway | 2.7027 | 4 | yes |
GO:0099643 | signal release from synapse | 2.7027 | 5 | yes |
GO:1902692 | regulation of neuroblast proliferation | 2.7027 | 6 | yes |
GO:1903531 | negative regulation of secretion by cell | 2.7027 | 5 | yes |
GO:1904950 | negative regulation of establishment of protein localization | 2.7027 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in NF1_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 4.0541 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 4.0541 | 5 | no |
DOID:114 | heart disease | 4.0541 | 3 | no |
DOID:0111253 | neurofibromatosis 1 | 2.7027 | 3 | yes |
DOID:0050686 | organ system cancer | 2.7027 | 3 | no |
DOID:6457 | Cowden syndrome | 2.7027 | 3 | no |
DOID:2843 | long QT syndrome | 2.7027 | 6 | no |
DOID:612 | primary immunodeficiency disease | 2.7027 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
NF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SDC2_HUMAN | [view interactions] | Low throughput | no | yes |
SDC3_HUMAN | [view interactions] | Low throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SPRE1_HUMAN | [view interactions] | Low throughput | no | yes |
SPRE2_HUMAN | [view interactions] | Low throughput | no | yes |
SPRE3_HUMAN | [view interactions] | Low throughput | no | no |
SUMO1_HUMAN | [view interactions] | Low throughput | no | yes |
1433F_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RASH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
PML_HUMAN | [view interactions] | Low throughput | no | yes |
CSKP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STAT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DYHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RASK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
LIMK2_HUMAN | [view interactions] | Low throughput | no | yes |
FAF2_HUMAN | [view interactions] | Low throughput | no | yes |
TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NSF1C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CAV1_HUMAN | [view interactions] | Low throughput | no | no |
ATF2_HUMAN | [view interactions] | Low throughput | no | yes |
5HT6R_HUMAN | [view interactions] | Low throughput | no | yes |
LZTR1_HUMAN | [view interactions] | Low throughput | no | no |
FA12_HUMAN | [view interactions] | Low throughput | no | no |
PO2F1_HUMAN | [view interactions] | Low throughput | no | yes |
BRCA1_HUMAN | [view interactions] | Low throughput | no | yes |
SDC1_HUMAN | [view interactions] | High throughput | no | no |
SDC4_HUMAN | [view interactions] | High throughput | no | yes |
TIRAP_HUMAN | [view interactions] | High throughput | no | no |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KI67_HUMAN | [view interactions] | High throughput | no | no |
LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NOLC1_HUMAN | [view interactions] | High throughput | no | yes |
KS6A6_HUMAN | [view interactions] | High throughput | no | yes |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
ABCF1_HUMAN | [view interactions] | High throughput | no | yes |
HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYOME_HUMAN | [view interactions] | High throughput | no | no |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
EFS_HUMAN | [view interactions] | High throughput | no | no |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
NADK_HUMAN | [view interactions] | High throughput | no | yes |
RTKN_HUMAN | [view interactions] | High throughput | no | yes |
OSBL6_HUMAN | [view interactions] | High throughput | no | yes |
SIN1_HUMAN | [view interactions] | High throughput | no | yes |
SH3R3_HUMAN | [view interactions] | High throughput | no | yes |
DEN1A_HUMAN | [view interactions] | High throughput | no | no |
KSR1_HUMAN | [view interactions] | High throughput | no | yes |
PHLB2_HUMAN | [view interactions] | High throughput | no | yes |
MYCPP_HUMAN | [view interactions] | High throughput | no | no |
AN34A_HUMAN | [view interactions] | High throughput | no | no |
DEN4C_HUMAN | [view interactions] | High throughput | no | yes |
SPD2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
M3K21_HUMAN | [view interactions] | High throughput | no | yes |
PTN14_HUMAN | [view interactions] | High throughput | no | yes |
ZN638_HUMAN | [view interactions] | High throughput | no | yes |
TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTN13_HUMAN | [view interactions] | High throughput | no | yes |
CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
CDK16_HUMAN | [view interactions] | High throughput | no | yes |
MPIP3_HUMAN | [view interactions] | High throughput | no | yes |
MPIP2_HUMAN | [view interactions] | High throughput | no | no |
IF4E2_HUMAN | [view interactions] | High throughput | no | no |
MAST3_HUMAN | [view interactions] | High throughput | no | yes |
KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
GAB2_HUMAN | [view interactions] | High throughput | no | yes |
PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
FA53C_HUMAN | [view interactions] | High throughput | no | yes |
INP5E_HUMAN | [view interactions] | High throughput | no | yes |
TANC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LPIN3_HUMAN | [view interactions] | High throughput | no | yes |
PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
GGYF2_HUMAN | [view interactions] | High throughput | no | yes |
SYDE1_HUMAN | [view interactions] | High throughput | no | yes |
RGPS2_HUMAN | [view interactions] | High throughput | no | yes |
NAV1_HUMAN | [view interactions] | High throughput | no | yes |
F110B_HUMAN | [view interactions] | High throughput | no | yes |
SRS12_HUMAN | [view interactions] | High throughput | no | no |
MAGI1_HUMAN | [view interactions] | High throughput | no | no |
TESK2_HUMAN | [view interactions] | High throughput | no | yes |
KI13B_HUMAN | [view interactions] | High throughput | no | yes |
LRFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CING_HUMAN | [view interactions] | High throughput | no | no |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NGAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBP21_HUMAN | [view interactions] | High throughput | no | no |
ZBT21_HUMAN | [view interactions] | High throughput | no | yes |
AGAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CBY1_HUMAN | [view interactions] | High throughput | no | no |
STA13_HUMAN | [view interactions] | High throughput | no | yes |
SMCA4_HUMAN | [view interactions] | High throughput | no | yes |
RPB1_HUMAN | [view interactions] | High throughput | no | no |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SIR7_HUMAN | [view interactions] | High throughput | no | yes |
NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NXF1_HUMAN | [view interactions] | High throughput | no | yes |
CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
DPA1_HUMAN | [view interactions] | High throughput | no | yes |
EFNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PD1L1_HUMAN | [view interactions] | High throughput | no | no |
TN13B_HUMAN | [view interactions] | High throughput | no | no |
CAH14_HUMAN | [view interactions] | High throughput | no | yes |
SLAF1_HUMAN | [view interactions] | High throughput | no | no |
VSIG4_HUMAN | [view interactions] | High throughput | no | no |
TGON2_HUMAN | [view interactions] | High throughput | no | yes |
TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
CD79B_HUMAN | [view interactions] | High throughput | no | no |
P4HA3_HUMAN | [view interactions] | High throughput | no | no |
SCN3B_HUMAN | [view interactions] | High throughput | no | no |
VSIG1_HUMAN | [view interactions] | High throughput | no | no |
SIGL1_HUMAN | [view interactions] | High throughput | no | no |
EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
F174A_HUMAN | [view interactions] | High throughput | no | yes |
AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
CTDP1_HUMAN | [view interactions] | High throughput | no | yes |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HIDE1_HUMAN | [view interactions] | High throughput | no | no |
CDHR2_HUMAN | [view interactions] | High throughput | no | yes |
F234A_HUMAN | [view interactions] | High throughput | no | yes |
CD80_HUMAN | [view interactions] | High throughput | no | no |
SEM4C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IDD_HUMAN | [view interactions] | High throughput | no | no |
EFNA4_HUMAN | [view interactions] | High throughput | no | no |
PGES2_HUMAN | [view interactions] | High throughput | no | yes |
LRC25_HUMAN | [view interactions] | High throughput | no | yes |
EVI2A_HUMAN | [view interactions] | High throughput | no | no |
EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
TPST2_HUMAN | [view interactions] | High throughput | no | yes |
CC018_HUMAN | [view interactions] | High throughput | no | yes |
GLPA_HUMAN | [view interactions] | High throughput | no | no |
HCST_HUMAN | [view interactions] | High throughput | no | no |
TACD2_HUMAN | [view interactions] | High throughput | no | no |
OPALI_HUMAN | [view interactions] | High throughput | no | yes |
IL2RA_HUMAN | [view interactions] | High throughput | no | no |
CD226_HUMAN | [view interactions] | High throughput | no | yes |
SIR6_HUMAN | [view interactions] | High throughput | no | yes |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOP1_HUMAN | [view interactions] | High throughput | no | yes |
TOP2A_HUMAN | [view interactions] | High throughput | no | no |
TOP3A_HUMAN | [view interactions] | High throughput | no | yes |
FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ATG7_HUMAN | [view interactions] | High throughput | no | yes |
CLK1_HUMAN | [view interactions] | High throughput | no | yes |
AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPHA2_HUMAN | [view interactions] | High throughput | no | no |
MP2K3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SOX4_HUMAN | [view interactions] | High throughput | no | yes |
NOSIP_HUMAN | [view interactions] | High throughput | no | yes |
BIRC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VP13B_HUMAN | [view interactions] | High throughput | no | no |
GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PSA6_HUMAN | [view interactions] | Computational | no | yes |
PSB3_HUMAN | [view interactions] | Computational | no | yes |
KAPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PSB1_HUMAN | [view interactions] | Computational | no | yes |
PSA1_HUMAN | [view interactions] | Computational | no | yes |
PRS7_HUMAN | [view interactions] | Computational | no | yes |
PSB6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
T2EA_HUMAN | [view interactions] | Computational | no | yes |
RS27A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
UBB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RL40_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PSMD2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PSD12_HUMAN | [view interactions] | Computational | no | yes |
SMRC2_HUMAN | [view interactions] | Computational | no | yes |
RASM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PSB10_HUMAN | [view interactions] | Computational | no | no |
PRS6A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RRAS2_HUMAN | [view interactions] | Computational | no | yes |
PSA3_HUMAN | [view interactions] | Computational | no | no |
PSMD6_HUMAN | [view interactions] | Computational | no | yes |
SMRC1_HUMAN | [view interactions] | Computational | no | yes |
PSB5_HUMAN | [view interactions] | Computational | no | yes |
KBTB7_HUMAN | [view interactions] | Computational | no | yes |
RBX1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
TF2B_HUMAN | [view interactions] | Computational | no | yes |
PSMF1_HUMAN | [view interactions] | Computational | no | yes |
PSA2_HUMAN | [view interactions] | Computational | no | yes |
T2FA_HUMAN | [view interactions] | Computational | no | yes |
DPYL2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ZN148_HUMAN | [view interactions] | Computational | no | yes |
PSD11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PSB2_HUMAN | [view interactions] | Computational | no | yes |
ALK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SMCE1_HUMAN | [view interactions] | Computational | no | yes |
PSD10_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
P53_HUMAN | [view interactions] | Computational | no | no |
PSMA8_HUMAN | [view interactions] | Computational | no | no |
PSB4_HUMAN | [view interactions] | Computational | no | yes |
PRS10_HUMAN | [view interactions] | Computational | no | yes |
RRAS_HUMAN | [view interactions] | Computational | no | yes |
PRS6B_HUMAN | [view interactions] | Computational | no | yes |
PSA5_HUMAN | [view interactions] | Computational | no | yes |
PSB9_HUMAN | [view interactions] | Computational | no | no |
PSMD3_HUMAN | [view interactions] | Computational | no | yes |
CUL3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PSME2_HUMAN | [view interactions] | Computational | no | no |
PSMD9_HUMAN | [view interactions] | Computational | no | yes |
PRS8_HUMAN | [view interactions] | Computational | no | yes |
ARI1A_HUMAN | [view interactions] | Computational | no | yes |
PSDE_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PSB11_HUMAN | [view interactions] | Computational | no | no |
PSB7_HUMAN | [view interactions] | Computational | no | yes |
PSA7_HUMAN | [view interactions] | Computational | no | yes |
PSME1_HUMAN | [view interactions] | Computational | no | yes |
SMRD1_HUMAN | [view interactions] | Computational | no | yes |
TF2AA_HUMAN | [view interactions] | Computational | no | yes |
PSMD8_HUMAN | [view interactions] | Computational | no | yes |
PSMD5_HUMAN | [view interactions] | Computational | no | yes |
PSME4_HUMAN | [view interactions] | Computational | no | yes |
PRS4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PSMD7_HUMAN | [view interactions] | Computational | no | yes |
TF3A_HUMAN | [view interactions] | Computational | no | yes |
PSB8_HUMAN | [view interactions] | Computational | no | yes |
PSMD1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PSMD4_HUMAN | [view interactions] | Computational | no | yes |
PSA4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PSME3_HUMAN | [view interactions] | Computational | no | yes |
PSD13_HUMAN | [view interactions] | Computational | no | yes |
MERL_HUMAN | [view interactions] | Computational | no | yes |
SMAD4_HUMAN | [view interactions] | Computational | no | yes |