SDC2_HUMAN
Evidence for PS localization
Functions
Cell surface proteoglycan which regulates dendritic arbor morphogenesis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SDC2_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 40.4255 | 4 | no |
| GO:0000166 | nucleotide binding | 31.9149 | 4 | no |
| GO:0017076 | purine nucleotide binding | 31.9149 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 31.9149 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.7872 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 21.2766 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.2766 | 5 | no |
| GO:0030165 | PDZ domain binding | 4.2553 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SDC2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 68.0851 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 46.8085 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 46.8085 | 4 | no |
| GO:0022607 | cellular component assembly | 42.5532 | 4 | no |
| GO:0010646 | regulation of cell communication | 42.5532 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.5532 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 42.5532 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 42.5532 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 36.1702 | 4 | yes |
| GO:0006996 | organelle organization | 34.0426 | 4 | no |
| GO:0009966 | regulation of signal transduction | 34.0426 | 4 | no |
| GO:0051049 | regulation of transport | 34.0426 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 34.0426 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 34.0426 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 31.9149 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 31.9149 | 4 | no |
| GO:0010468 | regulation of gene expression | 31.9149 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 31.9149 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 31.9149 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.7872 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 29.7872 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 29.7872 | 5 | no |
| GO:0023056 | positive regulation of signaling | 29.7872 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 29.7872 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.7872 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.7872 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.7872 | 5 | no |
| GO:0030334 | regulation of cell migration | 29.7872 | 5 | no |
| GO:2000145 | regulation of cell motility | 29.7872 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 27.6596 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 27.6596 | 4 | no |
| GO:0008104 | protein localization | 27.6596 | 4 | no |
| GO:0007264 | small GTPase-mediated signal transduction | 25.5319 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 25.5319 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 25.5319 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.5319 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.5319 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.5319 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.5319 | 5 | no |
| GO:0030155 | regulation of cell adhesion | 25.5319 | 4 | no |
| GO:0030335 | positive regulation of cell migration | 25.5319 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 25.5319 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 25.5319 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 25.5319 | 4 | no |
| GO:0030030 | cell projection organization | 23.4043 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 23.4043 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 23.4043 | 4 | no |
| GO:0033043 | regulation of organelle organization | 23.4043 | 5 | no |
| GO:0043933 | protein-containing complex organization | 23.4043 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 23.4043 | 4 | no |
| GO:0009894 | regulation of catabolic process | 23.4043 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.4043 | 4 | no |
| GO:0051046 | regulation of secretion | 23.4043 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 23.4043 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.4043 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 21.2766 | 5 | yes |
| GO:0032880 | regulation of protein localization | 21.2766 | 5 | no |
| GO:0060341 | regulation of cellular localization | 21.2766 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.2766 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 21.2766 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 21.2766 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 21.2766 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 21.2766 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.2766 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 21.2766 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 21.2766 | 5 | no |
| GO:0051050 | positive regulation of transport | 21.2766 | 4 | no |
| GO:1903530 | regulation of secretion by cell | 21.2766 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 21.2766 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 21.2766 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 21.2766 | 4 | no |
| GO:0061024 | membrane organization | 21.2766 | 4 | no |
| GO:0010632 | regulation of epithelial cell migration | 21.2766 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 19.1489 | 6 | yes |
| GO:0010975 | regulation of neuron projection development | 10.6383 | 7 | yes |
| GO:0048812 | neuron projection morphogenesis | 6.3830 | 5 | yes |
| GO:0048813 | dendrite morphogenesis | 6.3830 | 6 | yes |
| GO:0048814 | regulation of dendrite morphogenesis | 6.3830 | 5 | yes |
| GO:0050773 | regulation of dendrite development | 6.3830 | 4 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 6.3830 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CSKP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SDC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FGF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SDC4_HUMAN | [view interactions] | Low throughput | no | yes |
| RASA1_HUMAN | [view interactions] | Low throughput | no | yes |
| SDC3_HUMAN | [view interactions] | Low throughput | no | yes |
| PCOC1_HUMAN | [view interactions] | Low throughput | no | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| E41L1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITPR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LAMA3_HUMAN | [view interactions] | Low throughput | no | no |
| CSF2R_HUMAN | [view interactions] | Low throughput | no | no |
| EZRI_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KALM_HUMAN | [view interactions] | Low throughput | no | no |
| HGF_HUMAN | [view interactions] | Low throughput | no | yes |
| CSF2_HUMAN | [view interactions] | Low throughput | no | no |
| REG3A_HUMAN | [view interactions] | Low throughput | no | no |
| FINC_HUMAN | [view interactions] | Low throughput | no | yes |
| KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CP2CI_HUMAN | [view interactions] | High throughput | no | no |
| A1AT_HUMAN | [view interactions] | High throughput | no | no |
| PP2BC_HUMAN | [view interactions] | High throughput | no | yes |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| IFIX_HUMAN | [view interactions] | High throughput | no | no |
| EFNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2A1_HUMAN | [view interactions] | High throughput | no | yes |
| TMM11_HUMAN | [view interactions] | High throughput | no | no |
| FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI4KA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPC_HUMAN | [view interactions] | High throughput | no | yes |
| DHRS2_HUMAN | [view interactions] | High throughput | no | no |
| MTR1L_HUMAN | [view interactions] | High throughput | no | no |
| ZN460_HUMAN | [view interactions] | High throughput | no | no |
| RN213_HUMAN | [view interactions] | High throughput | no | yes |
| HEAT6_HUMAN | [view interactions] | High throughput | no | no |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NBEL1_HUMAN | [view interactions] | High throughput | no | yes |
| SULF1_HUMAN | [view interactions] | High throughput | no | no |
| KLHL7_HUMAN | [view interactions] | High throughput | no | yes |
| FGRL1_HUMAN | [view interactions] | High throughput | no | yes |
| SNX33_HUMAN | [view interactions] | High throughput | no | yes |
| CTR3_HUMAN | [view interactions] | High throughput | no | no |
| TM186_HUMAN | [view interactions] | High throughput | no | no |
| TEFM_HUMAN | [view interactions] | High throughput | no | no |
| S10AD_HUMAN | [view interactions] | High throughput | no | yes |
| SEM3C_HUMAN | [view interactions] | High throughput | no | no |
| PRD10_HUMAN | [view interactions] | High throughput | no | yes |
| GMEB2_HUMAN | [view interactions] | High throughput | no | yes |
| VANG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TF3C3_HUMAN | [view interactions] | High throughput | no | no |
| GP183_HUMAN | [view interactions] | High throughput | no | yes |
| LIPG_HUMAN | [view interactions] | High throughput | no | no |
| FGF1_HUMAN | [view interactions] | High throughput | no | no |
| NCBP3_HUMAN | [view interactions] | High throughput | no | yes |
| PDPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPR37_HUMAN | [view interactions] | High throughput | no | no |
| GRN_HUMAN | [view interactions] | High throughput | no | no |
| ESRP1_HUMAN | [view interactions] | High throughput | no | yes |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SDC1_HUMAN | [view interactions] | High throughput | no | no |
| MYB_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| GRIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| SPAG6_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VMAT1_HUMAN | [view interactions] | High throughput | no | no |
| ATX3_HUMAN | [view interactions] | High throughput | no | yes |
| RPAB2_HUMAN | [view interactions] | High throughput | no | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| CBX4_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| TNKS1_HUMAN | [view interactions] | High throughput | no | yes |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| GMEB1_HUMAN | [view interactions] | High throughput | no | yes |
| PARP2_HUMAN | [view interactions] | High throughput | no | yes |
| DOP2_HUMAN | [view interactions] | High throughput | no | yes |
| AMPD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM192_HUMAN | [view interactions] | High throughput | no | yes |
| SNX18_HUMAN | [view interactions] | High throughput | no | no |
| TF3C2_HUMAN | [view interactions] | High throughput | no | no |
| VANG1_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| SULF2_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSBL8_HUMAN | [view interactions] | High throughput | no | yes |
| ZNF92_HUMAN | [view interactions] | High throughput | no | no |
| CNDH2_HUMAN | [view interactions] | High throughput | no | no |
| CAND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TF3C1_HUMAN | [view interactions] | High throughput | no | yes |
| SMC2_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EVA1B_HUMAN | [view interactions] | High throughput | no | yes |
| FGF4_HUMAN | [view interactions] | High throughput | no | no |
| CHD1L_HUMAN | [view interactions] | High throughput | no | yes |
| MON2_HUMAN | [view interactions] | High throughput | no | no |
| SYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELMO3_HUMAN | [view interactions] | High throughput | no | yes |
| TSNA1_HUMAN | [view interactions] | High throughput | no | yes |
| PLCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAN1_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOCK5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EXOC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ORC4_HUMAN | [view interactions] | High throughput | no | yes |
| TZAP_HUMAN | [view interactions] | High throughput | no | no |
| GT2D1_HUMAN | [view interactions] | High throughput | no | yes |
| TEX2_HUMAN | [view interactions] | High throughput | no | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEAT3_HUMAN | [view interactions] | High throughput | no | yes |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| H2A2B_HUMAN | [view interactions] | High throughput | no | yes |
| TSYL1_HUMAN | [view interactions] | High throughput | no | yes |
| H2AY_HUMAN | [view interactions] | High throughput | no | yes |
| PLPL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LYAR_HUMAN | [view interactions] | High throughput | no | no |
| KCNN4_HUMAN | [view interactions] | High throughput | no | no |
| ELAP2_HUMAN | [view interactions] | High throughput | no | no |
| HKDC1_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |