ITB4_HUMAN
Evidence for PS localization
Functions
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001551 | LIG_PTB_Phospho_1 | LIG | 1590 | 1596 | - |
| ELMI001551 | LIG_PTB_Phospho_1 | LIG | 1590 | 1596 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ITB4_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 29.6296 | 4 | yes |
| GO:0046872 | metal ion binding | 29.6296 | 5 | yes |
| GO:0043168 | anion binding | 22.2222 | 4 | no |
| GO:0003779 | actin binding | 22.2222 | 4 | no |
| GO:0001664 | G protein-coupled receptor binding | 11.1111 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ITB4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 59.2593 | 4 | no |
| GO:0022607 | cellular component assembly | 55.5556 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 55.5556 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 55.5556 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 55.5556 | 4 | no |
| GO:0009966 | regulation of signal transduction | 51.8519 | 4 | no |
| GO:0010646 | regulation of cell communication | 51.8519 | 4 | no |
| GO:0030030 | cell projection organization | 44.4444 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 44.4444 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 44.4444 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 40.7407 | 5 | yes |
| GO:0006996 | organelle organization | 40.7407 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 40.7407 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.7407 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 40.7407 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 37.0370 | 4 | no |
| GO:0010468 | regulation of gene expression | 37.0370 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 37.0370 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 37.0370 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 37.0370 | 5 | no |
| GO:0008104 | protein localization | 33.3333 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 33.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 33.3333 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
| GO:0030031 | cell projection assembly | 29.6296 | 5 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 29.6296 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 29.6296 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.6296 | 5 | no |
| GO:0007010 | cytoskeleton organization | 29.6296 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 29.6296 | 7 | no |
| GO:0051252 | regulation of RNA metabolic process | 29.6296 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 29.6296 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 29.6296 | 5 | no |
| GO:0030334 | regulation of cell migration | 29.6296 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.6296 | 5 | no |
| GO:2000145 | regulation of cell motility | 29.6296 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 29.6296 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 29.6296 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 29.6296 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 29.6296 | 4 | no |
| GO:0007229 | integrin-mediated signaling pathway | 25.9259 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 25.9259 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.9259 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 25.9259 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 25.9259 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.9259 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.9259 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.9259 | 4 | no |
| GO:0060341 | regulation of cellular localization | 25.9259 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 25.9259 | 6 | no |
| GO:0034330 | cell junction organization | 22.2222 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0031399 | regulation of protein modification process | 22.2222 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 22.2222 | 4 | no |
| GO:0051049 | regulation of transport | 22.2222 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.2222 | 5 | no |
| GO:0036211 | protein modification process | 22.2222 | 4 | no |
| GO:0043412 | macromolecule modification | 22.2222 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.2222 | 6 | no |
| GO:0030155 | regulation of cell adhesion | 22.2222 | 4 | no |
| GO:0030335 | positive regulation of cell migration | 22.2222 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.2222 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 22.2222 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 22.2222 | 5 | no |
| GO:0008284 | positive regulation of cell population proliferation | 22.2222 | 5 | no |
| GO:0009894 | regulation of catabolic process | 22.2222 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 22.2222 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 22.2222 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 22.2222 | 4 | no |
| GO:0080134 | regulation of response to stress | 22.2222 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 22.2222 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.2222 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.2222 | 5 | no |
| GO:0001667 | ameboidal-type cell migration | 14.8148 | 4 | yes |
| GO:0034329 | cell junction assembly | 14.8148 | 5 | yes |
| GO:0007044 | cell-substrate junction assembly | 11.1111 | 6 | yes |
| GO:0007160 | cell-matrix adhesion | 11.1111 | 4 | yes |
| GO:0031581 | hemidesmosome assembly | 11.1111 | 7 | yes |
| GO:0048333 | mesodermal cell differentiation | 11.1111 | 4 | yes |
| GO:0150115 | cell-substrate junction organization | 11.1111 | 5 | yes |
| GO:0032288 | myelin assembly | 7.4074 | 4 | yes |
| GO:0046847 | filopodium assembly | 7.4074 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| X3CL1_HUMAN | [view interactions] | Low throughput | no | yes |
| ARRD3_HUMAN | [view interactions] | Low throughput | no | no |
| S1PR3_HUMAN | [view interactions] | Low throughput | no | no |
| S1PR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CD151_HUMAN | [view interactions] | Low throughput | no | no |
| PLEC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| CADM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FABPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| IF6_HUMAN | [view interactions] | Low throughput | no | yes |
| ERBIN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COHA1_HUMAN | [view interactions] | Low throughput | no | no |
| DYST_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SDC1_HUMAN | [view interactions] | Low throughput | no | no |
| SDC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SDC3_HUMAN | [view interactions] | Low throughput | no | yes |
| ITA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ENPP2_HUMAN | [view interactions] | Low throughput | no | yes |
| LPAR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SE1L1_HUMAN | [view interactions] | Low throughput | no | yes |
| TGM2_HUMAN | [view interactions] | Low throughput | no | no |
| SDC4_HUMAN | [view interactions] | Low throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LOX12_HUMAN | [view interactions] | Low throughput | no | no |
| CADM4_HUMAN | [view interactions] | Low throughput | no | yes |
| CADM3_HUMAN | [view interactions] | Low throughput | no | no |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITA6_HUMAN | [view interactions] | Low throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| APOB_HUMAN | [view interactions] | High throughput | no | no |
| RM38_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP13_HUMAN | [view interactions] | High throughput | no | yes |
| DMD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRLL_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| LMX1B_HUMAN | [view interactions] | High throughput | no | no |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD3_HUMAN | [view interactions] | High throughput | no | yes |
| APBP2_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM1_HUMAN | [view interactions] | High throughput | no | no |
| TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
| TGM1_HUMAN | [view interactions] | High throughput | no | no |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| HXA1_HUMAN | [view interactions] | High throughput | no | no |
| OBF1_HUMAN | [view interactions] | High throughput | no | no |
| MYF5_HUMAN | [view interactions] | High throughput | no | no |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| PLS4_HUMAN | [view interactions] | High throughput | no | no |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| ECM1_HUMAN | [view interactions] | High throughput | no | no |
| ATL4_HUMAN | [view interactions] | High throughput | no | yes |
| KR171_HUMAN | [view interactions] | High throughput | no | no |
| KRA62_HUMAN | [view interactions] | High throughput | no | no |
| KR151_HUMAN | [view interactions] | High throughput | no | no |
| KR108_HUMAN | [view interactions] | High throughput | no | no |
| KRA11_HUMAN | [view interactions] | High throughput | no | no |
| CRTP1_HUMAN | [view interactions] | High throughput | no | yes |
| KPRP_HUMAN | [view interactions] | High throughput | no | no |
| KRA93_HUMAN | [view interactions] | High throughput | no | no |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| KR123_HUMAN | [view interactions] | High throughput | no | no |
| KRA24_HUMAN | [view interactions] | High throughput | no | no |
| KRA31_HUMAN | [view interactions] | High throughput | no | no |
| KR109_HUMAN | [view interactions] | High throughput | no | no |
| KRA13_HUMAN | [view interactions] | High throughput | no | no |
| KRA92_HUMAN | [view interactions] | High throughput | no | no |
| KRA42_HUMAN | [view interactions] | High throughput | no | no |
| NT2NA_HUMAN | [view interactions] | High throughput | no | no |
| KR107_HUMAN | [view interactions] | High throughput | no | no |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH13_HUMAN | [view interactions] | High throughput | no | no |
| TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI7_HUMAN | [view interactions] | High throughput | no | no |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| KLC3_HUMAN | [view interactions] | High throughput | no | no |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2R3C_HUMAN | [view interactions] | High throughput | no | yes |
| SKI_HUMAN | [view interactions] | High throughput | no | yes |
| GPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| FA24B_HUMAN | [view interactions] | High throughput | no | no |
| GXLT1_HUMAN | [view interactions] | High throughput | no | no |
| BRID5_HUMAN | [view interactions] | High throughput | no | no |
| ECEL1_HUMAN | [view interactions] | High throughput | no | yes |
| ADA30_HUMAN | [view interactions] | High throughput | no | no |
| SIRPD_HUMAN | [view interactions] | High throughput | no | no |
| NAAA_HUMAN | [view interactions] | High throughput | no | yes |
| DKKL1_HUMAN | [view interactions] | High throughput | no | no |
| TAZ_HUMAN | [view interactions] | High throughput | no | yes |
| CLC2B_HUMAN | [view interactions] | High throughput | no | yes |
| CST11_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| LAMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMB1_HUMAN | [view interactions] | High throughput | no | yes |
| LAMB2_HUMAN | [view interactions] | High throughput | no | yes |
| MCES_HUMAN | [view interactions] | High throughput | no | yes |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMC1_HUMAN | [view interactions] | High throughput | no | yes |
| RXRA_HUMAN | [view interactions] | High throughput | no | yes |
| DDR1_HUMAN | [view interactions] | High throughput | no | yes |
| CSTF3_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK1_HUMAN | [view interactions] | High throughput | no | yes |
| TRADD_HUMAN | [view interactions] | High throughput | no | yes |
| NT5D3_HUMAN | [view interactions] | High throughput | no | no |
| PGLT1_HUMAN | [view interactions] | High throughput | no | no |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| AP2C_HUMAN | [view interactions] | High throughput | no | no |
| ATF2_HUMAN | [view interactions] | High throughput | no | yes |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |