ITB4_HUMAN
Evidence for PS localization
Functions
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001551 | LIG_PTB_Phospho_1 | LIG | 1590 | 1596 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ITB4_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 26.8293 | 4 | no |
| GO:0019901 | protein kinase binding | 26.8293 | 5 | no |
| GO:0045296 | cadherin binding | 26.8293 | 4 | no |
| GO:0046872 | metal ion binding | 26.8293 | 4 | no |
| GO:0003723 | RNA binding | 21.9512 | 4 | no |
| GO:0017076 | purine nucleotide binding | 21.9512 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 21.9512 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.9512 | 4 | no |
| GO:0001664 | G protein-coupled receptor binding | 4.8780 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ITB4_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 75.6098 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 75.6098 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 73.1707 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 73.1707 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 73.1707 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 70.7317 | 4 | no |
| GO:0010646 | regulation of cell communication | 60.9756 | 4 | no |
| GO:0009966 | regulation of signal transduction | 56.0976 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 53.6585 | 4 | no |
| GO:0010468 | regulation of gene expression | 48.7805 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 48.7805 | 5 | no |
| GO:0022607 | cellular component assembly | 46.3415 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 46.3415 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 46.3415 | 5 | no |
| GO:0008104 | protein localization | 43.9024 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 43.9024 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 43.9024 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 43.9024 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 43.9024 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 43.9024 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 43.9024 | 4 | no |
| GO:0006996 | organelle organization | 41.4634 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 41.4634 | 6 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 41.4634 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 41.4634 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 41.4634 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 39.0244 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 39.0244 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 39.0244 | 5 | no |
| GO:0031399 | regulation of protein modification process | 39.0244 | 6 | no |
| GO:0051128 | regulation of cellular component organization | 39.0244 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 39.0244 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 39.0244 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 39.0244 | 6 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 36.5854 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 36.5854 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 36.5854 | 5 | no |
| GO:0023056 | positive regulation of signaling | 36.5854 | 4 | no |
| GO:0010941 | regulation of cell death | 34.1463 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 34.1463 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 34.1463 | 5 | no |
| GO:0030334 | regulation of cell migration | 31.7073 | 5 | no |
| GO:0032880 | regulation of protein localization | 31.7073 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 31.7073 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 31.7073 | 7 | no |
| GO:0043066 | negative regulation of apoptotic process | 31.7073 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 31.7073 | 6 | no |
| GO:0051049 | regulation of transport | 31.7073 | 4 | no |
| GO:0060341 | regulation of cellular localization | 31.7073 | 4 | no |
| GO:0060548 | negative regulation of cell death | 31.7073 | 5 | no |
| GO:2000145 | regulation of cell motility | 31.7073 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 29.2683 | 7 | no |
| GO:0009891 | positive regulation of biosynthetic process | 29.2683 | 5 | no |
| GO:0030155 | regulation of cell adhesion | 29.2683 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 29.2683 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 29.2683 | 6 | no |
| GO:0051050 | positive regulation of transport | 29.2683 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 29.2683 | 6 | no |
| GO:2000026 | regulation of multicellular organismal development | 29.2683 | 4 | no |
| GO:0007010 | cytoskeleton organization | 29.2683 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 29.2683 | 4 | no |
| GO:0007229 | integrin-mediated signaling pathway | 26.8293 | 4 | yes |
| GO:0030030 | cell projection organization | 26.8293 | 4 | yes |
| GO:0034330 | cell junction organization | 26.8293 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 26.8293 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 26.8293 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 26.8293 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 26.8293 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.8293 | 6 | no |
| GO:0051338 | regulation of transferase activity | 26.8293 | 4 | no |
| GO:0071702 | organic substance transport | 26.8293 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 26.8293 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 26.8293 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 24.3902 | 5 | yes |
| GO:0006886 | intracellular protein transport | 24.3902 | 4 | no |
| GO:0009894 | regulation of catabolic process | 24.3902 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.3902 | 6 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 24.3902 | 6 | no |
| GO:0015031 | protein transport | 24.3902 | 4 | no |
| GO:0036211 | protein modification process | 24.3902 | 4 | no |
| GO:0043412 | macromolecule modification | 24.3902 | 4 | no |
| GO:0043549 | regulation of kinase activity | 24.3902 | 5 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 24.3902 | 7 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 24.3902 | 7 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 24.3902 | 6 | no |
| GO:0051336 | regulation of hydrolase activity | 24.3902 | 4 | no |
| GO:0071310 | cellular response to organic substance | 24.3902 | 4 | no |
| GO:0071705 | nitrogen compound transport | 24.3902 | 4 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 24.3902 | 7 | no |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 24.3902 | 8 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.3902 | 5 | no |
| GO:0034329 | cell junction assembly | 21.9512 | 5 | yes |
| GO:0002684 | positive regulation of immune system process | 21.9512 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.9512 | 4 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 21.9512 | 4 | no |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 21.9512 | 5 | no |
| GO:0030335 | positive regulation of cell migration | 21.9512 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 21.9512 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 21.9512 | 7 | no |
| GO:0033043 | regulation of organelle organization | 21.9512 | 5 | no |
| GO:0040017 | positive regulation of locomotion | 21.9512 | 4 | no |
| GO:0045785 | positive regulation of cell adhesion | 21.9512 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 21.9512 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.9512 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.9512 | 6 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.9512 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 21.9512 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.9512 | 4 | no |
| GO:0001667 | ameboidal-type cell migration | 14.6341 | 4 | yes |
| GO:0007044 | cell-substrate junction assembly | 14.6341 | 6 | yes |
| GO:0030031 | cell projection assembly | 14.6341 | 5 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 14.6341 | 6 | yes |
| GO:0150115 | cell-substrate junction organization | 14.6341 | 5 | yes |
| GO:0007160 | cell-matrix adhesion | 9.7561 | 4 | yes |
| GO:0048333 | mesodermal cell differentiation | 9.7561 | 4 | yes |
| GO:0031581 | hemidesmosome assembly | 7.3171 | 7 | yes |
| GO:0032288 | myelin assembly | 4.8780 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ITB4_HUMAN |
|---|---|---|---|---|
| DOID:0050686 | organ system cancer | 4.8780 | 3 | no |
| DOID:114 | heart disease | 4.8780 | 3 | no |
| DOID:0080000 | muscular disease | 4.8780 | 3 | no |
| DOID:423 | myopathy | 4.8780 | 5 | no |
| DOID:66 | muscle tissue disease | 4.8780 | 4 | no |
| DOID:9884 | muscular dystrophy | 4.8780 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| LOX12_HUMAN | [view interactions] | Low throughput | no | no |
| CADM3_HUMAN | [view interactions] | Low throughput | no | no |
| CADM4_HUMAN | [view interactions] | Low throughput | no | yes |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITA6_HUMAN | [view interactions] | Low throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| X3CL1_HUMAN | [view interactions] | Low throughput | no | yes |
| ARRD3_HUMAN | [view interactions] | Low throughput | no | no |
| S1PR2_HUMAN | [view interactions] | Low throughput | no | no |
| S1PR3_HUMAN | [view interactions] | Low throughput | no | no |
| CD151_HUMAN | [view interactions] | Low throughput | no | no |
| PLEC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| CADM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FABPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| IF6_HUMAN | [view interactions] | Low throughput | no | yes |
| ERBIN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COHA1_HUMAN | [view interactions] | Low throughput | no | no |
| DYST_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SDC1_HUMAN | [view interactions] | Low throughput | no | no |
| SDC2_HUMAN | [view interactions] | Low throughput | no | yes |
| SDC3_HUMAN | [view interactions] | Low throughput | no | yes |
| ITA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ENPP2_HUMAN | [view interactions] | Low throughput | no | yes |
| LPAR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SE1L1_HUMAN | [view interactions] | Low throughput | no | yes |
| TGM2_HUMAN | [view interactions] | Low throughput | no | no |
| SDC4_HUMAN | [view interactions] | Low throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| AP2C_HUMAN | [view interactions] | High throughput | no | no |
| ATF2_HUMAN | [view interactions] | High throughput | no | yes |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRLL_HUMAN | [view interactions] | High throughput | no | yes |
| VAV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP13_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RM38_HUMAN | [view interactions] | High throughput | no | yes |
| LIPB1_HUMAN | [view interactions] | High throughput | no | yes |
| APOB_HUMAN | [view interactions] | High throughput | no | no |
| LMX1B_HUMAN | [view interactions] | High throughput | no | no |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD3_HUMAN | [view interactions] | High throughput | no | yes |
| APBP2_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM1_HUMAN | [view interactions] | High throughput | no | no |
| TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
| TGM1_HUMAN | [view interactions] | High throughput | no | no |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| HXA1_HUMAN | [view interactions] | High throughput | no | no |
| OBF1_HUMAN | [view interactions] | High throughput | no | no |
| MYF5_HUMAN | [view interactions] | High throughput | no | no |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| PLS4_HUMAN | [view interactions] | High throughput | no | no |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| ECM1_HUMAN | [view interactions] | High throughput | no | no |
| ATL4_HUMAN | [view interactions] | High throughput | no | yes |
| KR171_HUMAN | [view interactions] | High throughput | no | no |
| KRA62_HUMAN | [view interactions] | High throughput | no | no |
| KR151_HUMAN | [view interactions] | High throughput | no | no |
| KR108_HUMAN | [view interactions] | High throughput | no | no |
| KRA11_HUMAN | [view interactions] | High throughput | no | no |
| CRTP1_HUMAN | [view interactions] | High throughput | no | yes |
| KPRP_HUMAN | [view interactions] | High throughput | no | no |
| KRA93_HUMAN | [view interactions] | High throughput | no | no |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| KR123_HUMAN | [view interactions] | High throughput | no | no |
| KRA24_HUMAN | [view interactions] | High throughput | no | no |
| KRA31_HUMAN | [view interactions] | High throughput | no | no |
| KR109_HUMAN | [view interactions] | High throughput | no | no |
| KRA13_HUMAN | [view interactions] | High throughput | no | no |
| KRA92_HUMAN | [view interactions] | High throughput | no | no |
| KRA42_HUMAN | [view interactions] | High throughput | no | no |
| NT2NA_HUMAN | [view interactions] | High throughput | no | no |
| KR107_HUMAN | [view interactions] | High throughput | no | no |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH13_HUMAN | [view interactions] | High throughput | no | no |
| TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI7_HUMAN | [view interactions] | High throughput | no | no |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| KLC3_HUMAN | [view interactions] | High throughput | no | no |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2R3C_HUMAN | [view interactions] | High throughput | no | yes |
| SKI_HUMAN | [view interactions] | High throughput | no | yes |
| GPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| FA24B_HUMAN | [view interactions] | High throughput | no | no |
| GXLT1_HUMAN | [view interactions] | High throughput | no | no |
| BRID5_HUMAN | [view interactions] | High throughput | no | no |
| ECEL1_HUMAN | [view interactions] | High throughput | no | yes |
| ADA30_HUMAN | [view interactions] | High throughput | no | no |
| SIRPD_HUMAN | [view interactions] | High throughput | no | no |
| NAAA_HUMAN | [view interactions] | High throughput | no | yes |
| DKKL1_HUMAN | [view interactions] | High throughput | no | no |
| TAZ_HUMAN | [view interactions] | High throughput | no | yes |
| CLC2B_HUMAN | [view interactions] | High throughput | no | yes |
| CST11_HUMAN | [view interactions] | High throughput | no | no |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| LAMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMB1_HUMAN | [view interactions] | High throughput | no | yes |
| LAMB2_HUMAN | [view interactions] | High throughput | no | yes |
| ITAL_HUMAN | [view interactions] | Computational | no | no |
| ITA10_HUMAN | [view interactions] | Computational | no | no |
| GRB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AKT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LAMB3_HUMAN | [view interactions] | Computational | no | yes |
| LAMA3_HUMAN | [view interactions] | Computational | no | no |
| 1433B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ITA9_HUMAN | [view interactions] | Computational | no | no |
| LAMC1_HUMAN | [view interactions] | Computational | no | yes |
| LAMA1_HUMAN | [view interactions] | Computational | no | no |
| KPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LAMA2_HUMAN | [view interactions] | Computational | no | no |
| ERBB3_HUMAN | [view interactions] | Computational | no | yes |
| CASP3_HUMAN | [view interactions] | Computational | no | yes |
| ITA2_HUMAN | [view interactions] | Computational | no | yes |
| LAMC2_HUMAN | [view interactions] | Computational | no | no |
| ITAD_HUMAN | [view interactions] | Computational | no | no |
| PK3CA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ITA8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ITA1_HUMAN | [view interactions] | Computational | no | yes |
| ITB1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| 1433G_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ITA11_HUMAN | [view interactions] | Computational | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PMP22_HUMAN | [view interactions] | Computational | no | no |
| ITAM_HUMAN | [view interactions] | Computational | no | no |
| ITA2B_HUMAN | [view interactions] | Computational | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MET_HUMAN | [view interactions] | Computational | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ITA4_HUMAN | [view interactions] | Computational | no | no |
| RASH_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ITA5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| TLN1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ITAE_HUMAN | [view interactions] | Computational | no | no |
| ITA7_HUMAN | [view interactions] | Computational | no | yes |
| EGF_HUMAN | [view interactions] | Computational | no | no |
| P85A_HUMAN | [view interactions] | Computational | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ITAV_HUMAN | [view interactions] | Computational | no | yes |