VAV2_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VAV2_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 42.2222 | 4 | no |
| GO:0000166 | nucleotide binding | 37.7778 | 4 | no |
| GO:0017076 | purine nucleotide binding | 37.7778 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 37.7778 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 35.5556 | 4 | no |
| GO:0043169 | cation binding | 28.8889 | 4 | yes |
| GO:0046872 | metal ion binding | 28.8889 | 5 | yes |
| GO:0019900 | kinase binding | 28.8889 | 4 | no |
| GO:0019901 | protein kinase binding | 28.8889 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 28.8889 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 28.8889 | 5 | no |
| GO:0003723 | RNA binding | 26.6667 | 4 | no |
| GO:0005524 | ATP binding | 26.6667 | 5 | no |
| GO:0045296 | cadherin binding | 22.2222 | 4 | no |
| GO:0070851 | growth factor receptor binding | 11.1111 | 4 | yes |
| GO:0001784 | phosphotyrosine residue binding | 8.8889 | 5 | yes |
| GO:0030695 | GTPase regulator activity | 8.8889 | 4 | yes |
| GO:0045309 | protein phosphorylated amino acid binding | 8.8889 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 6.6667 | 5 | yes |
| GO:0005154 | epidermal growth factor receptor binding | 6.6667 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VAV2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 64.4444 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 60.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 60.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 55.5556 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 53.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 53.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 51.1111 | 5 | no |
| GO:0010646 | regulation of cell communication | 48.8889 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 46.6667 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 46.6667 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 46.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 46.6667 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 46.6667 | 4 | no |
| GO:0009966 | regulation of signal transduction | 44.4444 | 4 | yes |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 40.0000 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 37.7778 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 37.7778 | 5 | yes |
| GO:0010468 | regulation of gene expression | 37.7778 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 37.7778 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 35.5556 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 35.5556 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.5556 | 5 | no |
| GO:0036211 | protein modification process | 35.5556 | 4 | no |
| GO:0043412 | macromolecule modification | 35.5556 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 33.3333 | 5 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 31.1111 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 31.1111 | 4 | no |
| GO:0031399 | regulation of protein modification process | 31.1111 | 6 | no |
| GO:0051049 | regulation of transport | 31.1111 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 31.1111 | 4 | no |
| GO:0032880 | regulation of protein localization | 31.1111 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 31.1111 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 31.1111 | 4 | no |
| GO:0060341 | regulation of cellular localization | 31.1111 | 4 | no |
| GO:0030030 | cell projection organization | 28.8889 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 28.8889 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 28.8889 | 7 | no |
| GO:0006996 | organelle organization | 28.8889 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.8889 | 6 | no |
| GO:0030155 | regulation of cell adhesion | 28.8889 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.8889 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 28.8889 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 28.8889 | 7 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.8889 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.8889 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 28.8889 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 28.8889 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 28.8889 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 28.8889 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 28.8889 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 28.8889 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 26.6667 | 4 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 26.6667 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 26.6667 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.6667 | 5 | no |
| GO:0042327 | positive regulation of phosphorylation | 26.6667 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 26.6667 | 7 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 24.4444 | 4 | yes |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 24.4444 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 24.4444 | 5 | no |
| GO:0022407 | regulation of cell-cell adhesion | 24.4444 | 5 | no |
| GO:0043408 | regulation of MAPK cascade | 24.4444 | 6 | no |
| GO:0070201 | regulation of establishment of protein localization | 24.4444 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.4444 | 5 | no |
| GO:0050776 | regulation of immune response | 22.2222 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 22.2222 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 22.2222 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 22.2222 | 5 | no |
| GO:0032101 | regulation of response to external stimulus | 22.2222 | 4 | no |
| GO:0045785 | positive regulation of cell adhesion | 22.2222 | 5 | no |
| GO:0002694 | regulation of leukocyte activation | 22.2222 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 22.2222 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.2222 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.2222 | 4 | no |
| GO:0050865 | regulation of cell activation | 22.2222 | 4 | no |
| GO:0051338 | regulation of transferase activity | 22.2222 | 4 | no |
| GO:1903037 | regulation of leukocyte cell-cell adhesion | 22.2222 | 6 | no |
| GO:0051726 | regulation of cell cycle | 22.2222 | 4 | no |
| GO:0050778 | positive regulation of immune response | 15.5556 | 5 | yes |
| GO:0007264 | small GTPase-mediated signal transduction | 13.3333 | 5 | yes |
| GO:0030031 | cell projection assembly | 13.3333 | 5 | yes |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 11.1111 | 4 | yes |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 11.1111 | 4 | yes |
| GO:0032535 | regulation of cellular component size | 11.1111 | 4 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 11.1111 | 6 | yes |
| GO:0051896 | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 11.1111 | 6 | yes |
| GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 11.1111 | 7 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 11.1111 | 6 | yes |
| GO:0097581 | lamellipodium organization | 8.8889 | 6 | yes |
| GO:0002431 | Fc receptor mediated stimulatory signaling pathway | 6.6667 | 5 | yes |
| GO:0008361 | regulation of cell size | 6.6667 | 5 | yes |
| GO:0030032 | lamellipodium assembly | 6.6667 | 7 | yes |
| GO:0038093 | Fc receptor signaling pathway | 6.6667 | 5 | yes |
| GO:0038094 | Fc-gamma receptor signaling pathway | 6.6667 | 6 | yes |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 6.6667 | 4 | yes |
| GO:0043087 | regulation of GTPase activity | 6.6667 | 5 | yes |
| GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 6.6667 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PRLR_HUMAN | [view interactions] | Low throughput | no | no |
| NEK3_HUMAN | [view interactions] | Low throughput | no | no |
| KSYK_HUMAN | [view interactions] | Low throughput | no | no |
| CBL_HUMAN | [view interactions] | Low throughput | no | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| PGFRB_HUMAN | [view interactions] | Low throughput | no | yes |
| CBLB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TXNIP_HUMAN | [view interactions] | Low throughput | no | no |
| FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SOCS1_HUMAN | [view interactions] | Low throughput | no | yes |
| CD44_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CD19_HUMAN | [view interactions] | Low throughput | no | no |
| CTND1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| S12A6_HUMAN | [view interactions] | Low throughput | no | yes |
| ARAP3_HUMAN | [view interactions] | Low throughput | no | no |
| ACTS_HUMAN | [view interactions] | Low throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 3BP2_HUMAN | [view interactions] | Low throughput | no | yes |
| TM1L1_HUMAN | [view interactions] | Low throughput | no | yes |
| MARH7_HUMAN | [view interactions] | Low throughput | no | yes |
| CAV1_HUMAN | [view interactions] | Low throughput | no | no |
| FLT3_HUMAN | [view interactions] | Low throughput | no | no |
| NSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| PSB2_HUMAN | [view interactions] | High throughput | no | yes |
| HACD3_HUMAN | [view interactions] | High throughput | no | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THOC5_HUMAN | [view interactions] | High throughput | no | no |
| THOC7_HUMAN | [view interactions] | High throughput | no | yes |
| TIM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOX4_HUMAN | [view interactions] | High throughput | no | yes |
| UGGG1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR33_HUMAN | [view interactions] | High throughput | no | yes |
| YMEL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDR1_HUMAN | [view interactions] | High throughput | no | yes |
| EPHB3_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZAP70_HUMAN | [view interactions] | High throughput | no | no |
| DAB1_HUMAN | [view interactions] | High throughput | no | yes |
| GAB1_HUMAN | [view interactions] | High throughput | no | yes |
| GAB2_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCP2_HUMAN | [view interactions] | High throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
| SOCS3_HUMAN | [view interactions] | High throughput | no | yes |
| VAV_HUMAN | [view interactions] | High throughput | no | no |
| ITB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LARP1_HUMAN | [view interactions] | High throughput | no | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PA24A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC2_HUMAN | [view interactions] | High throughput | no | yes |
| SLIK6_HUMAN | [view interactions] | High throughput | no | yes |
| STAM2_HUMAN | [view interactions] | High throughput | no | yes |
| SYDE1_HUMAN | [view interactions] | High throughput | no | yes |
| SHC2_HUMAN | [view interactions] | High throughput | no | yes |
| SHIP1_HUMAN | [view interactions] | High throughput | no | no |
| SHF_HUMAN | [view interactions] | High throughput | no | no |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| SLAP1_HUMAN | [view interactions] | High throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAP2_HUMAN | [view interactions] | High throughput | no | yes |
| STAP1_HUMAN | [view interactions] | High throughput | no | no |
| STAT6_HUMAN | [view interactions] | High throughput | no | yes |
| TENS3_HUMAN | [view interactions] | High throughput | no | no |
| TYK2_HUMAN | [view interactions] | High throughput | no | no |
| SMAD3_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| SF01_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| RTEL1_HUMAN | [view interactions] | High throughput | no | no |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ABLM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAGD2_HUMAN | [view interactions] | High throughput | no | yes |
| S10A9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMCE1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MBP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THOP1_HUMAN | [view interactions] | High throughput | no | yes |
| TPD54_HUMAN | [view interactions] | High throughput | no | yes |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPH6_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| CCD14_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| TMG4_HUMAN | [view interactions] | High throughput | no | yes |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| IF4G3_HUMAN | [view interactions] | High throughput | no | yes |
| CCNO_HUMAN | [view interactions] | High throughput | no | no |
| BRDT_HUMAN | [view interactions] | High throughput | no | no |
| RBBP6_HUMAN | [view interactions] | High throughput | no | yes |
| F10A1_HUMAN | [view interactions] | High throughput | no | yes |
| VCIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BD1L1_HUMAN | [view interactions] | High throughput | no | yes |
| PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
| SRRT_HUMAN | [view interactions] | High throughput | no | yes |
| FNTA_HUMAN | [view interactions] | High throughput | no | yes |
| TCP11_HUMAN | [view interactions] | High throughput | no | no |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 5MP2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP38_HUMAN | [view interactions] | High throughput | no | no |
| SERB1_HUMAN | [view interactions] | High throughput | no | yes |
| GAPD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE4B_HUMAN | [view interactions] | High throughput | no | yes |
| MRGBP_HUMAN | [view interactions] | High throughput | no | no |
| POGZ_HUMAN | [view interactions] | High throughput | no | yes |
| SF3A3_HUMAN | [view interactions] | High throughput | no | yes |
| TRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| FUCO_HUMAN | [view interactions] | High throughput | no | yes |
| IPO4_HUMAN | [view interactions] | High throughput | no | no |
| CHMP3_HUMAN | [view interactions] | High throughput | no | yes |
| NCKP5_HUMAN | [view interactions] | High throughput | no | no |
| MED21_HUMAN | [view interactions] | High throughput | no | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| DJC21_HUMAN | [view interactions] | High throughput | no | yes |
| RD23A_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCNL4_HUMAN | [view interactions] | High throughput | no | yes |
| TITIN_HUMAN | [view interactions] | High throughput | no | no |
| STK24_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1B_HUMAN | [view interactions] | High throughput | no | yes |
| PHF10_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARI1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPC9_HUMAN | [view interactions] | High throughput | no | yes |
| CCD12_HUMAN | [view interactions] | High throughput | no | yes |
| ESPL1_HUMAN | [view interactions] | High throughput | no | yes |
| KAP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| CAH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALU_HUMAN | [view interactions] | High throughput | no | yes |
| CCD50_HUMAN | [view interactions] | High throughput | no | yes |
| CCNT1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX42_HUMAN | [view interactions] | High throughput | no | yes |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| FIP1_HUMAN | [view interactions] | High throughput | no | yes |
| GLOD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| MFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| AF1Q_HUMAN | [view interactions] | High throughput | no | yes |