Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PA24A_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production . Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed, PubMed, PubMed, PubMed, PubMed). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PA24A_HUMAN
GO:0043168 anion binding 55.8824 4 yes
GO:0000166 nucleotide binding 38.2353 4 no
GO:0017076 purine nucleotide binding 38.2353 5 no
GO:0043169 cation binding 35.2941 4 yes
GO:0046872 metal ion binding 35.2941 5 yes
GO:0030554 adenyl nucleotide binding 35.2941 6 no
GO:0032555 purine ribonucleotide binding 32.3529 4 no
GO:0035639 purine ribonucleoside triphosphate binding 32.3529 4 no
GO:0005524 ATP binding 29.4118 5 no
GO:0032559 adenyl ribonucleotide binding 29.4118 5 no
GO:0003723 RNA binding 26.4706 4 no
GO:0045296 cadherin binding 23.5294 4 no
GO:0005509 calcium ion binding 14.7059 6 yes
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 11.7647 4 yes
GO:0005544 calcium-dependent phospholipid binding 8.8235 4 yes
GO:0035091 phosphatidylinositol binding 8.8235 4 yes
GO:1901981 phosphatidylinositol phosphate binding 8.8235 5 yes
GO:0004620 phospholipase activity 5.8824 5 yes
GO:0004623 phospholipase A2 activity 5.8824 5 yes
GO:0008374 O-acyltransferase activity 5.8824 5 yes
GO:0010314 phosphatidylinositol-5-phosphate binding 5.8824 6 yes
GO:0016298 lipase activity 5.8824 4 yes
GO:0032266 phosphatidylinositol-3-phosphate binding 5.8824 6 yes
GO:0047499 calcium-independent phospholipase A2 activity 5.8824 6 yes
GO:0052689 carboxylic ester hydrolase activity 5.8824 4 yes
GO:0070273 phosphatidylinositol-4-phosphate binding 5.8824 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PA24A_HUMAN
GO:0048522 positive regulation of cellular process 70.5882 4 yes
GO:0060255 regulation of macromolecule metabolic process 58.8235 4 no
GO:0080090 regulation of primary metabolic process 58.8235 4 no
GO:0031323 regulation of cellular metabolic process 52.9412 4 no
GO:0048584 positive regulation of response to stimulus 50.0000 4 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0009891 positive regulation of biosynthetic process 47.0588 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 47.0588 6 no
GO:0010646 regulation of cell communication 47.0588 4 no
GO:0031325 positive regulation of cellular metabolic process 47.0588 5 no
GO:0031328 positive regulation of cellular biosynthetic process 47.0588 6 no
GO:0048523 negative regulation of cellular process 47.0588 4 no
GO:0009966 regulation of signal transduction 44.1176 4 no
GO:0010468 regulation of gene expression 44.1176 6 no
GO:0023056 positive regulation of signaling 44.1176 4 no
GO:0051246 regulation of protein metabolic process 44.1176 5 no
GO:0022607 cellular component assembly 44.1176 4 no
GO:0010647 positive regulation of cell communication 41.1765 5 no
GO:0009967 positive regulation of signal transduction 38.2353 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 38.2353 5 no
GO:0051247 positive regulation of protein metabolic process 35.2941 6 no
GO:0051128 regulation of cellular component organization 35.2941 4 no
GO:0051049 regulation of transport 32.3529 4 yes
GO:0009892 negative regulation of metabolic process 32.3529 4 no
GO:0009894 regulation of catabolic process 32.3529 4 no
GO:0010605 negative regulation of macromolecule metabolic process 32.3529 5 no
GO:0010628 positive regulation of gene expression 32.3529 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 32.3529 5 no
GO:0060341 regulation of cellular localization 32.3529 4 no
GO:0006996 organelle organization 32.3529 4 no
GO:0002684 positive regulation of immune system process 32.3529 4 yes
GO:0042127 regulation of cell population proliferation 29.4118 4 yes
GO:0010243 response to organonitrogen compound 29.4118 4 no
GO:0032101 regulation of response to external stimulus 29.4118 4 no
GO:0051252 regulation of RNA metabolic process 29.4118 5 no
GO:0080134 regulation of response to stress 29.4118 4 no
GO:0090304 nucleic acid metabolic process 29.4118 4 no
GO:0036211 protein modification process 29.4118 4 no
GO:0043412 macromolecule modification 29.4118 4 no
GO:0043933 protein-containing complex organization 29.4118 4 no
GO:0051240 positive regulation of multicellular organismal process 26.4706 4 yes
GO:0014070 response to organic cyclic compound 26.4706 4 no
GO:0043085 positive regulation of catalytic activity 26.4706 4 no
GO:0045595 regulation of cell differentiation 26.4706 4 no
GO:0051094 positive regulation of developmental process 26.4706 4 no
GO:0071310 cellular response to organic substance 26.4706 4 no
GO:0141124 intracellular signaling cassette 26.4706 4 no
GO:0042981 regulation of apoptotic process 26.4706 5 no
GO:0043067 regulation of programmed cell death 26.4706 4 no
GO:0051248 negative regulation of protein metabolic process 26.4706 6 no
GO:0065003 protein-containing complex assembly 26.4706 5 no
GO:1902531 regulation of intracellular signal transduction 26.4706 5 no
GO:0006796 phosphate-containing compound metabolic process 26.4706 4 yes
GO:0071702 organic substance transport 23.5294 4 yes
GO:0008104 protein localization 23.5294 4 no
GO:0031324 negative regulation of cellular metabolic process 23.5294 5 no
GO:0034097 response to cytokine 23.5294 4 no
GO:0048585 negative regulation of response to stimulus 23.5294 4 no
GO:0051254 positive regulation of RNA metabolic process 23.5294 6 no
GO:0033043 regulation of organelle organization 23.5294 5 no
GO:0051130 positive regulation of cellular component organization 23.5294 5 no
GO:1902533 positive regulation of intracellular signal transduction 23.5294 6 no
GO:0098657 import into cell 23.5294 4 no
GO:0050776 regulation of immune response 20.5882 4 yes
GO:0050778 positive regulation of immune response 20.5882 5 yes
GO:0051050 positive regulation of transport 20.5882 4 yes
GO:0006355 regulation of DNA-templated transcription 20.5882 7 no
GO:0006357 regulation of transcription by RNA polymerase II 20.5882 8 no
GO:0008284 positive regulation of cell population proliferation 20.5882 5 no
GO:0009059 macromolecule biosynthetic process 20.5882 4 no
GO:0016070 RNA metabolic process 20.5882 5 no
GO:0019220 regulation of phosphate metabolic process 20.5882 6 no
GO:0030162 regulation of proteolysis 20.5882 6 no
GO:0030334 regulation of cell migration 20.5882 5 no
GO:0034654 nucleobase-containing compound biosynthetic process 20.5882 4 no
GO:0045893 positive regulation of DNA-templated transcription 20.5882 8 no
GO:0045944 positive regulation of transcription by RNA polymerase II 20.5882 9 no
GO:0051093 negative regulation of developmental process 20.5882 4 no
GO:0051174 regulation of phosphorus metabolic process 20.5882 5 no
GO:0141187 nucleic acid biosynthetic process 20.5882 5 no
GO:1901362 organic cyclic compound biosynthetic process 20.5882 4 no
GO:1902680 positive regulation of RNA biosynthetic process 20.5882 7 no
GO:2000026 regulation of multicellular organismal development 20.5882 4 no
GO:2000145 regulation of cell motility 20.5882 4 no
GO:2001141 regulation of RNA biosynthetic process 20.5882 6 no
GO:0043066 negative regulation of apoptotic process 20.5882 6 no
GO:0043069 negative regulation of programmed cell death 20.5882 5 no
GO:0031399 regulation of protein modification process 20.5882 6 no
GO:1901701 cellular response to oxygen-containing compound 20.5882 4 no
GO:0060627 regulation of vesicle-mediated transport 20.5882 4 no
GO:1901565 organonitrogen compound catabolic process 14.7059 4 yes
GO:1905952 regulation of lipid localization 14.7059 4 yes
GO:0032368 regulation of lipid transport 11.7647 5 yes
GO:0050865 regulation of cell activation 11.7647 4 yes
GO:0051046 regulation of secretion 11.7647 5 yes
GO:1903530 regulation of secretion by cell 11.7647 4 yes
GO:0044242 cellular lipid catabolic process 8.8235 4 yes
GO:1905954 positive regulation of lipid localization 8.8235 4 yes
GO:0006869 lipid transport 8.8235 5 yes
GO:0010543 regulation of platelet activation 8.8235 5 yes
GO:0016042 lipid catabolic process 8.8235 4 yes
GO:0032309 icosanoid secretion 5.8824 5 yes
GO:0032370 positive regulation of lipid transport 5.8824 5 yes
GO:0046434 organophosphate catabolic process 5.8824 4 yes
GO:0046475 glycerophospholipid catabolic process 5.8824 6 yes
GO:0046486 glycerolipid metabolic process 5.8824 4 yes
GO:0046503 glycerolipid catabolic process 5.8824 5 yes
GO:0046903 secretion 5.8824 4 yes
GO:0046942 carboxylic acid transport 5.8824 6 yes
GO:0050482 arachidonic acid secretion 5.8824 6 yes
GO:0050867 positive regulation of cell activation 5.8824 5 yes
GO:0051047 positive regulation of secretion 5.8824 5 yes
GO:0071715 icosanoid transport 5.8824 7 yes
GO:0090407 organophosphate biosynthetic process 5.8824 4 yes
GO:1901566 organonitrogen compound biosynthetic process 5.8824 4 yes
GO:1903532 positive regulation of secretion by cell 5.8824 5 yes
GO:1903963 arachidonate transport 5.8824 8 yes
GO:0002694 regulation of leukocyte activation 5.8824 4 yes
GO:0002696 positive regulation of leukocyte activation 5.8824 5 yes
GO:0002819 regulation of adaptive immune response 5.8824 5 yes
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 5.8824 6 yes
GO:0002825 regulation of T-helper 1 type immune response 5.8824 7 yes
GO:0006644 phospholipid metabolic process 5.8824 4 yes
GO:0006650 glycerophospholipid metabolic process 5.8824 5 yes
GO:0009395 phospholipid catabolic process 5.8824 5 yes
GO:0015711 organic anion transport 5.8824 5 yes
GO:0015718 monocarboxylic acid transport 5.8824 7 yes
GO:0015849 organic acid transport 5.8824 5 yes
GO:0015908 fatty acid transport 5.8824 6 yes
GO:0015909 long-chain fatty acid transport 5.8824 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KAT5_HUMAN [view interactions] Low throughput no yes
SIR2_HUMAN [view entry] [view interactions] Low throughput yes yes
JAK1_HUMAN [view interactions] Low throughput no yes
S10AA_HUMAN [view interactions] Low throughput no no
ANXA2_HUMAN [view entry] [view interactions] Low throughput yes no
EHD1_HUMAN [view entry] [view interactions] Low throughput yes no
MK03_HUMAN [view entry] [view interactions] Low throughput yes yes
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
LOX12_HUMAN [view interactions] Low throughput no no
MYBB_HUMAN [view interactions] Low throughput no yes
ITB3_HUMAN [view entry] [view interactions] Low throughput yes no
VIME_HUMAN [view entry] [view interactions] Low throughput yes no
KSR1_HUMAN [view interactions] Low throughput no yes
I17RD_HUMAN [view interactions] Low throughput no yes
NCF1_HUMAN [view interactions] Low throughput no no
NCF2_HUMAN [view interactions] Low throughput no no
ANXA1_HUMAN [view entry] [view interactions] Low throughput yes no
S10AB_HUMAN [view interactions] Low throughput no no
CDK2_HUMAN [view interactions] Low throughput no yes
CCNA2_HUMAN [view interactions] Low throughput no no
ITA2B_HUMAN [view interactions] Low throughput no no
DYLT1_HUMAN [view interactions] High throughput no no
PRDX6_HUMAN [view entry] [view interactions] High throughput yes yes
NCPR_HUMAN [view entry] [view interactions] High throughput yes yes
NACAM_HUMAN [view interactions] High throughput no no
MK08_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
S52A2_HUMAN [view interactions] High throughput no no
GPNMB_HUMAN [view interactions] High throughput no no
MYCBP_HUMAN [view interactions] High throughput no yes
SPD2A_HUMAN [view entry] [view interactions] High throughput yes yes
TF65_HUMAN [view entry] [view interactions] High throughput yes yes
CAP1_HUMAN [view entry] [view interactions] High throughput yes yes
UBXN1_HUMAN [view interactions] High throughput no no
BORC6_HUMAN [view interactions] High throughput no yes
EIF3E_HUMAN [view entry] [view interactions] High throughput yes yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
DDX1_HUMAN [view entry] [view interactions] High throughput yes yes
VAV2_HUMAN [view entry] [view interactions] High throughput yes yes
CSN4_HUMAN [view interactions] High throughput no yes
ELF3_HUMAN [view interactions] High throughput no no
ABCF1_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
STAT3_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
SHBG_HUMAN [view interactions] High throughput no no
XAGE1_HUMAN [view interactions] High throughput no no
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
CCDC9_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
AHSA1_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
RPAP3_HUMAN [view interactions] High throughput no yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
SGT1_HUMAN [view interactions] High throughput no no
DJC17_HUMAN [view interactions] High throughput no yes
FKBP5_HUMAN [view interactions] High throughput no yes
PPP5_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
KCRB_HUMAN [view entry] [view interactions] High throughput yes no
RUVB2_HUMAN [view interactions] High throughput no yes
ANR28_HUMAN [view interactions] High throughput no no
RTN3_HUMAN [view entry] [view interactions] High throughput yes yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
CD9_HUMAN [view entry] [view interactions] High throughput yes no
DHYS_HUMAN [view interactions] High throughput no no
RSF1_HUMAN [view interactions] High throughput no yes
GBF1_HUMAN [view interactions] High throughput no yes
RHBL4_HUMAN [view interactions] High throughput no no
PHLP1_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes