PA24A_HUMAN
Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production . Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway (PubMed, PubMed, PubMed, PubMed, PubMed). In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids (PubMed). Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific (PubMed). Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides (PubMed). Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PA24A_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 42.4242 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 42.4242 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 42.4242 | 4 | no |
GO:0046872 | metal ion binding | 39.3939 | 4 | yes |
GO:0005524 | ATP binding | 36.3636 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 36.3636 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 36.3636 | 5 | no |
GO:0003723 | RNA binding | 27.2727 | 4 | no |
GO:0045296 | cadherin binding | 24.2424 | 4 | no |
GO:0016301 | kinase activity | 21.2121 | 4 | no |
GO:0005509 | calcium ion binding | 15.1515 | 5 | yes |
GO:0005544 | calcium-dependent phospholipid binding | 9.0909 | 4 | yes |
GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 9.0909 | 4 | yes |
GO:0035091 | phosphatidylinositol binding | 9.0909 | 4 | yes |
GO:1901981 | phosphatidylinositol phosphate binding | 9.0909 | 5 | yes |
GO:0004620 | phospholipase activity | 6.0606 | 5 | yes |
GO:0004623 | phospholipase A2 activity | 6.0606 | 5 | yes |
GO:0008374 | O-acyltransferase activity | 6.0606 | 5 | yes |
GO:0010314 | phosphatidylinositol-5-phosphate binding | 6.0606 | 6 | yes |
GO:0016298 | lipase activity | 6.0606 | 4 | yes |
GO:0032266 | phosphatidylinositol-3-phosphate binding | 6.0606 | 6 | yes |
GO:0047499 | calcium-independent phospholipase A2 activity | 6.0606 | 6 | yes |
GO:0052689 | carboxylic ester hydrolase activity | 6.0606 | 4 | yes |
GO:0070273 | phosphatidylinositol-4-phosphate binding | 6.0606 | 6 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PA24A_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 81.8182 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 69.6970 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 66.6667 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 66.6667 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 66.6667 | 4 | no |
GO:0010646 | regulation of cell communication | 63.6364 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 63.6364 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 57.5758 | 4 | yes |
GO:0009966 | regulation of signal transduction | 57.5758 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 57.5758 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 57.5758 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 57.5758 | 5 | no |
GO:0010468 | regulation of gene expression | 54.5455 | 5 | no |
GO:0023056 | positive regulation of signaling | 54.5455 | 4 | no |
GO:0010647 | positive regulation of cell communication | 51.5152 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 51.5152 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 48.4848 | 6 | no |
GO:0048523 | negative regulation of cellular process | 48.4848 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 45.4545 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 45.4545 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 45.4545 | 5 | no |
GO:0043085 | positive regulation of catalytic activity | 45.4545 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 42.4242 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 42.4242 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 39.3939 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 39.3939 | 5 | no |
GO:0051128 | regulation of cellular component organization | 39.3939 | 4 | no |
GO:0010628 | positive regulation of gene expression | 39.3939 | 6 | no |
GO:1902531 | regulation of intracellular signal transduction | 39.3939 | 5 | no |
GO:0042127 | regulation of cell population proliferation | 36.3636 | 4 | yes |
GO:0051049 | regulation of transport | 36.3636 | 4 | yes |
GO:0010243 | response to organonitrogen compound | 36.3636 | 4 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 36.3636 | 6 | no |
GO:0019220 | regulation of phosphate metabolic process | 36.3636 | 6 | no |
GO:0042325 | regulation of phosphorylation | 36.3636 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 36.3636 | 5 | no |
GO:0006796 | phosphate-containing compound metabolic process | 33.3333 | 4 | yes |
GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 33.3333 | 6 | no |
GO:0060341 | regulation of cellular localization | 33.3333 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | no |
GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
GO:0036211 | protein modification process | 33.3333 | 4 | no |
GO:0043412 | macromolecule modification | 33.3333 | 4 | no |
GO:0071310 | cellular response to organic substance | 33.3333 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 33.3333 | 4 | no |
GO:0002684 | positive regulation of immune system process | 30.3030 | 4 | yes |
GO:0051252 | regulation of RNA metabolic process | 30.3030 | 5 | no |
GO:0001932 | regulation of protein phosphorylation | 30.3030 | 7 | no |
GO:0014070 | response to organic cyclic compound | 30.3030 | 4 | no |
GO:0032101 | regulation of response to external stimulus | 30.3030 | 4 | no |
GO:0045595 | regulation of cell differentiation | 30.3030 | 4 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 30.3030 | 5 | no |
GO:0080134 | regulation of response to stress | 30.3030 | 4 | no |
GO:0051338 | regulation of transferase activity | 30.3030 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 30.3030 | 6 | no |
GO:0060627 | regulation of vesicle-mediated transport | 27.2727 | 4 | no |
GO:0050776 | regulation of immune response | 27.2727 | 4 | yes |
GO:0051336 | regulation of hydrolase activity | 27.2727 | 4 | no |
GO:0009894 | regulation of catabolic process | 27.2727 | 4 | no |
GO:0010941 | regulation of cell death | 27.2727 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 27.2727 | 5 | no |
GO:0051094 | positive regulation of developmental process | 27.2727 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 27.2727 | 5 | no |
GO:0051248 | negative regulation of protein metabolic process | 27.2727 | 6 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 27.2727 | 6 | no |
GO:0042327 | positive regulation of phosphorylation | 27.2727 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 27.2727 | 7 | no |
GO:0051347 | positive regulation of transferase activity | 27.2727 | 5 | no |
GO:0008284 | positive regulation of cell population proliferation | 24.2424 | 5 | no |
GO:0030162 | regulation of proteolysis | 24.2424 | 6 | no |
GO:0051254 | positive regulation of RNA metabolic process | 24.2424 | 6 | no |
GO:0042981 | regulation of apoptotic process | 24.2424 | 6 | no |
GO:0043067 | regulation of programmed cell death | 24.2424 | 5 | no |
GO:0045597 | positive regulation of cell differentiation | 24.2424 | 5 | no |
GO:1901701 | cellular response to oxygen-containing compound | 24.2424 | 4 | no |
GO:0001934 | positive regulation of protein phosphorylation | 24.2424 | 8 | no |
GO:0006996 | organelle organization | 24.2424 | 4 | no |
GO:0031401 | positive regulation of protein modification process | 24.2424 | 7 | no |
GO:0043549 | regulation of kinase activity | 24.2424 | 5 | no |
GO:0090304 | nucleic acid metabolic process | 24.2424 | 4 | no |
GO:0016192 | vesicle-mediated transport | 21.2121 | 4 | no |
GO:0030334 | regulation of cell migration | 21.2121 | 5 | no |
GO:0030335 | positive regulation of cell migration | 21.2121 | 6 | no |
GO:0033993 | response to lipid | 21.2121 | 4 | no |
GO:0034097 | response to cytokine | 21.2121 | 4 | no |
GO:0040017 | positive regulation of locomotion | 21.2121 | 4 | no |
GO:2000145 | regulation of cell motility | 21.2121 | 4 | no |
GO:2000147 | positive regulation of cell motility | 21.2121 | 5 | no |
GO:0016310 | phosphorylation | 21.2121 | 5 | no |
GO:0032386 | regulation of intracellular transport | 21.2121 | 5 | no |
GO:0050778 | positive regulation of immune response | 21.2121 | 5 | yes |
GO:0006355 | regulation of DNA-templated transcription | 21.2121 | 6 | no |
GO:0043933 | protein-containing complex organization | 21.2121 | 4 | no |
GO:0045893 | positive regulation of DNA-templated transcription | 21.2121 | 7 | no |
GO:0065003 | protein-containing complex assembly | 21.2121 | 5 | no |
GO:1902680 | positive regulation of RNA biosynthetic process | 21.2121 | 7 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 21.2121 | 7 | no |
GO:1903508 | positive regulation of nucleic acid-templated transcription | 21.2121 | 8 | no |
GO:2001141 | regulation of RNA biosynthetic process | 21.2121 | 6 | no |
GO:0018193 | peptidyl-amino acid modification | 21.2121 | 5 | no |
GO:0031329 | regulation of cellular catabolic process | 21.2121 | 5 | no |
GO:0031347 | regulation of defense response | 21.2121 | 5 | no |
GO:0033043 | regulation of organelle organization | 21.2121 | 5 | no |
GO:2000026 | regulation of multicellular organismal development | 21.2121 | 4 | no |
GO:0001817 | regulation of cytokine production | 21.2121 | 4 | no |
GO:0033674 | positive regulation of kinase activity | 21.2121 | 6 | no |
GO:0045859 | regulation of protein kinase activity | 21.2121 | 6 | no |
GO:0051050 | positive regulation of transport | 18.1818 | 4 | yes |
GO:0071702 | organic substance transport | 18.1818 | 4 | yes |
GO:0006811 | ion transport | 15.1515 | 4 | yes |
GO:0043269 | regulation of ion transport | 12.1212 | 5 | yes |
GO:0050865 | regulation of cell activation | 12.1212 | 4 | yes |
GO:1905952 | regulation of lipid localization | 12.1212 | 4 | yes |
GO:0002694 | regulation of leukocyte activation | 9.0909 | 4 | yes |
GO:0002696 | positive regulation of leukocyte activation | 9.0909 | 5 | yes |
GO:0010543 | regulation of platelet activation | 9.0909 | 5 | yes |
GO:0016042 | lipid catabolic process | 9.0909 | 4 | yes |
GO:0032368 | regulation of lipid transport | 9.0909 | 5 | yes |
GO:0044242 | cellular lipid catabolic process | 9.0909 | 4 | yes |
GO:0046903 | secretion | 9.0909 | 4 | yes |
GO:0050867 | positive regulation of cell activation | 9.0909 | 5 | yes |
GO:0051046 | regulation of secretion | 9.0909 | 5 | yes |
GO:1901565 | organonitrogen compound catabolic process | 9.0909 | 4 | yes |
GO:1903530 | regulation of secretion by cell | 9.0909 | 4 | yes |
GO:1905954 | positive regulation of lipid localization | 9.0909 | 4 | yes |
GO:0002819 | regulation of adaptive immune response | 6.0606 | 5 | yes |
GO:0002822 | regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 6.0606 | 6 | yes |
GO:0002825 | regulation of T-helper 1 type immune response | 6.0606 | 7 | yes |
GO:0006631 | fatty acid metabolic process | 6.0606 | 4 | yes |
GO:0006644 | phospholipid metabolic process | 6.0606 | 4 | yes |
GO:0006650 | glycerophospholipid metabolic process | 6.0606 | 5 | yes |
GO:0006820 | anion transport | 6.0606 | 5 | yes |
GO:0006869 | lipid transport | 6.0606 | 5 | yes |
GO:0009395 | phospholipid catabolic process | 6.0606 | 5 | yes |
GO:0015711 | organic anion transport | 6.0606 | 5 | yes |
GO:0015718 | monocarboxylic acid transport | 6.0606 | 7 | yes |
GO:0015849 | organic acid transport | 6.0606 | 5 | yes |
GO:0015908 | fatty acid transport | 6.0606 | 6 | yes |
GO:0015909 | long-chain fatty acid transport | 6.0606 | 7 | yes |
GO:0019752 | carboxylic acid metabolic process | 6.0606 | 5 | yes |
GO:0032309 | icosanoid secretion | 6.0606 | 5 | yes |
GO:0032370 | positive regulation of lipid transport | 6.0606 | 5 | yes |
GO:0032787 | monocarboxylic acid metabolic process | 6.0606 | 6 | yes |
GO:0043270 | positive regulation of ion transport | 6.0606 | 5 | yes |
GO:0043436 | oxoacid metabolic process | 6.0606 | 4 | yes |
GO:0046434 | organophosphate catabolic process | 6.0606 | 4 | yes |
GO:0046475 | glycerophospholipid catabolic process | 6.0606 | 6 | yes |
GO:0046486 | glycerolipid metabolic process | 6.0606 | 4 | yes |
GO:0046503 | glycerolipid catabolic process | 6.0606 | 5 | yes |
GO:0046942 | carboxylic acid transport | 6.0606 | 6 | yes |
GO:0050482 | arachidonic acid secretion | 6.0606 | 6 | yes |
GO:0071715 | icosanoid transport | 6.0606 | 7 | yes |
GO:0090407 | organophosphate biosynthetic process | 6.0606 | 4 | yes |
GO:1901566 | organonitrogen compound biosynthetic process | 6.0606 | 4 | yes |
GO:1903963 | arachidonate transport | 6.0606 | 8 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
KAT5_HUMAN | [view interactions] | Low throughput | no | yes |
SIR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
JAK1_HUMAN | [view interactions] | Low throughput | no | yes |
S10AA_HUMAN | [view interactions] | Low throughput | no | no |
ANXA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
EHD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
LOX12_HUMAN | [view interactions] | Low throughput | no | no |
MYBB_HUMAN | [view interactions] | Low throughput | no | yes |
ITB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
VIME_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
KSR1_HUMAN | [view interactions] | Low throughput | no | yes |
I17RD_HUMAN | [view interactions] | Low throughput | no | yes |
NCF1_HUMAN | [view interactions] | Low throughput | no | no |
NCF2_HUMAN | [view interactions] | Low throughput | no | no |
ANXA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
S10AB_HUMAN | [view interactions] | Low throughput | no | no |
CDK2_HUMAN | [view interactions] | Low throughput | no | yes |
CCNA2_HUMAN | [view interactions] | Low throughput | no | no |
ITA2B_HUMAN | [view interactions] | Low throughput | no | no |
STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SHBG_HUMAN | [view interactions] | High throughput | no | no |
XAGE1_HUMAN | [view interactions] | High throughput | no | no |
NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MOV10_HUMAN | [view interactions] | High throughput | no | no |
NXF1_HUMAN | [view interactions] | High throughput | no | yes |
CCDC9_HUMAN | [view interactions] | High throughput | no | yes |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPAP3_HUMAN | [view interactions] | High throughput | no | yes |
LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SGT1_HUMAN | [view interactions] | High throughput | no | no |
DJC17_HUMAN | [view interactions] | High throughput | no | yes |
FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
GBF1_HUMAN | [view interactions] | High throughput | no | yes |
RHBL4_HUMAN | [view interactions] | High throughput | no | no |
DYLT1_HUMAN | [view interactions] | High throughput | no | no |
PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NCPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NACAM_HUMAN | [view interactions] | High throughput | no | no |
MK08_HUMAN | [view interactions] | High throughput | no | yes |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
S52A2_HUMAN | [view interactions] | High throughput | no | no |
GPNMB_HUMAN | [view interactions] | High throughput | no | no |
MYCBP_HUMAN | [view interactions] | High throughput | no | yes |
SPD2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TF65_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBXN1_HUMAN | [view interactions] | High throughput | no | no |
BORC6_HUMAN | [view interactions] | High throughput | no | yes |
EIF3E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CSN4_HUMAN | [view interactions] | High throughput | no | yes |
VAV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ELF3_HUMAN | [view interactions] | High throughput | no | no |
ABCF1_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
GNAS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PGH1_HUMAN | [view interactions] | Computational | no | yes |
MP2K1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FCERB_HUMAN | [view interactions] | Computational | no | no |
PLD2_HUMAN | [view interactions] | Computational | no | yes |
PLPL9_HUMAN | [view interactions] | Computational | no | yes |
PAFA_HUMAN | [view interactions] | Computational | no | no |
PGH2_HUMAN | [view interactions] | Computational | no | no |
MK11_HUMAN | [view interactions] | Computational | no | yes |
PCAT2_HUMAN | [view interactions] | Computational | no | yes |
LOX15_HUMAN | [view interactions] | Computational | no | no |
GNAQ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LYN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
MK14_HUMAN | [view interactions] | Computational | no | yes |
KSYK_HUMAN | [view interactions] | Computational | no | no |
FCERG_HUMAN | [view interactions] | Computational | no | no |
LOX5_HUMAN | [view interactions] | Computational | no | no |
FCERA_HUMAN | [view interactions] | Computational | no | yes |
MP2K2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |