SPD2A_HUMAN
Evidence for PS localization
Functions
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SPD2A_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 31.7073 | 4 | yes |
| GO:0019900 | kinase binding | 29.2683 | 4 | no |
| GO:0019901 | protein kinase binding | 29.2683 | 5 | no |
| GO:0045296 | cadherin binding | 26.8293 | 4 | no |
| GO:0000166 | nucleotide binding | 24.3902 | 4 | no |
| GO:0017076 | purine nucleotide binding | 24.3902 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 24.3902 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.3902 | 4 | no |
| GO:0043169 | cation binding | 24.3902 | 4 | no |
| GO:0003723 | RNA binding | 24.3902 | 4 | no |
| GO:0046872 | metal ion binding | 21.9512 | 5 | no |
| GO:0035091 | phosphatidylinositol binding | 12.1951 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 12.1951 | 5 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 9.7561 | 6 | yes |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 7.3171 | 5 | yes |
| GO:0010314 | phosphatidylinositol-5-phosphate binding | 7.3171 | 6 | yes |
| GO:0032266 | phosphatidylinositol-3-phosphate binding | 7.3171 | 6 | yes |
| GO:0070273 | phosphatidylinositol-4-phosphate binding | 7.3171 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SPD2A_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 58.5366 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 58.5366 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 53.6585 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 51.2195 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.7805 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 46.3415 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.9024 | 4 | no |
| GO:0008104 | protein localization | 43.9024 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 39.0244 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 39.0244 | 4 | no |
| GO:0010468 | regulation of gene expression | 39.0244 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 39.0244 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 39.0244 | 5 | no |
| GO:0006996 | organelle organization | 36.5854 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 36.5854 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 36.5854 | 5 | no |
| GO:0009966 | regulation of signal transduction | 36.5854 | 4 | no |
| GO:0022607 | cellular component assembly | 34.1463 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 31.7073 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 31.7073 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.2683 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 26.8293 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 26.8293 | 5 | no |
| GO:0036211 | protein modification process | 26.8293 | 4 | no |
| GO:0043412 | macromolecule modification | 26.8293 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.8293 | 6 | no |
| GO:0050776 | regulation of immune response | 26.8293 | 4 | no |
| GO:0051049 | regulation of transport | 26.8293 | 4 | no |
| GO:0032880 | regulation of protein localization | 26.8293 | 5 | no |
| GO:0060341 | regulation of cellular localization | 26.8293 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 24.3902 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.3902 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 24.3902 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 24.3902 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.3902 | 5 | no |
| GO:0031399 | regulation of protein modification process | 24.3902 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 24.3902 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 24.3902 | 4 | no |
| GO:0007010 | cytoskeleton organization | 21.9512 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 21.9512 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.9512 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.9512 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.9512 | 6 | no |
| GO:0032101 | regulation of response to external stimulus | 21.9512 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 21.9512 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.9512 | 4 | no |
| GO:0050778 | positive regulation of immune response | 21.9512 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.9512 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.9512 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.9512 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.9512 | 6 | no |
| GO:0001701 | in utero embryonic development | 7.3171 | 6 | yes |
| GO:0009792 | embryo development ending in birth or egg hatching | 7.3171 | 4 | yes |
| GO:0043009 | chordate embryonic development | 7.3171 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ADA15_HUMAN | [view interactions] | Low throughput | no | yes |
| SOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AF1L2_HUMAN | [view interactions] | Low throughput | no | no |
| SRC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN764_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBP1L_HUMAN | [view interactions] | High throughput | no | yes |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARK3_HUMAN | [view interactions] | High throughput | no | yes |
| PHKG2_HUMAN | [view interactions] | High throughput | no | no |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| SPD2B_HUMAN | [view interactions] | High throughput | no | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNFL6_HUMAN | [view interactions] | High throughput | no | yes |
| ADA12_HUMAN | [view interactions] | High throughput | no | no |
| ADA19_HUMAN | [view interactions] | High throughput | no | no |
| MED28_HUMAN | [view interactions] | High throughput | no | yes |
| PA24A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKB2_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| FGD1_HUMAN | [view interactions] | High throughput | no | no |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHK1_HUMAN | [view interactions] | High throughput | no | no |
| DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| MAST3_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| NADK_HUMAN | [view interactions] | High throughput | no | yes |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MPIP2_HUMAN | [view interactions] | High throughput | no | no |
| MPIP3_HUMAN | [view interactions] | High throughput | no | yes |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| CDK16_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| PTN13_HUMAN | [view interactions] | High throughput | no | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MELK_HUMAN | [view interactions] | High throughput | no | yes |
| ZN638_HUMAN | [view interactions] | High throughput | no | yes |
| PTN14_HUMAN | [view interactions] | High throughput | no | yes |
| TBC25_HUMAN | [view interactions] | High throughput | no | yes |
| M3K21_HUMAN | [view interactions] | High throughput | no | yes |
| EDC3_HUMAN | [view interactions] | High throughput | no | yes |
| SH3R3_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| PHLB2_HUMAN | [view interactions] | High throughput | no | yes |
| MYCPP_HUMAN | [view interactions] | High throughput | no | no |
| RFIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4E2_HUMAN | [view interactions] | High throughput | no | no |
| DEN4C_HUMAN | [view interactions] | High throughput | no | yes |
| AN34A_HUMAN | [view interactions] | High throughput | no | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| LARP1_HUMAN | [view interactions] | High throughput | no | yes |
| GGYF2_HUMAN | [view interactions] | High throughput | no | yes |
| SYDE1_HUMAN | [view interactions] | High throughput | no | yes |
| RGPS2_HUMAN | [view interactions] | High throughput | no | yes |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| NAV1_HUMAN | [view interactions] | High throughput | no | yes |
| F110B_HUMAN | [view interactions] | High throughput | no | yes |
| DEN1A_HUMAN | [view interactions] | High throughput | no | no |
| HDAC7_HUMAN | [view interactions] | High throughput | no | no |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| SRS12_HUMAN | [view interactions] | High throughput | no | no |
| RAB3I_HUMAN | [view interactions] | High throughput | no | no |
| MAGI1_HUMAN | [view interactions] | High throughput | no | no |
| TESK2_HUMAN | [view interactions] | High throughput | no | yes |
| SIN1_HUMAN | [view interactions] | High throughput | no | yes |
| F110A_HUMAN | [view interactions] | High throughput | no | yes |
| LPIN3_HUMAN | [view interactions] | High throughput | no | yes |
| RTKN_HUMAN | [view interactions] | High throughput | no | yes |
| OSBL6_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TANC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI13B_HUMAN | [view interactions] | High throughput | no | yes |
| INP5E_HUMAN | [view interactions] | High throughput | no | yes |
| FA53C_HUMAN | [view interactions] | High throughput | no | yes |
| SH3B4_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CING_HUMAN | [view interactions] | High throughput | no | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NGAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP21_HUMAN | [view interactions] | High throughput | no | no |
| ZBT21_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
| GAB2_HUMAN | [view interactions] | High throughput | no | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| STA13_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NETR_HUMAN | [view interactions] | High throughput | no | yes |