SPD2A_HUMAN
Evidence for PS localization
Functions
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SPD2A_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 29.4118 | 4 | no |
| GO:0019901 | protein kinase binding | 26.4706 | 5 | no |
| GO:0003723 | RNA binding | 23.5294 | 4 | no |
| GO:0045296 | cadherin binding | 23.5294 | 4 | no |
| GO:0030695 | GTPase regulator activity | 23.5294 | 4 | no |
| GO:0017076 | purine nucleotide binding | 20.5882 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 20.5882 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.5882 | 4 | no |
| GO:0010314 | phosphatidylinositol-5-phosphate binding | 8.8235 | 6 | yes |
| GO:0032266 | phosphatidylinositol-3-phosphate binding | 8.8235 | 6 | yes |
| GO:0035091 | phosphatidylinositol binding | 8.8235 | 4 | yes |
| GO:0070273 | phosphatidylinositol-4-phosphate binding | 8.8235 | 6 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 8.8235 | 5 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 5.8824 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SPD2A_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 55.8824 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 47.0588 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 47.0588 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 44.1176 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.1176 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 44.1176 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 44.1176 | 4 | no |
| GO:0009966 | regulation of signal transduction | 41.1765 | 4 | no |
| GO:0008104 | protein localization | 38.2353 | 4 | no |
| GO:0071702 | organic substance transport | 38.2353 | 4 | no |
| GO:0006996 | organelle organization | 35.2941 | 4 | no |
| GO:0071705 | nitrogen compound transport | 32.3529 | 4 | no |
| GO:0022607 | cellular component assembly | 32.3529 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 32.3529 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 29.4118 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.4118 | 5 | no |
| GO:0015031 | protein transport | 29.4118 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.4118 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 29.4118 | 5 | no |
| GO:0010468 | regulation of gene expression | 29.4118 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 29.4118 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 29.4118 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 29.4118 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 26.4706 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.4706 | 5 | no |
| GO:0006886 | intracellular protein transport | 23.5294 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.5294 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 23.5294 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.5294 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.5294 | 5 | no |
| GO:0007010 | cytoskeleton organization | 23.5294 | 5 | no |
| GO:0010941 | regulation of cell death | 23.5294 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 23.5294 | 4 | no |
| GO:0030030 | cell projection organization | 23.5294 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 23.5294 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 23.5294 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.5294 | 4 | no |
| GO:0051049 | regulation of transport | 23.5294 | 4 | no |
| GO:0051336 | regulation of hydrolase activity | 23.5294 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 23.5294 | 4 | no |
| GO:0031399 | regulation of protein modification process | 20.5882 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.5882 | 6 | no |
| GO:0007264 | small GTPase mediated signal transduction | 20.5882 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 20.5882 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 20.5882 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.5882 | 5 | no |
| GO:0033043 | regulation of organelle organization | 20.5882 | 5 | no |
| GO:0043933 | protein-containing complex organization | 20.5882 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.5882 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 20.5882 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.5882 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 20.5882 | 7 | no |
| GO:0032880 | regulation of protein localization | 20.5882 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.5882 | 4 | no |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 20.5882 | 6 | no |
| GO:0060341 | regulation of cellular localization | 20.5882 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.5882 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 20.5882 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 20.5882 | 5 | no |
| GO:0036211 | protein modification process | 20.5882 | 4 | no |
| GO:0043412 | macromolecule modification | 20.5882 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.5882 | 4 | no |
| GO:0001701 | in utero embryonic development | 5.8824 | 6 | yes |
| GO:0009792 | embryo development ending in birth or egg hatching | 5.8824 | 4 | yes |
| GO:0043009 | chordate embryonic development | 5.8824 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ADA15_HUMAN | [view interactions] | Low throughput | no | yes |
| SOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AF1L2_HUMAN | [view interactions] | Low throughput | no | no |
| SRC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TNFL6_HUMAN | [view interactions] | High throughput | no | yes |
| ADA12_HUMAN | [view interactions] | High throughput | no | no |
| ADA19_HUMAN | [view interactions] | High throughput | no | no |
| MED28_HUMAN | [view interactions] | High throughput | no | yes |
| PA24A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKB2_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| FGD1_HUMAN | [view interactions] | High throughput | no | no |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHK1_HUMAN | [view interactions] | High throughput | no | no |
| DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| MAST3_HUMAN | [view interactions] | High throughput | no | yes |
| KIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| NADK_HUMAN | [view interactions] | High throughput | no | yes |
| NF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MPIP2_HUMAN | [view interactions] | High throughput | no | no |
| MPIP3_HUMAN | [view interactions] | High throughput | no | yes |
| AFAD_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| CDK16_HUMAN | [view interactions] | High throughput | no | yes |
| PTN13_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MELK_HUMAN | [view interactions] | High throughput | no | yes |
| ZN638_HUMAN | [view interactions] | High throughput | no | yes |
| PTN14_HUMAN | [view interactions] | High throughput | no | yes |
| TBC25_HUMAN | [view interactions] | High throughput | no | yes |
| M3K21_HUMAN | [view interactions] | High throughput | no | yes |
| EDC3_HUMAN | [view interactions] | High throughput | no | yes |
| SH3R3_HUMAN | [view interactions] | High throughput | no | yes |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| PHLB2_HUMAN | [view interactions] | High throughput | no | yes |
| MYCPP_HUMAN | [view interactions] | High throughput | no | no |
| RFIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4E2_HUMAN | [view interactions] | High throughput | no | no |
| DEN4C_HUMAN | [view interactions] | High throughput | no | yes |
| AN34A_HUMAN | [view interactions] | High throughput | no | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| LARP1_HUMAN | [view interactions] | High throughput | no | yes |
| GGYF2_HUMAN | [view interactions] | High throughput | no | yes |
| SYDE1_HUMAN | [view interactions] | High throughput | no | yes |
| RGPS2_HUMAN | [view interactions] | High throughput | no | yes |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| NAV1_HUMAN | [view interactions] | High throughput | no | yes |
| F110B_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC7_HUMAN | [view interactions] | High throughput | no | no |
| DEN1A_HUMAN | [view interactions] | High throughput | no | no |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| SRS12_HUMAN | [view interactions] | High throughput | no | no |
| RAB3I_HUMAN | [view interactions] | High throughput | no | no |
| MAGI1_HUMAN | [view interactions] | High throughput | no | no |
| TESK2_HUMAN | [view interactions] | High throughput | no | yes |
| SIN1_HUMAN | [view interactions] | High throughput | no | yes |
| F110A_HUMAN | [view interactions] | High throughput | no | yes |
| LPIN3_HUMAN | [view interactions] | High throughput | no | yes |
| RTKN_HUMAN | [view interactions] | High throughput | no | yes |
| OSBL6_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TANC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI13B_HUMAN | [view interactions] | High throughput | no | yes |
| INP5E_HUMAN | [view interactions] | High throughput | no | yes |
| FA53C_HUMAN | [view interactions] | High throughput | no | yes |
| SH3B4_HUMAN | [view interactions] | High throughput | no | yes |
| LRFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CING_HUMAN | [view interactions] | High throughput | no | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NGAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP21_HUMAN | [view interactions] | High throughput | no | no |
| ZBT21_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GAB2_HUMAN | [view interactions] | High throughput | no | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| STA13_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NETR_HUMAN | [view interactions] | High throughput | no | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN764_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBP1L_HUMAN | [view interactions] | High throughput | no | yes |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| SPD2B_HUMAN | [view interactions] | High throughput | no | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| COF1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| WASL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CY24A_HUMAN | [view interactions] | Computational | no | no |
| NOXA1_HUMAN | [view interactions] | Computational | no | yes |