MARK1_HUMAN
Evidence for PS localization
Functions
Serine/threonine-protein kinase (PubMed). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MARK1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 34.2105 | 4 | yes |
| GO:0046872 | metal ion binding | 34.2105 | 5 | yes |
| GO:0043168 | anion binding | 28.9474 | 4 | yes |
| GO:0003723 | RNA binding | 26.3158 | 4 | no |
| GO:0000166 | nucleotide binding | 23.6842 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 23.6842 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 23.6842 | 4 | yes |
| GO:0019900 | kinase binding | 23.6842 | 4 | no |
| GO:0019901 | protein kinase binding | 23.6842 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.0526 | 4 | yes |
| GO:0003779 | actin binding | 21.0526 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 15.7895 | 6 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 15.7895 | 5 | yes |
| GO:0035091 | phosphatidylinositol binding | 15.7895 | 4 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 15.7895 | 5 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 15.7895 | 6 | yes |
| GO:0000287 | magnesium ion binding | 13.1579 | 6 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 13.1579 | 4 | yes |
| GO:0005524 | ATP binding | 13.1579 | 5 | yes |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 13.1579 | 5 | yes |
| GO:0016301 | kinase activity | 13.1579 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 13.1579 | 4 | yes |
| GO:0048156 | tau protein binding | 13.1579 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 13.1579 | 4 | yes |
| GO:0050321 | tau-protein kinase activity | 7.8947 | 4 | yes |
| GO:0070300 | phosphatidic acid binding | 5.2632 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MARK1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.1579 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 60.5263 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 57.8947 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 55.2632 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 47.3684 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 44.7368 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 44.7368 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 44.7368 | 4 | yes |
| GO:0010468 | regulation of gene expression | 44.7368 | 6 | yes |
| GO:0051049 | regulation of transport | 42.1053 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.4737 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 39.4737 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 39.4737 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 39.4737 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 39.4737 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 39.4737 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 39.4737 | 4 | yes |
| GO:0010646 | regulation of cell communication | 36.8421 | 4 | no |
| GO:0006996 | organelle organization | 36.8421 | 4 | yes |
| GO:0008104 | protein localization | 34.2105 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 31.5789 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 31.5789 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 31.5789 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 28.9474 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 28.9474 | 6 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 28.9474 | 6 | yes |
| GO:0022607 | cellular component assembly | 28.9474 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 28.9474 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 28.9474 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.3158 | 6 | yes |
| GO:0036211 | protein modification process | 26.3158 | 4 | yes |
| GO:0043412 | macromolecule modification | 26.3158 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 26.3158 | 6 | no |
| GO:0031399 | regulation of protein modification process | 26.3158 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.3158 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 23.6842 | 7 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 23.6842 | 6 | no |
| GO:0060341 | regulation of cellular localization | 23.6842 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 23.6842 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 21.0526 | 5 | yes |
| GO:0051093 | negative regulation of developmental process | 21.0526 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.0526 | 6 | yes |
| GO:0034762 | regulation of transmembrane transport | 21.0526 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 21.0526 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 21.0526 | 7 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.0526 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 21.0526 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.0526 | 6 | no |
| GO:0032880 | regulation of protein localization | 21.0526 | 5 | no |
| GO:0071702 | organic substance transport | 21.0526 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.0526 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 21.0526 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.0526 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.0526 | 4 | no |
| GO:0030030 | cell projection organization | 21.0526 | 4 | no |
| GO:0031175 | neuron projection development | 21.0526 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.0526 | 5 | no |
| GO:0007010 | cytoskeleton organization | 21.0526 | 5 | yes |
| GO:0010629 | negative regulation of gene expression | 18.4211 | 7 | yes |
| GO:0010975 | regulation of neuron projection development | 18.4211 | 7 | yes |
| GO:0016310 | phosphorylation | 18.4211 | 5 | yes |
| GO:0045596 | negative regulation of cell differentiation | 18.4211 | 5 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 18.4211 | 4 | yes |
| GO:0006468 | protein phosphorylation | 18.4211 | 5 | yes |
| GO:0001764 | neuron migration | 13.1579 | 4 | yes |
| GO:0050773 | regulation of dendrite development | 10.5263 | 4 | yes |
| GO:0016055 | Wnt signaling pathway | 7.8947 | 4 | yes |
| GO:0018105 | peptidyl-serine phosphorylation | 7.8947 | 6 | yes |
| GO:0018193 | peptidyl-amino acid modification | 7.8947 | 5 | yes |
| GO:0018209 | peptidyl-serine modification | 7.8947 | 6 | yes |
| GO:0051654 | establishment of mitochondrion localization | 7.8947 | 4 | yes |
| GO:0010717 | regulation of epithelial to mesenchymal transition | 5.2632 | 5 | yes |
| GO:0010719 | negative regulation of epithelial to mesenchymal transition | 5.2632 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UBP21_HUMAN | [view interactions] | Low throughput | no | no |
| STK11_HUMAN | [view interactions] | Low throughput | no | yes |
| LATS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HGFL_HUMAN | [view interactions] | Low throughput | no | no |
| SCRIB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| MARK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MTAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAP4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC20_HUMAN | [view interactions] | High throughput | no | no |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| SF3A2_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEIOC_HUMAN | [view interactions] | High throughput | no | no |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| CXA5_HUMAN | [view interactions] | High throughput | no | yes |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| TCL1B_HUMAN | [view interactions] | High throughput | no | no |
| INCA1_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C102B_HUMAN | [view interactions] | High throughput | no | yes |
| YAF2_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CERT_HUMAN | [view interactions] | High throughput | no | yes |
| CAD19_HUMAN | [view interactions] | High throughput | no | no |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI11_HUMAN | [view interactions] | High throughput | no | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PNMA2_HUMAN | [view interactions] | High throughput | no | yes |
| APBA1_HUMAN | [view interactions] | High throughput | no | no |
| CE85L_HUMAN | [view interactions] | High throughput | no | yes |
| GPSM3_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| UTRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| FUCO_HUMAN | [view interactions] | High throughput | no | yes |
| SNTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGO1_HUMAN | [view interactions] | High throughput | no | no |
| AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGO3_HUMAN | [view interactions] | High throughput | no | yes |
| AGO4_HUMAN | [view interactions] | High throughput | no | no |
| SNTB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| DHR12_HUMAN | [view interactions] | High throughput | no | yes |
| SPD2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DTNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DTNB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDX6L_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R2_HUMAN | [view interactions] | High throughput | no | no |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| MARK3_HUMAN | [view interactions] | High throughput | no | yes |
| MARK4_HUMAN | [view interactions] | High throughput | no | yes |
| GRRE1_HUMAN | [view interactions] | High throughput | no | no |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |