Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MARK1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Serine/threonine-protein kinase (PubMed). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MARK1_HUMAN
GO:0046872 metal ion binding 28.5714 4 yes
GO:0019900 kinase binding 28.5714 4 no
GO:0019901 protein kinase binding 28.5714 5 no
GO:0017076 purine nucleotide binding 25.0000 4 yes
GO:0032555 purine ribonucleotide binding 25.0000 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 yes
GO:0003723 RNA binding 25.0000 4 no
GO:0003779 actin binding 21.4286 4 no
GO:0045296 cadherin binding 21.4286 4 no
GO:0035091 phosphatidylinositol binding 17.8571 4 yes
GO:0048156 tau protein binding 17.8571 4 yes
GO:1901981 phosphatidylinositol phosphate binding 17.8571 5 yes
GO:1902936 phosphatidylinositol bisphosphate binding 17.8571 6 yes
GO:0000287 magnesium ion binding 14.2857 5 yes
GO:0004674 protein serine/threonine kinase activity 14.2857 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 14.2857 4 yes
GO:0005524 ATP binding 14.2857 5 yes
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 14.2857 4 yes
GO:0016301 kinase activity 14.2857 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 14.2857 4 yes
GO:0030554 adenyl nucleotide binding 14.2857 5 yes
GO:0032559 adenyl ribonucleotide binding 14.2857 5 yes
GO:0106310 protein serine kinase activity 14.2857 4 yes
GO:0050321 tau-protein kinase activity 10.7143 4 yes
GO:0070300 phosphatidic acid binding 7.1429 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MARK1_HUMAN
GO:0060255 regulation of macromolecule metabolic process 75.0000 4 yes
GO:0048523 negative regulation of cellular process 71.4286 4 yes
GO:0048522 positive regulation of cellular process 64.2857 4 no
GO:0051128 regulation of cellular component organization 53.5714 4 yes
GO:0051049 regulation of transport 53.5714 4 no
GO:0031323 regulation of cellular metabolic process 53.5714 4 no
GO:0080090 regulation of primary metabolic process 53.5714 4 no
GO:0010468 regulation of gene expression 50.0000 5 yes
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0006996 organelle organization 46.4286 4 yes
GO:0009892 negative regulation of metabolic process 46.4286 4 yes
GO:0009893 positive regulation of metabolic process 46.4286 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 46.4286 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 46.4286 5 yes
GO:0045595 regulation of cell differentiation 42.8571 4 yes
GO:0010646 regulation of cell communication 42.8571 4 no
GO:0051246 regulation of protein metabolic process 39.2857 5 no
GO:0008104 protein localization 39.2857 4 no
GO:0071702 organic substance transport 39.2857 4 no
GO:0071705 nitrogen compound transport 39.2857 4 no
GO:0009966 regulation of signal transduction 35.7143 4 no
GO:0031324 negative regulation of cellular metabolic process 35.7143 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 35.7143 5 no
GO:0007010 cytoskeleton organization 32.1429 5 yes
GO:0031344 regulation of cell projection organization 32.1429 5 yes
GO:0036211 protein modification process 32.1429 4 yes
GO:0043412 macromolecule modification 32.1429 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 32.1429 6 yes
GO:0019220 regulation of phosphate metabolic process 32.1429 6 no
GO:0031399 regulation of protein modification process 32.1429 6 no
GO:0051174 regulation of phosphorus metabolic process 32.1429 5 no
GO:0071310 cellular response to organic substance 32.1429 4 no
GO:0043269 regulation of ion transport 32.1429 5 no
GO:0006796 phosphate-containing compound metabolic process 28.5714 4 yes
GO:0051093 negative regulation of developmental process 28.5714 4 yes
GO:0042127 regulation of cell population proliferation 28.5714 4 no
GO:0010941 regulation of cell death 28.5714 4 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 28.5714 5 no
GO:1901701 cellular response to oxygen-containing compound 28.5714 4 no
GO:0015031 protein transport 28.5714 4 no
GO:0034762 regulation of transmembrane transport 28.5714 4 no
GO:0034765 regulation of ion transmembrane transport 28.5714 5 no
GO:1904062 regulation of cation transmembrane transport 28.5714 6 no
GO:0010628 positive regulation of gene expression 25.0000 6 yes
GO:0010975 regulation of neuron projection development 25.0000 7 yes
GO:0045596 negative regulation of cell differentiation 25.0000 5 yes
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 yes
GO:0022607 cellular component assembly 25.0000 4 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:0006886 intracellular protein transport 25.0000 4 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0022898 regulation of transmembrane transporter activity 25.0000 4 no
GO:0042981 regulation of apoptotic process 25.0000 6 no
GO:0043067 regulation of programmed cell death 25.0000 5 no
GO:0006468 protein phosphorylation 21.4286 5 yes
GO:0010629 negative regulation of gene expression 21.4286 6 yes
GO:0016310 phosphorylation 21.4286 5 yes
GO:0060341 regulation of cellular localization 21.4286 4 no
GO:2000026 regulation of multicellular organismal development 21.4286 4 no
GO:0010563 negative regulation of phosphorus metabolic process 21.4286 6 no
GO:0022603 regulation of anatomical structure morphogenesis 21.4286 4 no
GO:0031400 negative regulation of protein modification process 21.4286 7 no
GO:0043549 regulation of kinase activity 21.4286 5 no
GO:0045936 negative regulation of phosphate metabolic process 21.4286 7 no
GO:0051129 negative regulation of cellular component organization 21.4286 5 no
GO:0051336 regulation of hydrolase activity 21.4286 4 no
GO:0051338 regulation of transferase activity 21.4286 4 no
GO:1902531 regulation of intracellular signal transduction 21.4286 5 no
GO:0001932 regulation of protein phosphorylation 21.4286 7 no
GO:0010243 response to organonitrogen compound 21.4286 4 no
GO:0071417 cellular response to organonitrogen compound 21.4286 4 no
GO:1901699 cellular response to nitrogen compound 21.4286 4 no
GO:0009889 regulation of biosynthetic process 21.4286 4 no
GO:0010556 regulation of macromolecule biosynthetic process 21.4286 5 no
GO:0031326 regulation of cellular biosynthetic process 21.4286 5 no
GO:0010959 regulation of metal ion transport 21.4286 6 no
GO:0032412 regulation of ion transmembrane transporter activity 21.4286 5 no
GO:0060548 negative regulation of cell death 21.4286 5 no
GO:0051726 regulation of cell cycle 21.4286 4 no
GO:0023056 positive regulation of signaling 21.4286 4 no
GO:0001764 neuron migration 17.8571 4 yes
GO:0050773 regulation of dendrite development 14.2857 4 yes
GO:0016055 Wnt signaling pathway 10.7143 5 yes
GO:0018105 peptidyl-serine phosphorylation 10.7143 6 yes
GO:0018193 peptidyl-amino acid modification 10.7143 5 yes
GO:0018209 peptidyl-serine modification 10.7143 6 yes
GO:0051654 establishment of mitochondrion localization 10.7143 4 yes
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 10.7143 4 yes
GO:0010717 regulation of epithelial to mesenchymal transition 7.1429 5 yes
GO:0010719 negative regulation of epithelial to mesenchymal transition 7.1429 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UBP21_HUMAN [view interactions] Low throughput no no
SCRIB_HUMAN [view entry] [view interactions] Low throughput yes no
HGFL_HUMAN [view interactions] Low throughput no no
LATS1_HUMAN [view interactions] Low throughput no yes
STK11_HUMAN [view interactions] Low throughput no yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRK2_HUMAN [view interactions] Low throughput no yes
MARK1_HUMAN [view entry] [view interactions] Low throughput yes no
MTAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
MAP4_HUMAN [view entry] [view interactions] Low throughput yes no
UBP7_HUMAN [view interactions] High throughput no yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
MARK2_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
CDC20_HUMAN [view interactions] High throughput no no
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
NEK4_HUMAN [view interactions] High throughput no yes
SF3A2_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
DAPK1_HUMAN [view entry] [view interactions] High throughput yes yes
MEIOC_HUMAN [view interactions] High throughput no no
CXA5_HUMAN [view interactions] High throughput no yes
DYLT1_HUMAN [view interactions] High throughput no no
TCL1B_HUMAN [view interactions] High throughput no no
INCA1_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
C102B_HUMAN [view interactions] High throughput no yes
YAF2_HUMAN [view interactions] High throughput no yes
AAPK1_HUMAN [view interactions] High throughput no no
HECW2_HUMAN [view entry] [view interactions] High throughput yes no
CERT_HUMAN [view interactions] High throughput no yes
CAD19_HUMAN [view interactions] High throughput no no
TNIP2_HUMAN [view interactions] High throughput no yes
TRI11_HUMAN [view interactions] High throughput no yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
PNMA2_HUMAN [view interactions] High throughput no yes
APBA1_HUMAN [view interactions] High throughput no no
CE85L_HUMAN [view interactions] High throughput no yes
GPSM3_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
UTRN_HUMAN [view entry] [view interactions] High throughput yes yes
MARK4_HUMAN [view interactions] High throughput no yes
GRRE1_HUMAN [view interactions] High throughput no no
CK052_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes