Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MTAP2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MTAP2_HUMAN
GO:0046872 metal ion binding 36.2069 4 no
GO:0019900 kinase binding 31.0345 4 no
GO:0019901 protein kinase binding 29.3103 5 no
GO:0017076 purine nucleotide binding 27.5862 4 no
GO:0032555 purine ribonucleotide binding 27.5862 4 no
GO:0030554 adenyl nucleotide binding 24.1379 5 no
GO:0032559 adenyl ribonucleotide binding 24.1379 5 no
GO:0035639 purine ribonucleoside triphosphate binding 24.1379 4 no
GO:0005524 ATP binding 20.6897 5 no
GO:0015631 tubulin binding 18.9655 4 yes
GO:0048156 tau protein binding 18.9655 4 yes
GO:0008017 microtubule binding 12.0690 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MTAP2_HUMAN
GO:0048522 positive regulation of cellular process 65.5172 4 yes
GO:0048523 negative regulation of cellular process 58.6207 4 yes
GO:0051128 regulation of cellular component organization 55.1724 4 yes
GO:0010646 regulation of cell communication 53.4483 4 no
GO:0060255 regulation of macromolecule metabolic process 53.4483 4 no
GO:0080090 regulation of primary metabolic process 51.7241 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0051246 regulation of protein metabolic process 48.2759 5 no
GO:0009893 positive regulation of metabolic process 44.8276 4 no
GO:0006996 organelle organization 44.8276 4 yes
GO:0022607 cellular component assembly 41.3793 4 no
GO:0009966 regulation of signal transduction 39.6552 4 no
GO:0010604 positive regulation of macromolecule metabolic process 39.6552 5 no
GO:0030030 cell projection organization 39.6552 4 yes
GO:0051049 regulation of transport 37.9310 4 yes
GO:0031325 positive regulation of cellular metabolic process 36.2069 5 no
GO:0050804 modulation of chemical synaptic transmission 36.2069 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 36.2069 5 no
GO:0099177 regulation of trans-synaptic signaling 36.2069 4 no
GO:0019220 regulation of phosphate metabolic process 36.2069 6 no
GO:0042325 regulation of phosphorylation 36.2069 7 no
GO:0051174 regulation of phosphorus metabolic process 36.2069 5 no
GO:0120036 plasma membrane bounded cell projection organization 34.4828 5 yes
GO:0031399 regulation of protein modification process 34.4828 6 no
GO:0007010 cytoskeleton organization 34.4828 5 yes
GO:0051247 positive regulation of protein metabolic process 32.7586 6 no
GO:0036211 protein modification process 32.7586 4 no
GO:0043412 macromolecule modification 32.7586 4 no
GO:0043549 regulation of kinase activity 32.7586 5 no
GO:0051338 regulation of transferase activity 32.7586 4 no
GO:0031344 regulation of cell projection organization 32.7586 5 yes
GO:0060341 regulation of cellular localization 31.0345 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 31.0345 6 yes
GO:0010468 regulation of gene expression 31.0345 5 no
GO:0043085 positive regulation of catalytic activity 31.0345 4 no
GO:0001932 regulation of protein phosphorylation 31.0345 7 no
GO:0009892 negative regulation of metabolic process 31.0345 4 no
GO:0010605 negative regulation of macromolecule metabolic process 31.0345 5 no
GO:0006796 phosphate-containing compound metabolic process 29.3103 4 no
GO:0031324 negative regulation of cellular metabolic process 29.3103 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 29.3103 5 no
GO:0051130 positive regulation of cellular component organization 29.3103 5 no
GO:0031175 neuron projection development 29.3103 6 yes
GO:0044087 regulation of cellular component biogenesis 29.3103 4 yes
GO:0051050 positive regulation of transport 27.5862 4 yes
GO:0043933 protein-containing complex organization 27.5862 4 no
GO:0045859 regulation of protein kinase activity 27.5862 6 no
GO:0010243 response to organonitrogen compound 25.8621 4 no
GO:0010562 positive regulation of phosphorus metabolic process 25.8621 6 no
GO:0042327 positive regulation of phosphorylation 25.8621 8 no
GO:0045937 positive regulation of phosphate metabolic process 25.8621 7 no
GO:0034762 regulation of transmembrane transport 24.1379 4 no
GO:0043269 regulation of ion transport 24.1379 5 no
GO:0065003 protein-containing complex assembly 24.1379 5 no
GO:0071310 cellular response to organic substance 24.1379 4 no
GO:0051248 negative regulation of protein metabolic process 24.1379 6 no
GO:0033674 positive regulation of kinase activity 24.1379 6 no
GO:0051347 positive regulation of transferase activity 24.1379 5 no
GO:1902531 regulation of intracellular signal transduction 24.1379 5 no
GO:0034330 cell junction organization 24.1379 4 no
GO:0022603 regulation of anatomical structure morphogenesis 24.1379 4 yes
GO:0032880 regulation of protein localization 24.1379 5 yes
GO:0033043 regulation of organelle organization 24.1379 5 yes
GO:0051129 negative regulation of cellular component organization 22.4138 5 yes
GO:0009889 regulation of biosynthetic process 22.4138 4 no
GO:0031326 regulation of cellular biosynthetic process 22.4138 5 no
GO:0034765 regulation of ion transmembrane transport 22.4138 5 no
GO:0050890 cognition 22.4138 4 no
GO:1901701 cellular response to oxygen-containing compound 22.4138 4 no
GO:0010941 regulation of cell death 22.4138 4 no
GO:0051726 regulation of cell cycle 22.4138 4 no
GO:0016310 phosphorylation 22.4138 5 no
GO:0008104 protein localization 22.4138 4 no
GO:0010975 regulation of neuron projection development 22.4138 7 yes
GO:0032990 cell part morphogenesis 22.4138 4 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 20.6897 6 yes
GO:1902903 regulation of supramolecular fiber organization 20.6897 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 20.6897 5 no
GO:0010647 positive regulation of cell communication 20.6897 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.6897 5 no
GO:0023056 positive regulation of signaling 20.6897 4 no
GO:0048584 positive regulation of response to stimulus 20.6897 4 no
GO:0051336 regulation of hydrolase activity 20.6897 4 no
GO:1904062 regulation of cation transmembrane transport 20.6897 6 no
GO:0010648 negative regulation of cell communication 20.6897 5 no
GO:0023057 negative regulation of signaling 20.6897 4 no
GO:0048585 negative regulation of response to stimulus 20.6897 4 no
GO:0031400 negative regulation of protein modification process 20.6897 7 no
GO:0071900 regulation of protein serine/threonine kinase activity 20.6897 7 no
GO:0001934 positive regulation of protein phosphorylation 20.6897 8 no
GO:0031401 positive regulation of protein modification process 20.6897 7 no
GO:0048812 neuron projection morphogenesis 20.6897 7 yes
GO:0048858 cell projection morphogenesis 20.6897 5 yes
GO:0043254 regulation of protein-containing complex assembly 18.9655 5 yes
GO:0043393 regulation of protein binding 18.9655 4 yes
GO:0051493 regulation of cytoskeleton organization 17.2414 6 yes
GO:0045595 regulation of cell differentiation 17.2414 4 yes
GO:0070507 regulation of microtubule cytoskeleton organization 15.5172 5 yes
GO:0032271 regulation of protein polymerization 15.5172 6 yes
GO:0032886 regulation of microtubule-based process 15.5172 4 yes
GO:0050770 regulation of axonogenesis 13.7931 5 yes
GO:0010639 negative regulation of organelle organization 13.7931 6 yes
GO:0031110 regulation of microtubule polymerization or depolymerization 13.7931 6 yes
GO:0031113 regulation of microtubule polymerization 13.7931 6 yes
GO:0032386 regulation of intracellular transport 13.7931 5 yes
GO:0051093 negative regulation of developmental process 12.0690 4 yes
GO:0051960 regulation of nervous system development 12.0690 5 yes
GO:0060284 regulation of cell development 12.0690 5 yes
GO:2000026 regulation of multicellular organismal development 12.0690 4 yes
GO:0001558 regulation of cell growth 12.0690 4 yes
GO:0031345 negative regulation of cell projection organization 12.0690 6 yes
GO:0050767 regulation of neurogenesis 12.0690 6 yes
GO:0051241 negative regulation of multicellular organismal process 10.3448 4 yes
GO:1902904 negative regulation of supramolecular fiber organization 10.3448 6 yes
GO:0032388 positive regulation of intracellular transport 10.3448 5 yes
GO:0048638 regulation of developmental growth 10.3448 4 yes
GO:0051494 negative regulation of cytoskeleton organization 8.6207 7 yes
GO:0061387 regulation of extent of cell growth 8.6207 5 yes
GO:1904526 regulation of microtubule binding 8.6207 5 yes
GO:0030516 regulation of axon extension 8.6207 5 yes
GO:0031111 negative regulation of microtubule polymerization or depolymerization 8.6207 7 yes
GO:0031333 negative regulation of protein-containing complex assembly 8.6207 6 yes
GO:0045596 negative regulation of cell differentiation 8.6207 5 yes
GO:0048666 neuron development 8.6207 4 yes
GO:0051100 negative regulation of binding 6.8966 4 yes
GO:0001578 microtubule bundle formation 6.8966 4 yes
GO:0010977 negative regulation of neuron projection development 6.8966 7 yes
GO:0031115 negative regulation of microtubule polymerization 6.8966 7 yes
GO:0032272 negative regulation of protein polymerization 6.8966 7 yes
GO:0050768 negative regulation of neurogenesis 5.1724 6 yes
GO:0050771 negative regulation of axonogenesis 5.1724 6 yes
GO:0051961 negative regulation of nervous system development 5.1724 5 yes
GO:1903649 regulation of cytoplasmic transport 5.1724 6 yes
GO:0010721 negative regulation of cell development 5.1724 6 yes
GO:0021954 central nervous system neuron development 5.1724 5 yes
GO:0030308 negative regulation of cell growth 5.1724 5 yes
GO:0032091 negative regulation of protein binding 5.1724 5 yes
GO:0045926 negative regulation of growth 5.1724 4 yes
GO:0048813 dendrite morphogenesis 5.1724 8 yes
GO:0060632 regulation of microtubule-based movement 3.4483 5 yes
GO:1901608 regulation of vesicle transport along microtubule 3.4483 7 yes
GO:1901610 positive regulation of vesicle transport along microtubule 3.4483 6 yes
GO:1901951 regulation of anterograde dense core granule transport 3.4483 8 yes
GO:1901953 positive regulation of anterograde dense core granule transport 3.4483 7 yes
GO:1902513 regulation of organelle transport along microtubule 3.4483 6 yes
GO:1902803 regulation of synaptic vesicle transport 3.4483 5 yes
GO:1902805 positive regulation of synaptic vesicle transport 3.4483 5 yes
GO:1903651 positive regulation of cytoplasmic transport 3.4483 6 yes
GO:1903742 regulation of anterograde synaptic vesicle transport 3.4483 6 yes
GO:1903744 positive regulation of anterograde synaptic vesicle transport 3.4483 6 yes
GO:1904527 negative regulation of microtubule binding 3.4483 6 yes
GO:1904809 regulation of dense core granule transport 3.4483 7 yes
GO:1904811 positive regulation of dense core granule transport 3.4483 7 yes
GO:0030517 negative regulation of axon extension 3.4483 6 yes
GO:0048640 negative regulation of developmental growth 3.4483 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in MTAP2_HUMAN
DOID:0080000 muscular disease 3.4483 3 no
DOID:0110274 autosomal recessive limb-girdle muscular dystrophy 3.4483 8 no
DOID:11724 limb-girdle muscular dystrophy 3.4483 7 no
DOID:423 myopathy 3.4483 5 no
DOID:66 muscle tissue disease 3.4483 4 no
DOID:9884 muscular dystrophy 3.4483 6 no
DOID:0050700 cardiomyopathy 3.4483 4 no
DOID:0060036 intrinsic cardiomyopathy 3.4483 5 no
DOID:114 heart disease 3.4483 3 no
DOID:2843 long QT syndrome 3.4483 6 no
DOID:1289 neurodegenerative disease 3.4483 4 no
DOID:331 central nervous system disease 3.4483 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CP110_HUMAN [view interactions] Low throughput no yes
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
KNDC1_HUMAN [view interactions] Low throughput no no
SYN1_HUMAN [view entry] [view interactions] Low throughput yes no
CPEB1_HUMAN [view entry] [view interactions] Low throughput yes no
DGKZ_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
DGKI_HUMAN [view entry] [view interactions] Low throughput yes no
CADM1_HUMAN [view entry] [view interactions] Low throughput yes no
VAC14_HUMAN [view entry] [view interactions] Low throughput yes yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
KCC2D_HUMAN [view entry] [view interactions] Low throughput yes yes
RUSC1_HUMAN [view entry] [view interactions] Low throughput yes yes
TBB3_HUMAN [view entry] [view interactions] Low throughput yes yes
MYO7A_HUMAN [view interactions] Low throughput no yes
DAG1_HUMAN [view entry] [view interactions] Low throughput yes no
TBA1A_HUMAN [view entry] [view interactions] Low throughput yes yes
SMO_HUMAN [view interactions] Low throughput no yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
NFL_HUMAN [view entry] [view interactions] Low throughput yes yes
MTAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
PLEC_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTB_HUMAN [view entry] [view interactions] Low throughput yes no
MARK4_HUMAN [view interactions] Low throughput no yes
MARK3_HUMAN [view interactions] Low throughput no yes
MARK1_HUMAN [view entry] [view interactions] Low throughput yes no
RAE1L_HUMAN [view interactions] Low throughput no no
NEUM_HUMAN [view entry] [view interactions] Low throughput yes yes
ADIP_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
DHB12_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
LRRK2_HUMAN [view interactions] High throughput no yes
MTR1B_HUMAN [view interactions] High throughput no yes
PSN1_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
PTBP3_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
PTPRT_HUMAN [view entry] [view interactions] High throughput yes yes
JUNB_HUMAN [view interactions] High throughput no yes
PEBB_HUMAN [view interactions] High throughput no no
SCHI1_HUMAN [view interactions] High throughput no yes
MDM2_HUMAN [view interactions] High throughput no yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] High throughput yes no
ATX3_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
KTNA1_HUMAN [view interactions] High throughput no yes
HECW2_HUMAN [view entry] [view interactions] High throughput yes no
ARMC1_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
NUFP1_HUMAN [view interactions] High throughput no yes
DGUOK_HUMAN [view interactions] High throughput no yes
KAP3_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
GLUC_HUMAN [view interactions] High throughput no no
FBXW8_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
INS_HUMAN [view interactions] High throughput no no
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
KAPCG_HUMAN [view interactions] High throughput no no
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
KAPCB_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3A_HUMAN [view interactions] High throughput no yes
KAP2_HUMAN [view entry] [view interactions] High throughput yes yes
THB_HUMAN [view interactions] High throughput no no
CNTP2_HUMAN [view entry] [view interactions] High throughput yes yes
NED4L_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
DHX9_HUMAN [view interactions] High throughput no yes
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
ROA0_HUMAN [view interactions] High throughput no yes
IF2B3_HUMAN [view interactions] High throughput no no
ABCF1_HUMAN [view interactions] High throughput no yes
DIM1_HUMAN [view interactions] High throughput no yes
EIF3C_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3K_HUMAN [view interactions] High throughput no yes
NMT1_HUMAN [view interactions] High throughput no yes
PA2G4_HUMAN [view interactions] High throughput no yes
YBOX1_HUMAN [view interactions] High throughput no yes
PRS8_HUMAN [view interactions] High throughput no yes
PSD13_HUMAN [view interactions] High throughput no yes
PSMD8_HUMAN [view interactions] High throughput no yes
RL23A_HUMAN [view entry] [view interactions] High throughput yes yes
EIFCL_HUMAN [view interactions] High throughput no yes
APOE_HUMAN [view entry] [view interactions] High throughput yes yes
STMN3_HUMAN [view interactions] High throughput no yes
VISL1_HUMAN [view entry] [view interactions] High throughput yes no
TTBK1_HUMAN [view interactions] High throughput no yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
TRI36_HUMAN [view interactions] High throughput no no
NEST_HUMAN [view interactions] Computational no no
MAP1B_HUMAN [view entry] [view interactions] Computational yes yes
BRSK2_HUMAN [view interactions] Computational no no
BRSK1_HUMAN [view entry] [view interactions] Computational yes no
SYPH_HUMAN [view entry] [view interactions] Computational yes yes
MARK2_HUMAN [view entry] [view interactions] Computational yes yes
S100B_HUMAN [view entry] [view interactions] Computational yes yes
RFOX3_HUMAN [view interactions] Computational no yes