MTAP2_HUMAN
Evidence for PS localization
Functions
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
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Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
![](/static/images/legend2.gif)
Network
Isoforms
Interacting regions
Canonical [MTAP2_HUMAN]
Isoform [A8MZ31] alignment
Isoform [E7EV03] alignment
Isoform [H7BZB9] alignment
Isoform [A0A024R3Z1] alignment
Isoform [P11137-2] alignment
Isoform [P11137-3] alignment
Isoform [P11137-4] alignment
Isoform [A0A669KB77] alignment
LOADING 95%
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Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in MTAP2_HUMAN |
---|---|---|---|---|
GO:0043169 | cation binding | 37.6812 | 4 | no |
GO:0046872 | metal ion binding | 37.6812 | 5 | no |
GO:0019900 | kinase binding | 34.7826 | 4 | no |
GO:0019901 | protein kinase binding | 31.8841 | 5 | no |
GO:0043168 | anion binding | 28.9855 | 4 | no |
GO:0000166 | nucleotide binding | 24.6377 | 4 | no |
GO:0017076 | purine nucleotide binding | 24.6377 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 24.6377 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 21.7391 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 20.2899 | 6 | no |
GO:0032559 | adenyl ribonucleotide binding | 20.2899 | 5 | no |
GO:0003723 | RNA binding | 20.2899 | 4 | no |
GO:0015631 | tubulin binding | 14.4928 | 4 | yes |
GO:0048156 | tau protein binding | 14.4928 | 4 | yes |
GO:0008017 | microtubule binding | 8.6957 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in MTAP2_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 65.2174 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 63.7681 | 4 | yes |
GO:0010646 | regulation of cell communication | 59.4203 | 4 | no |
GO:0051128 | regulation of cellular component organization | 59.4203 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 53.6232 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 53.6232 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 52.1739 | 4 | no |
GO:0009966 | regulation of signal transduction | 47.8261 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 44.9275 | 5 | no |
GO:0022607 | cellular component assembly | 44.9275 | 4 | no |
GO:0051049 | regulation of transport | 44.9275 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 39.1304 | 4 | no |
GO:0008104 | protein localization | 39.1304 | 4 | no |
GO:0006996 | organelle organization | 39.1304 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 37.6812 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 36.2319 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 36.2319 | 4 | no |
GO:0010468 | regulation of gene expression | 36.2319 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 36.2319 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 36.2319 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 36.2319 | 5 | no |
GO:0030030 | cell projection organization | 36.2319 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 34.7826 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 34.7826 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 34.7826 | 6 | no |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ABCF1_HUMAN | [view interactions] | High throughput | no | yes |
ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ACTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ADIP_HUMAN | [view interactions] | High throughput | no | yes |
AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
ATX3_HUMAN | [view interactions] | High throughput | no | yes |
BRSK2_HUMAN | [view interactions] | High throughput | no | no |
CADM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CP110_HUMAN | [view interactions] | Low throughput | no | yes |
CP135_HUMAN | [view interactions] | High throughput | no | no |
CPEB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DAG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |