SYN1_HUMAN
Evidence for PS localization
Functions
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 79 | Ser | Trp | Intellectualdevelopmentaldisorder,X-linked50(XLID50) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYN1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 32.2581 | 4 | yes |
| GO:0000166 | nucleotide binding | 30.6452 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 30.6452 | 5 | yes |
| GO:0043169 | cation binding | 30.6452 | 4 | no |
| GO:0046872 | metal ion binding | 30.6452 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 29.0323 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.0323 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 27.4194 | 6 | yes |
| GO:0005524 | ATP binding | 25.8065 | 5 | yes |
| GO:0019900 | kinase binding | 25.8065 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 25.8065 | 5 | yes |
| GO:0019901 | protein kinase binding | 22.5806 | 5 | yes |
| GO:0003779 | actin binding | 17.7419 | 4 | yes |
| GO:0106006 | cytoskeletal protein-membrane anchor activity | 3.2258 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYN1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 66.1290 | 4 | no |
| GO:0010646 | regulation of cell communication | 61.2903 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 59.6774 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 58.0645 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 56.4516 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 56.4516 | 4 | no |
| GO:0051049 | regulation of transport | 53.2258 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 43.5484 | 5 | no |
| GO:0006996 | organelle organization | 43.5484 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 43.5484 | 4 | no |
| GO:0010468 | regulation of gene expression | 43.5484 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 43.5484 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 43.5484 | 5 | no |
| GO:0009966 | regulation of signal transduction | 41.9355 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 38.7097 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 38.7097 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 37.0968 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 37.0968 | 5 | no |
| GO:0030030 | cell projection organization | 37.0968 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.4839 | 5 | no |
| GO:0022607 | cellular component assembly | 35.4839 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.4839 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 35.4839 | 5 | no |
| GO:0031399 | regulation of protein modification process | 35.4839 | 6 | no |
| GO:0051050 | positive regulation of transport | 33.8710 | 4 | no |
| GO:0008104 | protein localization | 32.2581 | 4 | no |
| GO:0060341 | regulation of cellular localization | 32.2581 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 32.2581 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 32.2581 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 30.6452 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 30.6452 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 30.6452 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.6452 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.6452 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.6452 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.6452 | 5 | no |
| GO:0034330 | cell junction organization | 29.0323 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 29.0323 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 29.0323 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 29.0323 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 29.0323 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 29.0323 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 29.0323 | 4 | no |
| GO:0032880 | regulation of protein localization | 29.0323 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 27.4194 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 27.4194 | 7 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.4194 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 25.8065 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.8065 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.8065 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 25.8065 | 7 | no |
| GO:0071310 | cellular response to organic substance | 25.8065 | 4 | no |
| GO:0050808 | synapse organization | 24.1935 | 5 | yes |
| GO:0031175 | neuron projection development | 24.1935 | 6 | no |
| GO:0051129 | negative regulation of cellular component organization | 24.1935 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 24.1935 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 24.1935 | 4 | no |
| GO:0043933 | protein-containing complex organization | 24.1935 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 24.1935 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 24.1935 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 24.1935 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 24.1935 | 6 | no |
| GO:0046903 | secretion | 22.5806 | 4 | yes |
| GO:0051046 | regulation of secretion | 22.5806 | 5 | yes |
| GO:0099536 | synaptic signaling | 22.5806 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 22.5806 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 22.5806 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 22.5806 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.5806 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 22.5806 | 4 | no |
| GO:0048812 | neuron projection morphogenesis | 22.5806 | 5 | no |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 22.5806 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 22.5806 | 6 | no |
| GO:0034762 | regulation of transmembrane transport | 22.5806 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 22.5806 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 22.5806 | 7 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 22.5806 | 5 | no |
| GO:0007010 | cytoskeleton organization | 22.5806 | 5 | no |
| GO:0007268 | chemical synaptic transmission | 20.9677 | 7 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 20.9677 | 6 | yes |
| GO:0098657 | import into cell | 20.9677 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 20.9677 | 8 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.9677 | 6 | no |
| GO:0071702 | organic substance transport | 20.9677 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.9677 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.9677 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.9677 | 4 | no |
| GO:0050890 | cognition | 20.9677 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 20.9677 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 20.9677 | 8 | no |
| GO:0009967 | positive regulation of signal transduction | 20.9677 | 5 | no |
| GO:0010959 | regulation of metal ion transport | 20.9677 | 6 | no |
| GO:0036211 | protein modification process | 20.9677 | 4 | no |
| GO:0043269 | regulation of monoatomic ion transport | 20.9677 | 5 | no |
| GO:0043412 | macromolecule modification | 20.9677 | 4 | no |
| GO:0051924 | regulation of calcium ion transport | 20.9677 | 7 | no |
| GO:0010243 | response to organonitrogen compound | 20.9677 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 20.9677 | 4 | no |
| GO:0016310 | phosphorylation | 20.9677 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 20.9677 | 5 | no |
| GO:0080134 | regulation of response to stress | 20.9677 | 4 | no |
| GO:0017157 | regulation of exocytosis | 19.3548 | 5 | yes |
| GO:0023061 | signal release | 17.7419 | 4 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 17.7419 | 5 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 16.1290 | 5 | yes |
| GO:0099643 | signal release from synapse | 16.1290 | 5 | yes |
| GO:0006836 | neurotransmitter transport | 12.9032 | 4 | yes |
| GO:0048666 | neuron development | 11.2903 | 4 | yes |
| GO:0097479 | synaptic vesicle localization | 11.2903 | 4 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 9.6774 | 6 | yes |
| GO:2000300 | regulation of synaptic vesicle exocytosis | 8.0645 | 6 | yes |
| GO:0007269 | neurotransmitter secretion | 6.4516 | 4 | yes |
| GO:0097091 | synaptic vesicle clustering | 6.4516 | 5 | yes |
| GO:0098693 | regulation of synaptic vesicle cycle | 4.8387 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CAPON_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| PSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SC6A3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RB6I2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PRIO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DGKZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DGKI_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BLM_HUMAN | [view interactions] | Low throughput | no | yes |
| NCF1_HUMAN | [view interactions] | Low throughput | no | no |
| BIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| CRK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3G2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRIC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DBNL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATG4A_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TF3C2_HUMAN | [view interactions] | High throughput | no | no |
| ANTR1_HUMAN | [view interactions] | High throughput | no | no |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| ERI1_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| SPTCS_HUMAN | [view interactions] | High throughput | no | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| KAT5_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX4_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERG_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| VPS54_HUMAN | [view interactions] | High throughput | no | no |
| LC7L3_HUMAN | [view interactions] | High throughput | no | yes |
| DGCR8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SP130_HUMAN | [view interactions] | High throughput | no | no |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DUS2_HUMAN | [view interactions] | High throughput | no | no |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRRT_HUMAN | [view interactions] | High throughput | no | yes |
| DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPLX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPLX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |