SYN1_HUMAN
Evidence for PS localization
Functions
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYN1_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 28.7671 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.0274 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.0274 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 26.0274 | 4 | yes |
| GO:0019900 | kinase binding | 26.0274 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 23.2877 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 23.2877 | 5 | yes |
| GO:0005524 | ATP binding | 23.2877 | 5 | yes |
| GO:0019901 | protein kinase binding | 23.2877 | 5 | yes |
| GO:0003779 | actin binding | 15.0685 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYN1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 68.4932 | 4 | no |
| GO:0010646 | regulation of cell communication | 58.9041 | 4 | yes |
| GO:0051049 | regulation of transport | 57.5342 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 57.5342 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.6849 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.6849 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 49.3151 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 49.3151 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 46.5753 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 46.5753 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 43.8356 | 4 | no |
| GO:0006996 | organelle organization | 42.4658 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 42.4658 | 4 | no |
| GO:0008104 | protein localization | 36.9863 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.9863 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.9863 | 4 | no |
| GO:0051050 | positive regulation of transport | 35.6164 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.6164 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 35.6164 | 5 | no |
| GO:0043269 | regulation of ion transport | 35.6164 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 34.2466 | 4 | yes |
| GO:0010468 | regulation of gene expression | 34.2466 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.2466 | 5 | no |
| GO:0022607 | cellular component assembly | 32.8767 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 32.8767 | 5 | no |
| GO:0046903 | secretion | 31.5068 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 31.5068 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 31.5068 | 5 | no |
| GO:0051046 | regulation of secretion | 30.1370 | 5 | yes |
| GO:1903530 | regulation of secretion by cell | 30.1370 | 4 | yes |
| GO:0071702 | organic substance transport | 30.1370 | 4 | no |
| GO:0071705 | nitrogen compound transport | 30.1370 | 4 | no |
| GO:0033043 | regulation of organelle organization | 30.1370 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.1370 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.1370 | 5 | no |
| GO:0023061 | signal release | 28.7671 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 28.7671 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.7671 | 6 | no |
| GO:0031399 | regulation of protein modification process | 28.7671 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 28.7671 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.7671 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.7671 | 5 | no |
| GO:0071310 | cellular response to organic substance | 28.7671 | 4 | no |
| GO:0099643 | signal release from synapse | 27.3973 | 5 | yes |
| GO:0099003 | vesicle-mediated transport in synapse | 27.3973 | 5 | no |
| GO:0043933 | protein-containing complex organization | 27.3973 | 4 | no |
| GO:0060341 | regulation of cellular localization | 27.3973 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 27.3973 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 27.3973 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.3973 | 5 | no |
| GO:0030030 | cell projection organization | 27.3973 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.3973 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 27.3973 | 7 | no |
| GO:0051094 | positive regulation of developmental process | 27.3973 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.3973 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.3973 | 5 | no |
| GO:0017157 | regulation of exocytosis | 26.0274 | 5 | yes |
| GO:0015031 | protein transport | 26.0274 | 4 | no |
| GO:0006887 | exocytosis | 24.6575 | 4 | no |
| GO:0032880 | regulation of protein localization | 24.6575 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 24.6575 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.6575 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 24.6575 | 7 | no |
| GO:0006355 | regulation of DNA-templated transcription | 24.6575 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 24.6575 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 24.6575 | 6 | no |
| GO:0034330 | cell junction organization | 23.2877 | 4 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 23.2877 | 5 | yes |
| GO:0099537 | trans-synaptic signaling | 23.2877 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 23.2877 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.2877 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.2877 | 4 | no |
| GO:0036211 | protein modification process | 23.2877 | 4 | no |
| GO:0043412 | macromolecule modification | 23.2877 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 23.2877 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 23.2877 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.2877 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 23.2877 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 21.9178 | 6 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 21.9178 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 21.9178 | 5 | yes |
| GO:0006897 | endocytosis | 21.9178 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 21.9178 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.9178 | 6 | no |
| GO:0010941 | regulation of cell death | 21.9178 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.9178 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.9178 | 7 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.9178 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.9178 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 21.9178 | 7 | no |
| GO:0034765 | regulation of ion transmembrane transport | 21.9178 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.9178 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 21.9178 | 4 | no |
| GO:0006836 | neurotransmitter transport | 20.5479 | 4 | yes |
| GO:0050808 | synapse organization | 20.5479 | 5 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 20.5479 | 5 | no |
| GO:0043549 | regulation of kinase activity | 20.5479 | 5 | no |
| GO:0051338 | regulation of transferase activity | 20.5479 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 20.5479 | 4 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 20.5479 | 5 | no |
| GO:0010959 | regulation of metal ion transport | 20.5479 | 6 | no |
| GO:0043270 | positive regulation of ion transport | 20.5479 | 5 | no |
| GO:0044057 | regulation of system process | 20.5479 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 20.5479 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.5479 | 5 | no |
| GO:1903305 | regulation of regulated secretory pathway | 16.4384 | 6 | yes |
| GO:0007269 | neurotransmitter secretion | 13.6986 | 4 | yes |
| GO:0097479 | synaptic vesicle localization | 12.3288 | 4 | yes |
| GO:2000300 | regulation of synaptic vesicle exocytosis | 10.9589 | 5 | yes |
| GO:0048666 | neuron development | 9.5890 | 4 | yes |
| GO:0097091 | synaptic vesicle clustering | 6.8493 | 5 | yes |
| GO:0098693 | regulation of synaptic vesicle cycle | 2.7397 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SYN1_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 2.7397 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 2.7397 | 5 | no |
| DOID:114 | heart disease | 2.7397 | 3 | no |
| DOID:2843 | long QT syndrome | 2.7397 | 6 | no |
| DOID:331 | central nervous system disease | 2.7397 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PRIO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DGKZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DGKI_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BLM_HUMAN | [view interactions] | Low throughput | no | yes |
| NCF1_HUMAN | [view interactions] | Low throughput | no | no |
| BIN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| CRK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3G2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRIC1_HUMAN | [view interactions] | Low throughput | no | yes |
| DBNL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAPON_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| PSN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SC6A3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RB6I2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| KAT5_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERG_HUMAN | [view interactions] | High throughput | no | yes |
| ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| VPS54_HUMAN | [view interactions] | High throughput | no | no |
| LC7L3_HUMAN | [view interactions] | High throughput | no | yes |
| DGCR8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SP130_HUMAN | [view interactions] | High throughput | no | no |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DUS2_HUMAN | [view interactions] | High throughput | no | no |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRRT_HUMAN | [view interactions] | High throughput | no | yes |
| DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPLX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPLX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAK3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERI1_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| ANTR1_HUMAN | [view interactions] | High throughput | no | no |
| TF3C2_HUMAN | [view interactions] | High throughput | no | no |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG4A_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VIAAT_HUMAN | [view interactions] | Computational | no | yes |
| SYT1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LIN7C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LIN7B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| UN13B_HUMAN | [view interactions] | Computational | no | no |
| STXB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYPH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SYT2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SYN3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LIN7A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| APBA1_HUMAN | [view interactions] | Computational | no | no |
| VGLU1_HUMAN | [view entry] [view interactions] | Computational | yes | no |