Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ROCK2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ROCK2_HUMAN
GO:0017076 purine nucleotide binding 43.3333 4 yes
GO:0032555 purine ribonucleotide binding 43.3333 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 43.3333 4 yes
GO:0019900 kinase binding 38.8889 4 no
GO:0019901 protein kinase binding 37.7778 5 no
GO:0003723 RNA binding 27.7778 4 yes
GO:0005524 ATP binding 27.7778 5 yes
GO:0030554 adenyl nucleotide binding 27.7778 5 yes
GO:0032559 adenyl ribonucleotide binding 27.7778 5 yes
GO:0046872 metal ion binding 21.1111 4 yes
GO:0016462 pyrophosphatase activity 21.1111 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 21.1111 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 21.1111 6 no
GO:0016301 kinase activity 17.7778 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 17.7778 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 15.5556 4 yes
GO:0004674 protein serine/threonine kinase activity 12.2222 4 yes
GO:0106310 protein serine kinase activity 12.2222 4 yes
GO:0051020 GTPase binding 6.6667 4 yes
GO:0048156 tau protein binding 5.5556 4 yes
GO:0031267 small GTPase binding 4.4444 5 yes
GO:0050321 tau-protein kinase activity 3.3333 4 yes
GO:0072518 Rho-dependent protein serine/threonine kinase activity 3.3333 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ROCK2_HUMAN
GO:0048522 positive regulation of cellular process 68.8889 4 yes
GO:0060255 regulation of macromolecule metabolic process 64.4444 4 yes
GO:0080090 regulation of primary metabolic process 62.2222 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 60.0000 4 yes
GO:0031323 regulation of cellular metabolic process 57.7778 4 yes
GO:0048523 negative regulation of cellular process 54.4444 4 yes
GO:0010468 regulation of gene expression 54.4444 5 yes
GO:0051246 regulation of protein metabolic process 52.2222 5 yes
GO:0051128 regulation of cellular component organization 51.1111 4 yes
GO:0006996 organelle organization 50.0000 4 yes
GO:0009893 positive regulation of metabolic process 48.8889 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 48.8889 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 47.7778 5 yes
GO:0010646 regulation of cell communication 47.7778 4 yes
GO:0009889 regulation of biosynthetic process 43.3333 4 yes
GO:0031325 positive regulation of cellular metabolic process 43.3333 5 yes
GO:0031326 regulation of cellular biosynthetic process 43.3333 5 yes
GO:0009966 regulation of signal transduction 42.2222 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 42.2222 5 yes
GO:0022607 cellular component assembly 41.1111 4 no
GO:0051247 positive regulation of protein metabolic process 40.0000 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 40.0000 5 yes
GO:0007010 cytoskeleton organization 38.8889 5 yes
GO:0051049 regulation of transport 36.6667 4 no
GO:0031399 regulation of protein modification process 35.5556 6 yes
GO:0051252 regulation of RNA metabolic process 34.4444 5 yes
GO:1902531 regulation of intracellular signal transduction 34.4444 5 yes
GO:0009892 negative regulation of metabolic process 34.4444 4 yes
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 yes
GO:0008104 protein localization 33.3333 4 yes
GO:0010647 positive regulation of cell communication 33.3333 5 yes
GO:0019220 regulation of phosphate metabolic process 33.3333 6 yes
GO:0023056 positive regulation of signaling 33.3333 4 yes
GO:0033043 regulation of organelle organization 32.2222 5 yes
GO:0042325 regulation of phosphorylation 32.2222 7 yes
GO:0048584 positive regulation of response to stimulus 32.2222 4 yes
GO:0071310 cellular response to organic substance 32.2222 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 32.2222 5 yes
GO:0036211 protein modification process 31.1111 4 yes
GO:0043412 macromolecule modification 31.1111 4 yes
GO:0045595 regulation of cell differentiation 31.1111 4 yes
GO:0010628 positive regulation of gene expression 31.1111 6 yes
GO:0043085 positive regulation of catalytic activity 30.0000 4 yes
GO:0060341 regulation of cellular localization 30.0000 4 yes
GO:0006796 phosphate-containing compound metabolic process 30.0000 4 yes
GO:0010941 regulation of cell death 30.0000 4 no
GO:0009967 positive regulation of signal transduction 30.0000 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 30.0000 4 yes
GO:0044087 regulation of cellular component biogenesis 28.8889 4 yes
GO:2000145 regulation of cell motility 28.8889 4 yes
GO:0042981 regulation of apoptotic process 28.8889 6 no
GO:0043067 regulation of programmed cell death 28.8889 5 no
GO:0042127 regulation of cell population proliferation 28.8889 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 27.7778 5 yes
GO:0001932 regulation of protein phosphorylation 27.7778 7 yes
GO:0043933 protein-containing complex organization 27.7778 4 no
GO:0006355 regulation of DNA-templated transcription 27.7778 6 no
GO:1903506 regulation of nucleic acid-templated transcription 27.7778 7 no
GO:2001141 regulation of RNA biosynthetic process 27.7778 6 no
GO:0030334 regulation of cell migration 27.7778 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 26.6667 6 yes
GO:0045937 positive regulation of phosphate metabolic process 26.6667 7 yes
GO:0030030 cell projection organization 26.6667 4 no
GO:0010562 positive regulation of phosphorus metabolic process 26.6667 6 yes
GO:0031324 negative regulation of cellular metabolic process 26.6667 5 yes
GO:0031401 positive regulation of protein modification process 26.6667 7 yes
GO:0051240 positive regulation of multicellular organismal process 25.5556 4 yes
GO:0051336 regulation of hydrolase activity 25.5556 4 yes
GO:0051493 regulation of cytoskeleton organization 25.5556 6 yes
GO:0032880 regulation of protein localization 25.5556 5 yes
GO:0042327 positive regulation of phosphorylation 24.4444 8 yes
GO:0051129 negative regulation of cellular component organization 24.4444 5 yes
GO:1901701 cellular response to oxygen-containing compound 24.4444 4 yes
GO:1902533 positive regulation of intracellular signal transduction 24.4444 6 yes
GO:0009891 positive regulation of biosynthetic process 24.4444 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 24.4444 6 no
GO:0031328 positive regulation of cellular biosynthetic process 24.4444 6 no
GO:0051726 regulation of cell cycle 23.3333 4 yes
GO:0080134 regulation of response to stress 23.3333 4 yes
GO:0120036 plasma membrane bounded cell projection organization 23.3333 5 no
GO:0051094 positive regulation of developmental process 23.3333 4 no
GO:0010243 response to organonitrogen compound 23.3333 4 yes
GO:0051130 positive regulation of cellular component organization 22.2222 5 yes
GO:0051254 positive regulation of RNA metabolic process 22.2222 6 yes
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 yes
GO:0051338 regulation of transferase activity 22.2222 4 no
GO:0031344 regulation of cell projection organization 22.2222 5 no
GO:0008284 positive regulation of cell population proliferation 22.2222 5 no
GO:0060548 negative regulation of cell death 22.2222 5 no
GO:0065003 protein-containing complex assembly 21.1111 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.1111 6 no
GO:0043066 negative regulation of apoptotic process 21.1111 7 no
GO:0009894 regulation of catabolic process 21.1111 4 yes
GO:0043069 negative regulation of programmed cell death 21.1111 6 no
GO:0032970 regulation of actin filament-based process 20.0000 4 yes
GO:0043408 regulation of MAPK cascade 20.0000 6 yes
GO:0051248 negative regulation of protein metabolic process 20.0000 6 yes
GO:1903829 positive regulation of protein localization 20.0000 5 yes
GO:0010629 negative regulation of gene expression 20.0000 6 yes
GO:2000026 regulation of multicellular organismal development 18.8889 4 yes
GO:2000112 regulation of cellular macromolecule biosynthetic process 18.8889 6 yes
GO:0014070 response to organic cyclic compound 18.8889 4 yes
GO:0016310 phosphorylation 18.8889 5 yes
GO:0030155 regulation of cell adhesion 18.8889 4 yes
GO:0032956 regulation of actin cytoskeleton organization 17.7778 5 yes
GO:0034248 regulation of cellular amide metabolic process 17.7778 5 yes
GO:0040017 positive regulation of locomotion 17.7778 4 yes
GO:1901699 cellular response to nitrogen compound 17.7778 4 yes
GO:2000147 positive regulation of cell motility 17.7778 5 yes
GO:0006468 protein phosphorylation 17.7778 5 yes
GO:0030335 positive regulation of cell migration 17.7778 6 yes
GO:0033993 response to lipid 16.6667 4 yes
GO:0043086 negative regulation of catalytic activity 16.6667 4 yes
GO:0043410 positive regulation of MAPK cascade 16.6667 7 yes
GO:0051093 negative regulation of developmental process 16.6667 4 yes
GO:0051241 negative regulation of multicellular organismal process 16.6667 4 yes
GO:0051345 positive regulation of hydrolase activity 16.6667 5 yes
GO:0070848 response to growth factor 16.6667 4 yes
GO:0080135 regulation of cellular response to stress 16.6667 4 yes
GO:1902903 regulation of supramolecular fiber organization 16.6667 5 yes
GO:0001817 regulation of cytokine production 16.6667 4 yes
GO:0006417 regulation of translation 16.6667 6 yes
GO:0010608 post-transcriptional regulation of gene expression 16.6667 6 yes
GO:0030162 regulation of proteolysis 16.6667 6 yes
GO:0031329 regulation of cellular catabolic process 16.6667 5 yes
GO:0044057 regulation of system process 15.5556 4 yes
GO:0071407 cellular response to organic cyclic compound 15.5556 5 yes
GO:0007264 small GTPase mediated signal transduction 15.5556 4 yes
GO:0009890 negative regulation of biosynthetic process 15.5556 5 yes
GO:0010638 positive regulation of organelle organization 15.5556 6 yes
GO:0018193 peptidyl-amino acid modification 15.5556 5 yes
GO:0044089 positive regulation of cellular component biogenesis 14.4444 5 yes
GO:0060284 regulation of cell development 14.4444 5 yes
GO:0007265 Ras protein signal transduction 14.4444 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 14.4444 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 14.4444 6 yes
GO:0045862 positive regulation of proteolysis 13.3333 7 yes
GO:0045936 negative regulation of phosphate metabolic process 13.3333 7 yes
GO:1901652 response to peptide 13.3333 4 yes
GO:0010563 negative regulation of phosphorus metabolic process 13.3333 6 yes
GO:0010632 regulation of epithelial cell migration 13.3333 4 yes
GO:0010810 regulation of cell-substrate adhesion 13.3333 5 yes
GO:0031400 negative regulation of protein modification process 13.3333 7 yes
GO:0045787 positive regulation of cell cycle 12.2222 5 yes
GO:0052547 regulation of peptidase activity 12.2222 5 yes
GO:0052548 regulation of endopeptidase activity 12.2222 6 yes
GO:0071396 cellular response to lipid 12.2222 5 yes
GO:0072657 protein localization to membrane 12.2222 4 yes
GO:0110053 regulation of actin filament organization 12.2222 6 yes
GO:0001819 positive regulation of cytokine production 12.2222 5 yes
GO:0009896 positive regulation of catabolic process 12.2222 5 yes
GO:0010564 regulation of cell cycle process 12.2222 5 yes
GO:0051346 negative regulation of hydrolase activity 11.1111 5 yes
GO:1901888 regulation of cell junction assembly 11.1111 5 yes
GO:0030865 cortical cytoskeleton organization 11.1111 6 yes
GO:0034250 positive regulation of cellular amide metabolic process 10.0000 6 yes
GO:0051495 positive regulation of cytoskeleton organization 10.0000 7 yes
GO:0150116 regulation of cell-substrate junction organization 10.0000 5 yes
GO:1902905 positive regulation of supramolecular fiber organization 10.0000 6 yes
GO:1990778 protein localization to cell periphery 10.0000 5 yes
GO:0001952 regulation of cell-matrix adhesion 10.0000 6 yes
GO:0007266 Rho protein signal transduction 10.0000 6 yes
GO:0018105 peptidyl-serine phosphorylation 10.0000 6 yes
GO:0018209 peptidyl-serine modification 10.0000 6 yes
GO:0032886 regulation of microtubule-based process 10.0000 4 yes
GO:0035303 regulation of dephosphorylation 8.8889 7 yes
GO:0043434 response to peptide hormone 8.8889 4 yes
GO:0051893 regulation of focal adhesion assembly 8.8889 7 yes
GO:0090068 positive regulation of cell cycle process 8.8889 6 yes
GO:0090109 regulation of cell-substrate junction assembly 8.8889 6 yes
GO:1901654 response to ketone 8.8889 4 yes
GO:1903311 regulation of mRNA metabolic process 8.8889 6 yes
GO:0010634 positive regulation of epithelial cell migration 8.8889 5 yes
GO:0010950 positive regulation of endopeptidase activity 8.8889 7 yes
GO:0010952 positive regulation of peptidase activity 8.8889 6 yes
GO:0031032 actomyosin structure organization 8.8889 4 yes
GO:0031331 positive regulation of cellular catabolic process 8.8889 6 yes
GO:0031644 regulation of nervous system process 8.8889 5 yes
GO:0032231 regulation of actin filament bundle assembly 8.8889 5 yes
GO:0043488 regulation of mRNA stability 7.7778 4 yes
GO:0045765 regulation of angiogenesis 7.7778 5 yes
GO:0051492 regulation of stress fiber assembly 7.7778 6 yes
GO:0061013 regulation of mRNA catabolic process 7.7778 6 yes
GO:0072659 protein localization to plasma membrane 7.7778 5 yes
GO:0110020 regulation of actomyosin structure organization 7.7778 6 yes
GO:1901342 regulation of vasculature development 7.7778 5 yes
GO:0010594 regulation of endothelial cell migration 7.7778 5 yes
GO:0018107 peptidyl-threonine phosphorylation 7.7778 6 yes
GO:0018210 peptidyl-threonine modification 7.7778 6 yes
GO:0035304 regulation of protein dephosphorylation 6.6667 7 yes
GO:0043666 regulation of phosphoprotein phosphatase activity 6.6667 6 yes
GO:0045428 regulation of nitric oxide biosynthetic process 6.6667 6 yes
GO:0051496 positive regulation of stress fiber assembly 6.6667 7 yes
GO:0061640 cytoskeleton-dependent cytokinesis 6.6667 4 yes
GO:0080164 regulation of nitric oxide metabolic process 6.6667 5 yes
GO:0090257 regulation of muscle system process 6.6667 5 yes
GO:1901655 cellular response to ketone 6.6667 5 yes
GO:1902991 regulation of amyloid precursor protein catabolic process 6.6667 6 yes
GO:0000281 mitotic cytokinesis 6.6667 4 yes
GO:0003018 vascular process in circulatory system 6.6667 4 yes
GO:0008277 regulation of G protein-coupled receptor signaling pathway 6.6667 5 yes
GO:0010921 regulation of phosphatase activity 6.6667 5 yes
GO:0032233 positive regulation of actin filament bundle assembly 6.6667 6 yes
GO:0034103 regulation of tissue remodeling 5.5556 4 yes
GO:0034249 negative regulation of cellular amide metabolic process 5.5556 6 yes
GO:0035305 negative regulation of dephosphorylation 5.5556 8 yes
GO:1901889 negative regulation of cell junction assembly 5.5556 6 yes
GO:1903313 positive regulation of mRNA metabolic process 5.5556 7 yes
GO:1903828 negative regulation of protein localization 5.5556 5 yes
GO:2000113 negative regulation of cellular macromolecule biosynthetic process 5.5556 7 yes
GO:0006936 muscle contraction 5.5556 4 yes
GO:0010595 positive regulation of endothelial cell migration 5.5556 6 yes
GO:0017148 negative regulation of translation 5.5556 7 yes
GO:0030866 cortical actin cytoskeleton organization 5.5556 4 yes
GO:0035150 regulation of tube size 4.4444 4 yes
GO:0035296 regulation of tube diameter 4.4444 5 yes
GO:0035308 negative regulation of protein dephosphorylation 4.4444 8 yes
GO:0035507 regulation of myosin-light-chain-phosphatase activity 4.4444 7 yes
GO:0043502 regulation of muscle adaptation 4.4444 4 yes
GO:0045601 regulation of endothelial cell differentiation 4.4444 6 yes
GO:0048762 mesenchymal cell differentiation 4.4444 4 yes
GO:0061014 positive regulation of mRNA catabolic process 4.4444 7 yes
GO:0070167 regulation of biomineral tissue development 4.4444 4 yes
GO:0097746 blood vessel diameter maintenance 4.4444 5 yes
GO:1901343 negative regulation of vasculature development 4.4444 5 yes
GO:1902003 regulation of amyloid-beta formation 4.4444 6 yes
GO:1902965 regulation of protein localization to early endosome 4.4444 7 yes
GO:1902966 positive regulation of protein localization to early endosome 4.4444 7 yes
GO:1902993 positive regulation of amyloid precursor protein catabolic process 4.4444 7 yes
GO:1905666 regulation of protein localization to endosome 4.4444 6 yes
GO:1905668 positive regulation of protein localization to endosome 4.4444 6 yes
GO:1990776 response to angiotensin 4.4444 5 yes
GO:2000114 regulation of establishment of cell polarity 4.4444 5 yes
GO:2000181 negative regulation of blood vessel morphogenesis 4.4444 5 yes
GO:0001837 epithelial to mesenchymal transition 4.4444 5 yes
GO:0006939 smooth muscle contraction 4.4444 5 yes
GO:0007249 I-kappaB kinase/NF-kappaB signaling 4.4444 4 yes
GO:0010611 regulation of cardiac muscle hypertrophy 4.4444 5 yes
GO:0010923 negative regulation of phosphatase activity 4.4444 6 yes
GO:0014743 regulation of muscle hypertrophy 4.4444 6 yes
GO:0016525 negative regulation of angiogenesis 4.4444 6 yes
GO:0030856 regulation of epithelial cell differentiation 4.4444 5 yes
GO:0032515 negative regulation of phosphoprotein phosphatase activity 4.4444 7 yes
GO:0032878 regulation of establishment or maintenance of cell polarity 4.4444 4 yes
GO:0033574 response to testosterone 3.3333 5 yes
GO:0034105 positive regulation of tissue remodeling 3.3333 5 yes
GO:0035509 negative regulation of myosin-light-chain-phosphatase activity 3.3333 8 yes
GO:0045604 regulation of epidermal cell differentiation 3.3333 5 yes
GO:0045616 regulation of keratinocyte differentiation 3.3333 6 yes
GO:0045682 regulation of epidermis development 3.3333 4 yes
GO:0046605 regulation of centrosome cycle 3.3333 5 yes
GO:0050779 RNA destabilization 3.3333 4 yes
GO:0061157 mRNA destabilization 3.3333 5 yes
GO:0070168 negative regulation of biomineral tissue development 3.3333 5 yes
GO:0071394 cellular response to testosterone stimulus 3.3333 6 yes
GO:0110061 regulation of angiotensin-activated signaling pathway 3.3333 6 yes
GO:0110150 negative regulation of biomineralization 3.3333 4 yes
GO:1901550 regulation of endothelial cell development 3.3333 6 yes
GO:1902004 positive regulation of amyloid-beta formation 3.3333 7 yes
GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 3.3333 7 yes
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 3.3333 8 yes
GO:1903140 regulation of establishment of endothelial barrier 3.3333 7 yes
GO:1903347 negative regulation of bicellular tight junction assembly 3.3333 7 yes
GO:1905203 regulation of connective tissue replacement 3.3333 5 yes
GO:1905205 positive regulation of connective tissue replacement 3.3333 6 yes
GO:1905245 regulation of aspartic-type peptidase activity 3.3333 6 yes
GO:1905247 positive regulation of aspartic-type peptidase activity 3.3333 7 yes
GO:2000810 regulation of bicellular tight junction assembly 3.3333 6 yes
GO:0003180 aortic valve morphogenesis 3.3333 4 yes
GO:0010613 positive regulation of cardiac muscle hypertrophy 3.3333 6 yes
GO:0010824 regulation of centrosome duplication 3.3333 6 yes
GO:0014742 positive regulation of muscle hypertrophy 3.3333 5 yes
GO:0045019 negative regulation of nitric oxide biosynthetic process 2.2222 7 yes
GO:0090270 regulation of fibroblast growth factor production 2.2222 5 yes
GO:0090271 positive regulation of fibroblast growth factor production 2.2222 6 yes
GO:0150031 regulation of protein localization to lysosome 2.2222 6 yes
GO:0150033 negative regulation of protein localization to lysosome 2.2222 6 yes
GO:1900037 regulation of cellular response to hypoxia 2.2222 5 yes
GO:1904406 negative regulation of nitric oxide metabolic process 2.2222 6 yes
GO:1905144 response to acetylcholine 2.2222 4 yes
GO:1905145 cellular response to acetylcholine 2.2222 5 yes
GO:0010825 positive regulation of centrosome duplication 2.2222 7 yes
GO:0032643 regulation of connective tissue growth factor production 2.2222 5 yes
GO:0032723 positive regulation of connective tissue growth factor production 2.2222 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in ROCK2_HUMAN
DOID:0050700 cardiomyopathy 3.3333 4 no
DOID:0060036 intrinsic cardiomyopathy 3.3333 5 no
DOID:114 heart disease 3.3333 3 no
DOID:12930 dilated cardiomyopathy 2.2222 6 no
DOID:0050686 organ system cancer 2.2222 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRM8_HUMAN [view interactions] Low throughput no no
CTRO_HUMAN [view entry] [view interactions] Low throughput yes yes
RAF1_HUMAN [view entry] [view interactions] Low throughput yes no
NUCL_HUMAN [view interactions] Low throughput no yes
STAT3_HUMAN [view entry] [view interactions] Low throughput yes yes
EP300_HUMAN [view interactions] Low throughput no yes
JAK3_HUMAN [view interactions] Low throughput no no
JAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
PP14B_HUMAN [view interactions] Low throughput no yes
IKBA_HUMAN [view interactions] Low throughput no yes
FLOT2_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGC1_HUMAN [view interactions] Low throughput no no
PTPRF_HUMAN [view entry] [view interactions] Low throughput yes yes
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
NPM_HUMAN [view entry] [view interactions] Low throughput yes yes
CDKN3_HUMAN [view interactions] Low throughput no no
MLRV_HUMAN [view interactions] Low throughput no no
BRCA2_HUMAN [view interactions] Low throughput no no
RHBT1_HUMAN [view interactions] Low throughput no yes
VIME_HUMAN [view entry] [view interactions] Low throughput yes no
TBG1_HUMAN [view entry] [view interactions] Low throughput yes yes
ROCK2_HUMAN [view entry] [view interactions] Low throughput yes yes
ROCK1_HUMAN [view entry] [view interactions] High throughput yes yes
KSR2_HUMAN [view interactions] High throughput no yes
DJB11_HUMAN [view interactions] High throughput no yes
FBX42_HUMAN [view interactions] High throughput no yes
AMRP_HUMAN [view interactions] High throughput no yes
CDC73_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
PDPK1_HUMAN [view entry] [view interactions] High throughput yes yes
H2B2E_HUMAN [view interactions] High throughput no yes
HNRC2_HUMAN [view interactions] High throughput no no
CSF1_HUMAN [view interactions] High throughput no no
MTR1B_HUMAN [view interactions] High throughput no yes
SGK3_HUMAN [view interactions] High throughput no yes
PHF5A_HUMAN [view interactions] High throughput no yes
AKP13_HUMAN [view interactions] High throughput no yes
DEF1_HUMAN [view interactions] High throughput no no
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
KS6A3_HUMAN [view entry] [view interactions] High throughput yes yes
STK16_HUMAN [view interactions] High throughput no no
IKKE_HUMAN [view interactions] High throughput no yes
SNW1_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
BMI1_HUMAN [view interactions] High throughput no yes
ML12A_HUMAN [view interactions] High throughput no no
MYPT1_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view interactions] High throughput no yes
LZTL1_HUMAN [view interactions] High throughput no no
PROF2_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
RPAC1_HUMAN [view interactions] High throughput no no
ADDB_HUMAN [view entry] [view interactions] High throughput yes yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
TRIP4_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
MGDP1_HUMAN [view interactions] High throughput no yes
MRP6_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
PFD1_HUMAN [view interactions] High throughput no yes
DUS16_HUMAN [view interactions] High throughput no yes
ZN641_HUMAN [view interactions] High throughput no yes
LURA1_HUMAN [view interactions] High throughput no yes
S39A7_HUMAN [view interactions] High throughput no yes
HTRA3_HUMAN [view interactions] High throughput no no
KPB2_HUMAN [view interactions] High throughput no yes
TYW3_HUMAN [view interactions] High throughput no yes
SMAD4_HUMAN [view interactions] High throughput no yes
LEG1_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
AHR_HUMAN [view interactions] High throughput no yes
ANR49_HUMAN [view interactions] High throughput no yes
SUV92_HUMAN [view interactions] High throughput no no
DNJC8_HUMAN [view interactions] High throughput no yes
SPRTN_HUMAN [view interactions] High throughput no yes
MED17_HUMAN [view interactions] High throughput no no
MILR1_HUMAN [view interactions] High throughput no no
TBCD9_HUMAN [view interactions] High throughput no yes
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
SPP2B_HUMAN [view interactions] High throughput no yes
ZN444_HUMAN [view interactions] High throughput no no
RL10_HUMAN [view entry] [view interactions] High throughput yes yes
BBS1_HUMAN [view interactions] High throughput no no
ZBTB2_HUMAN [view interactions] High throughput no yes
EGFL7_HUMAN [view interactions] High throughput no yes
KCNA3_HUMAN [view entry] [view interactions] High throughput yes no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RHOF_HUMAN [view interactions] High throughput no no
WASC5_HUMAN [view interactions] High throughput no yes
RABX5_HUMAN [view interactions] High throughput no no
WAC2A_HUMAN [view interactions] High throughput no yes
GEPH_HUMAN [view entry] [view interactions] High throughput yes yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
MTA2_HUMAN [view interactions] High throughput no yes
NH2L1_HUMAN [view interactions] High throughput no yes
ZW10_HUMAN [view interactions] High throughput no yes
RGAP1_HUMAN [view interactions] High throughput no no
SYDM_HUMAN [view interactions] High throughput no yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
IF4E_HUMAN [view entry] [view interactions] High throughput yes yes
LS14A_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
DHX9_HUMAN [view interactions] High throughput no yes
DC1I1_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
MBP_HUMAN [view entry] [view interactions] High throughput yes no
PABP1_HUMAN [view entry] [view interactions] High throughput yes yes
RL28_HUMAN [view entry] [view interactions] High throughput yes yes
RS6_HUMAN [view entry] [view interactions] High throughput yes yes
SYN1_HUMAN [view entry] [view interactions] High throughput yes no
SARNP_HUMAN [view interactions] High throughput no yes
HNRPU_HUMAN [view interactions] High throughput no yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
CATH_HUMAN [view interactions] High throughput no no
DDX6_HUMAN [view entry] [view interactions] High throughput yes yes
AINX_HUMAN [view entry] [view interactions] High throughput yes yes
PCBP1_HUMAN [view entry] [view interactions] High throughput yes yes
RL6_HUMAN [view entry] [view interactions] High throughput yes yes
RLA0_HUMAN [view entry] [view interactions] High throughput yes yes
RS4X_HUMAN [view entry] [view interactions] High throughput yes yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
DCA15_HUMAN [view interactions] High throughput no no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
MARE3_HUMAN [view entry] [view interactions] High throughput yes yes
PERI_HUMAN [view entry] [view interactions] High throughput yes no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
IFM3_HUMAN [view interactions] High throughput no yes
OPTN_HUMAN [view interactions] High throughput no yes
MYH10_HUMAN [view entry] [view interactions] Computational yes yes
MYL5_HUMAN [view interactions] Computational no no
PLK1_HUMAN [view interactions] Computational no yes
SL9A1_HUMAN [view interactions] Computational no no
MLRA_HUMAN [view interactions] Computational no no
LIMK2_HUMAN [view interactions] Computational no yes
PI51A_HUMAN [view interactions] Computational no yes
MYH9_HUMAN [view entry] [view interactions] Computational yes no
PAR3_HUMAN [view interactions] Computational no no
SL9A3_HUMAN [view interactions] Computational no yes
PI51C_HUMAN [view entry] [view interactions] Computational yes yes
PAR6A_HUMAN [view interactions] Computational no yes
KINH_HUMAN [view entry] [view interactions] Computational yes no
SRC_HUMAN [view entry] [view interactions] Computational yes no
MYH11_HUMAN [view entry] [view interactions] Computational yes no
SH3G2_HUMAN [view entry] [view interactions] Computational yes yes
MYL9_HUMAN [view interactions] Computational no no
PP1G_HUMAN [view entry] [view interactions] Computational yes yes
MYL10_HUMAN [view interactions] Computational no no
MYL6_HUMAN [view entry] [view interactions] Computational yes no
FHOD1_HUMAN [view interactions] Computational no no
ARHGB_HUMAN [view interactions] Computational no yes
SHRM3_HUMAN [view interactions] Computational no yes
CTNB1_HUMAN [view entry] [view interactions] Computational yes yes
GNA13_HUMAN [view entry] [view interactions] Computational yes yes
MYPT2_HUMAN [view interactions] Computational no no
TF65_HUMAN [view entry] [view interactions] Computational yes yes
NFKB1_HUMAN [view interactions] Computational no yes
PI51B_HUMAN [view interactions] Computational no yes
ML12B_HUMAN [view interactions] Computational no no
MK03_HUMAN [view entry] [view interactions] Computational yes yes
MOES_HUMAN [view entry] [view interactions] Computational yes no
HS90A_HUMAN [view entry] [view interactions] Computational yes yes
KPCZ_HUMAN [view entry] [view interactions] Computational yes yes
PP1B_HUMAN [view entry] [view interactions] Computational yes yes
MP2K4_HUMAN [view interactions] Computational no yes
MLRS_HUMAN [view interactions] Computational no no
FAK1_HUMAN [view entry] [view interactions] Computational yes yes
ETV5_HUMAN [view interactions] Computational no yes
CD44_HUMAN [view interactions] Computational no yes
VGFR2_HUMAN [view interactions] Computational no no
ARHGC_HUMAN [view interactions] Computational no yes
ARHG1_HUMAN [view interactions] Computational no no
SHB_HUMAN [view interactions] Computational no yes
GAB1_HUMAN [view interactions] Computational no yes
LIMK1_HUMAN [view interactions] Computational no yes
PTEN_HUMAN [view entry] [view interactions] Computational yes yes
COF1_HUMAN [view entry] [view interactions] Computational yes no
EZRI_HUMAN [view entry] [view interactions] Computational yes no
PP1A_HUMAN [view entry] [view interactions] Computational yes yes