Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PLCB3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
878 Ala Ser Spondylometaphysealdysplasiawithcornealdystrophy(SMDCD) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PLCB3_HUMAN
GO:0017076 purine nucleotide binding 55.1724 4 no
GO:0032555 purine ribonucleotide binding 55.1724 4 no
GO:0035639 purine ribonucleoside triphosphate binding 51.7241 4 no
GO:0019001 guanyl nucleotide binding 37.9310 5 no
GO:0032561 guanyl ribonucleotide binding 37.9310 5 no
GO:0005525 GTP binding 34.4828 5 no
GO:0046872 metal ion binding 31.0345 4 yes
GO:0003924 GTPase activity 31.0345 7 no
GO:0016462 pyrophosphatase activity 31.0345 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 31.0345 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 31.0345 6 no
GO:0030554 adenyl nucleotide binding 24.1379 5 no
GO:0032559 adenyl ribonucleotide binding 24.1379 5 no
GO:0005524 ATP binding 20.6897 5 no
GO:0016301 kinase activity 20.6897 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 20.6897 4 no
GO:0005509 calcium ion binding 13.7931 5 yes
GO:0045296 cadherin binding 13.7931 4 yes
GO:0042578 phosphoric ester hydrolase activity 10.3448 4 yes
GO:0004435 phosphatidylinositol phospholipase C activity 6.8966 7 yes
GO:0004620 phospholipase activity 6.8966 5 yes
GO:0004629 phospholipase C activity 6.8966 6 yes
GO:0008081 phosphoric diester hydrolase activity 6.8966 5 yes
GO:0016298 lipase activity 6.8966 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PLCB3_HUMAN
GO:0048523 negative regulation of cellular process 48.2759 4 no
GO:0031323 regulation of cellular metabolic process 44.8276 4 no
GO:0080090 regulation of primary metabolic process 41.3793 4 no
GO:0010646 regulation of cell communication 41.3793 4 no
GO:0048522 positive regulation of cellular process 41.3793 4 no
GO:0009892 negative regulation of metabolic process 34.4828 4 no
GO:0051171 regulation of nitrogen compound metabolic process 34.4828 4 no
GO:0051246 regulation of protein metabolic process 34.4828 5 no
GO:0060255 regulation of macromolecule metabolic process 34.4828 4 no
GO:0051128 regulation of cellular component organization 34.4828 4 no
GO:0009893 positive regulation of metabolic process 34.4828 4 no
GO:0009966 regulation of signal transduction 34.4828 4 no
GO:0051049 regulation of transport 31.0345 4 no
GO:0006996 organelle organization 31.0345 4 no
GO:0031325 positive regulation of cellular metabolic process 31.0345 5 no
GO:0010468 regulation of gene expression 27.5862 5 no
GO:0010605 negative regulation of macromolecule metabolic process 27.5862 5 no
GO:0006796 phosphate-containing compound metabolic process 27.5862 4 yes
GO:0008104 protein localization 27.5862 4 no
GO:0022607 cellular component assembly 27.5862 4 no
GO:0010604 positive regulation of macromolecule metabolic process 24.1379 5 no
GO:0031324 negative regulation of cellular metabolic process 24.1379 5 no
GO:0031326 regulation of cellular biosynthetic process 24.1379 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 24.1379 5 no
GO:0033043 regulation of organelle organization 24.1379 5 no
GO:0019220 regulation of phosphate metabolic process 24.1379 6 no
GO:0042325 regulation of phosphorylation 24.1379 7 no
GO:0051174 regulation of phosphorus metabolic process 24.1379 5 no
GO:0016192 vesicle-mediated transport 24.1379 4 no
GO:0061024 membrane organization 24.1379 4 no
GO:0009889 regulation of biosynthetic process 24.1379 4 no
GO:0010556 regulation of macromolecule biosynthetic process 20.6897 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 20.6897 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 20.6897 5 no
GO:0051247 positive regulation of protein metabolic process 20.6897 6 no
GO:0051252 regulation of RNA metabolic process 20.6897 5 no
GO:0031344 regulation of cell projection organization 20.6897 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.6897 6 no
GO:0007010 cytoskeleton organization 20.6897 5 no
GO:0044087 regulation of cellular component biogenesis 20.6897 4 no
GO:0051130 positive regulation of cellular component organization 20.6897 5 no
GO:1902531 regulation of intracellular signal transduction 20.6897 5 no
GO:0031399 regulation of protein modification process 20.6897 6 no
GO:0046486 glycerolipid metabolic process 20.6897 4 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 20.6897 4 no
GO:0071310 cellular response to organic substance 20.6897 4 no
GO:0071702 organic substance transport 20.6897 4 no
GO:0009894 regulation of catabolic process 20.6897 4 no
GO:0043086 negative regulation of catalytic activity 20.6897 4 no
GO:0006644 phospholipid metabolic process 17.2414 4 yes
GO:0006650 glycerophospholipid metabolic process 17.2414 5 yes
GO:0046488 phosphatidylinositol metabolic process 17.2414 6 yes
GO:0048015 phosphatidylinositol-mediated signaling 10.3448 5 yes
GO:0048017 inositol lipid-mediated signaling 10.3448 4 yes
GO:0016042 lipid catabolic process 6.8966 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in PLCB3_HUMAN
DOID:0050032 mineral metabolism disease 6.8966 3 no
DOID:0060699 familial hypocalciuric hypercalcemia 6.8966 6 no
DOID:10575 calcium metabolism disease 6.8966 4 no
DOID:12678 hypercalcemia 6.8966 5 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PAR6A_HUMAN [view interactions] Low throughput no yes
PARD3_HUMAN [view interactions] Low throughput no yes
NHRF2_HUMAN [view entry] [view interactions] Low throughput yes no
NHRF1_HUMAN [view interactions] Low throughput no no
EZRI_HUMAN [view entry] [view interactions] Low throughput yes no
PTN6_HUMAN [view interactions] Low throughput no no
GNAQ_HUMAN [view entry] [view interactions] Low throughput yes yes
ANXA6_HUMAN [view entry] [view interactions] Low throughput yes yes
KRIT1_HUMAN [view interactions] Low throughput no no
LPAR2_HUMAN [view interactions] Low throughput no yes
TRPM7_HUMAN [view interactions] Low throughput no no
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
SORT_HUMAN [view interactions] High throughput no yes
NEDD1_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no
LAMP1_HUMAN [view interactions] High throughput no yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
MAG_HUMAN [view entry] [view interactions] High throughput yes yes
PLCC_HUMAN [view interactions] High throughput no no
CB39L_HUMAN [view interactions] High throughput no yes
MILR1_HUMAN [view interactions] High throughput no no
KBP_HUMAN [view interactions] High throughput no yes
MND1_HUMAN [view interactions] High throughput no no
RYBP_HUMAN [view interactions] High throughput no no
FGOP2_HUMAN [view interactions] High throughput no yes
TMM51_HUMAN [view interactions] High throughput no yes
HAUS7_HUMAN [view interactions] High throughput no no
P66A_HUMAN [view interactions] High throughput no yes
RPC10_HUMAN [view interactions] High throughput no yes
TYW3_HUMAN [view interactions] High throughput no yes
CH076_HUMAN [view interactions] High throughput no yes
RT18C_HUMAN [view interactions] High throughput no yes
KCNE3_HUMAN [view interactions] High throughput no yes
STRN3_HUMAN [view interactions] High throughput no yes
FRIL_HUMAN [view interactions] High throughput no yes
RM38_HUMAN [view interactions] High throughput no yes
CTNA3_HUMAN [view interactions] High throughput no no
AP2S1_HUMAN [view entry] [view interactions] High throughput yes no
RNF31_HUMAN [view interactions] High throughput no yes
KAP0_HUMAN [view entry] [view interactions] High throughput yes yes
AT5F1_HUMAN [view interactions] High throughput no yes
DMAP1_HUMAN [view interactions] High throughput no yes
RAMAC_HUMAN [view interactions] High throughput no yes
ZN174_HUMAN [view interactions] High throughput no yes
JUNB_HUMAN [view interactions] High throughput no yes
KDM4B_HUMAN [view interactions] High throughput no no
APC16_HUMAN [view interactions] High throughput no yes
LIN7C_HUMAN [view entry] [view interactions] High throughput yes yes
IBP5_HUMAN [view interactions] High throughput no no
SKP2_HUMAN [view interactions] High throughput no yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOF_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
YTDC1_HUMAN [view interactions] High throughput no yes
NAA16_HUMAN [view interactions] High throughput no yes
XRCC5_HUMAN [view interactions] High throughput no yes
SMYD3_HUMAN [view interactions] High throughput no yes
KCC2G_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
GBG2_HUMAN [view entry] [view interactions] Computational yes yes
PI51A_HUMAN [view interactions] Computational no yes
ITPR3_HUMAN [view interactions] Computational no yes
PI51C_HUMAN [view entry] [view interactions] Computational yes yes
MTG1_HUMAN [view interactions] Computational no yes
PI42A_HUMAN [view entry] [view interactions] Computational yes yes
GNAT3_HUMAN [view interactions] Computational no no
PLCB2_HUMAN [view interactions] Computational no no
KGP1_HUMAN [view interactions] Computational no yes
EDN1_HUMAN [view interactions] Computational no no
PI42C_HUMAN [view interactions] Computational no yes
DGKI_HUMAN [view entry] [view interactions] Computational yes no
EDNRA_HUMAN [view interactions] Computational no yes
PLCB1_HUMAN [view entry] [view interactions] Computational yes yes
GPC6A_HUMAN [view interactions] Computational no no
EDNRB_HUMAN [view interactions] Computational no no
GNA14_HUMAN [view entry] [view interactions] Computational yes yes
PI51B_HUMAN [view interactions] Computational no yes
GBB1_HUMAN [view entry] [view interactions] Computational yes yes
GNA15_HUMAN [view interactions] Computational no yes
GNAI3_HUMAN [view entry] [view interactions] Computational yes yes
GNA11_HUMAN [view entry] [view interactions] Computational yes yes
CASR_HUMAN [view interactions] Computational no no
MK14_HUMAN [view interactions] Computational no yes
KGP2_HUMAN [view entry] [view interactions] Computational yes yes
PI5L1_HUMAN [view interactions] Computational no no
PI42B_HUMAN [view entry] [view interactions] Computational yes no