Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MAG_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 . Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane . Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth . Inhibits axon outgrowth by binding to RTN4R . Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
133 Ser Arg Spasticparaplegia75,autosomalrecessive(SPG75) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MAG_HUMAN
GO:0043169 cation binding 35.7143 4 no
GO:0046872 metal ion binding 35.7143 5 no
GO:0043168 anion binding 28.5714 4 yes
GO:0015631 tubulin binding 28.5714 4 no
GO:0008017 microtubule binding 21.4286 5 no
GO:0003779 actin binding 21.4286 4 no
GO:0019900 kinase binding 14.2857 4 yes
GO:0019901 protein kinase binding 14.2857 5 yes
GO:0031406 carboxylic acid binding 14.2857 4 yes
GO:0035594 ganglioside binding 14.2857 4 yes
GO:0043208 glycosphingolipid binding 14.2857 4 yes
GO:1905576 ganglioside GT1b binding 14.2857 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MAG_HUMAN
GO:0048522 positive regulation of cellular process 78.5714 4 yes
GO:0048523 negative regulation of cellular process 78.5714 4 yes
GO:0030030 cell projection organization 64.2857 4 yes
GO:0051128 regulation of cellular component organization 64.2857 4 yes
GO:0010646 regulation of cell communication 64.2857 4 no
GO:0051049 regulation of transport 57.1429 4 no
GO:0120036 plasma membrane bounded cell projection organization 57.1429 5 yes
GO:0050804 modulation of chemical synaptic transmission 50.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 50.0000 4 no
GO:0031344 regulation of cell projection organization 50.0000 5 yes
GO:0051129 negative regulation of cellular component organization 50.0000 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 50.0000 6 yes
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 42.8571 4 no
GO:1901701 cellular response to oxygen-containing compound 42.8571 4 no
GO:0022607 cellular component assembly 42.8571 4 yes
GO:0031175 neuron projection development 42.8571 6 yes
GO:0045595 regulation of cell differentiation 42.8571 4 yes
GO:0048638 regulation of developmental growth 42.8571 4 yes
GO:0009893 positive regulation of metabolic process 42.8571 4 no
GO:0010468 regulation of gene expression 42.8571 6 no
GO:0010556 regulation of macromolecule biosynthetic process 42.8571 5 no
GO:0010604 positive regulation of macromolecule metabolic process 42.8571 5 no
GO:0031325 positive regulation of cellular metabolic process 42.8571 5 no
GO:0031326 regulation of cellular biosynthetic process 42.8571 5 no
GO:0042325 regulation of phosphorylation 35.7143 7 no
GO:0050890 cognition 35.7143 4 no
GO:0051174 regulation of phosphorus metabolic process 35.7143 5 no
GO:0060341 regulation of cellular localization 35.7143 4 no
GO:0071310 cellular response to organic substance 35.7143 4 no
GO:0071417 cellular response to organonitrogen compound 35.7143 4 no
GO:1901699 cellular response to nitrogen compound 35.7143 4 no
GO:0044087 regulation of cellular component biogenesis 35.7143 4 no
GO:0051130 positive regulation of cellular component organization 35.7143 5 no
GO:0010975 regulation of neuron projection development 35.7143 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 35.7143 4 yes
GO:0051093 negative regulation of developmental process 35.7143 4 yes
GO:0051240 positive regulation of multicellular organismal process 35.7143 4 yes
GO:0009966 regulation of signal transduction 35.7143 4 no
GO:1902531 regulation of intracellular signal transduction 35.7143 5 no
GO:0009890 negative regulation of biosynthetic process 35.7143 5 no
GO:0009892 negative regulation of metabolic process 35.7143 4 no
GO:0010243 response to organonitrogen compound 35.7143 4 no
GO:0019220 regulation of phosphate metabolic process 35.7143 6 no
GO:0031324 negative regulation of cellular metabolic process 35.7143 5 no
GO:0034762 regulation of transmembrane transport 28.5714 4 no
GO:0042127 regulation of cell population proliferation 28.5714 4 no
GO:0042327 positive regulation of phosphorylation 28.5714 8 no
GO:0043269 regulation of monoatomic ion transport 28.5714 5 no
GO:0045937 positive regulation of phosphate metabolic process 28.5714 7 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0070201 regulation of establishment of protein localization 28.5714 6 no
GO:0080090 regulation of primary metabolic process 28.5714 4 no
GO:1903829 positive regulation of protein localization 28.5714 5 no
GO:0006996 organelle organization 28.5714 4 no
GO:0010970 transport along microtubule 28.5714 4 no
GO:0030705 cytoskeleton-dependent intracellular transport 28.5714 4 no
GO:0031346 positive regulation of cell projection organization 28.5714 6 no
GO:0033043 regulation of organelle organization 28.5714 5 no
GO:0099111 microtubule-based transport 28.5714 4 no
GO:0036211 protein modification process 28.5714 4 no
GO:0043412 macromolecule modification 28.5714 4 no
GO:0001558 regulation of cell growth 28.5714 4 yes
GO:0030516 regulation of axon extension 28.5714 5 yes
GO:0031345 negative regulation of cell projection organization 28.5714 6 yes
GO:0045596 negative regulation of cell differentiation 28.5714 5 yes
GO:0045664 regulation of neuron differentiation 28.5714 5 yes
GO:0050767 regulation of neurogenesis 28.5714 6 yes
GO:0050770 regulation of axonogenesis 28.5714 5 yes
GO:0051241 negative regulation of multicellular organismal process 28.5714 4 yes
GO:0051960 regulation of nervous system development 28.5714 5 yes
GO:0060284 regulation of cell development 28.5714 5 yes
GO:0061387 regulation of extent of cell growth 28.5714 5 yes
GO:0061564 axon development 28.5714 7 yes
GO:2000026 regulation of multicellular organismal development 28.5714 4 yes
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:0043085 positive regulation of catalytic activity 28.5714 4 no
GO:0048812 neuron projection morphogenesis 28.5714 5 no
GO:0080134 regulation of response to stress 28.5714 4 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 28.5714 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0010562 positive regulation of phosphorus metabolic process 28.5714 6 no
GO:0010605 negative regulation of macromolecule metabolic process 28.5714 5 no
GO:0010629 negative regulation of gene expression 28.5714 7 no
GO:0031327 negative regulation of cellular biosynthetic process 28.5714 6 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0034765 regulation of monoatomic ion transmembrane transport 21.4286 5 no
GO:0042326 negative regulation of phosphorylation 21.4286 8 no
GO:0043549 regulation of kinase activity 21.4286 5 no
GO:0045936 negative regulation of phosphate metabolic process 21.4286 7 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 21.4286 8 no
GO:0050807 regulation of synapse organization 21.4286 5 no
GO:0050848 regulation of calcium-mediated signaling 21.4286 6 no
GO:0051248 negative regulation of protein metabolic process 21.4286 6 no
GO:0051338 regulation of transferase activity 21.4286 4 no
GO:0051726 regulation of cell cycle 21.4286 4 no
GO:0051924 regulation of calcium ion transport 21.4286 7 no
GO:0106027 neuron projection organization 21.4286 6 no
GO:1903169 regulation of calcium ion transmembrane transport 21.4286 7 no
GO:1904062 regulation of monoatomic cation transmembrane transport 21.4286 6 no
GO:1904645 response to amyloid-beta 21.4286 4 no
GO:1904646 cellular response to amyloid-beta 21.4286 5 no
GO:1904951 positive regulation of establishment of protein localization 21.4286 6 no
GO:0007416 synapse assembly 21.4286 6 no
GO:0010638 positive regulation of organelle organization 21.4286 6 no
GO:0010639 negative regulation of organelle organization 21.4286 6 no
GO:0034329 cell junction assembly 21.4286 5 no
GO:0034330 cell junction organization 21.4286 4 no
GO:0043254 regulation of protein-containing complex assembly 21.4286 5 no
GO:0044089 positive regulation of cellular component biogenesis 21.4286 5 no
GO:0050808 synapse organization 21.4286 5 no
GO:0051654 establishment of mitochondrion localization 21.4286 4 no
GO:0071363 cellular response to growth factor stimulus 21.4286 4 no
GO:1902903 regulation of supramolecular fiber organization 21.4286 5 no
GO:1902905 positive regulation of supramolecular fiber organization 21.4286 6 no
GO:0051050 positive regulation of transport 21.4286 4 no
GO:0006796 phosphate-containing compound metabolic process 21.4286 4 no
GO:0006811 monoatomic ion transport 21.4286 4 no
GO:0006812 monoatomic cation transport 21.4286 5 no
GO:0009894 regulation of catabolic process 21.4286 4 no
GO:0030001 metal ion transport 21.4286 6 no
GO:0009891 positive regulation of biosynthetic process 21.4286 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.4286 6 no
GO:0010628 positive regulation of gene expression 21.4286 7 no
GO:0031328 positive regulation of cellular biosynthetic process 21.4286 6 no
GO:0010720 positive regulation of cell development 21.4286 6 yes
GO:0021762 substantia nigra development 21.4286 4 yes
GO:0042981 regulation of apoptotic process 21.4286 5 yes
GO:0043066 negative regulation of apoptotic process 21.4286 6 yes
GO:0043067 regulation of programmed cell death 21.4286 4 yes
GO:0043069 negative regulation of programmed cell death 21.4286 5 yes
GO:0045597 positive regulation of cell differentiation 21.4286 5 yes
GO:0045665 negative regulation of neuron differentiation 21.4286 6 yes
GO:0045926 negative regulation of growth 21.4286 4 yes
GO:0048640 negative regulation of developmental growth 21.4286 5 yes
GO:0050769 positive regulation of neurogenesis 21.4286 6 yes
GO:0051094 positive regulation of developmental process 21.4286 4 yes
GO:0051962 positive regulation of nervous system development 21.4286 5 yes
GO:0007409 axonogenesis 21.4286 6 no
GO:0009967 positive regulation of signal transduction 21.4286 5 no
GO:0032101 regulation of response to external stimulus 21.4286 4 no
GO:0048584 positive regulation of response to stimulus 21.4286 4 no
GO:0048585 negative regulation of response to stimulus 21.4286 4 no
GO:0051336 regulation of hydrolase activity 21.4286 4 no
GO:0051345 positive regulation of hydrolase activity 21.4286 5 no
GO:1902533 positive regulation of intracellular signal transduction 21.4286 6 no
GO:0001932 regulation of protein phosphorylation 21.4286 7 no
GO:0001934 positive regulation of protein phosphorylation 21.4286 8 no
GO:0007613 memory 21.4286 4 no
GO:0008285 negative regulation of cell population proliferation 21.4286 5 no
GO:0010563 negative regulation of phosphorus metabolic process 21.4286 6 no
GO:0010648 negative regulation of cell communication 21.4286 5 no
GO:0010959 regulation of metal ion transport 21.4286 6 no
GO:0023057 negative regulation of signaling 21.4286 4 no
GO:0030162 regulation of proteolysis 21.4286 6 no
GO:0031400 negative regulation of protein modification process 21.4286 7 no
GO:0031401 positive regulation of protein modification process 21.4286 7 no
GO:0010721 negative regulation of cell development 14.2857 6 yes
GO:0010977 negative regulation of neuron projection development 14.2857 7 yes
GO:0030308 negative regulation of cell growth 14.2857 5 yes
GO:0030517 negative regulation of axon extension 14.2857 6 yes
GO:0031102 neuron projection regeneration 14.2857 4 yes
GO:0031103 axon regeneration 14.2857 5 yes
GO:0031644 regulation of nervous system process 14.2857 5 yes
GO:0043523 regulation of neuron apoptotic process 14.2857 6 yes
GO:0044057 regulation of system process 14.2857 4 yes
GO:0048678 response to axon injury 14.2857 4 yes
GO:0050768 negative regulation of neurogenesis 14.2857 6 yes
GO:0050771 negative regulation of axonogenesis 14.2857 6 yes
GO:0051961 negative regulation of nervous system development 14.2857 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RTN4R_HUMAN [view entry] [view interactions] Low throughput yes no
FINC_HUMAN [view interactions] Low throughput no yes
MAP1B_HUMAN [view entry] [view interactions] Low throughput yes yes
CO1A1_HUMAN [view interactions] Low throughput no yes
CO2A1_HUMAN [view interactions] Low throughput no no
CO3A1_HUMAN [view interactions] Low throughput no no
CO4A1_HUMAN [view interactions] Low throughput no yes
CO5A1_HUMAN [view interactions] Low throughput no no
CO6A1_HUMAN [view interactions] Low throughput no no
CO9A1_HUMAN [view interactions] Low throughput no no
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
DYL1_HUMAN [view entry] [view interactions] Low throughput yes no
FTM_HUMAN [view interactions] High throughput no yes
IQCB1_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
RIN3_HUMAN [view interactions] High throughput no yes
PLCB3_HUMAN [view entry] [view interactions] High throughput yes no
SYMM_HUMAN [view interactions] High throughput no yes
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
OTUD4_HUMAN [view interactions] High throughput no yes
MYPR_HUMAN [view entry] [view interactions] High throughput yes yes
RASN_HUMAN [view entry] [view interactions] High throughput yes no