MAG_HUMAN
Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 . Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane . Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth . Inhibits axon outgrowth by binding to RTN4R . Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b . [View more on UniProt]
Interacting region for partners were not defined.
Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
133 | Ser | Arg | Spasticparaplegia75,autosomalrecessive(SPG75) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in MAG_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 23.8095 | 4 | no |
GO:0019900 | kinase binding | 14.2857 | 4 | yes |
GO:0019901 | protein kinase binding | 14.2857 | 5 | yes |
GO:0042803 | protein homodimerization activity | 14.2857 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in MAG_HUMAN |
---|---|---|---|---|
GO:0030030 | cell projection organization | 66.6667 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 61.9048 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 57.1429 | 4 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 57.1429 | 5 | yes |
GO:0010468 | regulation of gene expression | 52.3810 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 52.3810 | 4 | no |
GO:0031175 | neuron projection development | 47.6190 | 6 | yes |
GO:0031344 | regulation of cell projection organization | 47.6190 | 5 | yes |
GO:0051128 | regulation of cellular component organization | 47.6190 | 4 | yes |
GO:0051129 | negative regulation of cellular component organization | 47.6190 | 5 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 47.6190 | 6 | yes |
GO:0009893 | positive regulation of metabolic process | 47.6190 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 47.6190 | 5 | no |
GO:0010646 | regulation of cell communication | 42.8571 | 4 | no |
GO:0010941 | regulation of cell death | 38.0952 | 4 | yes |
GO:0010975 | regulation of neuron projection development | 38.0952 | 7 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 38.0952 | 4 | yes |
GO:0022607 | cellular component assembly | 38.0952 | 4 | yes |
GO:0031345 | negative regulation of cell projection organization | 38.0952 | 6 | yes |
GO:0045595 | regulation of cell differentiation | 38.0952 | 4 | yes |
GO:0051093 | negative regulation of developmental process | 38.0952 | 4 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 38.0952 | 4 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 38.0952 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 38.0952 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 38.0952 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 38.0952 | 5 | no |
GO:0071310 | cellular response to organic substance | 38.0952 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 38.0952 | 4 | no |
GO:1901701 | cellular response to oxygen-containing compound | 38.0952 | 4 | no |
GO:0051094 | positive regulation of developmental process | 33.3333 | 4 | yes |
GO:2000026 | regulation of multicellular organismal development | 33.3333 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
GO:0030162 | regulation of proteolysis | 33.3333 | 6 | no |
GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
GO:0043085 | positive regulation of catalytic activity | 33.3333 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
GO:0060341 | regulation of cellular localization | 33.3333 | 4 | no |
GO:0010243 | response to organonitrogen compound | 33.3333 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 33.3333 | 4 | no |
GO:0051049 | regulation of transport | 33.3333 | 4 | no |
GO:0021762 | substantia nigra development | 28.5714 | 4 | yes |
GO:0042981 | regulation of apoptotic process | 28.5714 | 6 | yes |
GO:0043067 | regulation of programmed cell death | 28.5714 | 5 | yes |
GO:0045596 | negative regulation of cell differentiation | 28.5714 | 5 | yes |
GO:0048638 | regulation of developmental growth | 28.5714 | 4 | yes |
GO:1901214 | regulation of neuron death | 28.5714 | 5 | yes |
GO:0006996 | organelle organization | 28.5714 | 4 | no |
GO:0010942 | positive regulation of cell death | 28.5714 | 5 | no |
GO:0010950 | positive regulation of endopeptidase activity | 28.5714 | 7 | no |
GO:0010952 | positive regulation of peptidase activity | 28.5714 | 6 | no |
GO:0019220 | regulation of phosphate metabolic process | 28.5714 | 6 | no |
GO:0031325 | positive regulation of cellular metabolic process | 28.5714 | 5 | no |
GO:0032880 | regulation of protein localization | 28.5714 | 5 | no |
GO:0042325 | regulation of phosphorylation | 28.5714 | 7 | no |
GO:0045862 | positive regulation of proteolysis | 28.5714 | 7 | no |
GO:0050804 | modulation of chemical synaptic transmission | 28.5714 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 28.5714 | 5 | no |
GO:0051336 | regulation of hydrolase activity | 28.5714 | 4 | no |
GO:0051345 | positive regulation of hydrolase activity | 28.5714 | 5 | no |
GO:0052547 | regulation of peptidase activity | 28.5714 | 5 | no |
GO:0052548 | regulation of endopeptidase activity | 28.5714 | 6 | no |
GO:0099177 | regulation of trans-synaptic signaling | 28.5714 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 28.5714 | 5 | no |
GO:1903829 | positive regulation of protein localization | 28.5714 | 5 | no |
GO:0010628 | positive regulation of gene expression | 28.5714 | 6 | no |
GO:0043269 | regulation of ion transport | 28.5714 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
GO:0071417 | cellular response to organonitrogen compound | 28.5714 | 4 | no |
GO:1901699 | cellular response to nitrogen compound | 28.5714 | 4 | no |
GO:0001558 | regulation of cell growth | 23.8095 | 4 | yes |
GO:0010977 | negative regulation of neuron projection development | 23.8095 | 7 | yes |
GO:0045597 | positive regulation of cell differentiation | 23.8095 | 5 | yes |
GO:0045664 | regulation of neuron differentiation | 23.8095 | 5 | yes |
GO:0050767 | regulation of neurogenesis | 23.8095 | 6 | yes |
GO:0050770 | regulation of axonogenesis | 23.8095 | 5 | yes |
GO:0051960 | regulation of nervous system development | 23.8095 | 5 | yes |
GO:0060284 | regulation of cell development | 23.8095 | 5 | yes |
GO:0060548 | negative regulation of cell death | 23.8095 | 5 | yes |
GO:0061564 | axon development | 23.8095 | 7 | yes |
GO:0010562 | positive regulation of phosphorus metabolic process | 23.8095 | 6 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 23.8095 | 5 | no |
GO:0031399 | regulation of protein modification process | 23.8095 | 6 | no |
GO:0042327 | positive regulation of phosphorylation | 23.8095 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 23.8095 | 7 | no |
GO:0050890 | cognition | 23.8095 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 23.8095 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 23.8095 | 5 | no |
GO:1901216 | positive regulation of neuron death | 23.8095 | 6 | no |
GO:2000116 | regulation of cysteine-type endopeptidase activity | 23.8095 | 7 | no |
GO:2001056 | positive regulation of cysteine-type endopeptidase activity | 23.8095 | 8 | no |
GO:0006796 | phosphate-containing compound metabolic process | 23.8095 | 4 | no |
GO:0002684 | positive regulation of immune system process | 23.8095 | 4 | no |
GO:0008285 | negative regulation of cell population proliferation | 23.8095 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 23.8095 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 23.8095 | 5 | no |
GO:0010647 | positive regulation of cell communication | 23.8095 | 5 | no |
GO:0010648 | negative regulation of cell communication | 23.8095 | 5 | no |
GO:0014070 | response to organic cyclic compound | 23.8095 | 4 | no |
GO:0023056 | positive regulation of signaling | 23.8095 | 4 | no |
GO:0023057 | negative regulation of signaling | 23.8095 | 4 | no |
GO:0030334 | regulation of cell migration | 23.8095 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 23.8095 | 5 | no |
GO:0032990 | cell part morphogenesis | 23.8095 | 4 | no |
GO:0033993 | response to lipid | 23.8095 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 23.8095 | 4 | no |
GO:0048812 | neuron projection morphogenesis | 23.8095 | 7 | no |
GO:0048858 | cell projection morphogenesis | 23.8095 | 5 | no |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 23.8095 | 6 | no |
GO:2000145 | regulation of cell motility | 23.8095 | 4 | no |
GO:1901652 | response to peptide | 23.8095 | 4 | no |
GO:1901653 | cellular response to peptide | 23.8095 | 5 | no |
GO:0051050 | positive regulation of transport | 23.8095 | 4 | no |
GO:0001817 | regulation of cytokine production | 23.8095 | 4 | no |
GO:0050776 | regulation of immune response | 23.8095 | 4 | no |
GO:0030516 | regulation of axon extension | 19.0476 | 5 | yes |
GO:0031102 | neuron projection regeneration | 19.0476 | 4 | yes |
GO:0043523 | regulation of neuron apoptotic process | 19.0476 | 6 | yes |
GO:0045665 | negative regulation of neuron differentiation | 19.0476 | 6 | yes |
GO:0061387 | regulation of extent of cell growth | 19.0476 | 5 | yes |
GO:0010720 | positive regulation of cell development | 14.2857 | 6 | yes |
GO:0010721 | negative regulation of cell development | 14.2857 | 6 | yes |
GO:0031103 | axon regeneration | 14.2857 | 5 | yes |
GO:0043066 | negative regulation of apoptotic process | 14.2857 | 7 | yes |
GO:0043069 | negative regulation of programmed cell death | 14.2857 | 6 | yes |
GO:0044057 | regulation of system process | 14.2857 | 4 | yes |
GO:0045926 | negative regulation of growth | 14.2857 | 4 | yes |
GO:0048640 | negative regulation of developmental growth | 14.2857 | 5 | yes |
GO:0048678 | response to axon injury | 14.2857 | 4 | yes |
GO:0050768 | negative regulation of neurogenesis | 14.2857 | 6 | yes |
GO:0050769 | positive regulation of neurogenesis | 14.2857 | 6 | yes |
GO:0050771 | negative regulation of axonogenesis | 14.2857 | 6 | yes |
GO:0051961 | negative regulation of nervous system development | 14.2857 | 5 | yes |
GO:0051962 | positive regulation of nervous system development | 14.2857 | 5 | yes |
GO:1901215 | negative regulation of neuron death | 14.2857 | 6 | yes |
GO:0030308 | negative regulation of cell growth | 9.5238 | 5 | yes |
GO:0030517 | negative regulation of axon extension | 9.5238 | 6 | yes |
GO:0031644 | regulation of nervous system process | 9.5238 | 5 | yes |
GO:0043524 | negative regulation of neuron apoptotic process | 9.5238 | 7 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RTN4R_HUMAN | [view interactions] | Low throughput | no | no |
FINC_HUMAN | [view interactions] | Low throughput | no | yes |
MAP1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CO1A1_HUMAN | [view interactions] | Low throughput | no | yes |
CO2A1_HUMAN | [view interactions] | Low throughput | no | no |
CO3A1_HUMAN | [view interactions] | Low throughput | no | no |
CO4A1_HUMAN | [view interactions] | Low throughput | no | yes |
CO5A1_HUMAN | [view interactions] | Low throughput | no | no |
CO6A1_HUMAN | [view interactions] | Low throughput | no | no |
CO9A1_HUMAN | [view interactions] | Low throughput | no | no |
FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DYL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
FTM_HUMAN | [view interactions] | High throughput | no | yes |
IQCB1_HUMAN | [view interactions] | High throughput | no | no |
PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RIN3_HUMAN | [view interactions] | High throughput | no | yes |
PLCB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYMM_HUMAN | [view interactions] | High throughput | no | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
MYPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CN37_HUMAN | [view entry] [view interactions] | Computational | yes | no |
MBP_HUMAN | [view entry] [view interactions] | Computational | yes | no |
OPALI_HUMAN | [view interactions] | Computational | no | yes |
RTN4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AGRV1_HUMAN | [view interactions] | Computational | no | no |
R4RL2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
MOG_HUMAN | [view entry] [view interactions] | Computational | yes | no |
TNR16_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SOX10_HUMAN | [view interactions] | Computational | no | yes |
EGR2_HUMAN | [view interactions] | Computational | no | no |
RHOA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
OMGP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LIGO1_HUMAN | [view entry] [view interactions] | Computational | yes | no |