Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MAG_HUMAN

Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 . Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane . Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth . Inhibits axon outgrowth by binding to RTN4R . Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b . [View more on UniProt]

Interacting region for partners were not defined.

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Position Amino acid Mutation Disease Overlap with binding region
133 Ser Arg Spasticparaplegia75,autosomalrecessive(SPG75) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in MAG_HUMAN
GO:0046872 metal ion binding 23.8095 4 no
GO:0019900 kinase binding 14.2857 4 yes
GO:0019901 protein kinase binding 14.2857 5 yes
GO:0042803 protein homodimerization activity 14.2857 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MAG_HUMAN
GO:0030030 cell projection organization 66.6667 4 yes
GO:0048523 negative regulation of cellular process 61.9048 4 yes
GO:0048522 positive regulation of cellular process 57.1429 4 yes
GO:0120036 plasma membrane bounded cell projection organization 57.1429 5 yes
GO:0010468 regulation of gene expression 52.3810 5 no
GO:0060255 regulation of macromolecule metabolic process 52.3810 4 no
GO:0031175 neuron projection development 47.6190 6 yes
GO:0031344 regulation of cell projection organization 47.6190 5 yes
GO:0051128 regulation of cellular component organization 47.6190 4 yes
GO:0051129 negative regulation of cellular component organization 47.6190 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 47.6190 6 yes
GO:0009893 positive regulation of metabolic process 47.6190 4 no
GO:0010604 positive regulation of macromolecule metabolic process 47.6190 5 no
GO:0010646 regulation of cell communication 42.8571 4 no
GO:0010941 regulation of cell death 38.0952 4 yes
GO:0010975 regulation of neuron projection development 38.0952 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 38.0952 4 yes
GO:0022607 cellular component assembly 38.0952 4 yes
GO:0031345 negative regulation of cell projection organization 38.0952 6 yes
GO:0045595 regulation of cell differentiation 38.0952 4 yes
GO:0051093 negative regulation of developmental process 38.0952 4 yes
GO:0051240 positive regulation of multicellular organismal process 38.0952 4 yes
GO:0051241 negative regulation of multicellular organismal process 38.0952 4 yes
GO:0031323 regulation of cellular metabolic process 38.0952 4 no
GO:0051171 regulation of nitrogen compound metabolic process 38.0952 4 no
GO:0051246 regulation of protein metabolic process 38.0952 5 no
GO:0071310 cellular response to organic substance 38.0952 4 no
GO:0080090 regulation of primary metabolic process 38.0952 4 no
GO:1901701 cellular response to oxygen-containing compound 38.0952 4 no
GO:0051094 positive regulation of developmental process 33.3333 4 yes
GO:2000026 regulation of multicellular organismal development 33.3333 4 yes
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0030162 regulation of proteolysis 33.3333 6 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0010243 response to organonitrogen compound 33.3333 4 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0021762 substantia nigra development 28.5714 4 yes
GO:0042981 regulation of apoptotic process 28.5714 6 yes
GO:0043067 regulation of programmed cell death 28.5714 5 yes
GO:0045596 negative regulation of cell differentiation 28.5714 5 yes
GO:0048638 regulation of developmental growth 28.5714 4 yes
GO:1901214 regulation of neuron death 28.5714 5 yes
GO:0006996 organelle organization 28.5714 4 no
GO:0010942 positive regulation of cell death 28.5714 5 no
GO:0010950 positive regulation of endopeptidase activity 28.5714 7 no
GO:0010952 positive regulation of peptidase activity 28.5714 6 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0045862 positive regulation of proteolysis 28.5714 7 no
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0051336 regulation of hydrolase activity 28.5714 4 no
GO:0051345 positive regulation of hydrolase activity 28.5714 5 no
GO:0052547 regulation of peptidase activity 28.5714 5 no
GO:0052548 regulation of endopeptidase activity 28.5714 6 no
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:1903829 positive regulation of protein localization 28.5714 5 no
GO:0010628 positive regulation of gene expression 28.5714 6 no
GO:0043269 regulation of ion transport 28.5714 5 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0071417 cellular response to organonitrogen compound 28.5714 4 no
GO:1901699 cellular response to nitrogen compound 28.5714 4 no
GO:0001558 regulation of cell growth 23.8095 4 yes
GO:0010977 negative regulation of neuron projection development 23.8095 7 yes
GO:0045597 positive regulation of cell differentiation 23.8095 5 yes
GO:0045664 regulation of neuron differentiation 23.8095 5 yes
GO:0050767 regulation of neurogenesis 23.8095 6 yes
GO:0050770 regulation of axonogenesis 23.8095 5 yes
GO:0051960 regulation of nervous system development 23.8095 5 yes
GO:0060284 regulation of cell development 23.8095 5 yes
GO:0060548 negative regulation of cell death 23.8095 5 yes
GO:0061564 axon development 23.8095 7 yes
GO:0010562 positive regulation of phosphorus metabolic process 23.8095 6 no
GO:0010605 negative regulation of macromolecule metabolic process 23.8095 5 no
GO:0031399 regulation of protein modification process 23.8095 6 no
GO:0042327 positive regulation of phosphorylation 23.8095 8 no
GO:0045937 positive regulation of phosphate metabolic process 23.8095 7 no
GO:0050890 cognition 23.8095 4 no
GO:0051130 positive regulation of cellular component organization 23.8095 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 23.8095 5 no
GO:1901216 positive regulation of neuron death 23.8095 6 no
GO:2000116 regulation of cysteine-type endopeptidase activity 23.8095 7 no
GO:2001056 positive regulation of cysteine-type endopeptidase activity 23.8095 8 no
GO:0006796 phosphate-containing compound metabolic process 23.8095 4 no
GO:0002684 positive regulation of immune system process 23.8095 4 no
GO:0008285 negative regulation of cell population proliferation 23.8095 5 no
GO:0009889 regulation of biosynthetic process 23.8095 4 no
GO:0009967 positive regulation of signal transduction 23.8095 5 no
GO:0010647 positive regulation of cell communication 23.8095 5 no
GO:0010648 negative regulation of cell communication 23.8095 5 no
GO:0014070 response to organic cyclic compound 23.8095 4 no
GO:0023056 positive regulation of signaling 23.8095 4 no
GO:0023057 negative regulation of signaling 23.8095 4 no
GO:0030334 regulation of cell migration 23.8095 5 no
GO:0031326 regulation of cellular biosynthetic process 23.8095 5 no
GO:0032990 cell part morphogenesis 23.8095 4 no
GO:0033993 response to lipid 23.8095 4 no
GO:0048585 negative regulation of response to stimulus 23.8095 4 no
GO:0048812 neuron projection morphogenesis 23.8095 7 no
GO:0048858 cell projection morphogenesis 23.8095 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 23.8095 6 no
GO:2000145 regulation of cell motility 23.8095 4 no
GO:1901652 response to peptide 23.8095 4 no
GO:1901653 cellular response to peptide 23.8095 5 no
GO:0051050 positive regulation of transport 23.8095 4 no
GO:0001817 regulation of cytokine production 23.8095 4 no
GO:0050776 regulation of immune response 23.8095 4 no
GO:0030516 regulation of axon extension 19.0476 5 yes
GO:0031102 neuron projection regeneration 19.0476 4 yes
GO:0043523 regulation of neuron apoptotic process 19.0476 6 yes
GO:0045665 negative regulation of neuron differentiation 19.0476 6 yes
GO:0061387 regulation of extent of cell growth 19.0476 5 yes
GO:0010720 positive regulation of cell development 14.2857 6 yes
GO:0010721 negative regulation of cell development 14.2857 6 yes
GO:0031103 axon regeneration 14.2857 5 yes
GO:0043066 negative regulation of apoptotic process 14.2857 7 yes
GO:0043069 negative regulation of programmed cell death 14.2857 6 yes
GO:0044057 regulation of system process 14.2857 4 yes
GO:0045926 negative regulation of growth 14.2857 4 yes
GO:0048640 negative regulation of developmental growth 14.2857 5 yes
GO:0048678 response to axon injury 14.2857 4 yes
GO:0050768 negative regulation of neurogenesis 14.2857 6 yes
GO:0050769 positive regulation of neurogenesis 14.2857 6 yes
GO:0050771 negative regulation of axonogenesis 14.2857 6 yes
GO:0051961 negative regulation of nervous system development 14.2857 5 yes
GO:0051962 positive regulation of nervous system development 14.2857 5 yes
GO:1901215 negative regulation of neuron death 14.2857 6 yes
GO:0030308 negative regulation of cell growth 9.5238 5 yes
GO:0030517 negative regulation of axon extension 9.5238 6 yes
GO:0031644 regulation of nervous system process 9.5238 5 yes
GO:0043524 negative regulation of neuron apoptotic process 9.5238 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RTN4R_HUMAN [view interactions] Low throughput no no
FINC_HUMAN [view interactions] Low throughput no yes
MAP1B_HUMAN [view entry] [view interactions] Low throughput yes yes
CO1A1_HUMAN [view interactions] Low throughput no yes
CO2A1_HUMAN [view interactions] Low throughput no no
CO3A1_HUMAN [view interactions] Low throughput no no
CO4A1_HUMAN [view interactions] Low throughput no yes
CO5A1_HUMAN [view interactions] Low throughput no no
CO6A1_HUMAN [view interactions] Low throughput no no
CO9A1_HUMAN [view interactions] Low throughput no no
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
DYL1_HUMAN [view entry] [view interactions] Low throughput yes no
FTM_HUMAN [view interactions] High throughput no yes
IQCB1_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
RIN3_HUMAN [view interactions] High throughput no yes
PLCB3_HUMAN [view entry] [view interactions] High throughput yes no
SYMM_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
OTUD4_HUMAN [view interactions] High throughput no yes
MYPR_HUMAN [view entry] [view interactions] High throughput yes yes
RASN_HUMAN [view entry] [view interactions] High throughput yes no
CN37_HUMAN [view entry] [view interactions] Computational yes no
MBP_HUMAN [view entry] [view interactions] Computational yes no
OPALI_HUMAN [view interactions] Computational no yes
RTN4_HUMAN [view entry] [view interactions] Computational yes yes
AGRV1_HUMAN [view interactions] Computational no no
R4RL2_HUMAN [view entry] [view interactions] Computational yes no
MOG_HUMAN [view entry] [view interactions] Computational yes no
TNR16_HUMAN [view entry] [view interactions] Computational yes no
SOX10_HUMAN [view interactions] Computational no yes
EGR2_HUMAN [view interactions] Computational no no
RHOA_HUMAN [view entry] [view interactions] Computational yes yes
OMGP_HUMAN [view entry] [view interactions] Computational yes yes
LIGO1_HUMAN [view entry] [view interactions] Computational yes no