RTN4R_HUMAN
Evidence for PS localization
Functions
Receptor for RTN4, OMG and MAG (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Functions as a receptor for the sialylated gangliosides GT1b and GM1 (PubMed). Besides, functions as a receptor for chondroitin sulfate proteoglycans . Can also bind heparin . Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed, PubMed). Mediates axonal growth inhibition (PubMed, PubMed, PubMed). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 119 | Arg | Trp | Schizophrenia(SCZD) | - |
| 196 | Arg | His | Schizophrenia(SCZD) | - |
| 292 | Arg | His | Schizophrenia(SCZD) | - |
| 377 | Arg | Gln | Schizophrenia(SCZD) | - |
| 377 | Arg | Trp | Schizophrenia(SCZD) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RTN4R_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 33.3333 | 4 | yes |
| GO:0031406 | carboxylic acid binding | 26.6667 | 4 | yes |
| GO:0043169 | cation binding | 26.6667 | 4 | no |
| GO:0046872 | metal ion binding | 26.6667 | 5 | no |
| GO:0035594 | ganglioside binding | 20.0000 | 4 | yes |
| GO:0043208 | glycosphingolipid binding | 20.0000 | 4 | yes |
| GO:1905576 | ganglioside GT1b binding | 20.0000 | 5 | yes |
| GO:0038131 | neuregulin receptor activity | 13.3333 | 4 | yes |
| GO:1905573 | ganglioside GM1 binding | 13.3333 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RTN4R_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 73.3333 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 73.3333 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 73.3333 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 66.6667 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 66.6667 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 60.0000 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 60.0000 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 53.3333 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 53.3333 | 5 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 53.3333 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 53.3333 | 4 | yes |
| GO:0030030 | cell projection organization | 53.3333 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 53.3333 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 53.3333 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 53.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 53.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 53.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 53.3333 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 53.3333 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 46.6667 | 5 | yes |
| GO:0032101 | regulation of response to external stimulus | 46.6667 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 46.6667 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 46.6667 | 6 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 46.6667 | 5 | yes |
| GO:0010468 | regulation of gene expression | 46.6667 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 46.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 46.6667 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 46.6667 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 46.6667 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 46.6667 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 40.0000 | 7 | yes |
| GO:0043085 | positive regulation of catalytic activity | 40.0000 | 4 | yes |
| GO:0048638 | regulation of developmental growth | 40.0000 | 4 | yes |
| GO:0051093 | negative regulation of developmental process | 40.0000 | 4 | yes |
| GO:0051960 | regulation of nervous system development | 40.0000 | 5 | yes |
| GO:0060284 | regulation of cell development | 40.0000 | 5 | yes |
| GO:0080134 | regulation of response to stress | 40.0000 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 40.0000 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 40.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 40.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:0001558 | regulation of cell growth | 33.3333 | 4 | yes |
| GO:0050767 | regulation of neurogenesis | 33.3333 | 6 | yes |
| GO:0051336 | regulation of hydrolase activity | 33.3333 | 4 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 33.3333 | 5 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 33.3333 | 7 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 33.3333 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 33.3333 | 6 | no |
| GO:0009968 | negative regulation of signal transduction | 33.3333 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 33.3333 | 5 | no |
| GO:0023057 | negative regulation of signaling | 33.3333 | 4 | no |
| GO:0030334 | regulation of cell migration | 33.3333 | 5 | no |
| GO:0031175 | neuron projection development | 33.3333 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 33.3333 | 4 | no |
| GO:0090287 | regulation of cellular response to growth factor stimulus | 33.3333 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 33.3333 | 5 | no |
| GO:2000145 | regulation of cell motility | 33.3333 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 33.3333 | 5 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
| GO:0010721 | negative regulation of cell development | 26.6667 | 6 | yes |
| GO:0010977 | negative regulation of neuron projection development | 26.6667 | 7 | yes |
| GO:0030308 | negative regulation of cell growth | 26.6667 | 5 | yes |
| GO:0030516 | regulation of axon extension | 26.6667 | 5 | yes |
| GO:0030517 | negative regulation of axon extension | 26.6667 | 6 | yes |
| GO:0031345 | negative regulation of cell projection organization | 26.6667 | 6 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 26.6667 | 5 | yes |
| GO:0045596 | negative regulation of cell differentiation | 26.6667 | 5 | yes |
| GO:0045926 | negative regulation of growth | 26.6667 | 4 | yes |
| GO:0048640 | negative regulation of developmental growth | 26.6667 | 5 | yes |
| GO:0050768 | negative regulation of neurogenesis | 26.6667 | 6 | yes |
| GO:0050770 | regulation of axonogenesis | 26.6667 | 5 | yes |
| GO:0050771 | negative regulation of axonogenesis | 26.6667 | 6 | yes |
| GO:0051129 | negative regulation of cellular component organization | 26.6667 | 5 | yes |
| GO:0051961 | negative regulation of nervous system development | 26.6667 | 5 | yes |
| GO:0061387 | regulation of extent of cell growth | 26.6667 | 5 | yes |
| GO:0032103 | positive regulation of response to external stimulus | 26.6667 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.6667 | 6 | no |
| GO:2001233 | regulation of apoptotic signaling pathway | 26.6667 | 5 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 26.6667 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 26.6667 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.6667 | 5 | no |
| GO:0032880 | regulation of protein localization | 26.6667 | 5 | no |
| GO:0050678 | regulation of epithelial cell proliferation | 26.6667 | 5 | no |
| GO:0060341 | regulation of cellular localization | 26.6667 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 26.6667 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 26.6667 | 6 | no |
| GO:0010629 | negative regulation of gene expression | 26.6667 | 7 | no |
| GO:0010632 | regulation of epithelial cell migration | 26.6667 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 26.6667 | 6 | no |
| GO:0007409 | axonogenesis | 20.0000 | 6 | yes |
| GO:0048812 | neuron projection morphogenesis | 20.0000 | 5 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 20.0000 | 6 | yes |
| GO:0051057 | positive regulation of small GTPase mediated signal transduction | 20.0000 | 7 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 20.0000 | 4 | yes |
| GO:1903034 | regulation of response to wounding | 20.0000 | 5 | yes |
| GO:1903035 | negative regulation of response to wounding | 20.0000 | 5 | yes |
| GO:0035023 | regulation of Rho protein signal transduction | 13.3333 | 7 | yes |
| GO:0035025 | positive regulation of Rho protein signal transduction | 13.3333 | 8 | yes |
| GO:0043087 | regulation of GTPase activity | 13.3333 | 5 | yes |
| GO:0043547 | positive regulation of GTPase activity | 13.3333 | 6 | yes |
| GO:0048679 | regulation of axon regeneration | 13.3333 | 5 | yes |
| GO:0048681 | negative regulation of axon regeneration | 13.3333 | 6 | yes |
| GO:0070570 | regulation of neuron projection regeneration | 13.3333 | 4 | yes |
| GO:0070571 | negative regulation of neuron projection regeneration | 13.3333 | 5 | yes |
| GO:0080135 | regulation of cellular response to stress | 13.3333 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| K319L_HUMAN | [view interactions] | Low throughput | no | yes |
| TNR16_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LIGO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MAG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RTN4R_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FGF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FGF4_HUMAN | [view interactions] | Low throughput | no | no |
| FGF1_HUMAN | [view interactions] | Low throughput | no | no |
| OMGP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGRB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| S10A9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FCGRN_HUMAN | [view interactions] | High throughput | no | yes |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| OTX1_HUMAN | [view interactions] | High throughput | no | no |
| HXA1_HUMAN | [view interactions] | High throughput | no | no |
| MGT5B_HUMAN | [view interactions] | High throughput | no | no |
| ARHGP_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| SPCS1_HUMAN | [view interactions] | High throughput | no | yes |
| SPCS2_HUMAN | [view interactions] | High throughput | no | yes |
| FUT11_HUMAN | [view interactions] | High throughput | no | yes |
| NGLY1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC32_HUMAN | [view interactions] | High throughput | no | no |
| KLH26_HUMAN | [view interactions] | High throughput | no | no |
| SPCS3_HUMAN | [view interactions] | High throughput | no | yes |
| GPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CRLF1_HUMAN | [view interactions] | High throughput | no | no |
| RHBT3_HUMAN | [view interactions] | High throughput | no | no |
| GANAB_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| LRIG2_HUMAN | [view interactions] | High throughput | no | yes |
| GSLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P3H3_HUMAN | [view interactions] | High throughput | no | yes |
| NEUFC_HUMAN | [view interactions] | High throughput | no | yes |
| SC11A_HUMAN | [view interactions] | High throughput | no | no |
| SC65_HUMAN | [view interactions] | High throughput | no | no |
| RUSF1_HUMAN | [view interactions] | High throughput | no | yes |
| TRM2A_HUMAN | [view interactions] | High throughput | no | yes |