Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TNR16_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed). Plays an important role in differentiation and survival of specific neuronal populations during development . Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake . Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TNR16_HUMAN
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 5 no
GO:0031625 ubiquitin protein ligase binding 29.6296 5 yes
GO:0044389 ubiquitin-like protein ligase binding 29.6296 4 yes
GO:0043121 neurotrophin binding 14.8148 4 yes
GO:0005035 death receptor activity 7.4074 4 yes
GO:0031267 small GTPase binding 7.4074 5 yes
GO:0048406 nerve growth factor binding 7.4074 5 yes
GO:0051020 GTPase binding 7.4074 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TNR16_HUMAN
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0048523 negative regulation of cellular process 66.6667 4 yes
GO:0060255 regulation of macromolecule metabolic process 59.2593 4 yes
GO:0009966 regulation of signal transduction 59.2593 4 yes
GO:0031323 regulation of cellular metabolic process 59.2593 4 yes
GO:0048522 positive regulation of cellular process 59.2593 4 yes
GO:0080090 regulation of primary metabolic process 55.5556 4 yes
GO:0009889 regulation of biosynthetic process 51.8519 4 yes
GO:0010468 regulation of gene expression 51.8519 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 51.8519 5 yes
GO:0031326 regulation of cellular biosynthetic process 51.8519 5 yes
GO:0051246 regulation of protein metabolic process 48.1481 5 yes
GO:1902531 regulation of intracellular signal transduction 44.4444 5 no
GO:0009893 positive regulation of metabolic process 44.4444 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 44.4444 5 yes
GO:0048584 positive regulation of response to stimulus 44.4444 4 yes
GO:0009892 negative regulation of metabolic process 40.7407 4 no
GO:0010605 negative regulation of macromolecule metabolic process 40.7407 5 no
GO:0051128 regulation of cellular component organization 40.7407 4 no
GO:0031325 positive regulation of cellular metabolic process 40.7407 5 yes
GO:0051247 positive regulation of protein metabolic process 37.0370 6 yes
GO:0036211 protein modification process 37.0370 4 no
GO:0043412 macromolecule modification 37.0370 4 no
GO:0031324 negative regulation of cellular metabolic process 37.0370 5 no
GO:0009891 positive regulation of biosynthetic process 37.0370 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 37.0370 6 yes
GO:0023056 positive regulation of signaling 37.0370 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 37.0370 6 yes
GO:0051252 regulation of RNA metabolic process 33.3333 5 yes
GO:0071310 cellular response to organic substance 33.3333 4 yes
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 yes
GO:0006355 regulation of DNA-templated transcription 33.3333 7 yes
GO:0009967 positive regulation of signal transduction 33.3333 5 yes
GO:0010647 positive regulation of cell communication 33.3333 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 yes
GO:0042127 regulation of cell population proliferation 33.3333 4 yes
GO:0042981 regulation of apoptotic process 33.3333 5 yes
GO:0043067 regulation of programmed cell death 33.3333 4 yes
GO:0043085 positive regulation of catalytic activity 33.3333 4 yes
GO:0022607 cellular component assembly 29.6296 4 no
GO:0009890 negative regulation of biosynthetic process 29.6296 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 29.6296 6 no
GO:0031327 negative regulation of cellular biosynthetic process 29.6296 6 no
GO:0031399 regulation of protein modification process 29.6296 6 no
GO:0051130 positive regulation of cellular component organization 29.6296 5 no
GO:0010648 negative regulation of cell communication 29.6296 5 yes
GO:0023057 negative regulation of signaling 29.6296 4 yes
GO:0030030 cell projection organization 29.6296 4 yes
GO:0048585 negative regulation of response to stimulus 29.6296 4 yes
GO:0051336 regulation of hydrolase activity 25.9259 4 yes
GO:0071702 organic substance transport 25.9259 4 yes
GO:0099177 regulation of trans-synaptic signaling 25.9259 4 yes
GO:1901701 cellular response to oxygen-containing compound 25.9259 4 yes
GO:2000026 regulation of multicellular organismal development 25.9259 4 yes
GO:0010628 positive regulation of gene expression 25.9259 7 no
GO:0019220 regulation of phosphate metabolic process 25.9259 6 no
GO:0031401 positive regulation of protein modification process 25.9259 7 no
GO:0051174 regulation of phosphorus metabolic process 25.9259 5 no
GO:0031344 regulation of cell projection organization 25.9259 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.9259 6 no
GO:0006915 apoptotic process 25.9259 4 yes
GO:0008104 protein localization 25.9259 4 yes
GO:0008284 positive regulation of cell population proliferation 25.9259 5 yes
GO:0009968 negative regulation of signal transduction 25.9259 5 yes
GO:0010243 response to organonitrogen compound 25.9259 4 yes
GO:0030162 regulation of proteolysis 25.9259 6 yes
GO:0050804 modulation of chemical synaptic transmission 25.9259 5 yes
GO:0051240 positive regulation of multicellular organismal process 25.9259 4 yes
GO:0051254 positive regulation of RNA metabolic process 22.2222 6 yes
GO:0051345 positive regulation of hydrolase activity 22.2222 5 yes
GO:0071417 cellular response to organonitrogen compound 22.2222 4 yes
GO:0071705 nitrogen compound transport 22.2222 4 yes
GO:0141124 intracellular signaling cassette 22.2222 4 yes
GO:1901699 cellular response to nitrogen compound 22.2222 4 yes
GO:1902680 positive regulation of RNA biosynthetic process 22.2222 7 yes
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0010562 positive regulation of phosphorus metabolic process 22.2222 6 no
GO:0042325 regulation of phosphorylation 22.2222 7 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 no
GO:0045595 regulation of cell differentiation 22.2222 4 no
GO:0045937 positive regulation of phosphate metabolic process 22.2222 7 no
GO:0080134 regulation of response to stress 22.2222 4 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:0010629 negative regulation of gene expression 22.2222 7 no
GO:0010975 regulation of neuron projection development 22.2222 7 no
GO:0051049 regulation of transport 22.2222 4 no
GO:0051248 negative regulation of protein metabolic process 22.2222 6 no
GO:0044087 regulation of cellular component biogenesis 22.2222 4 no
GO:0050890 cognition 22.2222 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 22.2222 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 22.2222 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 yes
GO:0045893 positive regulation of DNA-templated transcription 22.2222 8 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.2222 5 yes
GO:0051093 negative regulation of developmental process 22.2222 4 yes
GO:0051094 positive regulation of developmental process 22.2222 4 yes
GO:0051402 neuron apoptotic process 18.5185 5 yes
GO:0060341 regulation of cellular localization 18.5185 4 yes
GO:0120036 plasma membrane bounded cell projection organization 18.5185 5 yes
GO:2000145 regulation of cell motility 18.5185 4 yes
GO:0015031 protein transport 18.5185 4 yes
GO:0030334 regulation of cell migration 18.5185 5 yes
GO:0032880 regulation of protein localization 18.5185 5 yes
GO:0045862 positive regulation of proteolysis 18.5185 7 yes
GO:0051241 negative regulation of multicellular organismal process 18.5185 4 yes
GO:1903829 positive regulation of protein localization 14.8148 5 yes
GO:1904645 response to amyloid-beta 14.8148 4 yes
GO:1904646 cellular response to amyloid-beta 14.8148 5 yes
GO:2001233 regulation of apoptotic signaling pathway 14.8148 5 yes
GO:0006886 intracellular protein transport 14.8148 4 yes
GO:0008285 negative regulation of cell population proliferation 14.8148 5 yes
GO:0090287 regulation of cellular response to growth factor stimulus 11.1111 4 yes
GO:1900180 regulation of protein localization to nucleus 11.1111 6 yes
GO:1900182 positive regulation of protein localization to nucleus 11.1111 6 yes
GO:0007264 small GTPase-mediated signal transduction 11.1111 5 yes
GO:0007266 Rho protein signal transduction 11.1111 6 yes
GO:0007417 central nervous system development 11.1111 4 yes
GO:0031175 neuron projection development 11.1111 6 yes
GO:0042475 odontogenesis of dentin-containing tooth 11.1111 5 yes
GO:0042476 odontogenesis 11.1111 4 yes
GO:0043065 positive regulation of apoptotic process 11.1111 6 yes
GO:0043068 positive regulation of programmed cell death 11.1111 5 yes
GO:0051797 regulation of hair follicle development 7.4074 5 yes
GO:0051799 negative regulation of hair follicle development 7.4074 5 yes
GO:0052547 regulation of peptidase activity 7.4074 5 yes
GO:0052548 regulation of endopeptidase activity 7.4074 6 yes
GO:0060840 artery development 7.4074 4 yes
GO:0090288 negative regulation of cellular response to growth factor stimulus 7.4074 5 yes
GO:0097485 neuron projection guidance 7.4074 7 yes
GO:0099171 presynaptic modulation of chemical synaptic transmission 7.4074 6 yes
GO:0110110 positive regulation of animal organ morphogenesis 7.4074 5 yes
GO:1902893 regulation of miRNA transcription 7.4074 7 yes
GO:1902895 positive regulation of miRNA transcription 7.4074 8 yes
GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 7.4074 7 yes
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 7.4074 8 yes
GO:2000027 regulation of animal organ morphogenesis 7.4074 5 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 7.4074 7 yes
GO:2000146 negative regulation of cell motility 7.4074 5 yes
GO:2000628 regulation of miRNA metabolic process 7.4074 6 yes
GO:2000630 positive regulation of miRNA metabolic process 7.4074 7 yes
GO:2001056 positive regulation of cysteine-type endopeptidase activity 7.4074 8 yes
GO:2001235 positive regulation of apoptotic signaling pathway 7.4074 6 yes
GO:0001678 intracellular glucose homeostasis 7.4074 4 yes
GO:0001936 regulation of endothelial cell proliferation 7.4074 6 yes
GO:0001937 negative regulation of endothelial cell proliferation 7.4074 7 yes
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 7.4074 10 yes
GO:0007411 axon guidance 7.4074 8 yes
GO:0008543 fibroblast growth factor receptor signaling pathway 7.4074 6 yes
GO:0010950 positive regulation of endopeptidase activity 7.4074 7 yes
GO:0010952 positive regulation of peptidase activity 7.4074 6 yes
GO:0016048 detection of temperature stimulus 7.4074 4 yes
GO:0030336 negative regulation of cell migration 7.4074 6 yes
GO:0035904 aorta development 7.4074 5 yes
GO:0035907 dorsal aorta development 7.4074 6 yes
GO:0040013 negative regulation of locomotion 7.4074 4 yes
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway 7.4074 5 yes
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway 7.4074 6 yes
GO:0042481 regulation of odontogenesis 7.4074 6 yes
GO:0042482 positive regulation of odontogenesis 7.4074 6 yes
GO:0042487 regulation of odontogenesis of dentin-containing tooth 7.4074 7 yes
GO:0042488 positive regulation of odontogenesis of dentin-containing tooth 7.4074 7 yes
GO:0042593 glucose homeostasis 7.4074 4 yes
GO:0042634 regulation of hair cycle 7.4074 4 yes
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 7.4074 9 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 7.4074 8 yes
GO:0048145 regulation of fibroblast proliferation 7.4074 5 yes
GO:0048146 positive regulation of fibroblast proliferation 7.4074 6 yes
GO:0050678 regulation of epithelial cell proliferation 7.4074 5 yes
GO:0050680 negative regulation of epithelial cell proliferation 7.4074 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SALL2_HUMAN [view interactions] Low throughput no yes
BEX1_HUMAN [view interactions] Low throughput no yes
SORT_HUMAN [view interactions] Low throughput no yes
TRAF5_HUMAN [view interactions] Low throughput no yes
TRAF4_HUMAN [view interactions] Low throughput no yes
TRAF6_HUMAN [view entry] [view interactions] Low throughput yes yes
TRAF3_HUMAN [view entry] [view interactions] Low throughput yes yes
TRAF1_HUMAN [view interactions] Low throughput no no
TRAF2_HUMAN [view interactions] Low throughput no yes
RIPK2_HUMAN [view interactions] Low throughput no yes
GDIR1_HUMAN [view entry] [view interactions] Low throughput yes yes
NECD_HUMAN [view interactions] Low throughput no no
NSE3_HUMAN [view interactions] Low throughput no no
RTN4R_HUMAN [view entry] [view interactions] Low throughput yes no
LIGO1_HUMAN [view entry] [view interactions] Low throughput yes no
TNR16_HUMAN [view entry] [view interactions] Low throughput yes no
NGF_HUMAN [view interactions] Low throughput no no
SORC2_HUMAN [view entry] [view interactions] Low throughput yes no
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
NTF3_HUMAN [view interactions] Low throughput no no
TSC1_HUMAN [view entry] [view interactions] Low throughput yes yes
BEX3_HUMAN [view interactions] Low throughput no yes
NTRK1_HUMAN [view interactions] Low throughput no yes
PSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
TNR21_HUMAN [view interactions] Low throughput no yes
KAPCB_HUMAN [view entry] [view interactions] Low throughput yes yes
FSCN1_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGD1_HUMAN [view interactions] Low throughput no no
TCF19_HUMAN [view interactions] Low throughput no no
CBL_HUMAN [view interactions] Low throughput no yes
BFAR_HUMAN [view interactions] Low throughput no no
TRADD_HUMAN [view interactions] Low throughput no yes
MAGH1_HUMAN [view interactions] Low throughput no yes
SHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
SQSTM_HUMAN [view interactions] Low throughput no yes
IKKB_HUMAN [view interactions] Low throughput no yes
NTRK2_HUMAN [view entry] [view interactions] Low throughput yes yes
NTRK3_HUMAN [view entry] [view interactions] Low throughput yes yes
MDM2_HUMAN [view entry] [view interactions] Low throughput yes yes
P53_HUMAN [view interactions] Low throughput no no
BNI3L_HUMAN [view interactions] Low throughput no yes
SIAH1_HUMAN [view interactions] Low throughput no yes
ITA9_HUMAN [view interactions] Low throughput no no
PDLI1_HUMAN [view interactions] Low throughput no yes
KDIS_HUMAN [view entry] [view interactions] Low throughput yes yes
BACE1_HUMAN [view interactions] Low throughput no yes
IRAK1_HUMAN [view interactions] Low throughput no yes
MYD88_HUMAN [view interactions] Low throughput no yes
IKKA_HUMAN [view interactions] Low throughput no yes
SORC3_HUMAN [view entry] [view interactions] Low throughput yes no
CAV1_HUMAN [view interactions] Low throughput no no
EGR1_HUMAN [view interactions] Low throughput no yes
HIPK2_HUMAN [view interactions] Low throughput no yes
PO4F2_HUMAN [view interactions] Low throughput no no
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
ANXA7_HUMAN [view entry] [view interactions] High throughput yes yes
CDN1A_HUMAN [view interactions] High throughput no no
H2AX_HUMAN [view interactions] High throughput no yes
RCC1_HUMAN [view interactions] High throughput no yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
SMN_HUMAN [view interactions] High throughput no yes
STMN2_HUMAN [view interactions] High throughput no no
KITH_HUMAN [view interactions] High throughput no yes
TTHY_HUMAN [view interactions] High throughput no no
UFD1_HUMAN [view interactions] High throughput no no
CD80_HUMAN [view interactions] High throughput no no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SCN2A_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
SPRE1_HUMAN [view interactions] High throughput no yes
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes