Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LIGO1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed, PubMed). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in LIGO1_HUMAN
GO:0019900 kinase binding 23.5294 4 no
GO:0019901 protein kinase binding 23.5294 5 no
GO:0070851 growth factor receptor binding 17.6471 4 yes
GO:0005154 epidermal growth factor receptor binding 11.7647 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in LIGO1_HUMAN
GO:0048523 negative regulation of cellular process 58.8235 4 no
GO:0048522 positive regulation of cellular process 52.9412 4 no
GO:0051128 regulation of cellular component organization 47.0588 4 no
GO:0009966 regulation of signal transduction 47.0588 4 no
GO:0010646 regulation of cell communication 47.0588 4 no
GO:0010941 regulation of cell death 41.1765 4 no
GO:0030030 cell projection organization 41.1765 4 no
GO:0051241 negative regulation of multicellular organismal process 41.1765 4 no
GO:0009967 positive regulation of signal transduction 41.1765 5 no
GO:0010647 positive regulation of cell communication 41.1765 5 no
GO:0023056 positive regulation of signaling 41.1765 4 no
GO:0048584 positive regulation of response to stimulus 41.1765 4 no
GO:0051171 regulation of nitrogen compound metabolic process 41.1765 4 no
GO:0051246 regulation of protein metabolic process 41.1765 5 no
GO:0060255 regulation of macromolecule metabolic process 41.1765 4 no
GO:0080090 regulation of primary metabolic process 41.1765 4 no
GO:0022607 cellular component assembly 35.2941 4 no
GO:0031175 neuron projection development 35.2941 6 no
GO:0031344 regulation of cell projection organization 35.2941 5 no
GO:0042981 regulation of apoptotic process 35.2941 6 no
GO:0043067 regulation of programmed cell death 35.2941 5 no
GO:0045595 regulation of cell differentiation 35.2941 4 no
GO:0051093 negative regulation of developmental process 35.2941 4 no
GO:0051094 positive regulation of developmental process 35.2941 4 no
GO:0051240 positive regulation of multicellular organismal process 35.2941 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 35.2941 6 no
GO:0120036 plasma membrane bounded cell projection organization 35.2941 5 no
GO:2000026 regulation of multicellular organismal development 35.2941 4 no
GO:0030334 regulation of cell migration 35.2941 5 no
GO:2000145 regulation of cell motility 35.2941 4 no
GO:0009893 positive regulation of metabolic process 35.2941 4 no
GO:0010604 positive regulation of macromolecule metabolic process 35.2941 5 no
GO:0031323 regulation of cellular metabolic process 35.2941 4 no
GO:0033043 regulation of organelle organization 35.2941 5 no
GO:0010975 regulation of neuron projection development 29.4118 7 no
GO:0022603 regulation of anatomical structure morphogenesis 29.4118 4 no
GO:0044057 regulation of system process 29.4118 4 no
GO:0045596 negative regulation of cell differentiation 29.4118 5 no
GO:0051129 negative regulation of cellular component organization 29.4118 5 no
GO:0060548 negative regulation of cell death 29.4118 5 no
GO:0030335 positive regulation of cell migration 29.4118 6 no
GO:0040017 positive regulation of locomotion 29.4118 4 no
GO:0051336 regulation of hydrolase activity 29.4118 4 no
GO:0071310 cellular response to organic substance 29.4118 4 no
GO:2000147 positive regulation of cell motility 29.4118 5 no
GO:0009892 negative regulation of metabolic process 29.4118 4 no
GO:0010468 regulation of gene expression 29.4118 5 no
GO:0031324 negative regulation of cellular metabolic process 29.4118 5 no
GO:0031325 positive regulation of cellular metabolic process 29.4118 5 no
GO:0031399 regulation of protein modification process 29.4118 6 no
GO:0042127 regulation of cell population proliferation 29.4118 4 no
GO:0044087 regulation of cellular component biogenesis 29.4118 4 no
GO:0050807 regulation of synapse organization 29.4118 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 29.4118 5 no
GO:0051247 positive regulation of protein metabolic process 29.4118 6 no
GO:1902531 regulation of intracellular signal transduction 29.4118 5 no
GO:0031345 negative regulation of cell projection organization 23.5294 6 no
GO:0045597 positive regulation of cell differentiation 23.5294 5 no
GO:0050767 regulation of neurogenesis 23.5294 6 no
GO:0051960 regulation of nervous system development 23.5294 5 no
GO:0060284 regulation of cell development 23.5294 5 no
GO:0002684 positive regulation of immune system process 23.5294 4 no
GO:0002685 regulation of leukocyte migration 23.5294 4 no
GO:0002687 positive regulation of leukocyte migration 23.5294 5 no
GO:0036211 protein modification process 23.5294 4 no
GO:0043269 regulation of ion transport 23.5294 5 no
GO:0043412 macromolecule modification 23.5294 4 no
GO:0048878 chemical homeostasis 23.5294 4 no
GO:0051049 regulation of transport 23.5294 4 no
GO:0010628 positive regulation of gene expression 23.5294 6 no
GO:0031401 positive regulation of protein modification process 23.5294 7 no
GO:0032956 regulation of actin cytoskeleton organization 23.5294 5 no
GO:0032970 regulation of actin filament-based process 23.5294 4 no
GO:0043085 positive regulation of catalytic activity 23.5294 4 no
GO:0051130 positive regulation of cellular component organization 23.5294 5 no
GO:0051345 positive regulation of hydrolase activity 23.5294 5 no
GO:0051493 regulation of cytoskeleton organization 23.5294 6 no
GO:0099175 regulation of postsynapse organization 23.5294 6 no
GO:1901701 cellular response to oxygen-containing compound 23.5294 4 no
GO:1901888 regulation of cell junction assembly 23.5294 5 no
GO:1902533 positive regulation of intracellular signal transduction 23.5294 6 no
GO:0009889 regulation of biosynthetic process 23.5294 4 no
GO:0009891 positive regulation of biosynthetic process 23.5294 5 no
GO:0010243 response to organonitrogen compound 23.5294 4 no
GO:0010556 regulation of macromolecule biosynthetic process 23.5294 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.5294 6 no
GO:0031326 regulation of cellular biosynthetic process 23.5294 5 no
GO:0031328 positive regulation of cellular biosynthetic process 23.5294 6 no
GO:0032880 regulation of protein localization 23.5294 5 no
GO:0060341 regulation of cellular localization 23.5294 4 no
GO:0006996 organelle organization 23.5294 4 no
GO:0008104 protein localization 23.5294 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
LIGO1_HUMAN [view entry] [view interactions] Low throughput yes no
RTN4R_HUMAN [view interactions] Low throughput no no
TNR16_HUMAN [view entry] [view interactions] Low throughput yes no
EGFR_HUMAN [view interactions] Low throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
TRI27_HUMAN [view interactions] High throughput no yes
SPAG5_HUMAN [view interactions] High throughput no yes
3BHS7_HUMAN [view interactions] High throughput no no
KRA92_HUMAN [view interactions] High throughput no no
KRA59_HUMAN [view interactions] High throughput no no
FRS3_HUMAN [view interactions] High throughput no no
MACOI_HUMAN [view interactions] High throughput no no
KRA56_HUMAN [view interactions] High throughput no no
FBXW7_HUMAN [view interactions] High throughput no yes
FBLN4_HUMAN [view interactions] High throughput no no
KR412_HUMAN [view interactions] High throughput no no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
FBLN1_HUMAN [view interactions] High throughput no yes
NTRI_HUMAN [view interactions] High throughput no yes
KR101_HUMAN [view interactions] High throughput no no
PON2_HUMAN [view interactions] High throughput no yes
LIGO2_HUMAN [view interactions] High throughput no yes
H2A2C_HUMAN [view interactions] High throughput no yes
LRFN4_HUMAN [view entry] [view interactions] High throughput yes yes
LMA2L_HUMAN [view interactions] High throughput no yes
CC185_HUMAN [view interactions] High throughput no no
LRC33_HUMAN [view interactions] High throughput no yes
F241A_HUMAN [view interactions] High throughput no yes
SC5AB_HUMAN [view interactions] High throughput no no
PSMG2_HUMAN [view interactions] High throughput no yes
PCDBB_HUMAN [view interactions] High throughput no no
NGLY1_HUMAN [view interactions] High throughput no yes
CL12B_HUMAN [view interactions] High throughput no no
ST14_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
CCL3_HUMAN [view interactions] High throughput no no
MSMB_HUMAN [view interactions] High throughput no no
LCN6_HUMAN [view interactions] High throughput no no
INS_HUMAN [view interactions] High throughput no no
DJC25_HUMAN [view interactions] High throughput no yes
C1QT7_HUMAN [view interactions] High throughput no no
ACAD9_HUMAN [view interactions] High throughput no yes
CLC4A_HUMAN [view interactions] High throughput no no
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
S27A6_HUMAN [view interactions] High throughput no yes
LY86_HUMAN [view interactions] High throughput no no
CNPY3_HUMAN [view interactions] High throughput no yes
POMP_HUMAN [view interactions] High throughput no yes
LEG8_HUMAN [view entry] [view interactions] High throughput yes yes
SGCB_HUMAN [view interactions] High throughput no no
CXD3_HUMAN [view interactions] High throughput no no
TNR19_HUMAN [view interactions] Computational no no
OMGP_HUMAN [view entry] [view interactions] Computational yes yes
RHOA_HUMAN [view entry] [view interactions] Computational yes yes
WNK1_HUMAN [view entry] [view interactions] Computational yes no
GDIR1_HUMAN [view entry] [view interactions] Computational yes yes
RTN4_HUMAN [view entry] [view interactions] Computational yes yes
MAG_HUMAN [view entry] [view interactions] Computational yes yes