Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ST14_HUMAN

Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing. [View more on UniProt]

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Position Amino acid Mutation Disease Overlap with binding region
827 Gly Arg Ichthyosis,congenital,autosomalrecessive11(ARCI11) -
ELM instance Name Type Start End Partner
ELMI004277 TRG_DiLeu_BaEn_3 TRG 33 39 -

Molecular function

Term Name % Distance from the top of the tree Annotated in ST14_HUMAN
GO:0004175 endopeptidase activity 12.5000 4 yes
GO:0004252 serine-type endopeptidase activity 9.3750 5 yes
GO:0008236 serine-type peptidase activity 9.3750 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ST14_HUMAN
GO:0010646 regulation of cell communication 62.5000 4 no
GO:0009966 regulation of signal transduction 56.2500 4 no
GO:0060255 regulation of macromolecule metabolic process 56.2500 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0010468 regulation of gene expression 43.7500 5 no
GO:0051246 regulation of protein metabolic process 43.7500 5 no
GO:0042127 regulation of cell population proliferation 40.6250 4 no
GO:0009892 negative regulation of metabolic process 37.5000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 37.5000 5 no
GO:0031323 regulation of cellular metabolic process 37.5000 4 no
GO:0051240 positive regulation of multicellular organismal process 37.5000 4 no
GO:0031399 regulation of protein modification process 34.3750 6 no
GO:0045595 regulation of cell differentiation 34.3750 4 no
GO:0032880 regulation of protein localization 31.2500 5 no
GO:0060341 regulation of cellular localization 31.2500 4 no
GO:0008284 positive regulation of cell population proliferation 31.2500 5 no
GO:0009893 positive regulation of metabolic process 31.2500 4 no
GO:0010604 positive regulation of macromolecule metabolic process 31.2500 5 no
GO:0010941 regulation of cell death 31.2500 4 no
GO:0030334 regulation of cell migration 31.2500 5 no
GO:0031344 regulation of cell projection organization 31.2500 5 no
GO:0036211 protein modification process 31.2500 4 no
GO:0043412 macromolecule modification 31.2500 4 no
GO:0048585 negative regulation of response to stimulus 31.2500 4 no
GO:0051049 regulation of transport 31.2500 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 31.2500 6 no
GO:2000026 regulation of multicellular organismal development 31.2500 4 no
GO:2000145 regulation of cell motility 31.2500 4 no
GO:0010647 positive regulation of cell communication 31.2500 5 no
GO:0023056 positive regulation of signaling 31.2500 4 no
GO:0048584 positive regulation of response to stimulus 31.2500 4 no
GO:0001932 regulation of protein phosphorylation 28.1250 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.1250 5 no
GO:0019220 regulation of phosphate metabolic process 28.1250 6 no
GO:0042325 regulation of phosphorylation 28.1250 7 no
GO:0042981 regulation of apoptotic process 28.1250 6 no
GO:0043067 regulation of programmed cell death 28.1250 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 28.1250 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 28.1250 5 no
GO:0051174 regulation of phosphorus metabolic process 28.1250 5 no
GO:0051247 positive regulation of protein metabolic process 28.1250 6 no
GO:0051252 regulation of RNA metabolic process 28.1250 5 no
GO:0071310 cellular response to organic substance 28.1250 4 no
GO:0009967 positive regulation of signal transduction 28.1250 5 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0006355 regulation of DNA-templated transcription 25.0000 6 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0010628 positive regulation of gene expression 25.0000 6 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0030335 positive regulation of cell migration 25.0000 6 no
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0034097 response to cytokine 25.0000 4 no
GO:0040017 positive regulation of locomotion 25.0000 4 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0060548 negative regulation of cell death 25.0000 5 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:1903506 regulation of nucleic acid-templated transcription 25.0000 7 no
GO:2000147 positive regulation of cell motility 25.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:1904375 regulation of protein localization to cell periphery 21.8750 6 no
GO:1905475 regulation of protein localization to membrane 21.8750 6 no
GO:0001558 regulation of cell growth 21.8750 4 no
GO:0002684 positive regulation of immune system process 21.8750 4 no
GO:0006357 regulation of transcription by RNA polymerase II 21.8750 7 no
GO:0009894 regulation of catabolic process 21.8750 4 no
GO:0010629 negative regulation of gene expression 21.8750 6 no
GO:0030155 regulation of cell adhesion 21.8750 4 no
GO:0030162 regulation of proteolysis 21.8750 6 no
GO:0033043 regulation of organelle organization 21.8750 5 no
GO:0043549 regulation of kinase activity 21.8750 5 no
GO:0045859 regulation of protein kinase activity 21.8750 6 no
GO:0051050 positive regulation of transport 21.8750 4 no
GO:0051248 negative regulation of protein metabolic process 21.8750 6 no
GO:0051960 regulation of nervous system development 21.8750 5 no
GO:0060284 regulation of cell development 21.8750 5 no
GO:0080134 regulation of response to stress 21.8750 4 no
GO:1901214 regulation of neuron death 21.8750 5 no
GO:1901701 cellular response to oxygen-containing compound 21.8750 4 no
GO:1903829 positive regulation of protein localization 21.8750 5 no
GO:0032101 regulation of response to external stimulus 21.8750 4 no
GO:0050804 modulation of chemical synaptic transmission 21.8750 5 no
GO:0099177 regulation of trans-synaptic signaling 21.8750 4 no
GO:0051130 positive regulation of cellular component organization 21.8750 5 no
GO:0006508 proteolysis 15.6250 4 yes
GO:0030855 epithelial cell differentiation 12.5000 4 yes
GO:0009913 epidermal cell differentiation 9.3750 5 yes
GO:0030216 keratinocyte differentiation 9.3750 6 yes
GO:0000904 cell morphogenesis involved in differentiation 6.2500 4 yes
GO:0001843 neural tube closure 6.2500 5 yes
GO:0003382 epithelial cell morphogenesis 6.2500 5 yes
GO:0060606 tube closure 6.2500 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in ST14_HUMAN
DOID:0060655 autosomal recessive congenital ichthyosis 6.2500 5 yes
DOID:0060720 autosomal recessive congenital ichthyosis 11 6.2500 6 yes
DOID:1697 ichthyosis 6.2500 4 yes
DOID:37 skin disease 6.2500 3 yes
DOID:0050686 organ system cancer 6.2500 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PDGFC_HUMAN [view interactions] Low throughput no no
HV323_HUMAN [view interactions] Low throughput no no
ST14_HUMAN [view entry] [view interactions] Low throughput yes yes
IBP7_HUMAN [view interactions] Low throughput no no
HGFL_HUMAN [view interactions] Low throughput no no
SPIT1_HUMAN [view interactions] Low throughput no yes
FEM1A_HUMAN [view interactions] High throughput no no
TGBR3_HUMAN [view interactions] High throughput no yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
CRIM1_HUMAN [view interactions] High throughput no yes
GLBL2_HUMAN [view interactions] High throughput no no
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
NOMO3_HUMAN [view interactions] High throughput no yes
MA1A1_HUMAN [view interactions] High throughput no yes
VEGFB_HUMAN [view interactions] High throughput no no
TUSC3_HUMAN [view interactions] High throughput no yes
ENTP7_HUMAN [view interactions] High throughput no no
FKBP2_HUMAN [view interactions] High throughput no yes
ERO1B_HUMAN [view interactions] High throughput no yes
HPLN3_HUMAN [view interactions] High throughput no yes
ADPGK_HUMAN [view interactions] High throughput no no
LCAP_HUMAN [view interactions] High throughput no yes
UST_HUMAN [view interactions] High throughput no yes
RNAS4_HUMAN [view interactions] High throughput no no
FBLN1_HUMAN [view interactions] High throughput no yes
GALT7_HUMAN [view interactions] High throughput no no
RL23_HUMAN [view entry] [view interactions] High throughput yes yes
RFNG_HUMAN [view interactions] High throughput no yes
TPA_HUMAN [view entry] [view interactions] High throughput yes no
OST48_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP7_HUMAN [view interactions] High throughput no yes
PCSK5_HUMAN [view interactions] High throughput no yes
PGLT1_HUMAN [view interactions] High throughput no no
UD3A2_HUMAN [view interactions] High throughput no no
LMF2_HUMAN [view interactions] High throughput no yes
EOGT_HUMAN [view interactions] High throughput no yes
LAMA3_HUMAN [view interactions] High throughput no no
GCNT1_HUMAN [view interactions] High throughput no yes
DIK1A_HUMAN [view interactions] High throughput no yes
T106A_HUMAN [view interactions] High throughput no no
WNT3A_HUMAN [view entry] [view interactions] High throughput yes no
ASIC4_HUMAN [view interactions] High throughput no no
ISK1_HUMAN [view interactions] High throughput no no
LYPD4_HUMAN [view interactions] High throughput no no
ECEL1_HUMAN [view interactions] High throughput no yes
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
UD17_HUMAN [view interactions] High throughput no no
GXLT1_HUMAN [view interactions] High throughput no no
LYZL1_HUMAN [view interactions] High throughput no no
PSPC_HUMAN [view interactions] High throughput no no
KLK15_HUMAN [view interactions] High throughput no no
SIA8E_HUMAN [view interactions] High throughput no yes
DNSL1_HUMAN [view interactions] High throughput no yes
BTNL2_HUMAN [view interactions] High throughput no no
HLAG_HUMAN [view interactions] High throughput no no
P2RX2_HUMAN [view interactions] High throughput no no
PRG2_HUMAN [view interactions] High throughput no no
ADA30_HUMAN [view interactions] High throughput no no
OGFD3_HUMAN [view interactions] High throughput no no
HLAC_HUMAN [view interactions] High throughput no no
ESPB1_HUMAN [view interactions] High throughput no no
SLUR1_HUMAN [view interactions] High throughput no no
CLC2B_HUMAN [view interactions] High throughput no yes
CFC1_HUMAN [view interactions] High throughput no no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
AHNK_HUMAN [view entry] [view interactions] High throughput yes yes
RGS16_HUMAN [view interactions] High throughput no no
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
APC_HUMAN [view entry] [view interactions] High throughput yes no
CASP8_HUMAN [view interactions] High throughput no yes
CDN2C_HUMAN [view interactions] High throughput no yes
CHK2_HUMAN [view interactions] High throughput no yes
NOTC2_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
RAD51_HUMAN [view interactions] High throughput no yes
STK11_HUMAN [view interactions] High throughput no yes
TGFB1_HUMAN [view interactions] High throughput no no
SMAD4_HUMAN [view interactions] High throughput no yes
DAF_HUMAN [view interactions] High throughput no no
NET1_HUMAN [view interactions] High throughput no no
WNT5A_HUMAN [view entry] [view interactions] High throughput yes no
MGAT1_HUMAN [view interactions] High throughput no yes
MGAT2_HUMAN [view interactions] High throughput no yes
HMR1_HUMAN [view interactions] High throughput no no
INHBE_HUMAN [view interactions] High throughput no no
ITA5_HUMAN [view entry] [view interactions] High throughput yes no
VLDLR_HUMAN [view interactions] High throughput no yes
NOMO1_HUMAN [view entry] [view interactions] High throughput yes yes
SMOC1_HUMAN [view interactions] High throughput no no
ANR46_HUMAN [view interactions] High throughput no yes
SPON1_HUMAN [view interactions] High throughput no no
EFNA5_HUMAN [view interactions] High throughput no yes
TM9S2_HUMAN [view interactions] High throughput no yes
D19L4_HUMAN [view interactions] High throughput no no
EPHB4_HUMAN [view interactions] High throughput no yes
PLXA2_HUMAN [view entry] [view interactions] High throughput yes yes
POMT1_HUMAN [view interactions] High throughput no no
TM39A_HUMAN [view interactions] High throughput no yes
LDLR_HUMAN [view interactions] High throughput no yes
ASPG_HUMAN [view interactions] High throughput no yes
KPCI_HUMAN [view entry] [view interactions] High throughput yes yes
MET_HUMAN [view interactions] High throughput no yes
PDIA5_HUMAN [view interactions] High throughput no yes
NDST1_HUMAN [view interactions] High throughput no yes
MA2A1_HUMAN [view interactions] High throughput no no
GPC3_HUMAN [view interactions] High throughput no no
FBN1_HUMAN [view interactions] High throughput no no
MFGM_HUMAN [view interactions] High throughput no no
NEUS_HUMAN [view interactions] High throughput no yes
GDN_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
IL6RB_HUMAN [view interactions] High throughput no no
GAS6_HUMAN [view interactions] High throughput no no
GLT16_HUMAN [view interactions] High throughput no yes
SE1L3_HUMAN [view interactions] High throughput no yes
ATS1_HUMAN [view interactions] High throughput no no
BACE2_HUMAN [view interactions] High throughput no yes
TM87B_HUMAN [view interactions] High throughput no yes
TMX4_HUMAN [view interactions] High throughput no yes
TM59L_HUMAN [view interactions] High throughput no yes
LSR_HUMAN [view interactions] High throughput no yes
CATL2_HUMAN [view interactions] High throughput no yes
MKS3_HUMAN [view interactions] High throughput no no
LIGO1_HUMAN [view entry] [view interactions] High throughput yes no
ALG12_HUMAN [view interactions] High throughput no yes
LRP11_HUMAN [view interactions] High throughput no no
FBN2_HUMAN [view interactions] High throughput no no
ALG9_HUMAN [view interactions] High throughput no yes
GPC2_HUMAN [view interactions] High throughput no no
DIK2A_HUMAN [view interactions] High throughput no yes
APLP2_HUMAN [view interactions] High throughput no yes
ZN664_HUMAN [view interactions] High throughput no no
GPC6_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRS_HUMAN [view entry] [view interactions] High throughput yes no
TIMP3_HUMAN [view interactions] High throughput no no
ULBP3_HUMAN [view interactions] High throughput no yes
JAG2_HUMAN [view interactions] High throughput no yes
SEM6A_HUMAN [view interactions] High throughput no yes
CBPE_HUMAN [view interactions] High throughput no yes
B4GT1_HUMAN [view interactions] High throughput no yes
B4GT7_HUMAN [view interactions] High throughput no yes
SPIT2_HUMAN [view interactions] High throughput no yes
OAF_HUMAN [view interactions] High throughput no no
SIA7D_HUMAN [view interactions] High throughput no no
TOR3A_HUMAN [view interactions] High throughput no no
STC2_HUMAN [view interactions] High throughput no no
CREL2_HUMAN [view interactions] High throughput no yes
ADAM9_HUMAN [view interactions] High throughput no no
LIPT2_HUMAN [view interactions] High throughput no yes
SEM3C_HUMAN [view interactions] High throughput no no
FBLN5_HUMAN [view interactions] High throughput no no
H6ST2_HUMAN [view interactions] High throughput no no
GALT3_HUMAN [view interactions] High throughput no yes
GALT2_HUMAN [view interactions] High throughput no yes
PEDF_HUMAN [view interactions] High throughput no no
IBP2_HUMAN [view interactions] High throughput no no
MPRI_HUMAN [view interactions] High throughput no yes
TLL2_HUMAN [view interactions] High throughput no no
TAZ_HUMAN [view interactions] High throughput no yes
GPC4_HUMAN [view entry] [view interactions] High throughput yes yes
C1GLT_HUMAN [view interactions] High throughput no yes
FAM3C_HUMAN [view interactions] High throughput no yes
E2AK3_HUMAN [view interactions] High throughput no yes
SULF1_HUMAN [view interactions] High throughput no no
K319L_HUMAN [view interactions] High throughput no yes
AMD_HUMAN [view interactions] High throughput no yes
ASTRA_HUMAN [view interactions] High throughput no no
NETO2_HUMAN [view entry] [view interactions] High throughput yes yes
GLMP_HUMAN [view interactions] High throughput no no
ATRN_HUMAN [view interactions] High throughput no yes
IGSF3_HUMAN [view interactions] High throughput no yes
EGFL7_HUMAN [view interactions] High throughput no yes
TOR1A_HUMAN [view interactions] High throughput no yes
IF5A2_HUMAN [view interactions] High throughput no yes
ATS15_HUMAN [view interactions] High throughput no no
PCOC2_HUMAN [view interactions] High throughput no no
LAMB1_HUMAN [view interactions] High throughput no yes
CHLE_HUMAN [view interactions] High throughput no no
COCH_HUMAN [view interactions] High throughput no no
ITA6_HUMAN [view interactions] High throughput no yes
NRP2_HUMAN [view entry] [view interactions] High throughput yes yes
CRLD1_HUMAN [view interactions] High throughput no yes
DNJB9_HUMAN [view interactions] High throughput no yes
TXD11_HUMAN [view interactions] High throughput no yes
TOR2A_HUMAN [view interactions] High throughput no no
PLAC1_HUMAN [view interactions] High throughput no no
JPH1_HUMAN [view interactions] High throughput no no
SLIT2_HUMAN [view interactions] High throughput no no
NECT2_HUMAN [view interactions] High throughput no no
GSLG1_HUMAN [view entry] [view interactions] High throughput yes yes
LMAN1_HUMAN [view interactions] High throughput no yes
GALT6_HUMAN [view interactions] High throughput no yes
CHID1_HUMAN [view interactions] High throughput no yes
CGT_HUMAN [view interactions] High throughput no no
GL8D2_HUMAN [view interactions] High throughput no yes
C1GLC_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
EMC1_HUMAN [view interactions] High throughput no yes
IGSF8_HUMAN [view entry] [view interactions] High throughput yes no
NOTC3_HUMAN [view interactions] High throughput no yes
CSPG2_HUMAN [view entry] [view interactions] High throughput yes no
B4GT2_HUMAN [view interactions] High throughput no no
KLK5_HUMAN [view interactions] Computational no no
FILA_HUMAN [view interactions] Computational no no