Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PLXA2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in PLXA2_HUMAN
GO:0000166 nucleotide binding 35.2941 4 no
GO:0017076 purine nucleotide binding 35.2941 5 no
GO:0032555 purine ribonucleotide binding 35.2941 4 no
GO:0043168 anion binding 35.2941 4 no
GO:0035639 purine ribonucleoside triphosphate binding 29.4118 4 no
GO:0016301 kinase activity 23.5294 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 23.5294 4 no
GO:0030554 adenyl nucleotide binding 23.5294 6 no
GO:0032559 adenyl ribonucleotide binding 23.5294 5 no
GO:0017154 semaphorin receptor activity 17.6471 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PLXA2_HUMAN
GO:0048522 positive regulation of cellular process 64.7059 4 yes
GO:0048523 negative regulation of cellular process 52.9412 4 yes
GO:0051128 regulation of cellular component organization 52.9412 4 yes
GO:0031344 regulation of cell projection organization 47.0588 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 47.0588 6 yes
GO:0051130 positive regulation of cellular component organization 41.1765 5 yes
GO:0022607 cellular component assembly 41.1765 4 no
GO:0048584 positive regulation of response to stimulus 41.1765 4 no
GO:0010646 regulation of cell communication 41.1765 4 no
GO:0010975 regulation of neuron projection development 35.2941 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 35.2941 4 yes
GO:0031346 positive regulation of cell projection organization 35.2941 6 yes
GO:0045595 regulation of cell differentiation 35.2941 4 yes
GO:0050767 regulation of neurogenesis 35.2941 6 yes
GO:0051240 positive regulation of multicellular organismal process 35.2941 4 yes
GO:0051960 regulation of nervous system development 35.2941 5 yes
GO:0060284 regulation of cell development 35.2941 5 yes
GO:2000026 regulation of multicellular organismal development 35.2941 4 yes
GO:0008104 protein localization 35.2941 4 no
GO:0031323 regulation of cellular metabolic process 35.2941 4 no
GO:0031399 regulation of protein modification process 35.2941 6 no
GO:0051246 regulation of protein metabolic process 35.2941 5 no
GO:0060255 regulation of macromolecule metabolic process 35.2941 4 no
GO:0080090 regulation of primary metabolic process 35.2941 4 no
GO:0030334 regulation of cell migration 29.4118 5 yes
GO:0050770 regulation of axonogenesis 29.4118 5 yes
GO:2000145 regulation of cell motility 29.4118 4 yes
GO:0009893 positive regulation of metabolic process 29.4118 4 no
GO:0031325 positive regulation of cellular metabolic process 29.4118 5 no
GO:0009966 regulation of signal transduction 29.4118 4 no
GO:0009967 positive regulation of signal transduction 29.4118 5 no
GO:0010647 positive regulation of cell communication 29.4118 5 no
GO:0023056 positive regulation of signaling 29.4118 4 no
GO:0030030 cell projection organization 29.4118 4 no
GO:0031175 neuron projection development 29.4118 6 no
GO:0042981 regulation of apoptotic process 29.4118 5 no
GO:0043067 regulation of programmed cell death 29.4118 4 no
GO:0048812 neuron projection morphogenesis 29.4118 5 no
GO:0050804 modulation of chemical synaptic transmission 29.4118 5 no
GO:0099177 regulation of trans-synaptic signaling 29.4118 4 no
GO:0120036 plasma membrane bounded cell projection organization 29.4118 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 29.4118 4 no
GO:1902531 regulation of intracellular signal transduction 29.4118 5 no
GO:1902533 positive regulation of intracellular signal transduction 29.4118 6 no
GO:0034330 cell junction organization 29.4118 4 no
GO:0042127 regulation of cell population proliferation 29.4118 4 no
GO:0010720 positive regulation of cell development 23.5294 6 yes
GO:0030155 regulation of cell adhesion 23.5294 4 yes
GO:0045597 positive regulation of cell differentiation 23.5294 5 yes
GO:0050769 positive regulation of neurogenesis 23.5294 6 yes
GO:0051094 positive regulation of developmental process 23.5294 4 yes
GO:0051962 positive regulation of nervous system development 23.5294 5 yes
GO:0006996 organelle organization 23.5294 4 no
GO:0009894 regulation of catabolic process 23.5294 4 no
GO:0015031 protein transport 23.5294 4 no
GO:0036211 protein modification process 23.5294 4 no
GO:0043412 macromolecule modification 23.5294 4 no
GO:0071702 organic substance transport 23.5294 4 no
GO:0071705 nitrogen compound transport 23.5294 4 no
GO:0140546 defense response to symbiont 23.5294 4 no
GO:0002684 positive regulation of immune system process 23.5294 4 no
GO:0032101 regulation of response to external stimulus 23.5294 4 no
GO:0032102 negative regulation of response to external stimulus 23.5294 5 no
GO:0048585 negative regulation of response to stimulus 23.5294 4 no
GO:0050776 regulation of immune response 23.5294 4 no
GO:0050778 positive regulation of immune response 23.5294 5 no
GO:0001764 neuron migration 23.5294 4 no
GO:0001932 regulation of protein phosphorylation 23.5294 7 no
GO:0001934 positive regulation of protein phosphorylation 23.5294 8 no
GO:0007167 enzyme-linked receptor protein signaling pathway 23.5294 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 23.5294 5 no
GO:0007411 axon guidance 23.5294 8 no
GO:0009057 macromolecule catabolic process 23.5294 4 no
GO:0009889 regulation of biosynthetic process 23.5294 4 no
GO:0010468 regulation of gene expression 23.5294 6 no
GO:0010556 regulation of macromolecule biosynthetic process 23.5294 5 no
GO:0010562 positive regulation of phosphorus metabolic process 23.5294 6 no
GO:0010604 positive regulation of macromolecule metabolic process 23.5294 5 no
GO:0019220 regulation of phosphate metabolic process 23.5294 6 no
GO:0031326 regulation of cellular biosynthetic process 23.5294 5 no
GO:0031345 negative regulation of cell projection organization 23.5294 6 no
GO:0031401 positive regulation of protein modification process 23.5294 7 no
GO:0042325 regulation of phosphorylation 23.5294 7 no
GO:0042327 positive regulation of phosphorylation 23.5294 8 no
GO:0043066 negative regulation of apoptotic process 23.5294 6 no
GO:0043069 negative regulation of programmed cell death 23.5294 5 no
GO:0045937 positive regulation of phosphate metabolic process 23.5294 7 no
GO:0051049 regulation of transport 23.5294 4 no
GO:0051129 negative regulation of cellular component organization 23.5294 5 no
GO:0051174 regulation of phosphorus metabolic process 23.5294 5 no
GO:0051247 positive regulation of protein metabolic process 23.5294 6 no
GO:0097485 neuron projection guidance 23.5294 7 no
GO:0006915 apoptotic process 23.5294 4 no
GO:0034329 cell junction assembly 23.5294 5 no
GO:0044087 regulation of cellular component biogenesis 23.5294 4 no
GO:0044089 positive regulation of cellular component biogenesis 23.5294 5 no
GO:0050808 synapse organization 23.5294 5 no
GO:0008284 positive regulation of cell population proliferation 23.5294 5 no
GO:0043523 regulation of neuron apoptotic process 23.5294 6 no
GO:0045596 negative regulation of cell differentiation 23.5294 5 no
GO:0051093 negative regulation of developmental process 23.5294 4 no
GO:0022604 regulation of cell morphogenesis 17.6471 5 yes
GO:0050772 positive regulation of axonogenesis 17.6471 6 yes
GO:0071526 semaphorin-plexin signaling pathway 17.6471 4 yes
GO:0007162 negative regulation of cell adhesion 11.7647 5 yes
GO:0009952 anterior/posterior pattern specification 11.7647 4 yes
GO:0021535 cell migration in hindbrain 11.7647 4 yes
GO:0021915 neural tube development 11.7647 4 yes
GO:0021934 hindbrain tangential cell migration 11.7647 5 yes
GO:0021935 cerebellar granule cell precursor tangential migration 11.7647 6 yes
GO:0035282 segmentation 11.7647 4 yes
GO:0060037 pharyngeal system development 11.7647 4 yes
GO:0060429 epithelium development 11.7647 4 yes
GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance 11.7647 5 yes
GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance 11.7647 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RND1_HUMAN [view interactions] Low throughput no no
NRP1_HUMAN [view entry] [view interactions] Low throughput yes yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
SEM6A_HUMAN [view interactions] Low throughput no yes
PLXA2_HUMAN [view entry] [view interactions] Low throughput yes yes
LEG1_HUMAN [view interactions] High throughput no yes
LYZL6_HUMAN [view interactions] High throughput no no
CA054_HUMAN [view interactions] High throughput no yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
HYOU1_HUMAN [view interactions] High throughput no yes
WFD11_HUMAN [view interactions] High throughput no no
NDP_HUMAN [view interactions] High throughput no no
RYK_HUMAN [view entry] [view interactions] High throughput yes no
DB136_HUMAN [view interactions] High throughput no no
LCFC1_HUMAN [view interactions] High throughput no no
HDBP1_HUMAN [view interactions] High throughput no no
CAH6_HUMAN [view interactions] High throughput no no
CLC4A_HUMAN [view interactions] High throughput no no
PCDB1_HUMAN [view interactions] High throughput no no
GLT10_HUMAN [view interactions] High throughput no no
DB135_HUMAN [view interactions] High throughput no no
REL1_HUMAN [view interactions] High throughput no no
CST9L_HUMAN [view interactions] High throughput no no
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
CL12B_HUMAN [view interactions] High throughput no no
NKG2A_HUMAN [view interactions] High throughput no no
EP3B_HUMAN [view interactions] High throughput no no
F234A_HUMAN [view interactions] High throughput no yes
PATE1_HUMAN [view interactions] High throughput no no
CRLF2_HUMAN [view interactions] High throughput no no
BTNL3_HUMAN [view interactions] High throughput no no
MFAP4_HUMAN [view interactions] High throughput no no
TMPS2_HUMAN [view interactions] High throughput no no
TMPS4_HUMAN [view interactions] High throughput no yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
SEM3D_HUMAN [view interactions] High throughput no no
SEM5B_HUMAN [view interactions] High throughput no yes
SEM6B_HUMAN [view interactions] High throughput no yes
SEM6D_HUMAN [view interactions] High throughput no no
SYF1_HUMAN [view interactions] High throughput no no
MICA2_HUMAN [view interactions] High throughput no yes
MICA3_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
UBP2L_HUMAN [view interactions] High throughput no yes
FNBP4_HUMAN [view interactions] High throughput no yes
CEMIP_HUMAN [view interactions] High throughput no no
PDC6I_HUMAN [view entry] [view interactions] High throughput yes yes
HACE1_HUMAN [view interactions] High throughput no no
DHX37_HUMAN [view interactions] High throughput no yes
SG1D1_HUMAN [view interactions] High throughput no no
CC50B_HUMAN [view interactions] High throughput no yes
NUFP1_HUMAN [view interactions] High throughput no yes
KI3L2_HUMAN [view interactions] High throughput no no
DEF5_HUMAN [view interactions] High throughput no no
ADA32_HUMAN [view interactions] High throughput no no
ISK4_HUMAN [view interactions] High throughput no no
DEF1_HUMAN [view interactions] High throughput no no
INSL5_HUMAN [view interactions] High throughput no no
SLAF1_HUMAN [view interactions] High throughput no no
OS9_HUMAN [view interactions] High throughput no yes
SIA8D_HUMAN [view interactions] High throughput no yes
GPHA2_HUMAN [view interactions] High throughput no no
TAFA4_HUMAN [view interactions] High throughput no no
TNFA_HUMAN [view interactions] High throughput no no
ADA21_HUMAN [view interactions] High throughput no no
CD1E_HUMAN [view interactions] High throughput no yes
GALT6_HUMAN [view interactions] High throughput no yes
CCL22_HUMAN [view interactions] High throughput no no
TECT2_HUMAN [view interactions] High throughput no yes
LACRT_HUMAN [view interactions] High throughput no no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
IFT80_HUMAN [view interactions] High throughput no yes
TAZ_HUMAN [view interactions] High throughput no yes
SUSD4_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRK_HUMAN [view interactions] High throughput no no
MPPE1_HUMAN [view interactions] High throughput no no
ADA30_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
HFE_HUMAN [view interactions] High throughput no yes
EP3A_HUMAN [view interactions] High throughput no no
DQA1_HUMAN [view interactions] High throughput no yes
BRID5_HUMAN [view interactions] High throughput no no
ST14_HUMAN [view entry] [view interactions] High throughput yes yes
RETNB_HUMAN [view interactions] High throughput no no
IGFL3_HUMAN [view interactions] High throughput no no
LYPD2_HUMAN [view interactions] High throughput no yes
C1QA_HUMAN [view entry] [view interactions] High throughput yes no