SUSD4_HUMAN
Evidence for PS localization
Functions
Acts as a complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SUSD4_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 50.0000 | 4 | no |
| GO:0046872 | metal ion binding | 50.0000 | 5 | no |
| GO:0000166 | nucleotide binding | 41.6667 | 4 | no |
| GO:0017076 | purine nucleotide binding | 41.6667 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | no |
| GO:0043168 | anion binding | 33.3333 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 25.0000 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.0000 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.0000 | 6 | no |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 6 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SUSD4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.3333 | 4 | no |
| GO:0030334 | regulation of cell migration | 33.3333 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 33.3333 | 4 | no |
| GO:2000145 | regulation of cell motility | 33.3333 | 4 | no |
| GO:0008104 | protein localization | 33.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | yes |
| GO:0006996 | organelle organization | 25.0000 | 4 | no |
| GO:0030030 | cell projection organization | 25.0000 | 4 | no |
| GO:0030155 | regulation of cell adhesion | 25.0000 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 25.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | no |
| GO:0051960 | regulation of nervous system development | 25.0000 | 5 | no |
| GO:0051962 | positive regulation of nervous system development | 25.0000 | 5 | no |
| GO:0006811 | monoatomic ion transport | 25.0000 | 4 | no |
| GO:0006812 | monoatomic cation transport | 25.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0098655 | monoatomic cation transmembrane transport | 25.0000 | 4 | no |
| GO:0098662 | inorganic cation transmembrane transport | 25.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 25.0000 | 4 | no |
| GO:0098657 | import into cell | 25.0000 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 16.6667 | 4 | yes |
| GO:0080134 | regulation of response to stress | 16.6667 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AT12A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FAT1_HUMAN | [view interactions] | High throughput | no | yes |
| LRP5_HUMAN | [view interactions] | High throughput | no | yes |
| FRAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ITAV_HUMAN | [view interactions] | High throughput | no | yes |
| DHB8_HUMAN | [view interactions] | High throughput | no | yes |
| NID2_HUMAN | [view interactions] | High throughput | no | yes |
| ENTP6_HUMAN | [view interactions] | High throughput | no | yes |
| ARSK_HUMAN | [view interactions] | High throughput | no | no |
| LAMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GFPT2_HUMAN | [view interactions] | High throughput | no | yes |
| PLGT3_HUMAN | [view interactions] | High throughput | no | no |
| TXD11_HUMAN | [view interactions] | High throughput | no | yes |
| ITA8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DHYS_HUMAN | [view interactions] | High throughput | no | no |
| ANAG_HUMAN | [view interactions] | High throughput | no | no |
| CC85C_HUMAN | [view interactions] | High throughput | no | yes |
| PLXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITA7_HUMAN | [view interactions] | High throughput | no | yes |
| F234B_HUMAN | [view interactions] | High throughput | no | yes |
| CATF_HUMAN | [view interactions] | High throughput | no | yes |
| ATS2_HUMAN | [view interactions] | High throughput | no | yes |
| NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CA2D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMD_HUMAN | [view interactions] | High throughput | no | yes |
| FUT11_HUMAN | [view interactions] | High throughput | no | yes |
| I17RA_HUMAN | [view interactions] | High throughput | no | yes |
| PGLT1_HUMAN | [view interactions] | High throughput | no | no |
| TOR3A_HUMAN | [view interactions] | High throughput | no | no |
| GT253_HUMAN | [view interactions] | High throughput | no | yes |
| ARSB_HUMAN | [view interactions] | High throughput | no | yes |
| MOXD1_HUMAN | [view interactions] | High throughput | no | no |
| PCOC2_HUMAN | [view interactions] | High throughput | no | no |
| MA2A2_HUMAN | [view interactions] | High throughput | no | no |
| DC2I2_HUMAN | [view interactions] | High throughput | no | yes |
| HPLN3_HUMAN | [view interactions] | High throughput | no | yes |
| TECT1_HUMAN | [view interactions] | High throughput | no | yes |
| TXD16_HUMAN | [view interactions] | High throughput | no | yes |
| ECE1_HUMAN | [view interactions] | High throughput | no | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARSA_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| CNTP3_HUMAN | [view interactions] | High throughput | no | yes |
| NNTM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |