ITA8_HUMAN
Evidence for PS localization
Functions
Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ITA8_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 21.4286 | 4 | yes |
| GO:0046872 | metal ion binding | 21.4286 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ITA8_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 57.1429 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 57.1429 | 4 | no |
| GO:0010646 | regulation of cell communication | 57.1429 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | yes |
| GO:0008104 | protein localization | 50.0000 | 4 | yes |
| GO:0030030 | cell projection organization | 42.8571 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 42.8571 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 42.8571 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 42.8571 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 42.8571 | 4 | yes |
| GO:0010468 | regulation of gene expression | 42.8571 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 42.8571 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 35.7143 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 35.7143 | 6 | yes |
| GO:0048584 | positive regulation of response to stimulus | 35.7143 | 4 | yes |
| GO:0042127 | regulation of cell population proliferation | 35.7143 | 4 | no |
| GO:0006996 | organelle organization | 35.7143 | 4 | no |
| GO:0015031 | protein transport | 35.7143 | 4 | no |
| GO:0071702 | organic substance transport | 35.7143 | 4 | no |
| GO:0071705 | nitrogen compound transport | 35.7143 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 35.7143 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 35.7143 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 35.7143 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.7143 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 28.5714 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 28.5714 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 28.5714 | 5 | no |
| GO:0023057 | negative regulation of signaling | 28.5714 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0051049 | regulation of transport | 28.5714 | 4 | no |
| GO:0051050 | positive regulation of transport | 28.5714 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 28.5714 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 28.5714 | 4 | no |
| GO:0080134 | regulation of response to stress | 28.5714 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.5714 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 28.5714 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 28.5714 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 28.5714 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.4286 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 21.4286 | 5 | yes |
| GO:0090287 | regulation of cellular response to growth factor stimulus | 21.4286 | 4 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 21.4286 | 6 | yes |
| GO:0009968 | negative regulation of signal transduction | 21.4286 | 5 | no |
| GO:0032880 | regulation of protein localization | 21.4286 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 21.4286 | 4 | no |
| GO:0045596 | negative regulation of cell differentiation | 21.4286 | 5 | no |
| GO:0051093 | negative regulation of developmental process | 21.4286 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 21.4286 | 4 | no |
| GO:0060341 | regulation of cellular localization | 21.4286 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 21.4286 | 4 | no |
| GO:0022607 | cellular component assembly | 21.4286 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 21.4286 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 21.4286 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 21.4286 | 5 | no |
| GO:0043933 | protein-containing complex organization | 21.4286 | 4 | no |
| GO:0009894 | regulation of catabolic process | 21.4286 | 4 | no |
| GO:0036211 | protein modification process | 21.4286 | 4 | no |
| GO:0043412 | macromolecule modification | 21.4286 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.4286 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 21.4286 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 21.4286 | 7 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.4286 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 21.4286 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.4286 | 7 | yes |
| GO:0030198 | extracellular matrix organization | 14.2857 | 5 | yes |
| GO:0042692 | muscle cell differentiation | 14.2857 | 4 | yes |
| GO:0043062 | extracellular structure organization | 14.2857 | 4 | yes |
| GO:0045229 | external encapsulating structure organization | 14.2857 | 4 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 14.2857 | 8 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 14.2857 | 5 | yes |
| GO:0048333 | mesodermal cell differentiation | 14.2857 | 4 | yes |
| GO:0048745 | smooth muscle tissue development | 14.2857 | 5 | yes |
| GO:0050890 | cognition | 14.2857 | 4 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 14.2857 | 6 | yes |
| GO:0060537 | muscle tissue development | 14.2857 | 4 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 14.2857 | 7 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 14.2857 | 8 | yes |
| GO:0007160 | cell-matrix adhesion | 14.2857 | 4 | yes |
| GO:0007229 | integrin-mediated signaling pathway | 14.2857 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ITB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NPNT_HUMAN | [view interactions] | Low throughput | no | no |
| BTNL8_HUMAN | [view interactions] | High throughput | no | no |
| DKKL1_HUMAN | [view interactions] | High throughput | no | no |
| SIA8D_HUMAN | [view interactions] | High throughput | no | yes |
| CCL22_HUMAN | [view interactions] | High throughput | no | no |
| CALR3_HUMAN | [view interactions] | High throughput | no | no |
| SG1D4_HUMAN | [view interactions] | High throughput | no | no |
| KCRU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| TAZ_HUMAN | [view interactions] | High throughput | no | yes |
| SUSD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAR3_HUMAN | [view interactions] | High throughput | no | no |
| PTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRK_HUMAN | [view interactions] | High throughput | no | no |
| SIAE_HUMAN | [view interactions] | High throughput | no | yes |
| PPARG_HUMAN | [view interactions] | High throughput | no | yes |
| CLUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIPR1_HUMAN | [view interactions] | High throughput | no | no |
| TMM25_HUMAN | [view interactions] | High throughput | no | yes |
| CEAM8_HUMAN | [view interactions] | High throughput | no | no |
| THEM6_HUMAN | [view interactions] | High throughput | no | no |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITIH2_HUMAN | [view interactions] | High throughput | no | no |
| BY55_HUMAN | [view interactions] | High throughput | no | no |
| SUSD5_HUMAN | [view interactions] | High throughput | no | no |
| LCN9_HUMAN | [view interactions] | High throughput | no | no |
| PCDGA_HUMAN | [view interactions] | High throughput | no | no |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| CLDN1_HUMAN | [view interactions] | High throughput | no | yes |
| DB136_HUMAN | [view interactions] | High throughput | no | no |
| HDBP1_HUMAN | [view interactions] | High throughput | no | no |
| DSC3_HUMAN | [view interactions] | High throughput | no | no |
| ZDH17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAN1_HUMAN | [view interactions] | High throughput | no | yes |
| GPC5C_HUMAN | [view interactions] | High throughput | no | no |
| HIG1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDH18_HUMAN | [view interactions] | High throughput | no | yes |
| TAFA4_HUMAN | [view interactions] | High throughput | no | no |
| GML_HUMAN | [view interactions] | High throughput | no | no |
| NPAP1_HUMAN | [view interactions] | High throughput | no | no |
| EP3A_HUMAN | [view interactions] | High throughput | no | no |
| LCTL_HUMAN | [view interactions] | High throughput | no | no |
| TPPC5_HUMAN | [view interactions] | High throughput | no | yes |
| DECR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| BIG1_HUMAN | [view interactions] | High throughput | no | yes |
| DHRS7_HUMAN | [view interactions] | High throughput | no | yes |
| BST1_HUMAN | [view interactions] | High throughput | no | no |
| LCFC1_HUMAN | [view interactions] | High throughput | no | no |
| LY65C_HUMAN | [view interactions] | High throughput | no | no |
| PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NGBR_HUMAN | [view interactions] | High throughput | no | no |
| FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DB135_HUMAN | [view interactions] | High throughput | no | no |
| ZNRF3_HUMAN | [view interactions] | High throughput | no | no |
| TENA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |