Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ITA8_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ITA8_HUMAN
GO:0046872 metal ion binding 26.3158 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ITA8_HUMAN
GO:0010646 regulation of cell communication 63.1579 4 yes
GO:0048522 positive regulation of cellular process 63.1579 4 yes
GO:0048523 negative regulation of cellular process 63.1579 4 no
GO:0009966 regulation of signal transduction 52.6316 4 yes
GO:0030030 cell projection organization 52.6316 4 yes
GO:0060255 regulation of macromolecule metabolic process 52.6316 4 yes
GO:0009893 positive regulation of metabolic process 47.3684 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 47.3684 5 yes
GO:0120036 plasma membrane bounded cell projection organization 47.3684 5 no
GO:0051128 regulation of cellular component organization 42.1053 4 no
GO:0007229 integrin-mediated signaling pathway 36.8421 4 yes
GO:0008104 protein localization 36.8421 4 yes
GO:0010647 positive regulation of cell communication 36.8421 5 yes
GO:0023056 positive regulation of signaling 36.8421 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 36.8421 4 yes
GO:0080090 regulation of primary metabolic process 36.8421 4 yes
GO:0022607 cellular component assembly 36.8421 4 no
GO:0030334 regulation of cell migration 36.8421 5 no
GO:2000145 regulation of cell motility 36.8421 4 no
GO:0009967 positive regulation of signal transduction 31.5789 5 yes
GO:0010468 regulation of gene expression 31.5789 5 yes
GO:0031323 regulation of cellular metabolic process 31.5789 4 yes
GO:0031325 positive regulation of cellular metabolic process 31.5789 5 yes
GO:0048584 positive regulation of response to stimulus 31.5789 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 31.5789 5 yes
GO:0030335 positive regulation of cell migration 31.5789 6 no
GO:0040017 positive regulation of locomotion 31.5789 4 no
GO:0042127 regulation of cell population proliferation 31.5789 4 no
GO:0045595 regulation of cell differentiation 31.5789 4 no
GO:1902531 regulation of intracellular signal transduction 31.5789 5 no
GO:2000147 positive regulation of cell motility 31.5789 5 no
GO:0010648 negative regulation of cell communication 31.5789 5 no
GO:0023057 negative regulation of signaling 31.5789 4 no
GO:0051093 negative regulation of developmental process 31.5789 4 no
GO:0051129 negative regulation of cellular component organization 31.5789 5 no
GO:0006996 organelle organization 31.5789 4 no
GO:0016192 vesicle-mediated transport 31.5789 4 no
GO:0032880 regulation of protein localization 31.5789 5 no
GO:0051049 regulation of transport 31.5789 4 no
GO:0060341 regulation of cellular localization 31.5789 4 no
GO:0007160 cell-matrix adhesion 26.3158 4 yes
GO:0048333 mesodermal cell differentiation 26.3158 4 yes
GO:0050890 cognition 26.3158 4 yes
GO:0010941 regulation of cell death 26.3158 4 no
GO:0030155 regulation of cell adhesion 26.3158 4 no
GO:0031399 regulation of protein modification process 26.3158 6 no
GO:0042981 regulation of apoptotic process 26.3158 6 no
GO:0043066 negative regulation of apoptotic process 26.3158 7 no
GO:0043067 regulation of programmed cell death 26.3158 5 no
GO:0043069 negative regulation of programmed cell death 26.3158 6 no
GO:0051246 regulation of protein metabolic process 26.3158 5 no
GO:0060548 negative regulation of cell death 26.3158 5 no
GO:0080134 regulation of response to stress 26.3158 4 no
GO:0034330 cell junction organization 26.3158 4 no
GO:0045596 negative regulation of cell differentiation 26.3158 5 no
GO:0048585 negative regulation of response to stimulus 26.3158 4 no
GO:0051240 positive regulation of multicellular organismal process 26.3158 4 no
GO:2000026 regulation of multicellular organismal development 26.3158 4 no
GO:0051050 positive regulation of transport 26.3158 4 no
GO:0015031 protein transport 26.3158 4 no
GO:0071702 organic substance transport 26.3158 4 no
GO:0071705 nitrogen compound transport 26.3158 4 no
GO:0090287 regulation of cellular response to growth factor stimulus 21.0526 4 yes
GO:0001932 regulation of protein phosphorylation 21.0526 7 no
GO:0001934 positive regulation of protein phosphorylation 21.0526 8 no
GO:0008284 positive regulation of cell population proliferation 21.0526 5 no
GO:0010562 positive regulation of phosphorus metabolic process 21.0526 6 no
GO:0010632 regulation of epithelial cell migration 21.0526 4 no
GO:0019220 regulation of phosphate metabolic process 21.0526 6 no
GO:0022603 regulation of anatomical structure morphogenesis 21.0526 4 no
GO:0031175 neuron projection development 21.0526 6 no
GO:0031401 positive regulation of protein modification process 21.0526 7 no
GO:0033043 regulation of organelle organization 21.0526 5 no
GO:0042325 regulation of phosphorylation 21.0526 7 no
GO:0042327 positive regulation of phosphorylation 21.0526 8 no
GO:0043085 positive regulation of catalytic activity 21.0526 4 no
GO:0045937 positive regulation of phosphate metabolic process 21.0526 7 no
GO:0051174 regulation of phosphorus metabolic process 21.0526 5 no
GO:0051247 positive regulation of protein metabolic process 21.0526 6 no
GO:0009968 negative regulation of signal transduction 21.0526 5 no
GO:0046578 regulation of Ras protein signal transduction 21.0526 7 no
GO:0051056 regulation of small GTPase mediated signal transduction 21.0526 6 no
GO:0010628 positive regulation of gene expression 21.0526 6 no
GO:0051130 positive regulation of cellular component organization 21.0526 5 no
GO:0030100 regulation of endocytosis 21.0526 5 no
GO:0048259 regulation of receptor-mediated endocytosis 21.0526 6 no
GO:0060627 regulation of vesicle-mediated transport 21.0526 4 no
GO:0000904 cell morphogenesis involved in differentiation 15.7895 4 yes
GO:0006355 regulation of DNA-templated transcription 15.7895 6 yes
GO:0007613 memory 15.7895 4 yes
GO:0009889 regulation of biosynthetic process 15.7895 4 yes
GO:0009891 positive regulation of biosynthetic process 15.7895 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 15.7895 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 15.7895 5 yes
GO:0030198 extracellular matrix organization 15.7895 5 yes
GO:0031326 regulation of cellular biosynthetic process 15.7895 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 15.7895 6 yes
GO:0043062 extracellular structure organization 15.7895 4 yes
GO:0045229 external encapsulating structure organization 15.7895 4 yes
GO:0051252 regulation of RNA metabolic process 15.7895 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 15.7895 7 yes
GO:2001141 regulation of RNA biosynthetic process 15.7895 6 yes
GO:0006357 regulation of transcription by RNA polymerase II 10.5263 7 yes
GO:0007420 brain development 10.5263 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 10.5263 6 yes
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 10.5263 6 yes
GO:0034446 substrate adhesion-dependent cell spreading 10.5263 4 yes
GO:0045893 positive regulation of DNA-templated transcription 10.5263 7 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 10.5263 6 yes
GO:0048745 smooth muscle tissue development 10.5263 5 yes
GO:0051254 positive regulation of RNA metabolic process 10.5263 6 yes
GO:0060537 muscle tissue development 10.5263 4 yes
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 10.5263 5 yes
GO:1902680 positive regulation of RNA biosynthetic process 10.5263 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 10.5263 8 yes
GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 10.5263 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ITB1_HUMAN [view entry] [view interactions] Low throughput yes no
NPNT_HUMAN [view interactions] Low throughput no no
BTNL8_HUMAN [view interactions] High throughput no no
DKKL1_HUMAN [view interactions] High throughput no no
SIA8D_HUMAN [view interactions] High throughput no yes
CCL22_HUMAN [view interactions] High throughput no no
CALR3_HUMAN [view interactions] High throughput no no
SG1D4_HUMAN [view interactions] High throughput no no
KCRU_HUMAN [view entry] [view interactions] High throughput yes yes
H14_HUMAN [view interactions] High throughput no yes
TAZ_HUMAN [view interactions] High throughput no yes
SUSD4_HUMAN [view interactions] High throughput no yes
NAR3_HUMAN [view interactions] High throughput no no
PTC1_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRK_HUMAN [view interactions] High throughput no no
SIAE_HUMAN [view interactions] High throughput no yes
PPARG_HUMAN [view interactions] High throughput no yes
CLUS_HUMAN [view entry] [view interactions] High throughput yes yes
LIPR1_HUMAN [view interactions] High throughput no no
TMM25_HUMAN [view interactions] High throughput no yes
CEAM8_HUMAN [view interactions] High throughput no no
THEM6_HUMAN [view interactions] High throughput no no
HOOK3_HUMAN [view entry] [view interactions] High throughput yes yes
ITIH2_HUMAN [view interactions] High throughput no no
BY55_HUMAN [view interactions] High throughput no no
SUSD5_HUMAN [view interactions] High throughput no no
LCN9_HUMAN [view interactions] High throughput no no
PCDGA_HUMAN [view interactions] High throughput no no
PGFRA_HUMAN [view interactions] High throughput no no
CLDN1_HUMAN [view interactions] High throughput no yes
DB136_HUMAN [view interactions] High throughput no no
HDBP1_HUMAN [view interactions] High throughput no no
DSC3_HUMAN [view interactions] High throughput no no
ZDH17_HUMAN [view interactions] High throughput no yes
MAN1_HUMAN [view interactions] High throughput no yes
GPC5C_HUMAN [view interactions] High throughput no no
HIG1A_HUMAN [view entry] [view interactions] High throughput yes yes
ZDH18_HUMAN [view interactions] High throughput no yes
TAFA4_HUMAN [view interactions] High throughput no no
GML_HUMAN [view interactions] High throughput no no
NPAP1_HUMAN [view interactions] High throughput no no
EP3A_HUMAN [view interactions] High throughput no no
LCTL_HUMAN [view interactions] High throughput no no
TPPC5_HUMAN [view interactions] High throughput no yes
DECR2_HUMAN [view entry] [view interactions] High throughput yes no
LEG1_HUMAN [view interactions] High throughput no yes
BIG1_HUMAN [view interactions] High throughput no yes
DHRS7_HUMAN [view interactions] High throughput no yes
BST1_HUMAN [view interactions] High throughput no no
LCFC1_HUMAN [view interactions] High throughput no no
LY65C_HUMAN [view interactions] High throughput no no
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
NGBR_HUMAN [view interactions] High throughput no no
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
BIG2_HUMAN [view entry] [view interactions] High throughput yes yes
DB135_HUMAN [view interactions] High throughput no no
ZNRF3_HUMAN [view interactions] High throughput no no
TENA_HUMAN [view entry] [view interactions] High throughput yes no
ITA3_HUMAN [view entry] [view interactions] Computational yes yes
JAM2_HUMAN [view interactions] Computational no no
LAMA3_HUMAN [view interactions] Computational no no
ITB6_HUMAN [view interactions] Computational no no
ITB2_HUMAN [view interactions] Computational no no
ARF6_HUMAN [view entry] [view interactions] Computational yes yes
ITA2_HUMAN [view interactions] Computational no yes
TENN_HUMAN [view interactions] Computational no no
CD28_HUMAN [view interactions] Computational no no
LAMA2_HUMAN [view interactions] Computational no no
ITB5_HUMAN [view interactions] Computational no yes
ITB4_HUMAN [view entry] [view interactions] Computational yes yes
ITB3_HUMAN [view entry] [view interactions] Computational yes no
TENR_HUMAN [view entry] [view interactions] Computational yes no
VTNC_HUMAN [view interactions] Computational no no
FINC_HUMAN [view interactions] Computational no yes
LAMA1_HUMAN [view interactions] Computational no no
CD80_HUMAN [view interactions] Computational no no
ITAD_HUMAN [view interactions] Computational no no
ITB8_HUMAN [view interactions] Computational no no
ITA5_HUMAN [view entry] [view interactions] Computational yes no
FREM2_HUMAN [view interactions] Computational no no
ITA4_HUMAN [view interactions] Computational no no
FRAS1_HUMAN [view interactions] Computational no yes
ITA10_HUMAN [view interactions] Computational no no
ITAL_HUMAN [view interactions] Computational no no
ITB7_HUMAN [view interactions] Computational no no
OSTP_HUMAN [view interactions] Computational no yes
ITA11_HUMAN [view interactions] Computational no yes
ITAV_HUMAN [view interactions] Computational no yes
JAM3_HUMAN [view interactions] Computational no no
TENX_HUMAN [view interactions] Computational no no
ITA1_HUMAN [view interactions] Computational no yes
FAK1_HUMAN [view entry] [view interactions] Computational yes yes
CO4A1_HUMAN [view interactions] Computational no yes