KCRU_HUMAN
Evidence for PS localization
Functions
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KCRU_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 30.7692 | 4 | no |
| GO:0019900 | kinase binding | 25.6410 | 4 | no |
| GO:0019901 | protein kinase binding | 23.0769 | 5 | no |
| GO:0017076 | purine nucleotide binding | 15.3846 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 15.3846 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 15.3846 | 4 | yes |
| GO:0005524 | ATP binding | 10.2564 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 10.2564 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 10.2564 | 5 | yes |
| GO:0016301 | kinase activity | 7.6923 | 4 | yes |
| GO:0004111 | creatine kinase activity | 5.1282 | 5 | yes |
| GO:0016775 | phosphotransferase activity, nitrogenous group as acceptor | 5.1282 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KCRU_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.4103 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 53.8462 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 53.8462 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 53.8462 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.7179 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 48.7179 | 4 | no |
| GO:0010646 | regulation of cell communication | 46.1538 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 43.5897 | 4 | no |
| GO:0009966 | regulation of signal transduction | 43.5897 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 41.0256 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.4615 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 38.4615 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 35.8974 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 35.8974 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 35.8974 | 4 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 30.7692 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 30.7692 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.7692 | 5 | no |
| GO:0010941 | regulation of cell death | 30.7692 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.7692 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.7692 | 5 | no |
| GO:0043269 | regulation of ion transport | 30.7692 | 5 | no |
| GO:0006996 | organelle organization | 30.7692 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.7692 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.7692 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 28.2051 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 28.2051 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.6410 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.6410 | 5 | no |
| GO:0031399 | regulation of protein modification process | 25.6410 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 25.6410 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.6410 | 5 | no |
| GO:0071702 | organic substance transport | 25.6410 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.6410 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 25.6410 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 23.0769 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 23.0769 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 23.0769 | 7 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 23.0769 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 23.0769 | 6 | no |
| GO:0009894 | regulation of catabolic process | 23.0769 | 4 | no |
| GO:0022607 | cellular component assembly | 23.0769 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 23.0769 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.0769 | 4 | no |
| GO:0008104 | protein localization | 23.0769 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 23.0769 | 5 | no |
| GO:1904062 | regulation of cation transmembrane transport | 23.0769 | 6 | no |
| GO:0010959 | regulation of metal ion transport | 20.5128 | 6 | no |
| GO:0051050 | positive regulation of transport | 20.5128 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.5128 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.5128 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.5128 | 4 | no |
| GO:0036211 | protein modification process | 20.5128 | 4 | no |
| GO:0043412 | macromolecule modification | 20.5128 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.5128 | 7 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.5128 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 20.5128 | 4 | no |
| GO:0051345 | positive regulation of hydrolase activity | 20.5128 | 5 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 20.5128 | 4 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 20.5128 | 5 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 10.2564 | 4 | yes |
| GO:0090407 | organophosphate biosynthetic process | 7.6923 | 4 | yes |
| GO:0006599 | phosphagen metabolic process | 5.1282 | 4 | yes |
| GO:0006603 | phosphocreatine metabolic process | 5.1282 | 5 | yes |
| GO:0042396 | phosphagen biosynthetic process | 5.1282 | 5 | yes |
| GO:0042398 | cellular modified amino acid biosynthetic process | 5.1282 | 4 | yes |
| GO:0046314 | phosphocreatine biosynthetic process | 5.1282 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in KCRU_HUMAN |
|---|---|---|---|---|
| DOID:574 | peripheral nervous system disease | 7.6923 | 3 | no |
| DOID:870 | neuropathy | 7.6923 | 4 | no |
| DOID:0080000 | muscular disease | 5.1282 | 3 | no |
| DOID:3191 | nemaline myopathy | 5.1282 | 7 | no |
| DOID:422 | congenital structural myopathy | 5.1282 | 6 | no |
| DOID:423 | myopathy | 5.1282 | 5 | no |
| DOID:66 | muscle tissue disease | 5.1282 | 4 | no |
| DOID:0050700 | cardiomyopathy | 5.1282 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 5.1282 | 5 | no |
| DOID:114 | heart disease | 5.1282 | 3 | no |
| DOID:2843 | long QT syndrome | 5.1282 | 6 | no |
| DOID:1891 | optic nerve disease | 5.1282 | 6 | no |
| DOID:5656 | cranial nerve disease | 5.1282 | 5 | no |
| DOID:5723 | optic atrophy | 5.1282 | 7 | no |
| DOID:700 | mitochondrial metabolism disease | 5.1282 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KCRU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| ELK1_HUMAN | [view interactions] | Low throughput | no | yes |
| ASB9_HUMAN | [view interactions] | Low throughput | no | no |
| LCORL_HUMAN | [view interactions] | High throughput | no | yes |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| OMA1_HUMAN | [view interactions] | High throughput | no | no |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| YMEL1_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FADD_HUMAN | [view interactions] | High throughput | no | yes |
| CTNA3_HUMAN | [view interactions] | High throughput | no | no |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HECW2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| KCRS_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| RHG36_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGF_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARHGQ_HUMAN | [view interactions] | High throughput | no | yes |
| ARG39_HUMAN | [view interactions] | High throughput | no | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| CAH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTBP2_HUMAN | [view interactions] | High throughput | no | no |
| CSN7B_HUMAN | [view interactions] | High throughput | no | yes |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| G3PT_HUMAN | [view interactions] | High throughput | no | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IGBP1_HUMAN | [view interactions] | High throughput | no | yes |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| GALK1_HUMAN | [view interactions] | High throughput | no | yes |
| PGAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HYEP_HUMAN | [view interactions] | High throughput | no | no |
| GPD1L_HUMAN | [view interactions] | High throughput | no | no |
| CH10_HUMAN | [view interactions] | High throughput | no | yes |
| HDDC2_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLPB_HUMAN | [view interactions] | High throughput | no | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| OPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2551_HUMAN | [view interactions] | High throughput | no | no |
| SURF1_HUMAN | [view interactions] | High throughput | no | yes |
| TIM29_HUMAN | [view interactions] | High throughput | no | no |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| LAMB3_HUMAN | [view interactions] | High throughput | no | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| OPA3_HUMAN | [view interactions] | High throughput | no | yes |
| PAK4_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITA8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KAT6B_HUMAN | [view interactions] | High throughput | no | yes |
| NPT2A_HUMAN | [view interactions] | High throughput | no | no |
| ARI2O_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MX1_HUMAN | [view interactions] | High throughput | no | yes |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| SFRP4_HUMAN | [view interactions] | High throughput | no | no |
| ONCO_HUMAN | [view interactions] | High throughput | no | no |
| NTF2_HUMAN | [view interactions] | High throughput | no | yes |
| RXRG_HUMAN | [view interactions] | High throughput | no | no |
| HPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCRM_HUMAN | [view interactions] | High throughput | no | no |
| PP16A_HUMAN | [view interactions] | High throughput | no | no |
| PRS6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JPH3_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| RAB28_HUMAN | [view interactions] | Computational | no | yes |
| STRC_HUMAN | [view interactions] | Computational | no | yes |
| GAMT_HUMAN | [view interactions] | Computational | no | no |
| SC6A8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NDKM_HUMAN | [view interactions] | Computational | no | yes |
| LDH6A_HUMAN | [view interactions] | Computational | no | no |
| LDH6B_HUMAN | [view interactions] | Computational | no | no |