HPCA_HUMAN
Evidence for PS localization
Functions
Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (PubMed). May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 71 | Thr | Asn | Dystonia2,torsion,autosomalrecessive(DYT2) | - |
| 75 | Asn | Lys | Dystonia2,torsion,autosomalrecessive(DYT2) | - |
| 190 | Ala | Thr | Dystonia2,torsion,autosomalrecessive(DYT2) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in HPCA_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 40.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 40.0000 | 5 | yes |
| GO:0003779 | actin binding | 30.0000 | 4 | yes |
| GO:0005509 | calcium ion binding | 30.0000 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in HPCA_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 30.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 30.0000 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 30.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 30.0000 | 4 | no |
| GO:0010038 | response to metal ion | 20.0000 | 4 | yes |
| GO:0019722 | calcium-mediated signaling | 20.0000 | 5 | yes |
| GO:0032880 | regulation of protein localization | 20.0000 | 5 | yes |
| GO:0051049 | regulation of transport | 20.0000 | 4 | yes |
| GO:0051592 | response to calcium ion | 20.0000 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 20.0000 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 20.0000 | 4 | yes |
| GO:0070201 | regulation of establishment of protein localization | 20.0000 | 6 | yes |
| GO:0141124 | intracellular signaling cassette | 20.0000 | 4 | yes |
| GO:1903829 | positive regulation of protein localization | 20.0000 | 5 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 20.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KCMA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| M3K10_HUMAN | [view interactions] | Low throughput | no | yes |
| NMT1_HUMAN | [view interactions] | Low throughput | no | yes |
| BIRC1_HUMAN | [view interactions] | Low throughput | no | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| DTX2_HUMAN | [view interactions] | High throughput | no | yes |
| MYDGF_HUMAN | [view interactions] | High throughput | no | yes |
| PRR35_HUMAN | [view interactions] | High throughput | no | no |
| C1QT2_HUMAN | [view interactions] | High throughput | no | yes |
| VWC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT4_HUMAN | [view interactions] | High throughput | no | yes |
| AP4AT_HUMAN | [view interactions] | High throughput | no | no |
| KCRU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GATA5_HUMAN | [view interactions] | High throughput | no | no |
| I36RA_HUMAN | [view interactions] | High throughput | no | no |
| QCR7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AF10_HUMAN | [view interactions] | High throughput | no | no |
| CREM_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| ABHD6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HPCL1_HUMAN | [view interactions] | High throughput | no | yes |
| PUSL1_HUMAN | [view interactions] | High throughput | no | yes |
| NMT2_HUMAN | [view interactions] | High throughput | no | yes |
| TR3N_HUMAN | [view interactions] | High throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCALD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHDDS_HUMAN | [view interactions] | High throughput | no | no |
| M3K21_HUMAN | [view interactions] | High throughput | no | yes |
| CYTC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AN33B_HUMAN | [view interactions] | High throughput | no | no |
| TPP2_HUMAN | [view interactions] | High throughput | no | yes |
| M3K9_HUMAN | [view interactions] | High throughput | no | yes |
| IRAK4_HUMAN | [view interactions] | High throughput | no | yes |
| M3K11_HUMAN | [view interactions] | High throughput | no | yes |
| VISL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTK7_HUMAN | [view interactions] | High throughput | no | yes |