Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ABHD6_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways . Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids . Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ABHD6_HUMAN
GO:0046872 metal ion binding 55.5556 4 no
GO:0016298 lipase activity 44.4444 4 yes
GO:0047372 acylglycerol lipase activity 44.4444 5 yes
GO:0052689 carboxylic ester hydrolase activity 44.4444 4 yes
GO:0005509 calcium ion binding 33.3333 5 no
GO:0005216 ion channel activity 22.2222 4 no
GO:0008324 cation transmembrane transporter activity 22.2222 4 no
GO:0015267 channel activity 22.2222 4 no
GO:0022836 gated channel activity 22.2222 5 no
GO:0022890 inorganic cation transmembrane transporter activity 22.2222 4 no
GO:0046873 metal ion transmembrane transporter activity 22.2222 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in ABHD6_HUMAN
GO:0080090 regulation of primary metabolic process 55.5556 4 yes
GO:0001676 long-chain fatty acid metabolic process 44.4444 5 yes
GO:0006631 fatty acid metabolic process 44.4444 4 yes
GO:0006690 icosanoid metabolic process 44.4444 6 yes
GO:0009892 negative regulation of metabolic process 44.4444 4 yes
GO:0009893 positive regulation of metabolic process 44.4444 4 yes
GO:0016042 lipid catabolic process 44.4444 4 yes
GO:0019369 arachidonic acid metabolic process 44.4444 4 yes
GO:0019752 carboxylic acid metabolic process 44.4444 5 yes
GO:0032787 monocarboxylic acid metabolic process 44.4444 6 yes
GO:0033559 unsaturated fatty acid metabolic process 44.4444 5 yes
GO:0043436 oxoacid metabolic process 44.4444 4 yes
GO:0031323 regulation of cellular metabolic process 44.4444 4 no
GO:0048522 positive regulation of cellular process 44.4444 4 no
GO:0051128 regulation of cellular component organization 44.4444 4 no
GO:0006638 neutral lipid metabolic process 33.3333 4 yes
GO:0006639 acylglycerol metabolic process 33.3333 5 yes
GO:0009966 regulation of signal transduction 33.3333 4 yes
GO:0010646 regulation of cell communication 33.3333 4 yes
GO:0044242 cellular lipid catabolic process 33.3333 4 yes
GO:0046461 neutral lipid catabolic process 33.3333 5 yes
GO:0046464 acylglycerol catabolic process 33.3333 6 yes
GO:0046486 glycerolipid metabolic process 33.3333 4 yes
GO:0046503 glycerolipid catabolic process 33.3333 5 yes
GO:0048523 negative regulation of cellular process 33.3333 4 yes
GO:0099537 trans-synaptic signaling 33.3333 4 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0051171 regulation of nitrogen compound metabolic process 33.3333 4 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:1903829 positive regulation of protein localization 33.3333 5 no
GO:0009889 regulation of biosynthetic process 22.2222 4 yes
GO:0019216 regulation of lipid metabolic process 22.2222 5 yes
GO:0045834 positive regulation of lipid metabolic process 22.2222 5 yes
GO:0046462 monoacylglycerol metabolic process 22.2222 6 yes
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 yes
GO:0051241 negative regulation of multicellular organismal process 22.2222 4 yes
GO:0052651 monoacylglycerol catabolic process 22.2222 7 yes
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 yes
GO:0007215 glutamate receptor signaling pathway 22.2222 4 no
GO:0007216 G protein-coupled glutamate receptor signaling pathway 22.2222 4 no
GO:0007405 neuroblast proliferation 22.2222 4 no
GO:0022008 neurogenesis 22.2222 4 no
GO:0031325 positive regulation of cellular metabolic process 22.2222 5 no
GO:0031347 regulation of defense response 22.2222 5 no
GO:0032101 regulation of response to external stimulus 22.2222 4 no
GO:0038171 cannabinoid signaling pathway 22.2222 4 no
GO:0042136 neurotransmitter biosynthetic process 22.2222 4 no
GO:0050727 regulation of inflammatory response 22.2222 5 no
GO:0071926 endocannabinoid signaling pathway 22.2222 5 no
GO:0080134 regulation of response to stress 22.2222 4 no
GO:0098917 retrograde trans-synaptic signaling 22.2222 5 no
GO:0098920 retrograde trans-synaptic signaling by lipid 22.2222 6 no
GO:0098921 retrograde trans-synaptic signaling by endocannabinoid 22.2222 7 no
GO:0099541 trans-synaptic signaling by lipid 22.2222 5 no
GO:0099542 trans-synaptic signaling by endocannabinoid 22.2222 6 no
GO:0022607 cellular component assembly 22.2222 4 no
GO:0030030 cell projection organization 22.2222 4 no
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 no
GO:0006873 cellular ion homeostasis 22.2222 4 no
GO:0006874 cellular calcium ion homeostasis 22.2222 7 no
GO:0006875 cellular metal ion homeostasis 22.2222 6 no
GO:0009967 positive regulation of signal transduction 22.2222 5 no
GO:0010604 positive regulation of macromolecule metabolic process 22.2222 5 no
GO:0010647 positive regulation of cell communication 22.2222 5 no
GO:0010975 regulation of neuron projection development 22.2222 7 no
GO:0023056 positive regulation of signaling 22.2222 4 no
GO:0030003 cellular cation homeostasis 22.2222 5 no
GO:0031344 regulation of cell projection organization 22.2222 5 no
GO:0048584 positive regulation of response to stimulus 22.2222 4 no
GO:0048878 chemical homeostasis 22.2222 4 no
GO:0050801 ion homeostasis 22.2222 5 no
GO:0051094 positive regulation of developmental process 22.2222 4 no
GO:0051130 positive regulation of cellular component organization 22.2222 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 22.2222 5 no
GO:0051240 positive regulation of multicellular organismal process 22.2222 4 no
GO:0051246 regulation of protein metabolic process 22.2222 5 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 no
GO:0055065 metal ion homeostasis 22.2222 7 no
GO:0055074 calcium ion homeostasis 22.2222 8 no
GO:0055080 cation homeostasis 22.2222 6 no
GO:0060255 regulation of macromolecule metabolic process 22.2222 4 no
GO:0072503 cellular divalent inorganic cation homeostasis 22.2222 6 no
GO:0072507 divalent inorganic cation homeostasis 22.2222 7 no
GO:0098771 inorganic ion homeostasis 22.2222 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 22.2222 6 no
GO:1902531 regulation of intracellular signal transduction 22.2222 5 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:0006140 regulation of nucleotide metabolic process 22.2222 5 no
GO:0010563 negative regulation of phosphorus metabolic process 22.2222 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0019722 calcium-mediated signaling 22.2222 5 no
GO:0019932 second-messenger-mediated signaling 22.2222 4 no
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 no
GO:0032386 regulation of intracellular transport 22.2222 5 no
GO:0032388 positive regulation of intracellular transport 22.2222 5 no
GO:0033157 regulation of intracellular protein transport 22.2222 6 no
GO:0043085 positive regulation of catalytic activity 22.2222 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 22.2222 6 no
GO:0045936 negative regulation of phosphate metabolic process 22.2222 7 no
GO:0045980 negative regulation of nucleotide metabolic process 22.2222 6 no
GO:0051049 regulation of transport 22.2222 4 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 22.2222 5 no
GO:0051222 positive regulation of protein transport 22.2222 5 no
GO:0051223 regulation of protein transport 22.2222 5 no
GO:0051336 regulation of hydrolase activity 22.2222 4 no
GO:0051345 positive regulation of hydrolase activity 22.2222 5 no
GO:0062012 regulation of small molecule metabolic process 22.2222 4 no
GO:0062014 negative regulation of small molecule metabolic process 22.2222 5 no
GO:0070201 regulation of establishment of protein localization 22.2222 6 no
GO:0090313 regulation of protein targeting to membrane 22.2222 7 no
GO:0090314 positive regulation of protein targeting to membrane 22.2222 7 no
GO:0090316 positive regulation of intracellular protein transport 22.2222 6 no
GO:1900542 regulation of purine nucleotide metabolic process 22.2222 6 no
GO:1900543 negative regulation of purine nucleotide metabolic process 22.2222 7 no
GO:1903533 regulation of protein targeting 22.2222 7 no
GO:1904951 positive regulation of establishment of protein localization 22.2222 6 no
GO:1905475 regulation of protein localization to membrane 22.2222 6 no
GO:1905477 positive regulation of protein localization to membrane 22.2222 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UFL1_HUMAN [view interactions] High throughput no yes
C5AR2_HUMAN [view interactions] High throughput no yes
FSHR_HUMAN [view interactions] High throughput no no
NCS1_HUMAN [view entry] [view interactions] High throughput yes yes
KCRS_HUMAN [view interactions] High throughput no no
PCGF2_HUMAN [view interactions] High throughput no no
RTP2_HUMAN [view interactions] High throughput no no
FIS1_HUMAN [view entry] [view interactions] High throughput yes yes
TV23B_HUMAN [view interactions] High throughput no no
SCAM4_HUMAN [view interactions] High throughput no yes
PCDA3_HUMAN [view interactions] High throughput no no
RNF4_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
DX39A_HUMAN [view interactions] High throughput no yes
O10H2_HUMAN [view interactions] High throughput no no
HPCA_HUMAN [view entry] [view interactions] High throughput yes yes
MARH4_HUMAN [view interactions] High throughput no yes
TTMP_HUMAN [view interactions] High throughput no no
O10H1_HUMAN [view interactions] High throughput no no
TTYH1_HUMAN [view entry] [view interactions] High throughput yes no
RXFP1_HUMAN [view interactions] High throughput no yes
PCDGL_HUMAN [view interactions] High throughput no no
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
ABD12_HUMAN [view interactions] Computational no no
FAAH1_HUMAN [view entry] [view interactions] Computational yes yes
NAPEP_HUMAN [view interactions] Computational no yes
DGLA_HUMAN [view entry] [view interactions] Computational yes yes
DGLB_HUMAN [view entry] [view interactions] Computational yes no