Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ABHD6_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways . Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids . Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ABHD6_HUMAN
GO:0005509 calcium ion binding 42.8571 6 no
GO:0043169 cation binding 42.8571 4 no
GO:0046872 metal ion binding 42.8571 5 no
GO:0005216 monoatomic ion channel activity 42.8571 4 no
GO:0015267 channel activity 42.8571 4 no
GO:0022836 gated channel activity 42.8571 5 no
GO:0022890 inorganic cation transmembrane transporter activity 42.8571 4 no
GO:0019900 kinase binding 28.5714 4 no
GO:0015276 ligand-gated monoatomic ion channel activity 28.5714 5 no
GO:0022834 ligand-gated channel activity 28.5714 6 no
GO:0008324 monoatomic cation transmembrane transporter activity 28.5714 4 no
GO:0046873 metal ion transmembrane transporter activity 28.5714 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in ABHD6_HUMAN
GO:0009893 positive regulation of metabolic process 57.1429 4 yes
GO:0010646 regulation of cell communication 57.1429 4 yes
GO:0048523 negative regulation of cellular process 57.1429 4 yes
GO:0048522 positive regulation of cellular process 57.1429 4 no
GO:0051128 regulation of cellular component organization 57.1429 4 no
GO:0022607 cellular component assembly 42.8571 4 no
GO:0009889 regulation of biosynthetic process 42.8571 4 yes
GO:0009892 negative regulation of metabolic process 42.8571 4 yes
GO:0009966 regulation of signal transduction 42.8571 4 yes
GO:0050804 modulation of chemical synaptic transmission 42.8571 5 yes
GO:0080090 regulation of primary metabolic process 42.8571 4 yes
GO:0099177 regulation of trans-synaptic signaling 42.8571 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 42.8571 5 no
GO:0010647 positive regulation of cell communication 42.8571 5 no
GO:0023056 positive regulation of signaling 42.8571 4 no
GO:0031323 regulation of cellular metabolic process 42.8571 4 no
GO:0060255 regulation of macromolecule metabolic process 42.8571 4 no
GO:0010038 response to metal ion 28.5714 4 no
GO:0010243 response to organonitrogen compound 28.5714 4 no
GO:0014070 response to organic cyclic compound 28.5714 4 no
GO:0043200 response to amino acid 28.5714 4 no
GO:0071229 cellular response to acid chemical 28.5714 4 no
GO:0071230 cellular response to amino acid stimulus 28.5714 5 no
GO:0071310 cellular response to organic substance 28.5714 4 no
GO:0071417 cellular response to organonitrogen compound 28.5714 4 no
GO:1901699 cellular response to nitrogen compound 28.5714 4 no
GO:1901701 cellular response to oxygen-containing compound 28.5714 4 no
GO:0007416 synapse assembly 28.5714 6 no
GO:0010468 regulation of gene expression 28.5714 6 no
GO:0010556 regulation of macromolecule biosynthetic process 28.5714 5 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0034329 cell junction assembly 28.5714 5 no
GO:0034330 cell junction organization 28.5714 4 no
GO:0050806 positive regulation of synaptic transmission 28.5714 5 no
GO:0050808 synapse organization 28.5714 5 no
GO:0010975 regulation of neuron projection development 28.5714 7 no
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 no
GO:0009891 positive regulation of biosynthetic process 28.5714 5 yes
GO:0010648 negative regulation of cell communication 28.5714 5 yes
GO:0023057 negative regulation of signaling 28.5714 4 yes
GO:0050805 negative regulation of synaptic transmission 28.5714 5 yes
GO:0051241 negative regulation of multicellular organismal process 28.5714 4 yes
GO:0060292 long-term synaptic depression 28.5714 4 yes
GO:0006873 intracellular monoatomic ion homeostasis 28.5714 4 no
GO:0006874 intracellular calcium ion homeostasis 28.5714 5 no
GO:0009967 positive regulation of signal transduction 28.5714 5 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0030003 intracellular monoatomic cation homeostasis 28.5714 5 no
GO:0031324 negative regulation of cellular metabolic process 28.5714 5 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0051049 regulation of transport 28.5714 4 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0055074 calcium ion homeostasis 28.5714 4 no
GO:0055080 monoatomic cation homeostasis 28.5714 4 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0070201 regulation of establishment of protein localization 28.5714 6 no
GO:0090313 regulation of protein targeting to membrane 28.5714 7 no
GO:0090314 positive regulation of protein targeting to membrane 28.5714 7 no
GO:1903533 regulation of protein targeting 28.5714 7 no
GO:1903829 positive regulation of protein localization 28.5714 5 no
GO:1904951 positive regulation of establishment of protein localization 28.5714 6 no
GO:1905475 regulation of protein localization to membrane 28.5714 6 no
GO:1905477 positive regulation of protein localization to membrane 28.5714 6 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
UFL1_HUMAN [view interactions] High throughput no yes
C5AR2_HUMAN [view interactions] High throughput no yes
FSHR_HUMAN [view interactions] High throughput no no
NCS1_HUMAN [view entry] [view interactions] High throughput yes yes
KCRS_HUMAN [view interactions] High throughput no no
PCGF2_HUMAN [view interactions] High throughput no no
RTP2_HUMAN [view interactions] High throughput no no
FIS1_HUMAN [view entry] [view interactions] High throughput yes yes
TV23B_HUMAN [view interactions] High throughput no no
SCAM4_HUMAN [view interactions] High throughput no yes
PCDA3_HUMAN [view interactions] High throughput no no
RNF4_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
DX39A_HUMAN [view interactions] High throughput no yes
O10H2_HUMAN [view interactions] High throughput no no
HPCA_HUMAN [view entry] [view interactions] High throughput yes yes
MARH4_HUMAN [view interactions] High throughput no yes
TTMP_HUMAN [view interactions] High throughput no no
O10H1_HUMAN [view interactions] High throughput no no
TTYH1_HUMAN [view entry] [view interactions] High throughput yes no
RXFP1_HUMAN [view interactions] High throughput no yes
PCDGL_HUMAN [view interactions] High throughput no no
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
STING_HUMAN [view interactions] High throughput no yes
GRIA1_HUMAN [view entry] [view interactions] High throughput yes yes