NCS1_HUMAN
Evidence for PS localization
Functions
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin . Stimulates PI4KB kinase activity . Involved in long-term synaptic plasticity through its interaction with PICK1 . May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NCS1_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 34.7826 | 4 | yes |
| GO:0005216 | ion channel activity | 21.7391 | 4 | yes |
| GO:0005261 | cation channel activity | 21.7391 | 5 | yes |
| GO:0008324 | cation transmembrane transporter activity | 21.7391 | 4 | yes |
| GO:0015267 | channel activity | 21.7391 | 4 | yes |
| GO:0022836 | gated channel activity | 21.7391 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 21.7391 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 21.7391 | 5 | yes |
| GO:0003723 | RNA binding | 21.7391 | 4 | no |
| GO:0019900 | kinase binding | 21.7391 | 4 | no |
| GO:0019901 | protein kinase binding | 21.7391 | 5 | no |
| GO:0005244 | voltage-gated ion channel activity | 17.3913 | 4 | yes |
| GO:0022832 | voltage-gated channel activity | 17.3913 | 6 | yes |
| GO:0022843 | voltage-gated cation channel activity | 17.3913 | 5 | yes |
| GO:0005262 | calcium channel activity | 13.0435 | 6 | yes |
| GO:0005509 | calcium ion binding | 13.0435 | 5 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 13.0435 | 6 | yes |
| GO:0005245 | voltage-gated calcium channel activity | 8.6957 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NCS1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 60.8696 | 4 | no |
| GO:0010646 | regulation of cell communication | 56.5217 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 52.1739 | 4 | yes |
| GO:0051049 | regulation of transport | 47.8261 | 4 | no |
| GO:0008104 | protein localization | 43.4783 | 4 | no |
| GO:0009966 | regulation of signal transduction | 43.4783 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.4783 | 4 | no |
| GO:0071702 | organic substance transport | 43.4783 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.4783 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 43.4783 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 39.1304 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.1304 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 39.1304 | 5 | no |
| GO:0023057 | negative regulation of signaling | 39.1304 | 4 | no |
| GO:0006886 | intracellular protein transport | 34.7826 | 4 | no |
| GO:0015031 | protein transport | 34.7826 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 34.7826 | 5 | no |
| GO:0071705 | nitrogen compound transport | 34.7826 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 34.7826 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 30.4348 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 30.4348 | 4 | no |
| GO:0022607 | cellular component assembly | 30.4348 | 4 | no |
| GO:0051050 | positive regulation of transport | 26.0870 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.0870 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.0870 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.0870 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 26.0870 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.0870 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 26.0870 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 26.0870 | 5 | no |
| GO:0010468 | regulation of gene expression | 26.0870 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 26.0870 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 26.0870 | 5 | no |
| GO:0043269 | regulation of ion transport | 26.0870 | 5 | no |
| GO:0048878 | chemical homeostasis | 21.7391 | 4 | no |
| GO:0050801 | ion homeostasis | 21.7391 | 5 | no |
| GO:0051223 | regulation of protein transport | 21.7391 | 5 | no |
| GO:0051726 | regulation of cell cycle | 21.7391 | 4 | no |
| GO:0055065 | metal ion homeostasis | 21.7391 | 7 | no |
| GO:0055080 | cation homeostasis | 21.7391 | 6 | no |
| GO:0060341 | regulation of cellular localization | 21.7391 | 4 | no |
| GO:0070201 | regulation of establishment of protein localization | 21.7391 | 6 | no |
| GO:0098771 | inorganic ion homeostasis | 21.7391 | 6 | no |
| GO:1904062 | regulation of cation transmembrane transport | 21.7391 | 6 | no |
| GO:0016192 | vesicle-mediated transport | 21.7391 | 4 | no |
| GO:0050805 | negative regulation of synaptic transmission | 21.7391 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 21.7391 | 4 | no |
| GO:0006811 | ion transport | 21.7391 | 4 | no |
| GO:0051046 | regulation of secretion | 21.7391 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 21.7391 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.7391 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.7391 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 21.7391 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.7391 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.7391 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.7391 | 5 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 21.7391 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.7391 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 21.7391 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.7391 | 4 | no |
| GO:0006873 | cellular ion homeostasis | 21.7391 | 4 | no |
| GO:0006875 | cellular metal ion homeostasis | 21.7391 | 6 | no |
| GO:0010959 | regulation of metal ion transport | 21.7391 | 6 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 21.7391 | 4 | no |
| GO:0030003 | cellular cation homeostasis | 21.7391 | 5 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 21.7391 | 5 | no |
| GO:0032880 | regulation of protein localization | 21.7391 | 5 | no |
| GO:0036211 | protein modification process | 21.7391 | 4 | no |
| GO:0043412 | macromolecule modification | 21.7391 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 17.3913 | 7 | yes |
| GO:0031344 | regulation of cell projection organization | 17.3913 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 17.3913 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in NCS1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 8.6957 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ITPR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CNR1_HUMAN | [view interactions] | Low throughput | no | yes |
| CABP8_HUMAN | [view interactions] | Low throughput | no | yes |
| IRPL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DRD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PI4KB_HUMAN | [view interactions] | Low throughput | no | yes |
| DRD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCND2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMT1_HUMAN | [view interactions] | Low throughput | no | yes |
| NCS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRK1_HUMAN | [view interactions] | Low throughput | no | no |
| UBP24_HUMAN | [view interactions] | High throughput | no | yes |
| ABHD6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BSPRY_HUMAN | [view interactions] | High throughput | no | no |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT3_HUMAN | [view interactions] | High throughput | no | yes |
| NMT2_HUMAN | [view interactions] | High throughput | no | yes |
| DHB3_HUMAN | [view interactions] | High throughput | no | no |
| FCG3A_HUMAN | [view interactions] | High throughput | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M3K9_HUMAN | [view interactions] | High throughput | no | yes |
| M3K21_HUMAN | [view interactions] | High throughput | no | yes |
| NBL1_HUMAN | [view interactions] | High throughput | no | no |
| PRDM4_HUMAN | [view interactions] | High throughput | no | no |
| CTG1B_HUMAN | [view interactions] | High throughput | no | no |
| SIGL9_HUMAN | [view interactions] | High throughput | no | yes |
| SPRE2_HUMAN | [view interactions] | High throughput | no | yes |
| ZC3HA_HUMAN | [view interactions] | High throughput | no | yes |
| FZD7_HUMAN | [view interactions] | High throughput | no | yes |
| OXER1_HUMAN | [view interactions] | High throughput | no | yes |
| SFPA2_HUMAN | [view interactions] | High throughput | no | no |
| LY66D_HUMAN | [view interactions] | High throughput | no | no |
| C1QT2_HUMAN | [view interactions] | High throughput | no | yes |
| OSTP_HUMAN | [view interactions] | High throughput | no | yes |
| RNH1_HUMAN | [view interactions] | High throughput | no | yes |
| CEP89_HUMAN | [view interactions] | High throughput | no | no |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| HOIL1_HUMAN | [view interactions] | High throughput | no | no |
| SHRPN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TANK_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| CREM_HUMAN | [view interactions] | High throughput | no | no |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| MID49_HUMAN | [view interactions] | High throughput | no | yes |
| CDSN_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| FSD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| RN19B_HUMAN | [view interactions] | High throughput | no | yes |
| HSFX1_HUMAN | [view interactions] | High throughput | no | no |
| DB116_HUMAN | [view interactions] | High throughput | no | no |
| CA115_HUMAN | [view interactions] | High throughput | no | no |
| INT4_HUMAN | [view interactions] | High throughput | no | yes |
| L37A2_HUMAN | [view interactions] | High throughput | no | no |
| CD69_HUMAN | [view interactions] | High throughput | no | no |
| FXL22_HUMAN | [view interactions] | High throughput | no | no |
| NPIB6_HUMAN | [view interactions] | High throughput | no | yes |
| SSX3_HUMAN | [view interactions] | High throughput | no | no |
| GSX1_HUMAN | [view interactions] | High throughput | no | no |
| MGLL_HUMAN | [view interactions] | High throughput | no | yes |
| HMOX1_HUMAN | [view interactions] | High throughput | no | no |
| RPC9_HUMAN | [view interactions] | High throughput | no | yes |
| CC014_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDM3B_HUMAN | [view interactions] | High throughput | no | yes |
| KI21A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAF1_HUMAN | [view interactions] | High throughput | no | yes |
| RSMB_HUMAN | [view interactions] | High throughput | no | yes |
| SRP68_HUMAN | [view interactions] | High throughput | no | yes |
| DTX2_HUMAN | [view interactions] | High throughput | no | yes |
| ICAM1_HUMAN | [view interactions] | High throughput | no | no |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| RIC8A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KCNC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARBK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PICK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |