Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DRD3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DRD3_HUMAN
GO:0003723 RNA binding 23.8095 4 no
GO:0043169 cation binding 23.8095 4 no
GO:0001664 G protein-coupled receptor binding 23.8095 4 no
GO:0045296 cadherin binding 23.8095 4 no
GO:0004930 G protein-coupled receptor activity 14.2857 4 yes
GO:0004952 dopamine neurotransmitter receptor activity 9.5238 5 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 9.5238 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DRD3_HUMAN
GO:0048522 positive regulation of cellular process 61.9048 4 yes
GO:0010646 regulation of cell communication 57.1429 4 yes
GO:0048523 negative regulation of cellular process 52.3810 4 yes
GO:0009966 regulation of signal transduction 52.3810 4 yes
GO:0051049 regulation of transport 47.6190 4 yes
GO:0051128 regulation of cellular component organization 47.6190 4 yes
GO:0060255 regulation of macromolecule metabolic process 47.6190 4 yes
GO:0008104 protein localization 47.6190 4 no
GO:0031323 regulation of cellular metabolic process 47.6190 4 yes
GO:0080090 regulation of primary metabolic process 42.8571 4 no
GO:0009889 regulation of biosynthetic process 42.8571 4 yes
GO:0010468 regulation of gene expression 38.0952 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 38.0952 5 yes
GO:0031326 regulation of cellular biosynthetic process 38.0952 5 yes
GO:0048584 positive regulation of response to stimulus 33.3333 4 yes
GO:0048585 negative regulation of response to stimulus 33.3333 4 yes
GO:0051050 positive regulation of transport 33.3333 4 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0010647 positive regulation of cell communication 33.3333 5 yes
GO:0023056 positive regulation of signaling 33.3333 4 yes
GO:0060341 regulation of cellular localization 28.5714 4 yes
GO:0071702 organic substance transport 28.5714 4 yes
GO:1902531 regulation of intracellular signal transduction 28.5714 5 yes
GO:0022607 cellular component assembly 28.5714 4 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0006996 organelle organization 28.5714 4 no
GO:0007010 cytoskeleton organization 28.5714 5 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 28.5714 4 yes
GO:0009967 positive regulation of signal transduction 28.5714 5 yes
GO:0010648 negative regulation of cell communication 28.5714 5 yes
GO:0014070 response to organic cyclic compound 28.5714 4 yes
GO:0023057 negative regulation of signaling 28.5714 4 yes
GO:0032880 regulation of protein localization 28.5714 5 yes
GO:0033043 regulation of organelle organization 28.5714 5 yes
GO:0050804 modulation of chemical synaptic transmission 23.8095 5 yes
GO:0051130 positive regulation of cellular component organization 23.8095 5 yes
GO:0051223 regulation of protein transport 23.8095 5 yes
GO:0051726 regulation of cell cycle 23.8095 4 yes
GO:0070201 regulation of establishment of protein localization 23.8095 6 yes
GO:0099177 regulation of trans-synaptic signaling 23.8095 4 yes
GO:0009893 positive regulation of metabolic process 23.8095 4 no
GO:0009894 regulation of catabolic process 23.8095 4 no
GO:0031344 regulation of cell projection organization 23.8095 5 no
GO:0042176 regulation of protein catabolic process 23.8095 5 no
GO:0071310 cellular response to organic substance 23.8095 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.8095 6 no
GO:1903829 positive regulation of protein localization 23.8095 5 no
GO:0071705 nitrogen compound transport 23.8095 4 no
GO:0034330 cell junction organization 23.8095 4 no
GO:0044087 regulation of cellular component biogenesis 23.8095 4 no
GO:0009968 negative regulation of signal transduction 23.8095 5 yes
GO:0010243 response to organonitrogen compound 23.8095 4 yes
GO:0010564 regulation of cell cycle process 23.8095 5 yes
GO:0010959 regulation of metal ion transport 23.8095 6 yes
GO:0043269 regulation of monoatomic ion transport 23.8095 5 yes
GO:0045787 positive regulation of cell cycle 19.0476 5 yes
GO:0051046 regulation of secretion 19.0476 5 yes
GO:0051588 regulation of neurotransmitter transport 19.0476 5 yes
GO:0051952 regulation of amine transport 19.0476 5 yes
GO:0090068 positive regulation of cell cycle process 19.0476 6 yes
GO:0098657 import into cell 19.0476 4 yes
GO:1903530 regulation of secretion by cell 19.0476 4 yes
GO:0009416 response to light stimulus 19.0476 4 yes
GO:0010638 positive regulation of organelle organization 19.0476 6 yes
GO:0032101 regulation of response to external stimulus 19.0476 4 yes
GO:0050433 regulation of catecholamine secretion 14.2857 5 yes
GO:0050708 regulation of protein secretion 14.2857 5 yes
GO:0051051 negative regulation of transport 14.2857 4 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 14.2857 6 yes
GO:0060134 prepulse inhibition 14.2857 6 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 14.2857 5 yes
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 14.2857 5 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 14.2857 4 yes
GO:0007346 regulation of mitotic cell cycle 14.2857 5 yes
GO:0032102 negative regulation of response to external stimulus 14.2857 5 yes
GO:0043266 regulation of potassium ion transport 14.2857 7 yes
GO:0043279 response to alkaloid 14.2857 5 yes
GO:0045595 regulation of cell differentiation 14.2857 4 yes
GO:0046903 secretion 9.5238 4 yes
GO:0046942 carboxylic acid transport 9.5238 6 yes
GO:0048148 behavioral response to cocaine 9.5238 4 yes
GO:0050805 negative regulation of synaptic transmission 9.5238 5 yes
GO:0050890 cognition 9.5238 4 yes
GO:0051241 negative regulation of multicellular organismal process 9.5238 4 yes
GO:0051302 regulation of cell division 9.5238 4 yes
GO:0051580 regulation of neurotransmitter uptake 9.5238 6 yes
GO:0051584 regulation of dopamine uptake involved in synaptic transmission 9.5238 7 yes
GO:0051781 positive regulation of cell division 9.5238 5 yes
GO:0051940 regulation of catecholamine uptake involved in synaptic transmission 9.5238 6 yes
GO:0055074 calcium ion homeostasis 9.5238 4 yes
GO:0055080 monoatomic cation homeostasis 9.5238 4 yes
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway 9.5238 4 yes
GO:0060159 regulation of dopamine receptor signaling pathway 9.5238 5 yes
GO:0071875 adrenergic receptor signaling pathway 9.5238 4 yes
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 9.5238 5 yes
GO:1902532 negative regulation of intracellular signal transduction 9.5238 6 yes
GO:2000026 regulation of multicellular organismal development 9.5238 4 yes
GO:0006576 biogenic amine metabolic process 9.5238 5 yes
GO:0006584 catecholamine metabolic process 9.5238 6 yes
GO:0006873 intracellular monoatomic ion homeostasis 9.5238 4 yes
GO:0006874 intracellular calcium ion homeostasis 9.5238 5 yes
GO:0006898 receptor-mediated endocytosis 9.5238 4 yes
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway 9.5238 4 yes
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway 9.5238 4 yes
GO:0007612 learning 9.5238 4 yes
GO:0008306 associative learning 9.5238 5 yes
GO:0008542 visual learning 9.5238 4 yes
GO:0009308 amine metabolic process 9.5238 4 yes
GO:0009712 catechol-containing compound metabolic process 9.5238 5 yes
GO:0014059 regulation of dopamine secretion 9.5238 6 yes
GO:0015711 organic anion transport 9.5238 5 yes
GO:0015849 organic acid transport 9.5238 5 yes
GO:0018958 phenol-containing compound metabolic process 9.5238 4 yes
GO:0030003 intracellular monoatomic cation homeostasis 9.5238 5 yes
GO:0031623 receptor internalization 9.5238 5 yes
GO:0032465 regulation of cytokinesis 9.5238 5 yes
GO:0032467 positive regulation of cytokinesis 9.5238 6 yes
GO:0042220 response to cocaine 9.5238 4 yes
GO:0042417 dopamine metabolic process 9.5238 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
COPB_HUMAN [view interactions] Low throughput no yes
COPD_HUMAN [view entry] [view interactions] Low throughput yes yes
COPG1_HUMAN [view interactions] Low throughput no yes
GP143_HUMAN [view interactions] Low throughput no yes
AA2AR_HUMAN [view entry] [view interactions] Low throughput yes yes
FLNA_HUMAN [view entry] [view interactions] Low throughput yes no
CLIC6_HUMAN [view interactions] Low throughput no no
MPDZ_HUMAN [view entry] [view interactions] Low throughput yes yes
GIPC1_HUMAN [view entry] [view interactions] Low throughput yes yes
RADI_HUMAN [view entry] [view interactions] Low throughput yes yes
E41L1_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP48_HUMAN [view interactions] Low throughput no yes
PDC6I_HUMAN [view entry] [view interactions] Low throughput yes yes
NCS1_HUMAN [view entry] [view interactions] Low throughput yes yes
PALM_HUMAN [view entry] [view interactions] Low throughput yes yes
SL9A3_HUMAN [view interactions] Low throughput no yes
KPCB_HUMAN [view entry] [view interactions] Low throughput yes yes
DRD1_HUMAN [view entry] [view interactions] Low throughput yes no
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
MDM2_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP33_HUMAN [view interactions] Low throughput no yes
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
RGS9_HUMAN [view entry] [view interactions] Low throughput yes no
SH3G1_HUMAN [view entry] [view interactions] High throughput yes no
SH3G3_HUMAN [view entry] [view interactions] High throughput yes no
SH3G2_HUMAN [view entry] [view interactions] High throughput yes yes
H15_HUMAN [view interactions] High throughput no no
DUS14_HUMAN [view interactions] High throughput no yes
PTSS2_HUMAN [view interactions] High throughput no yes
MRS2_HUMAN [view interactions] High throughput no no
LRC15_HUMAN [view interactions] High throughput no no
DSG4_HUMAN [view interactions] High throughput no no
SBP1_HUMAN [view interactions] High throughput no no
BRI3B_HUMAN [view interactions] High throughput no yes
TM9S4_HUMAN [view interactions] High throughput no yes
VSIG8_HUMAN [view interactions] High throughput no no
SNH28_HUMAN [view interactions] High throughput no no
KC1D_HUMAN [view entry] [view interactions] High throughput yes yes