DRD3_HUMAN
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in DRD3_HUMAN |
---|---|---|---|---|
GO:0001664 | G protein-coupled receptor binding | 27.2727 | 4 | yes |
GO:0046872 | metal ion binding | 22.7273 | 4 | no |
GO:0045296 | cadherin binding | 22.7273 | 4 | no |
GO:0004930 | G protein-coupled receptor activity | 18.1818 | 4 | yes |
GO:0004952 | dopamine neurotransmitter receptor activity | 13.6364 | 5 | yes |
GO:0098960 | postsynaptic neurotransmitter receptor activity | 13.6364 | 4 | yes |
GO:0001591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go | 9.0909 | 6 | yes |
GO:0050780 | dopamine receptor binding | 9.0909 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in DRD3_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 59.0909 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 54.5455 | 4 | yes |
GO:0010646 | regulation of cell communication | 54.5455 | 4 | yes |
GO:0009966 | regulation of signal transduction | 50.0000 | 4 | yes |
GO:0051049 | regulation of transport | 45.4545 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 45.4545 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 45.4545 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 45.4545 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 45.4545 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 45.4545 | 4 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 40.9091 | 4 | yes |
GO:0008104 | protein localization | 40.9091 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 36.3636 | 5 | no |
GO:0010468 | regulation of gene expression | 36.3636 | 5 | yes |
GO:0010647 | positive regulation of cell communication | 36.3636 | 5 | yes |
GO:0023056 | positive regulation of signaling | 36.3636 | 4 | yes |
GO:0048584 | positive regulation of response to stimulus | 31.8182 | 4 | yes |
GO:0051046 | regulation of secretion | 31.8182 | 5 | yes |
GO:0051050 | positive regulation of transport | 31.8182 | 4 | yes |
GO:0071702 | organic substance transport | 31.8182 | 4 | yes |
GO:1903530 | regulation of secretion by cell | 31.8182 | 4 | yes |
GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 31.8182 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 31.8182 | 4 | yes |
GO:0009967 | positive regulation of signal transduction | 31.8182 | 5 | yes |
GO:0048585 | negative regulation of response to stimulus | 27.2727 | 4 | yes |
GO:0051588 | regulation of neurotransmitter transport | 27.2727 | 5 | yes |
GO:1902531 | regulation of intracellular signal transduction | 27.2727 | 5 | yes |
GO:0006996 | organelle organization | 27.2727 | 4 | no |
GO:0007010 | cytoskeleton organization | 27.2727 | 5 | no |
GO:0071310 | cellular response to organic substance | 27.2727 | 4 | no |
GO:0033043 | regulation of organelle organization | 27.2727 | 5 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 22.7273 | 5 | yes |
GO:0051130 | positive regulation of cellular component organization | 22.7273 | 5 | yes |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.7273 | 5 | yes |
GO:0060341 | regulation of cellular localization | 22.7273 | 4 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 22.7273 | 4 | yes |
GO:0015031 | protein transport | 22.7273 | 4 | no |
GO:0017157 | regulation of exocytosis | 22.7273 | 5 | no |
GO:0022607 | cellular component assembly | 22.7273 | 4 | no |
GO:0034330 | cell junction organization | 22.7273 | 4 | no |
GO:0043933 | protein-containing complex organization | 22.7273 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 22.7273 | 4 | no |
GO:0071705 | nitrogen compound transport | 22.7273 | 4 | no |
GO:0006811 | ion transport | 22.7273 | 4 | yes |
GO:0001932 | regulation of protein phosphorylation | 22.7273 | 7 | no |
GO:0019220 | regulation of phosphate metabolic process | 22.7273 | 6 | no |
GO:0031399 | regulation of protein modification process | 22.7273 | 6 | no |
GO:0042325 | regulation of phosphorylation | 22.7273 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 22.7273 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 22.7273 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 22.7273 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 22.7273 | 5 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 22.7273 | 5 | yes |
GO:0010648 | negative regulation of cell communication | 22.7273 | 5 | yes |
GO:0010959 | regulation of metal ion transport | 22.7273 | 6 | yes |
GO:0016192 | vesicle-mediated transport | 22.7273 | 4 | yes |
GO:0023057 | negative regulation of signaling | 22.7273 | 4 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 22.7273 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 22.7273 | 5 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 22.7273 | 5 | yes |
GO:0032880 | regulation of protein localization | 22.7273 | 5 | yes |
GO:0034762 | regulation of transmembrane transport | 22.7273 | 4 | yes |
GO:0043269 | regulation of ion transport | 22.7273 | 5 | yes |
GO:0044106 | cellular amine metabolic process | 18.1818 | 4 | yes |
GO:0045595 | regulation of cell differentiation | 18.1818 | 4 | yes |
GO:0051051 | negative regulation of transport | 18.1818 | 4 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 18.1818 | 5 | yes |
GO:0051223 | regulation of protein transport | 18.1818 | 5 | yes |
GO:0051252 | regulation of RNA metabolic process | 18.1818 | 5 | yes |
GO:0051726 | regulation of cell cycle | 18.1818 | 4 | yes |
GO:0051924 | regulation of calcium ion transport | 18.1818 | 7 | yes |
GO:0051952 | regulation of amine transport | 18.1818 | 5 | yes |
GO:0070201 | regulation of establishment of protein localization | 18.1818 | 6 | yes |
GO:1903506 | regulation of nucleic acid-templated transcription | 18.1818 | 7 | yes |
GO:1904062 | regulation of cation transmembrane transport | 18.1818 | 6 | yes |
GO:2001141 | regulation of RNA biosynthetic process | 18.1818 | 6 | yes |
GO:0006355 | regulation of DNA-templated transcription | 18.1818 | 6 | yes |
GO:0006576 | cellular biogenic amine metabolic process | 18.1818 | 5 | yes |
GO:0006584 | catecholamine metabolic process | 18.1818 | 6 | yes |
GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 18.1818 | 5 | yes |
GO:0009308 | amine metabolic process | 18.1818 | 4 | yes |
GO:0009712 | catechol-containing compound metabolic process | 18.1818 | 5 | yes |
GO:0009968 | negative regulation of signal transduction | 18.1818 | 5 | yes |
GO:0010243 | response to organonitrogen compound | 18.1818 | 4 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 18.1818 | 5 | yes |
GO:0010564 | regulation of cell cycle process | 18.1818 | 5 | yes |
GO:0014070 | response to organic cyclic compound | 18.1818 | 4 | yes |
GO:0018958 | phenol-containing compound metabolic process | 18.1818 | 4 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 18.1818 | 5 | yes |
GO:0032101 | regulation of response to external stimulus | 18.1818 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 18.1818 | 5 | yes |
GO:0042417 | dopamine metabolic process | 18.1818 | 7 | yes |
GO:0043086 | negative regulation of catalytic activity | 18.1818 | 4 | yes |
GO:0045761 | regulation of adenylate cyclase activity | 13.6364 | 5 | yes |
GO:0045787 | positive regulation of cell cycle | 13.6364 | 5 | yes |
GO:0046903 | secretion | 13.6364 | 4 | yes |
GO:0046942 | carboxylic acid transport | 13.6364 | 6 | yes |
GO:0048148 | behavioral response to cocaine | 13.6364 | 4 | yes |
GO:0048259 | regulation of receptor-mediated endocytosis | 13.6364 | 6 | yes |
GO:0048878 | chemical homeostasis | 13.6364 | 4 | yes |
GO:0050708 | regulation of protein secretion | 13.6364 | 5 | yes |
GO:0050801 | ion homeostasis | 13.6364 | 5 | yes |
GO:0051047 | positive regulation of secretion | 13.6364 | 5 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 13.6364 | 4 | yes |
GO:0051339 | regulation of lyase activity | 13.6364 | 4 | yes |
GO:0051580 | regulation of neurotransmitter uptake | 13.6364 | 4 | yes |
GO:0051584 | regulation of dopamine uptake involved in synaptic transmission | 13.6364 | 6 | yes |
GO:0051940 | regulation of catecholamine uptake involved in synaptic transmission | 13.6364 | 5 | yes |
GO:0051966 | regulation of synaptic transmission, glutamatergic | 13.6364 | 6 | yes |
GO:0055065 | metal ion homeostasis | 13.6364 | 7 | yes |
GO:0055074 | calcium ion homeostasis | 13.6364 | 8 | yes |
GO:0055080 | cation homeostasis | 13.6364 | 6 | yes |
GO:0060134 | prepulse inhibition | 13.6364 | 6 | yes |
GO:0060548 | negative regulation of cell death | 13.6364 | 5 | yes |
GO:0072503 | cellular divalent inorganic cation homeostasis | 13.6364 | 6 | yes |
GO:0072507 | divalent inorganic cation homeostasis | 13.6364 | 7 | yes |
GO:0090068 | positive regulation of cell cycle process | 13.6364 | 6 | yes |
GO:0098771 | inorganic ion homeostasis | 13.6364 | 6 | yes |
GO:1903169 | regulation of calcium ion transmembrane transport | 13.6364 | 7 | yes |
GO:0006820 | anion transport | 13.6364 | 5 | yes |
GO:0006873 | cellular ion homeostasis | 13.6364 | 4 | yes |
GO:0006874 | cellular calcium ion homeostasis | 13.6364 | 7 | yes |
GO:0006875 | cellular metal ion homeostasis | 13.6364 | 6 | yes |
GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | 13.6364 | 5 | yes |
GO:0007195 | adenylate cyclase-inhibiting dopamine receptor signaling pathway | 13.6364 | 4 | yes |
GO:0009416 | response to light stimulus | 13.6364 | 4 | yes |
GO:0010638 | positive regulation of organelle organization | 13.6364 | 6 | yes |
GO:0010941 | regulation of cell death | 13.6364 | 4 | yes |
GO:0015711 | organic anion transport | 13.6364 | 5 | yes |
GO:0015849 | organic acid transport | 13.6364 | 5 | yes |
GO:0030003 | cellular cation homeostasis | 13.6364 | 5 | yes |
GO:0030100 | regulation of endocytosis | 13.6364 | 5 | yes |
GO:0031279 | regulation of cyclase activity | 13.6364 | 4 | yes |
GO:0032102 | negative regulation of response to external stimulus | 13.6364 | 5 | yes |
GO:0034763 | negative regulation of transmembrane transport | 13.6364 | 5 | yes |
GO:0042981 | regulation of apoptotic process | 13.6364 | 6 | yes |
GO:0043066 | negative regulation of apoptotic process | 13.6364 | 7 | yes |
GO:0043067 | regulation of programmed cell death | 13.6364 | 5 | yes |
GO:0043069 | negative regulation of programmed cell death | 13.6364 | 6 | yes |
GO:0043266 | regulation of potassium ion transport | 13.6364 | 7 | yes |
GO:0043271 | negative regulation of ion transport | 9.0909 | 5 | yes |
GO:0043279 | response to alkaloid | 9.0909 | 5 | yes |
GO:0044057 | regulation of system process | 9.0909 | 4 | yes |
GO:0044062 | regulation of excretion | 9.0909 | 5 | yes |
GO:0045187 | regulation of circadian sleep/wake cycle, sleep | 9.0909 | 5 | yes |
GO:0045892 | negative regulation of DNA-templated transcription | 9.0909 | 7 | yes |
GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 9.0909 | 6 | yes |
GO:0050433 | regulation of catecholamine secretion | 9.0909 | 5 | yes |
GO:0050482 | arachidonic acid secretion | 9.0909 | 6 | yes |
GO:0050709 | negative regulation of protein secretion | 9.0909 | 6 | yes |
GO:0050795 | regulation of behavior | 9.0909 | 4 | yes |
GO:0050805 | negative regulation of synaptic transmission | 9.0909 | 5 | yes |
GO:0050890 | cognition | 9.0909 | 4 | yes |
GO:0051048 | negative regulation of secretion | 9.0909 | 5 | yes |
GO:0051224 | negative regulation of protein transport | 9.0909 | 5 | yes |
GO:0051253 | negative regulation of RNA metabolic process | 9.0909 | 6 | yes |
GO:0051302 | regulation of cell division | 9.0909 | 4 | yes |
GO:0051350 | negative regulation of lyase activity | 9.0909 | 5 | yes |
GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway | 9.0909 | 4 | yes |
GO:0051781 | positive regulation of cell division | 9.0909 | 5 | yes |
GO:0051926 | negative regulation of calcium ion transport | 9.0909 | 6 | yes |
GO:0060158 | phospholipase C-activating dopamine receptor signaling pathway | 9.0909 | 4 | yes |
GO:0060159 | regulation of dopamine receptor signaling pathway | 9.0909 | 5 | yes |
GO:0060284 | regulation of cell development | 9.0909 | 5 | yes |
GO:0071715 | icosanoid transport | 9.0909 | 7 | yes |
GO:0071875 | adrenergic receptor signaling pathway | 9.0909 | 4 | yes |
GO:0071880 | adenylate cyclase-activating adrenergic receptor signaling pathway | 9.0909 | 5 | yes |
GO:0098801 | regulation of renal system process | 9.0909 | 5 | yes |
GO:1901019 | regulation of calcium ion transmembrane transporter activity | 9.0909 | 6 | yes |
GO:1901020 | negative regulation of calcium ion transmembrane transporter activity | 9.0909 | 6 | yes |
GO:1901385 | regulation of voltage-gated calcium channel activity | 9.0909 | 7 | yes |
GO:1901386 | negative regulation of voltage-gated calcium channel activity | 9.0909 | 7 | yes |
GO:1902305 | regulation of sodium ion transmembrane transport | 9.0909 | 7 | yes |
GO:1902679 | negative regulation of RNA biosynthetic process | 9.0909 | 7 | yes |
GO:1903170 | negative regulation of calcium ion transmembrane transport | 9.0909 | 7 | yes |
GO:1903507 | negative regulation of nucleic acid-templated transcription | 9.0909 | 8 | yes |
GO:1903531 | negative regulation of secretion by cell | 9.0909 | 5 | yes |
GO:1903828 | negative regulation of protein localization | 9.0909 | 5 | yes |
GO:1903963 | arachidonate transport | 9.0909 | 8 | yes |
GO:1904063 | negative regulation of cation transmembrane transport | 9.0909 | 7 | yes |
GO:1904950 | negative regulation of establishment of protein localization | 9.0909 | 6 | yes |
GO:2000026 | regulation of multicellular organismal development | 9.0909 | 4 | yes |
GO:2000649 | regulation of sodium ion transmembrane transporter activity | 9.0909 | 6 | yes |
GO:2001257 | regulation of cation channel activity | 9.0909 | 6 | yes |
GO:2001258 | negative regulation of cation channel activity | 9.0909 | 6 | yes |
GO:0002028 | regulation of sodium ion transport | 9.0909 | 7 | yes |
GO:0002090 | regulation of receptor internalization | 9.0909 | 7 | yes |
GO:0006357 | regulation of transcription by RNA polymerase II | 9.0909 | 7 | yes |
GO:0006869 | lipid transport | 9.0909 | 5 | yes |
GO:0006897 | endocytosis | 9.0909 | 5 | yes |
GO:0006898 | receptor-mediated endocytosis | 9.0909 | 6 | yes |
GO:0007191 | adenylate cyclase-activating dopamine receptor signaling pathway | 9.0909 | 4 | yes |
GO:0007194 | negative regulation of adenylate cyclase activity | 9.0909 | 6 | yes |
GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | 9.0909 | 4 | yes |
GO:0007346 | regulation of mitotic cell cycle | 9.0909 | 5 | yes |
GO:0007612 | learning | 9.0909 | 4 | yes |
GO:0008306 | associative learning | 9.0909 | 5 | yes |
GO:0008542 | visual learning | 9.0909 | 4 | yes |
GO:0009890 | negative regulation of biosynthetic process | 9.0909 | 5 | yes |
GO:0009891 | positive regulation of biosynthetic process | 9.0909 | 5 | yes |
GO:0010155 | regulation of proton transport | 9.0909 | 7 | yes |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 9.0909 | 6 | yes |
GO:0015718 | monocarboxylic acid transport | 9.0909 | 7 | yes |
GO:0015908 | fatty acid transport | 9.0909 | 6 | yes |
GO:0015909 | long-chain fatty acid transport | 9.0909 | 7 | yes |
GO:0022898 | regulation of transmembrane transporter activity | 9.0909 | 4 | yes |
GO:0031280 | negative regulation of cyclase activity | 9.0909 | 5 | yes |
GO:0031327 | negative regulation of cellular biosynthetic process | 9.0909 | 6 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 9.0909 | 6 | yes |
GO:0031623 | receptor internalization | 9.0909 | 7 | yes |
GO:0032309 | icosanoid secretion | 9.0909 | 5 | yes |
GO:0032410 | negative regulation of transporter activity | 9.0909 | 4 | yes |
GO:0032412 | regulation of ion transmembrane transporter activity | 9.0909 | 5 | yes |
GO:0032413 | negative regulation of ion transmembrane transporter activity | 9.0909 | 5 | yes |
GO:0032415 | regulation of sodium:proton antiporter activity | 9.0909 | 7 | yes |
GO:0032465 | regulation of cytokinesis | 9.0909 | 5 | yes |
GO:0032467 | positive regulation of cytokinesis | 9.0909 | 6 | yes |
GO:0034766 | negative regulation of ion transmembrane transport | 9.0909 | 6 | yes |
GO:0034776 | response to histamine | 9.0909 | 5 | yes |
GO:0035813 | regulation of renal sodium excretion | 9.0909 | 6 | yes |
GO:0035815 | positive regulation of renal sodium excretion | 9.0909 | 5 | yes |
GO:0042127 | regulation of cell population proliferation | 9.0909 | 4 | yes |
GO:0042749 | regulation of circadian sleep/wake cycle | 9.0909 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
FLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CLIC6_HUMAN | [view interactions] | Low throughput | no | no |
MPDZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GIPC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RADI_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
E41L1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
UBP48_HUMAN | [view interactions] | Low throughput | no | yes |
PDC6I_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NCS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PALM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SL9A3_HUMAN | [view interactions] | Low throughput | no | yes |
KPCB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DRD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
GNAO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MDM2_HUMAN | [view interactions] | Low throughput | no | yes |
GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RGS9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
COPG1_HUMAN | [view interactions] | Low throughput | no | yes |
COPD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
COPB_HUMAN | [view interactions] | Low throughput | no | yes |
GP143_HUMAN | [view interactions] | Low throughput | no | yes |
AA2AR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SH3G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H15_HUMAN | [view interactions] | High throughput | no | no |
DUS14_HUMAN | [view interactions] | High throughput | no | yes |
PTSS2_HUMAN | [view interactions] | High throughput | no | yes |
MRS2_HUMAN | [view interactions] | High throughput | no | no |
LRC15_HUMAN | [view interactions] | High throughput | no | no |
DSG4_HUMAN | [view interactions] | High throughput | no | no |
SBP1_HUMAN | [view interactions] | High throughput | no | no |
BRI3B_HUMAN | [view interactions] | High throughput | no | yes |
TM9S4_HUMAN | [view interactions] | High throughput | no | yes |
VSIG8_HUMAN | [view interactions] | High throughput | no | no |
SNH28_HUMAN | [view interactions] | High throughput | no | no |
KC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COMT_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DRD4_HUMAN | [view entry] [view interactions] | Computational | yes | no |