Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RGS9_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
299 Trp Arg Prolongedelectroretinalresponsesuppression(PERRS) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RGS9_HUMAN
GO:0016462 pyrophosphatase activity 54.1667 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 54.1667 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 54.1667 6 yes
GO:0003924 GTPase activity 50.0000 7 yes
GO:0046872 metal ion binding 33.3333 4 no
GO:0001664 G protein-coupled receptor binding 33.3333 4 no
GO:0005096 GTPase activator activity 29.1667 4 yes
GO:0030695 GTPase regulator activity 29.1667 4 yes
GO:0017076 purine nucleotide binding 25.0000 4 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0005525 GTP binding 20.8333 5 no
GO:0019001 guanyl nucleotide binding 20.8333 5 no
GO:0032561 guanyl ribonucleotide binding 20.8333 5 no
GO:0019900 kinase binding 20.8333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in RGS9_HUMAN
GO:0009966 regulation of signal transduction 83.3333 4 yes
GO:0010646 regulation of cell communication 83.3333 4 yes
GO:0048523 negative regulation of cellular process 83.3333 4 yes
GO:0048522 positive regulation of cellular process 66.6667 4 no
GO:0010648 negative regulation of cell communication 58.3333 5 yes
GO:0023057 negative regulation of signaling 58.3333 4 yes
GO:0009968 negative regulation of signal transduction 54.1667 5 yes
GO:0048585 negative regulation of response to stimulus 54.1667 4 yes
GO:0031323 regulation of cellular metabolic process 54.1667 4 no
GO:0051049 regulation of transport 50.0000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0010647 positive regulation of cell communication 45.8333 5 no
GO:0023056 positive regulation of signaling 45.8333 4 no
GO:0043085 positive regulation of catalytic activity 45.8333 4 no
GO:0043269 regulation of ion transport 45.8333 5 no
GO:0060255 regulation of macromolecule metabolic process 45.8333 4 no
GO:0080090 regulation of primary metabolic process 45.8333 4 no
GO:0008277 regulation of G protein-coupled receptor signaling pathway 41.6667 5 yes
GO:0009967 positive regulation of signal transduction 41.6667 5 no
GO:0048584 positive regulation of response to stimulus 41.6667 4 no
GO:0051336 regulation of hydrolase activity 41.6667 4 no
GO:1902531 regulation of intracellular signal transduction 41.6667 5 no
GO:0009893 positive regulation of metabolic process 37.5000 4 no
GO:0010243 response to organonitrogen compound 37.5000 4 no
GO:0010959 regulation of metal ion transport 37.5000 6 no
GO:0031325 positive regulation of cellular metabolic process 37.5000 5 no
GO:0034762 regulation of transmembrane transport 37.5000 4 no
GO:0034765 regulation of ion transmembrane transport 37.5000 5 no
GO:0051050 positive regulation of transport 37.5000 4 no
GO:1904062 regulation of cation transmembrane transport 37.5000 6 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 33.3333 4 no
GO:0010941 regulation of cell death 33.3333 4 no
GO:0042981 regulation of apoptotic process 33.3333 6 no
GO:0043067 regulation of programmed cell death 33.3333 5 no
GO:0010468 regulation of gene expression 29.1667 5 no
GO:0010556 regulation of macromolecule biosynthetic process 29.1667 5 no
GO:0022607 cellular component assembly 29.1667 4 no
GO:0044057 regulation of system process 29.1667 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 29.1667 5 no
GO:0051252 regulation of RNA metabolic process 29.1667 5 no
GO:0051345 positive regulation of hydrolase activity 29.1667 5 no
GO:0009892 negative regulation of metabolic process 29.1667 4 no
GO:0019220 regulation of phosphate metabolic process 29.1667 6 no
GO:0031324 negative regulation of cellular metabolic process 29.1667 5 no
GO:0031399 regulation of protein modification process 29.1667 6 no
GO:0045595 regulation of cell differentiation 29.1667 4 no
GO:0051094 positive regulation of developmental process 29.1667 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 29.1667 5 no
GO:0051174 regulation of phosphorus metabolic process 29.1667 5 no
GO:0051240 positive regulation of multicellular organismal process 29.1667 4 no
GO:0022898 regulation of transmembrane transporter activity 29.1667 4 no
GO:0032412 regulation of ion transmembrane transporter activity 29.1667 5 no
GO:0051128 regulation of cellular component organization 29.1667 4 no
GO:1902533 positive regulation of intracellular signal transduction 29.1667 6 no
GO:0032880 regulation of protein localization 29.1667 5 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0010604 positive regulation of macromolecule metabolic process 25.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0043270 positive regulation of ion transport 25.0000 5 no
GO:1903506 regulation of nucleic acid-templated transcription 25.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0006996 organelle organization 25.0000 4 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0043066 negative regulation of apoptotic process 25.0000 7 no
GO:0043069 negative regulation of programmed cell death 25.0000 6 no
GO:0043086 negative regulation of catalytic activity 25.0000 4 no
GO:0060548 negative regulation of cell death 25.0000 5 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0043087 regulation of GTPase activity 25.0000 5 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:2001257 regulation of cation channel activity 25.0000 6 no
GO:0051051 negative regulation of transport 25.0000 4 no
GO:0014070 response to organic cyclic compound 25.0000 4 no
GO:0009416 response to light stimulus 20.8333 4 yes
GO:0006355 regulation of DNA-templated transcription 20.8333 6 no
GO:0007612 learning 20.8333 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 20.8333 6 no
GO:0034764 positive regulation of transmembrane transport 20.8333 5 no
GO:0034767 positive regulation of ion transmembrane transport 20.8333 6 no
GO:0043933 protein-containing complex organization 20.8333 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 20.8333 6 no
GO:0050890 cognition 20.8333 4 no
GO:0051247 positive regulation of protein metabolic process 20.8333 6 no
GO:0051924 regulation of calcium ion transport 20.8333 7 no
GO:0097305 response to alcohol 20.8333 4 no
GO:1904064 positive regulation of cation transmembrane transport 20.8333 7 no
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 20.8333 5 no
GO:0043547 positive regulation of GTPase activity 20.8333 6 no
GO:0045597 positive regulation of cell differentiation 20.8333 5 no
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 20.8333 6 no
GO:0051248 negative regulation of protein metabolic process 20.8333 6 no
GO:0070372 regulation of ERK1 and ERK2 cascade 20.8333 7 no
GO:2000026 regulation of multicellular organismal development 20.8333 4 no
GO:0033043 regulation of organelle organization 20.8333 5 no
GO:0043410 positive regulation of MAPK cascade 20.8333 7 no
GO:0051130 positive regulation of cellular component organization 20.8333 5 no
GO:0051241 negative regulation of multicellular organismal process 20.8333 4 no
GO:0071310 cellular response to organic substance 20.8333 4 no
GO:0008104 protein localization 20.8333 4 no
GO:0060627 regulation of vesicle-mediated transport 20.8333 4 no
GO:0032101 regulation of response to external stimulus 20.8333 4 no
GO:0051726 regulation of cell cycle 20.8333 4 no
GO:0007600 sensory perception 12.5000 4 yes
GO:0009642 response to light intensity 8.3333 5 yes
GO:0009646 response to absence of light 8.3333 6 yes
GO:0036367 light adaption 8.3333 6 yes
GO:0071478 cellular response to radiation 8.3333 4 yes
GO:0071482 cellular response to light stimulus 8.3333 5 yes
GO:0071484 cellular response to light intensity 8.3333 6 yes
GO:0071485 cellular response to absence of light 8.3333 7 yes
GO:1990603 dark adaptation 8.3333 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GNB5_HUMAN [view entry] [view interactions] Low throughput yes yes
R9BP_HUMAN [view interactions] Low throughput no no
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTN4_HUMAN [view entry] [view interactions] Low throughput yes yes
DRD3_HUMAN [view entry] [view interactions] Low throughput yes no
NEB2_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
OPRM_HUMAN [view entry] [view interactions] Low throughput yes no
ACTN2_HUMAN [view entry] [view interactions] Low throughput yes yes
R7BP_HUMAN [view entry] [view interactions] Low throughput yes yes
PR40B_HUMAN [view interactions] High throughput no yes
RBM25_HUMAN [view interactions] High throughput no yes
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
CHLE_HUMAN [view interactions] High throughput no no
GNAT1_HUMAN [view interactions] High throughput no no
GTPB8_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SF3A3_HUMAN [view interactions] High throughput no yes
H33_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
RGS12_HUMAN [view interactions] Computational no no
CNRG_HUMAN [view interactions] Computational no no
GBB1_HUMAN [view entry] [view interactions] Computational yes yes
RGS14_HUMAN [view entry] [view interactions] Computational yes yes
RGS16_HUMAN [view interactions] Computational no no
RGS7_HUMAN [view entry] [view interactions] Computational yes yes
PDE6B_HUMAN [view interactions] Computational no no
RGS11_HUMAN [view interactions] Computational no yes
RGS13_HUMAN [view interactions] Computational no no
GBG1_HUMAN [view interactions] Computational no no
RGS5_HUMAN [view interactions] Computational no no
CNCG_HUMAN [view interactions] Computational no no
RGS10_HUMAN [view interactions] Computational no yes
GNAT3_HUMAN [view interactions] Computational no no
GNAT2_HUMAN [view interactions] Computational no no
RGS21_HUMAN [view interactions] Computational no no
RGS8_HUMAN [view entry] [view interactions] Computational yes yes
RGS4_HUMAN [view interactions] Computational no no
RGS20_HUMAN [view interactions] Computational no no
KPCT_HUMAN [view interactions] Computational no no
PDE6C_HUMAN [view interactions] Computational no no
PDE6A_HUMAN [view interactions] Computational no no
GNAI3_HUMAN [view entry] [view interactions] Computational yes yes
RGS1_HUMAN [view interactions] Computational no yes
KPCA_HUMAN [view entry] [view interactions] Computational yes yes
GNAI1_HUMAN [view entry] [view interactions] Computational yes yes
RGS6_HUMAN [view entry] [view interactions] Computational yes no
GNAI2_HUMAN [view entry] [view interactions] Computational yes yes
RGS3_HUMAN [view interactions] Computational no no
RGS17_HUMAN [view entry] [view interactions] Computational yes yes
RGS18_HUMAN [view interactions] Computational no yes
RGS19_HUMAN [view interactions] Computational no yes