Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RGS9_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
299 Trp Arg Prolongedelectroretinalresponsesuppression1(PERRS1) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RGS9_HUMAN
GO:0043169 cation binding 40.0000 4 no
GO:0046872 metal ion binding 33.3333 5 no
GO:0001664 G protein-coupled receptor binding 33.3333 4 no
GO:0019900 kinase binding 33.3333 4 no
GO:0016462 pyrophosphatase activity 26.6667 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 26.6667 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 26.6667 6 yes
GO:0003779 actin binding 26.6667 4 no
GO:0043168 anion binding 26.6667 4 no
GO:0003924 GTPase activity 20.0000 7 yes
GO:0005096 GTPase activator activity 13.3333 4 yes
GO:0030695 GTPase regulator activity 13.3333 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RGS9_HUMAN
GO:0048523 negative regulation of cellular process 86.6667 4 yes
GO:0009966 regulation of signal transduction 80.0000 4 yes
GO:0010646 regulation of cell communication 80.0000 4 yes
GO:0048522 positive regulation of cellular process 73.3333 4 no
GO:0051049 regulation of transport 73.3333 4 yes
GO:0048584 positive regulation of response to stimulus 60.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 60.0000 4 no
GO:0009967 positive regulation of signal transduction 60.0000 5 no
GO:0010647 positive regulation of cell communication 60.0000 5 no
GO:0023056 positive regulation of signaling 60.0000 4 no
GO:0031323 regulation of cellular metabolic process 60.0000 4 no
GO:0080090 regulation of primary metabolic process 53.3333 4 no
GO:0034762 regulation of transmembrane transport 53.3333 4 yes
GO:0009889 regulation of biosynthetic process 53.3333 4 no
GO:0009893 positive regulation of metabolic process 53.3333 4 no
GO:0022607 cellular component assembly 46.6667 4 no
GO:0051128 regulation of cellular component organization 46.6667 4 no
GO:0060341 regulation of cellular localization 46.6667 4 no
GO:0009968 negative regulation of signal transduction 46.6667 5 yes
GO:0010648 negative regulation of cell communication 46.6667 5 yes
GO:0010959 regulation of metal ion transport 46.6667 6 yes
GO:0023057 negative regulation of signaling 46.6667 4 yes
GO:0043269 regulation of monoatomic ion transport 46.6667 5 yes
GO:0048585 negative regulation of response to stimulus 46.6667 4 yes
GO:0009891 positive regulation of biosynthetic process 46.6667 5 no
GO:0010556 regulation of macromolecule biosynthetic process 46.6667 5 no
GO:0010604 positive regulation of macromolecule metabolic process 46.6667 5 no
GO:0031325 positive regulation of cellular metabolic process 46.6667 5 no
GO:0031326 regulation of cellular biosynthetic process 46.6667 5 no
GO:0051050 positive regulation of transport 40.0000 4 no
GO:1902531 regulation of intracellular signal transduction 40.0000 5 no
GO:0001932 regulation of protein phosphorylation 40.0000 7 no
GO:0019220 regulation of phosphate metabolic process 40.0000 6 no
GO:0031399 regulation of protein modification process 40.0000 6 no
GO:0032880 regulation of protein localization 40.0000 5 no
GO:0042325 regulation of phosphorylation 40.0000 7 no
GO:0043933 protein-containing complex organization 40.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 40.0000 5 no
GO:0051051 negative regulation of transport 40.0000 4 no
GO:0051094 positive regulation of developmental process 40.0000 4 no
GO:0051130 positive regulation of cellular component organization 40.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 40.0000 5 no
GO:0051246 regulation of protein metabolic process 40.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 40.0000 4 no
GO:0010243 response to organonitrogen compound 40.0000 4 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 40.0000 5 yes
GO:0008104 protein localization 40.0000 4 no
GO:0010468 regulation of gene expression 40.0000 6 no
GO:0010557 positive regulation of macromolecule biosynthetic process 40.0000 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 40.0000 5 no
GO:0022898 regulation of transmembrane transporter activity 40.0000 4 no
GO:0031328 positive regulation of cellular biosynthetic process 40.0000 6 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 40.0000 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:1902533 positive regulation of intracellular signal transduction 33.3333 6 no
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 no
GO:0007612 learning 33.3333 4 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0050890 cognition 33.3333 4 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0065003 protein-containing complex assembly 33.3333 5 no
GO:1904062 regulation of monoatomic cation transmembrane transport 33.3333 6 yes
GO:0006355 regulation of DNA-templated transcription 33.3333 7 no
GO:0006996 organelle organization 33.3333 4 no
GO:0043270 positive regulation of monoatomic ion transport 26.6667 5 no
GO:0045893 positive regulation of DNA-templated transcription 26.6667 8 no
GO:0045944 positive regulation of transcription by RNA polymerase II 26.6667 9 no
GO:0051254 positive regulation of RNA metabolic process 26.6667 6 no
GO:0071702 organic substance transport 26.6667 4 no
GO:1902680 positive regulation of RNA biosynthetic process 26.6667 7 no
GO:0009892 negative regulation of metabolic process 26.6667 4 no
GO:0010638 positive regulation of organelle organization 26.6667 6 no
GO:0033043 regulation of organelle organization 26.6667 5 no
GO:0043408 regulation of MAPK cascade 26.6667 6 no
GO:0043549 regulation of kinase activity 26.6667 5 no
GO:0051338 regulation of transferase activity 26.6667 4 no
GO:0060627 regulation of vesicle-mediated transport 26.6667 4 no
GO:0071310 cellular response to organic substance 26.6667 4 no
GO:0098657 import into cell 26.6667 4 no
GO:1902532 negative regulation of intracellular signal transduction 26.6667 6 no
GO:1903828 negative regulation of protein localization 26.6667 5 no
GO:0043085 positive regulation of catalytic activity 26.6667 4 no
GO:0001934 positive regulation of protein phosphorylation 26.6667 8 no
GO:0010562 positive regulation of phosphorus metabolic process 26.6667 6 no
GO:0042327 positive regulation of phosphorylation 26.6667 8 no
GO:0045937 positive regulation of phosphate metabolic process 26.6667 7 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 26.6667 4 no
GO:0090304 nucleic acid metabolic process 26.6667 4 no
GO:0045595 regulation of cell differentiation 26.6667 4 no
GO:0008277 regulation of G protein-coupled receptor signaling pathway 26.6667 5 yes
GO:0009416 response to light stimulus 26.6667 4 yes
GO:0014070 response to organic cyclic compound 26.6667 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 26.6667 8 no
GO:0034764 positive regulation of transmembrane transport 26.6667 5 no
GO:0034767 positive regulation of monoatomic ion transmembrane transport 26.6667 6 no
GO:0042981 regulation of apoptotic process 26.6667 5 no
GO:0043067 regulation of programmed cell death 26.6667 4 no
GO:0051924 regulation of calcium ion transport 20.0000 7 yes
GO:1903169 regulation of calcium ion transmembrane transport 20.0000 7 yes
GO:0001975 response to amphetamine 13.3333 6 yes
GO:0007399 nervous system development 13.3333 4 yes
GO:0007600 sensory perception 13.3333 4 yes
GO:0009642 response to light intensity 13.3333 5 yes
GO:0009646 response to absence of light 13.3333 6 yes
GO:0014075 response to amine 13.3333 5 yes
GO:0032355 response to estradiol 13.3333 4 yes
GO:0033993 response to lipid 13.3333 4 yes
GO:0036367 light adaption 13.3333 6 yes
GO:0071478 cellular response to radiation 13.3333 4 yes
GO:0071482 cellular response to light stimulus 13.3333 5 yes
GO:0071484 cellular response to light intensity 13.3333 6 yes
GO:0071485 cellular response to absence of light 13.3333 7 yes
GO:1990603 dark adaptation 13.3333 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NEB2_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
OPRM_HUMAN [view entry] [view interactions] Low throughput yes no
ACTN2_HUMAN [view entry] [view interactions] Low throughput yes yes
R7BP_HUMAN [view entry] [view interactions] Low throughput yes yes
GNB5_HUMAN [view entry] [view interactions] Low throughput yes yes
R9BP_HUMAN [view interactions] Low throughput no no
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTN4_HUMAN [view entry] [view interactions] Low throughput yes yes
DRD3_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SF3A3_HUMAN [view interactions] High throughput no yes
H33_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
PR40B_HUMAN [view interactions] High throughput no yes
RBM25_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
UBP48_HUMAN [view interactions] High throughput no yes
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
CHLE_HUMAN [view interactions] High throughput no no
GNAT1_HUMAN [view interactions] High throughput no no
GTPB8_HUMAN [view interactions] High throughput no yes