GNB5_HUMAN
Evidence for PS localization
Functions
Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (PubMed). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 123 | Ser | Leu | Languagedelayandattentiondeficit-hyperactivitydisorder/cognitiveimpairmentwithorwithoutcardiacarrhythmia(LADCI) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GNB5_HUMAN |
|---|---|---|---|---|
| GO:0016462 | pyrophosphatase activity | 40.0000 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 40.0000 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 40.0000 | 6 | yes |
| GO:0017076 | purine nucleotide binding | 40.0000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 40.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.0000 | 4 | no |
| GO:0046872 | metal ion binding | 30.7692 | 4 | no |
| GO:0003924 | GTPase activity | 29.2308 | 7 | yes |
| GO:0005524 | ATP binding | 23.0769 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 23.0769 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.0769 | 5 | no |
| GO:0030695 | GTPase regulator activity | 15.3846 | 4 | yes |
| GO:0005096 | GTPase activator activity | 12.3077 | 4 | yes |
| GO:0030159 | signaling receptor complex adaptor activity | 4.6154 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GNB5_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 52.3077 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 52.3077 | 4 | no |
| GO:0009966 | regulation of signal transduction | 49.2308 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.6923 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 47.6923 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.1538 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 46.1538 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 46.1538 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.9231 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 35.3846 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 35.3846 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 33.8462 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.3077 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 32.3077 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 32.3077 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.7692 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 29.2308 | 5 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 29.2308 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 29.2308 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.2308 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.2308 | 5 | no |
| GO:0033043 | regulation of organelle organization | 29.2308 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.2308 | 5 | no |
| GO:0051049 | regulation of transport | 27.6923 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 27.6923 | 4 | no |
| GO:0060341 | regulation of cellular localization | 27.6923 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.1538 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.1538 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.1538 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.1538 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 26.1538 | 6 | no |
| GO:0051336 | regulation of hydrolase activity | 24.6154 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 24.6154 | 5 | no |
| GO:0023056 | positive regulation of signaling | 24.6154 | 4 | no |
| GO:0071310 | cellular response to organic substance | 24.6154 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 24.6154 | 6 | no |
| GO:0032880 | regulation of protein localization | 24.6154 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.0769 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 23.0769 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.0769 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.0769 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.0769 | 4 | no |
| GO:0043269 | regulation of ion transport | 21.5385 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 21.5385 | 5 | no |
| GO:0022607 | cellular component assembly | 21.5385 | 4 | no |
| GO:0030334 | regulation of cell migration | 21.5385 | 5 | no |
| GO:0031399 | regulation of protein modification process | 21.5385 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 21.5385 | 7 | no |
| GO:2000145 | regulation of cell motility | 21.5385 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 21.5385 | 4 | no |
| GO:0070201 | regulation of establishment of protein localization | 21.5385 | 6 | no |
| GO:1903829 | positive regulation of protein localization | 21.5385 | 5 | no |
| GO:0043408 | regulation of MAPK cascade | 21.5385 | 6 | no |
| GO:0034762 | regulation of transmembrane transport | 16.9231 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 16.9231 | 5 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 16.9231 | 5 | yes |
| GO:0010959 | regulation of metal ion transport | 15.3846 | 6 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 15.3846 | 6 | yes |
| GO:0051924 | regulation of calcium ion transport | 12.3077 | 7 | yes |
| GO:0009416 | response to light stimulus | 10.7692 | 4 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 10.7692 | 4 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 10.7692 | 5 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 10.7692 | 7 | yes |
| GO:2001257 | regulation of cation channel activity | 10.7692 | 6 | yes |
| GO:0043087 | regulation of GTPase activity | 9.2308 | 5 | yes |
| GO:0051051 | negative regulation of transport | 9.2308 | 4 | yes |
| GO:0043547 | positive regulation of GTPase activity | 7.6923 | 6 | yes |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 7.6923 | 6 | yes |
| GO:0043271 | negative regulation of ion transport | 6.1538 | 5 | yes |
| GO:1901385 | regulation of voltage-gated calcium channel activity | 6.1538 | 7 | yes |
| GO:0009642 | response to light intensity | 4.6154 | 5 | yes |
| GO:0009646 | response to absence of light | 4.6154 | 6 | yes |
| GO:0032410 | negative regulation of transporter activity | 4.6154 | 4 | yes |
| GO:0032413 | negative regulation of ion transmembrane transporter activity | 4.6154 | 5 | yes |
| GO:0034763 | negative regulation of transmembrane transport | 4.6154 | 5 | yes |
| GO:0034766 | negative regulation of ion transmembrane transport | 4.6154 | 6 | yes |
| GO:0036367 | light adaption | 4.6154 | 6 | yes |
| GO:0051926 | negative regulation of calcium ion transport | 4.6154 | 6 | yes |
| GO:0071478 | cellular response to radiation | 4.6154 | 4 | yes |
| GO:0071482 | cellular response to light stimulus | 4.6154 | 5 | yes |
| GO:0071484 | cellular response to light intensity | 4.6154 | 6 | yes |
| GO:0071485 | cellular response to absence of light | 4.6154 | 7 | yes |
| GO:1901020 | negative regulation of calcium ion transmembrane transporter activity | 4.6154 | 6 | yes |
| GO:1901386 | negative regulation of voltage-gated calcium channel activity | 4.6154 | 7 | yes |
| GO:1903170 | negative regulation of calcium ion transmembrane transport | 4.6154 | 7 | yes |
| GO:1904063 | negative regulation of cation transmembrane transport | 4.6154 | 7 | yes |
| GO:1990603 | dark adaptation | 4.6154 | 8 | yes |
| GO:2001258 | negative regulation of cation channel activity | 4.6154 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NEB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBG13_HUMAN | [view interactions] | Low throughput | no | no |
| R7BP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RGS7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS11_HUMAN | [view interactions] | Low throughput | no | yes |
| RGS9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DRD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GP158_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNB5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANXA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BNI3L_HUMAN | [view interactions] | High throughput | no | yes |
| CDN1A_HUMAN | [view interactions] | High throughput | no | no |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRIA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E2F2_HUMAN | [view interactions] | High throughput | no | no |
| PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MVD1_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3J_HUMAN | [view interactions] | High throughput | no | yes |
| NR6A1_HUMAN | [view interactions] | High throughput | no | no |
| NOE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| PFD2_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFD5_HUMAN | [view interactions] | High throughput | no | yes |
| GBG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG5_HUMAN | [view interactions] | High throughput | no | no |
| GBG4_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLP_HUMAN | [view interactions] | High throughput | no | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP38_HUMAN | [view interactions] | High throughput | no | no |
| TCPW_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| PR40B_HUMAN | [view interactions] | High throughput | no | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG8_HUMAN | [view interactions] | High throughput | no | no |
| FOXK2_HUMAN | [view interactions] | High throughput | no | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDLR_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AASD1_HUMAN | [view interactions] | High throughput | no | yes |
| PAK3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPAR5_HUMAN | [view interactions] | Computational | no | yes |
| RGS20_HUMAN | [view interactions] | Computational | no | no |
| ADCY9_HUMAN | [view interactions] | Computational | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNA13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LPAR3_HUMAN | [view interactions] | Computational | no | no |
| CA2D2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| OPSD_HUMAN | [view interactions] | Computational | no | no |
| GBG1_HUMAN | [view interactions] | Computational | no | no |
| CAC1D_HUMAN | [view interactions] | Computational | no | yes |
| GNAT1_HUMAN | [view interactions] | Computational | no | no |
| PAK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCB2_HUMAN | [view interactions] | Computational | no | no |
| GNAT2_HUMAN | [view interactions] | Computational | no | no |
| CNCG_HUMAN | [view interactions] | Computational | no | no |
| CCNH_HUMAN | [view interactions] | Computational | no | yes |
| GNAS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PDE6B_HUMAN | [view interactions] | Computational | no | no |
| GNAZ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CACB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GGT5_HUMAN | [view interactions] | Computational | no | yes |
| TA2R_HUMAN | [view interactions] | Computational | no | no |
| CNRG_HUMAN | [view interactions] | Computational | no | no |
| ACM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNA14_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNA12_HUMAN | [view interactions] | Computational | no | no |
| MAT1_HUMAN | [view interactions] | Computational | no | yes |
| KCNJ6_HUMAN | [view interactions] | Computational | no | no |
| GNAL_HUMAN | [view interactions] | Computational | no | yes |
| RGS17_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ACM2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LPAR1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PAR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LPAR4_HUMAN | [view interactions] | Computational | no | no |
| CACB2_HUMAN | [view interactions] | Computational | no | yes |
| NHRF1_HUMAN | [view interactions] | Computational | no | no |
| CAC1B_HUMAN | [view interactions] | Computational | no | yes |
| KCNJ3_HUMAN | [view interactions] | Computational | no | yes |
| PLCB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNA11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LPAR2_HUMAN | [view interactions] | Computational | no | yes |
| LPAR6_HUMAN | [view interactions] | Computational | no | no |
| KPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CDK7_HUMAN | [view interactions] | Computational | no | yes |
| MK14_HUMAN | [view interactions] | Computational | no | yes |
| GNA15_HUMAN | [view interactions] | Computational | no | yes |
| R9BP_HUMAN | [view interactions] | Computational | no | no |
| KPCT_HUMAN | [view interactions] | Computational | no | no |
| PDE6C_HUMAN | [view interactions] | Computational | no | no |
| GBGT2_HUMAN | [view interactions] | Computational | no | no |
| PDE6A_HUMAN | [view interactions] | Computational | no | no |
| GNAO_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GABR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |