GNB5_HUMAN
Evidence for PS localization
Functions
Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (PubMed). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 123 | Ser | Leu | Languagedelayandattentiondeficit-hyperactivitydisorder/cognitiveimpairmentwithorwithoutcardiacarrhythmia(LADCI) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GNB5_HUMAN |
|---|---|---|---|---|
| GO:0016462 | pyrophosphatase activity | 36.9565 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 36.9565 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 36.9565 | 6 | yes |
| GO:0000166 | nucleotide binding | 32.6087 | 4 | no |
| GO:0017076 | purine nucleotide binding | 32.6087 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 30.4348 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.4348 | 4 | no |
| GO:0043168 | anion binding | 30.4348 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 26.0870 | 6 | no |
| GO:0005524 | ATP binding | 23.9130 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.9130 | 5 | no |
| GO:0003924 | GTPase activity | 21.7391 | 7 | yes |
| GO:0043169 | cation binding | 21.7391 | 4 | no |
| GO:0030695 | GTPase regulator activity | 13.0435 | 4 | yes |
| GO:0005096 | GTPase activator activity | 10.8696 | 4 | yes |
| GO:0030159 | signaling receptor complex adaptor activity | 6.5217 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GNB5_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 52.1739 | 4 | no |
| GO:0010646 | regulation of cell communication | 52.1739 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.8261 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 47.8261 | 4 | no |
| GO:0009966 | regulation of signal transduction | 45.6522 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 43.4783 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 43.4783 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 43.4783 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 43.4783 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.4783 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.9565 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.9565 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 34.7826 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.6087 | 5 | no |
| GO:0033043 | regulation of organelle organization | 32.6087 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 30.4348 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 30.4348 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 30.4348 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.2609 | 5 | no |
| GO:0060341 | regulation of cellular localization | 28.2609 | 4 | no |
| GO:0010468 | regulation of gene expression | 28.2609 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.2609 | 5 | no |
| GO:0051049 | regulation of transport | 26.0870 | 4 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 26.0870 | 5 | no |
| GO:0071310 | cellular response to organic substance | 26.0870 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.9130 | 4 | yes |
| GO:0010638 | positive regulation of organelle organization | 23.9130 | 6 | no |
| GO:0032880 | regulation of protein localization | 23.9130 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 23.9130 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 23.9130 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.9130 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 23.9130 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.9130 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.9130 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 21.7391 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 21.7391 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.7391 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.7391 | 4 | no |
| GO:0014070 | response to organic cyclic compound | 21.7391 | 4 | no |
| GO:0022607 | cellular component assembly | 21.7391 | 4 | no |
| GO:0010959 | regulation of metal ion transport | 15.2174 | 6 | yes |
| GO:0034762 | regulation of transmembrane transport | 15.2174 | 4 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 15.2174 | 5 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 13.0435 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 13.0435 | 4 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 13.0435 | 5 | yes |
| GO:0009416 | response to light stimulus | 10.8696 | 4 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 10.8696 | 4 | yes |
| GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 10.8696 | 5 | yes |
| GO:0051051 | negative regulation of transport | 10.8696 | 4 | yes |
| GO:0051924 | regulation of calcium ion transport | 10.8696 | 7 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 10.8696 | 6 | yes |
| GO:0043087 | regulation of GTPase activity | 8.6957 | 5 | yes |
| GO:0043547 | positive regulation of GTPase activity | 8.6957 | 6 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 8.6957 | 7 | yes |
| GO:0009642 | response to light intensity | 6.5217 | 5 | yes |
| GO:0009646 | response to absence of light | 6.5217 | 6 | yes |
| GO:0032410 | negative regulation of transporter activity | 6.5217 | 4 | yes |
| GO:0032413 | negative regulation of ion transmembrane transporter activity | 6.5217 | 5 | yes |
| GO:0034763 | negative regulation of transmembrane transport | 6.5217 | 5 | yes |
| GO:0034766 | negative regulation of monoatomic ion transmembrane transport | 6.5217 | 6 | yes |
| GO:0036367 | light adaption | 6.5217 | 6 | yes |
| GO:0043271 | negative regulation of monoatomic ion transport | 6.5217 | 5 | yes |
| GO:0051926 | negative regulation of calcium ion transport | 6.5217 | 6 | yes |
| GO:0071478 | cellular response to radiation | 6.5217 | 4 | yes |
| GO:0071482 | cellular response to light stimulus | 6.5217 | 5 | yes |
| GO:0071484 | cellular response to light intensity | 6.5217 | 6 | yes |
| GO:0071485 | cellular response to absence of light | 6.5217 | 7 | yes |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 6.5217 | 6 | yes |
| GO:1901020 | negative regulation of calcium ion transmembrane transporter activity | 6.5217 | 6 | yes |
| GO:1901385 | regulation of voltage-gated calcium channel activity | 6.5217 | 7 | yes |
| GO:1901386 | negative regulation of voltage-gated calcium channel activity | 6.5217 | 7 | yes |
| GO:1903170 | negative regulation of calcium ion transmembrane transport | 6.5217 | 7 | yes |
| GO:1904063 | negative regulation of cation transmembrane transport | 6.5217 | 7 | yes |
| GO:1990603 | dark adaptation | 6.5217 | 8 | yes |
| GO:2001257 | regulation of cation channel activity | 6.5217 | 6 | yes |
| GO:2001258 | negative regulation of cation channel activity | 6.5217 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MGLYR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNB5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RPB1_HUMAN | [view interactions] | Low throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBG13_HUMAN | [view interactions] | Low throughput | no | no |
| R7BP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RGS7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS11_HUMAN | [view interactions] | Low throughput | no | yes |
| RGS9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DRD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC4C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BNI3L_HUMAN | [view interactions] | High throughput | no | yes |
| CDN1A_HUMAN | [view interactions] | High throughput | no | no |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T22D1_HUMAN | [view interactions] | High throughput | no | no |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRIA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E2F2_HUMAN | [view interactions] | High throughput | no | no |
| PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MVD1_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3J_HUMAN | [view interactions] | High throughput | no | yes |
| NR6A1_HUMAN | [view interactions] | High throughput | no | no |
| NOE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC_HUMAN | [view interactions] | High throughput | no | yes |
| PFD2_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFD5_HUMAN | [view interactions] | High throughput | no | yes |
| GBG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG5_HUMAN | [view interactions] | High throughput | no | no |
| GBG4_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLP_HUMAN | [view interactions] | High throughput | no | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP38_HUMAN | [view interactions] | High throughput | no | no |
| TCPW_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| PR40B_HUMAN | [view interactions] | High throughput | no | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG8_HUMAN | [view interactions] | High throughput | no | no |
| FOXK2_HUMAN | [view interactions] | High throughput | no | yes |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDLR_HUMAN | [view interactions] | High throughput | no | yes |
| ASPM_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AASD1_HUMAN | [view interactions] | High throughput | no | yes |
| PAK3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |