MLF2_HUMAN
Evidence for PS localization
Functions
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MLF2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 43.1373 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 37.2549 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 35.2941 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 31.3725 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 27.4510 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 27.4510 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 27.4510 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.4902 | 5 | no |
| GO:0005524 | ATP binding | 23.5294 | 5 | no |
| GO:0031625 | ubiquitin protein ligase binding | 21.5686 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 21.5686 | 4 | no |
| GO:0046872 | metal ion binding | 21.5686 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MLF2_HUMAN |
|---|---|---|---|---|
| GO:0080090 | regulation of primary metabolic process | 62.7451 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 60.7843 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 58.8235 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 58.8235 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 49.0196 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 45.0980 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 39.2157 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 39.2157 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 37.2549 | 4 | yes |
| GO:0010468 | regulation of gene expression | 37.2549 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 37.2549 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 37.2549 | 4 | no |
| GO:0071310 | cellular response to organic substance | 37.2549 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.2941 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 35.2941 | 4 | no |
| GO:0010646 | regulation of cell communication | 35.2941 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0009894 | regulation of catabolic process | 31.3725 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.3725 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.3725 | 5 | no |
| GO:0006996 | organelle organization | 29.4118 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 27.4510 | 6 | yes |
| GO:0051252 | regulation of RNA metabolic process | 27.4510 | 5 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 27.4510 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 27.4510 | 6 | yes |
| GO:0009892 | negative regulation of metabolic process | 27.4510 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 27.4510 | 4 | no |
| GO:0030162 | regulation of proteolysis | 25.4902 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.4902 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.4902 | 4 | no |
| GO:0051049 | regulation of transport | 25.4902 | 4 | no |
| GO:0008104 | protein localization | 25.4902 | 4 | no |
| GO:0010941 | regulation of cell death | 23.5294 | 4 | no |
| GO:0031399 | regulation of protein modification process | 23.5294 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 23.5294 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 23.5294 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.5294 | 5 | no |
| GO:0071702 | organic substance transport | 23.5294 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.5686 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.5686 | 5 | no |
| GO:0031329 | regulation of cellular catabolic process | 21.5686 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.5686 | 5 | no |
| GO:0006986 | response to unfolded protein | 21.5686 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 21.5686 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.5686 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.5686 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.5686 | 4 | no |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MLF2_HUMAN |
|---|---|---|---|---|
| DOID:0111198 | autosomal dominant distal hereditary motor neuronopathy | 3.9216 | 7 | no |
| DOID:0111206 | distal hereditary motor neuronopathy type 2 | 3.9216 | 8 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 3.9216 | 6 | no |
| DOID:12377 | spinal muscular atrophy | 3.9216 | 6 | no |
| DOID:1289 | neurodegenerative disease | 3.9216 | 4 | no |
| DOID:231 | motor neuron disease | 3.9216 | 5 | no |
| DOID:331 | central nervous system disease | 3.9216 | 3 | no |
| DOID:440 | neuromuscular disease | 3.9216 | 5 | no |
| DOID:574 | peripheral nervous system disease | 3.9216 | 3 | no |
| DOID:870 | neuropathy | 3.9216 | 4 | no |
| DOID:0050700 | cardiomyopathy | 3.9216 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 3.9216 | 5 | no |
| DOID:114 | heart disease | 3.9216 | 3 | no |
| DOID:12930 | dilated cardiomyopathy | 3.9216 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SEGN_HUMAN | [view interactions] | Low throughput | no | no |
| STAT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUX4_HUMAN | [view interactions] | High throughput | no | no |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| HDA11_HUMAN | [view interactions] | High throughput | no | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAG4_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| MTA70_HUMAN | [view interactions] | High throughput | no | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| KPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAT7_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| NRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGS20_HUMAN | [view interactions] | High throughput | no | no |
| CIAO1_HUMAN | [view interactions] | High throughput | no | yes |
| CIA2B_HUMAN | [view interactions] | High throughput | no | yes |
| ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MMS19_HUMAN | [view interactions] | High throughput | no | yes |
| PMVK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| ZN211_HUMAN | [view interactions] | High throughput | no | yes |
| ERLN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBL1_HUMAN | [view interactions] | High throughput | no | no |
| P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
| MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| IRS4_HUMAN | [view interactions] | High throughput | no | no |
| GNB5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TET3_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD3_HUMAN | [view interactions] | High throughput | no | yes |
| PRP6_HUMAN | [view interactions] | High throughput | no | yes |
| REC8_HUMAN | [view interactions] | High throughput | no | yes |
| MOS_HUMAN | [view interactions] | High throughput | no | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBB4A_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GNAZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERCC3_HUMAN | [view interactions] | High throughput | no | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNA15_HUMAN | [view interactions] | High throughput | no | yes |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| CACP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAL12_HUMAN | [view interactions] | High throughput | no | yes |
| GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SKP2_HUMAN | [view interactions] | High throughput | no | yes |
| SIM2_HUMAN | [view interactions] | High throughput | no | yes |
| RCN2_HUMAN | [view interactions] | High throughput | no | yes |
| SETB1_HUMAN | [view interactions] | High throughput | no | yes |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| KLH38_HUMAN | [view interactions] | High throughput | no | no |
| EIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GET4_HUMAN | [view interactions] | High throughput | no | yes |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| HUS1B_HUMAN | [view interactions] | High throughput | no | no |
| SMRD2_HUMAN | [view interactions] | High throughput | no | no |
| KAT5_HUMAN | [view interactions] | High throughput | no | yes |
| ERF1_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| TSSK6_HUMAN | [view interactions] | High throughput | no | no |
| TBB1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR55_HUMAN | [view interactions] | High throughput | no | yes |
| TLR7_HUMAN | [view interactions] | High throughput | no | no |
| E2AK4_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANR50_HUMAN | [view interactions] | High throughput | no | no |
| DYN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NOD1_HUMAN | [view interactions] | High throughput | no | no |
| SYFA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| COPG1_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GASP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| NANOG_HUMAN | [view interactions] | High throughput | no | no |
| PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| HYPK_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| AMRA1_HUMAN | [view interactions] | High throughput | no | yes |
| FAF1_HUMAN | [view interactions] | High throughput | no | yes |
| CCND1_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| ARHG4_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA4_HUMAN | [view interactions] | High throughput | no | yes |
| ZKSC1_HUMAN | [view interactions] | High throughput | no | yes |
| HS71L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJB5_HUMAN | [view interactions] | High throughput | no | yes |
| HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZNRF4_HUMAN | [view interactions] | High throughput | no | no |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| DCAF8_HUMAN | [view interactions] | High throughput | no | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| RBX1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| PDE2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHBT2_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| GCN1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF15_HUMAN | [view interactions] | High throughput | no | no |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| LRBA_HUMAN | [view interactions] | High throughput | no | yes |
| SRP72_HUMAN | [view interactions] | High throughput | no | yes |
| POP1_HUMAN | [view interactions] | High throughput | no | no |
| RPP30_HUMAN | [view interactions] | High throughput | no | yes |
| UBP19_HUMAN | [view interactions] | High throughput | no | no |
| PHLB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| CMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| CATS_HUMAN | [view interactions] | High throughput | no | no |
| DDAH2_HUMAN | [view interactions] | Computational | no | yes |
| ARFG2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |