QCR2_HUMAN
Evidence for PS localization
Functions
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c . The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties . May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). [View more on UniProt]
Protein features
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Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
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Network
Isoforms
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Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in QCR2_HUMAN |
---|---|---|---|---|
GO:0000166 | nucleotide binding | 35.8696 | 4 | no |
GO:0043168 | anion binding | 34.2391 | 4 | no |
GO:0017076 | purine nucleotide binding | 32.0652 | 5 | no |
GO:0043169 | cation binding | 30.4348 | 4 | yes |
GO:0046872 | metal ion binding | 28.8043 | 5 | yes |
GO:0032555 | purine ribonucleotide binding | 28.8043 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 27.7174 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 21.7391 | 6 | no |
GO:0003723 | RNA binding | 20.6522 | 4 | no |
GO:0016462 | pyrophosphatase activity | 20.6522 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.6522 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 20.6522 | 6 | no |
GO:0004175 | endopeptidase activity | 2.7174 | 4 | yes |
GO:0008237 | metallopeptidase activity | 2.1739 | 4 | yes |
GO:0004222 | metalloendopeptidase activity | 1.6304 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in QCR2_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 42.3913 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 38.0435 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 35.8696 | 4 | no |
GO:0048523 | negative regulation of cellular process | 35.3261 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 34.7826 | 4 | no |
GO:0010646 | regulation of cell communication | 31.5217 | 4 | no |
GO:0022607 | cellular component assembly | 31.5217 | 4 | no |
GO:0006996 | organelle organization | 30.4348 | 4 | no |
GO:0051128 | regulation of cellular component organization | 30.4348 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 29.3478 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 27.1739 | 4 | no |
GO:0008104 | protein localization | 27.1739 | 4 | no |
GO:0009966 | regulation of signal transduction | 26.6304 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 26.0870 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 26.0870 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 25.5435 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
GO:0006796 | phosphate-containing compound metabolic process | 25.0000 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
GO:0043933 | protein-containing complex organization | 24.4565 | 4 | no |
GO:0071702 | organic substance transport | 23.9130 | 4 | no |
GO:0051049 | regulation of transport | 23.3696 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 22.8261 | 4 | no |
GO:0010468 | regulation of gene expression | 21.7391 | 6 | no |
GO:0042981 | regulation of apoptotic process | 21.7391 | 5 | no |
Disease
No data found.
All partners
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
AAPK1_HUMAN | [view interactions] | High throughput | no | no |
AAR2_HUMAN | [view interactions] | High throughput | no | no |
AATM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACADM_HUMAN | [view interactions] | High throughput | no | yes |
ACAP1_HUMAN | [view interactions] | High throughput | no | yes |
ACE2_HUMAN | [view interactions] | High throughput | no | no |
ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACPM_HUMAN | [view interactions] | High throughput | no | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ADAS_HUMAN | [view interactions] | High throughput | no | yes |
ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
AKTIP_HUMAN | [view interactions] | High throughput | no | yes |
AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
ALDH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AMPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AN34C_HUMAN | [view interactions] | High throughput | no | no |