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QCR2_HUMAN

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c . The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties . May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). [View more on UniProt]

050100150200250300350400450
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%

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050100150200250300350400450
QCR2_HUMAN
LOADING 67%
050100150200250300350400450
QCR2_HUMAN
LOADING 67%
050100150200250300350400450
QCR2_HUMAN
LOADING 67%
050100150200250300350400450
QCR2_HUMAN
LOADING 67%
050100150200250300350400450
QCR2_HUMAN
LOADING 67%
Download full PS network for entry.
050100150200250300350400450
Interacting regions
Canonical [QCR2_HUMAN]
Isoform [H3BUI9] alignment
Isoform [H3BUE4] alignment
Isoform [H3BSJ9] alignment
Isoform [H3BRG4] alignment
Isoform [H3BP04] alignment
Isoform [A0A087WVZ4] alignment
LOADING 94%

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Biological process

Disease

No data found.

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