NDUAC_HUMAN
Evidence for PS localization
Functions
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NDUAC_HUMAN |
|---|---|---|---|---|
| GO:0015399 | primary active transmembrane transporter activity | 38.5542 | 4 | yes |
| GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 36.1446 | 5 | yes |
| GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | 28.9157 | 4 | yes |
| GO:0046872 | metal ion binding | 28.9157 | 4 | no |
| GO:0050136 | NADH dehydrogenase (quinone) activity | 27.7108 | 5 | yes |
| GO:0003954 | NADH dehydrogenase activity | 27.7108 | 4 | yes |
| GO:0003955 | NAD(P)H dehydrogenase (quinone) activity | 27.7108 | 5 | yes |
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity | 27.7108 | 4 | yes |
| GO:0003723 | RNA binding | 20.4819 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NDUAC_HUMAN |
|---|---|---|---|---|
| GO:0022607 | cellular component assembly | 42.1687 | 4 | yes |
| GO:0009060 | aerobic respiration | 39.7590 | 6 | no |
| GO:0015980 | energy derivation by oxidation of organic compounds | 39.7590 | 4 | no |
| GO:0045333 | cellular respiration | 39.7590 | 5 | no |
| GO:0022900 | electron transport chain | 38.5542 | 4 | yes |
| GO:0022904 | respiratory electron transport chain | 38.5542 | 5 | yes |
| GO:0019646 | aerobic electron transport chain | 36.1446 | 6 | no |
| GO:0043933 | protein-containing complex organization | 34.9398 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 33.7349 | 5 | yes |
| GO:0006996 | organelle organization | 27.7108 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 26.5060 | 4 | no |
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone | 25.3012 | 7 | no |
| GO:0033108 | mitochondrial respiratory chain complex assembly | 24.0964 | 6 | yes |
| GO:0031323 | regulation of cellular metabolic process | 22.8916 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 22.8916 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 22.8916 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 22.8916 | 4 | no |
| GO:0010257 | NADH dehydrogenase complex assembly | 21.6867 | 6 | yes |
| GO:0032981 | mitochondrial respiratory chain complex I assembly | 21.6867 | 7 | yes |
| GO:0051128 | regulation of cellular component organization | 20.4819 | 4 | no |
| GO:0042773 | ATP synthesis coupled electron transport | 6.0241 | 6 | yes |
| GO:0042775 | mitochondrial ATP synthesis coupled electron transport | 6.0241 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in NDUAC_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 3.6145 | 3 | no |
| DOID:700 | mitochondrial metabolism disease | 2.4096 | 3 | no |
| DOID:1289 | neurodegenerative disease | 2.4096 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NDUA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NDUA5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUS8_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUA7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUS2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUV3_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUA9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUV2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NDUS4_HUMAN | [view interactions] | Low throughput | no | yes |
| NDUS6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDUA6_HUMAN | [view interactions] | Low throughput | no | no |
| ACPM_HUMAN | [view interactions] | Low throughput | no | yes |
| HDBP1_HUMAN | [view interactions] | High throughput | no | no |
| WIF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DJC30_HUMAN | [view interactions] | High throughput | no | no |
| DRB1_HUMAN | [view interactions] | High throughput | no | no |
| NTNG1_HUMAN | [view interactions] | High throughput | no | no |
| EMP3_HUMAN | [view interactions] | High throughput | no | no |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| SURF1_HUMAN | [view interactions] | High throughput | no | yes |
| RM15_HUMAN | [view interactions] | High throughput | no | yes |
| ABCD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MPV17_HUMAN | [view interactions] | High throughput | no | no |
| ERLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
| CISD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| MPCP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| QCR7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPD_HUMAN | [view interactions] | High throughput | no | yes |
| AT5L2_HUMAN | [view interactions] | High throughput | no | no |
| ATP5L_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDH3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP5I_HUMAN | [view interactions] | High throughput | no | yes |
| COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTRFR_HUMAN | [view interactions] | High throughput | no | yes |
| CQ080_HUMAN | [view interactions] | High throughput | no | yes |
| C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| MRES1_HUMAN | [view interactions] | High throughput | no | yes |
| CH082_HUMAN | [view interactions] | High throughput | no | yes |
| MCUR1_HUMAN | [view interactions] | High throughput | no | no |
| CC90B_HUMAN | [view interactions] | High throughput | no | yes |
| CHCH1_HUMAN | [view interactions] | High throughput | no | yes |
| QOR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX28_HUMAN | [view interactions] | High throughput | no | yes |
| DHX30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD2_HUMAN | [view interactions] | High throughput | no | no |
| FAKD3_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD5_HUMAN | [view interactions] | High throughput | no | yes |
| EFGM_HUMAN | [view interactions] | High throughput | no | yes |
| RRF2M_HUMAN | [view interactions] | High throughput | no | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| ICT1_HUMAN | [view interactions] | High throughput | no | yes |
| LONM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCU_HUMAN | [view interactions] | High throughput | no | yes |
| MCUB_HUMAN | [view interactions] | High throughput | no | no |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET15_HUMAN | [view interactions] | High throughput | no | no |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| RM11_HUMAN | [view interactions] | High throughput | no | yes |
| RT12_HUMAN | [view interactions] | High throughput | no | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| RRFM_HUMAN | [view interactions] | High throughput | no | yes |
| MTEF3_HUMAN | [view interactions] | High throughput | no | no |
| MTG1_HUMAN | [view interactions] | High throughput | no | yes |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| NGRN_HUMAN | [view interactions] | High throughput | no | yes |
| OTC_HUMAN | [view interactions] | High throughput | no | no |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| MPPB_HUMAN | [view interactions] | High throughput | no | yes |
| RMND1_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD3_HUMAN | [view interactions] | High throughput | no | yes |
| RUSD4_HUMAN | [view interactions] | High throughput | no | yes |
| S2551_HUMAN | [view interactions] | High throughput | no | no |
| SLIRP_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| TEFM_HUMAN | [view interactions] | High throughput | no | no |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC15_HUMAN | [view interactions] | High throughput | no | no |
| TIM14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC28_HUMAN | [view interactions] | High throughput | no | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN768_HUMAN | [view interactions] | High throughput | no | yes |
| MIC27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUBB_HUMAN | [view interactions] | High throughput | no | yes |
| NU1M_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAB_HUMAN | [view interactions] | High throughput | no | no |
| NU5M_HUMAN | [view interactions] | High throughput | no | no |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB3_HUMAN | [view interactions] | High throughput | no | yes |
| MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB5_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX6C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS5_HUMAN | [view interactions] | High throughput | no | yes |
| CIA30_HUMAN | [view interactions] | High throughput | no | yes |
| TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF3_HUMAN | [view interactions] | High throughput | no | yes |
| C3AR_HUMAN | [view interactions] | High throughput | no | no |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDPD5_HUMAN | [view interactions] | High throughput | no | no |
| YBEY_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IL1R2_HUMAN | [view interactions] | High throughput | no | no |
| GALT6_HUMAN | [view interactions] | High throughput | no | yes |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNH2_HUMAN | [view interactions] | High throughput | no | no |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| SYT4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMED8_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDM2_HUMAN | [view interactions] | High throughput | no | yes |
| AKIP_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| OMA1_HUMAN | [view interactions] | High throughput | no | no |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| TRM1_HUMAN | [view interactions] | High throughput | no | yes |
| GP107_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| NDUC2_HUMAN | [view interactions] | High throughput | no | yes |
| CREL1_HUMAN | [view interactions] | High throughput | no | yes |
| S22A4_HUMAN | [view interactions] | High throughput | no | yes |
| TSH2_HUMAN | [view interactions] | High throughput | no | yes |
| CXA8_HUMAN | [view interactions] | High throughput | no | no |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| NDUA1_HUMAN | [view interactions] | High throughput | no | yes |
| DQB1_HUMAN | [view interactions] | High throughput | no | no |
| CP2J2_HUMAN | [view interactions] | High throughput | no | no |
| EXTL3_HUMAN | [view interactions] | High throughput | no | yes |
| NU4M_HUMAN | [view interactions] | Computational | no | yes |
| QCR10_HUMAN | [view interactions] | Computational | no | no |
| NDUF2_HUMAN | [view interactions] | Computational | no | yes |
| QCR9_HUMAN | [view interactions] | Computational | no | no |
| COA6_HUMAN | [view interactions] | Computational | no | yes |
| FXRD1_HUMAN | [view interactions] | Computational | no | no |
| QCR8_HUMAN | [view interactions] | Computational | no | yes |
| CX6A2_HUMAN | [view interactions] | Computational | no | no |
| CYB_HUMAN | [view interactions] | Computational | no | yes |
| NU6M_HUMAN | [view interactions] | Computational | no | no |
| NDUA3_HUMAN | [view interactions] | Computational | no | yes |
| ROMO1_HUMAN | [view interactions] | Computational | no | yes |
| MIC26_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NDUB2_HUMAN | [view interactions] | Computational | no | yes |
| COX42_HUMAN | [view interactions] | Computational | no | no |
| ATPMK_HUMAN | [view interactions] | Computational | no | no |
| CX6B2_HUMAN | [view interactions] | Computational | no | no |
| NDUF5_HUMAN | [view interactions] | Computational | no | yes |
| COX41_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NU2M_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ATPO_HUMAN | [view interactions] | Computational | no | yes |
| NU4LM_HUMAN | [view interactions] | Computational | no | no |
| MPC2_HUMAN | [view interactions] | Computational | no | yes |
| NDUCR_HUMAN | [view interactions] | Computational | no | yes |
| ATPK_HUMAN | [view interactions] | Computational | no | yes |
| COX5B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NU3M_HUMAN | [view interactions] | Computational | no | yes |
| AT5G3_HUMAN | [view interactions] | Computational | no | no |
| NDUC1_HUMAN | [view interactions] | Computational | no | yes |
| C560_HUMAN | [view interactions] | Computational | no | no |
| ATP5J_HUMAN | [view interactions] | Computational | no | yes |
| NDUB1_HUMAN | [view interactions] | Computational | no | yes |
| AT5F1_HUMAN | [view interactions] | Computational | no | yes |