CISD1_HUMAN
Evidence for PS localization
Functions
Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation . May be involved in Fe-S cluster shuttling and/or in redox reactions. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CISD1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 33.3333 | 4 | yes |
| GO:0000166 | nucleotide binding | 33.3333 | 4 | no |
| GO:0046872 | metal ion binding | 30.3030 | 5 | yes |
| GO:0043168 | anion binding | 28.7879 | 4 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 28.7879 | 4 | no |
| GO:0015078 | proton transmembrane transporter activity | 28.7879 | 5 | no |
| GO:0015399 | primary active transmembrane transporter activity | 28.7879 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 28.7879 | 4 | no |
| GO:0017076 | purine nucleotide binding | 28.7879 | 5 | no |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 27.2727 | 4 | no |
| GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 25.7576 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 22.7273 | 4 | no |
| GO:0019001 | guanyl nucleotide binding | 21.2121 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 21.2121 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.2121 | 4 | no |
| GO:0051536 | iron-sulfur cluster binding | 12.1212 | 4 | yes |
| GO:0051537 | 2 iron, 2 sulfur cluster binding | 6.0606 | 5 | yes |
| GO:0042803 | protein homodimerization activity | 4.5455 | 4 | yes |
| GO:0008483 | transaminase activity | 3.0303 | 4 | yes |
| GO:0030170 | pyridoxal phosphate binding | 3.0303 | 4 | yes |
| GO:0047801 | L-cysteine transaminase activity | 3.0303 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CISD1_HUMAN |
|---|---|---|---|---|
| GO:0022607 | cellular component assembly | 42.4242 | 4 | no |
| GO:0006996 | organelle organization | 40.9091 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 31.8182 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 30.3030 | 4 | no |
| GO:0009060 | aerobic respiration | 27.2727 | 6 | no |
| GO:0015980 | energy derivation by oxidation of organic compounds | 27.2727 | 4 | no |
| GO:0022900 | electron transport chain | 27.2727 | 4 | no |
| GO:0022904 | respiratory electron transport chain | 27.2727 | 5 | no |
| GO:0045333 | cellular respiration | 27.2727 | 5 | no |
| GO:0043933 | protein-containing complex organization | 27.2727 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 27.2727 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.7576 | 4 | yes |
| GO:0019646 | aerobic electron transport chain | 25.7576 | 6 | no |
| GO:0033043 | regulation of organelle organization | 25.7576 | 5 | no |
| GO:0061024 | membrane organization | 25.7576 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 24.2424 | 4 | no |
| GO:0006163 | purine nucleotide metabolic process | 24.2424 | 5 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 24.2424 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 24.2424 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 24.2424 | 5 | no |
| GO:0072521 | purine-containing compound metabolic process | 24.2424 | 4 | no |
| GO:0008104 | protein localization | 22.7273 | 4 | no |
| GO:0010646 | regulation of cell communication | 22.7273 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.7273 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.7273 | 4 | no |
| GO:0009150 | purine ribonucleotide metabolic process | 22.7273 | 6 | no |
| GO:0009259 | ribonucleotide metabolic process | 22.7273 | 5 | no |
| GO:0019693 | ribose phosphate metabolic process | 22.7273 | 4 | no |
| GO:0071702 | organic substance transport | 22.7273 | 4 | no |
| GO:0007005 | mitochondrion organization | 21.2121 | 5 | no |
| GO:0009966 | regulation of signal transduction | 21.2121 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 21.2121 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 21.2121 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 21.2121 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.2121 | 4 | no |
| GO:0009894 | regulation of catabolic process | 13.6364 | 4 | yes |
| GO:0010506 | regulation of autophagy | 10.6061 | 6 | yes |
| GO:0031329 | regulation of cellular catabolic process | 10.6061 | 5 | yes |
| GO:0043467 | regulation of generation of precursor metabolites and energy | 6.0606 | 5 | yes |
| GO:0043457 | regulation of cellular respiration | 4.5455 | 6 | yes |
| GO:0051604 | protein maturation | 3.0303 | 4 | yes |
| GO:0097428 | protein maturation by iron-sulfur cluster transfer | 3.0303 | 5 | yes |
| GO:0106034 | protein maturation by [2Fe-2S] cluster transfer | 3.0303 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CISD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| IT70B_HUMAN | [view interactions] | High throughput | no | no |
| NR4A2_HUMAN | [view interactions] | High throughput | no | yes |
| TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNRPA_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| CISD2_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
| WIPI4_HUMAN | [view interactions] | High throughput | no | no |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| PDE2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRRAP_HUMAN | [view interactions] | High throughput | no | no |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| RN207_HUMAN | [view interactions] | High throughput | no | no |
| MTX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM7_HUMAN | [view interactions] | High throughput | no | no |
| RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| ANX11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD7_HUMAN | [view interactions] | High throughput | no | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| TECR_HUMAN | [view interactions] | High throughput | no | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| TSPO_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5I_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5J_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS5_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDH3G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDH3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ISCA1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA6_HUMAN | [view interactions] | High throughput | no | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAVS_HUMAN | [view interactions] | High throughput | no | yes |
| MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |