CISD1_HUMAN
Evidence for PS localization
Functions
Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation . May be involved in Fe-S cluster shuttling and/or in redox reactions. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CISD1_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 31.7460 | 4 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 30.1587 | 4 | no |
| GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 26.9841 | 5 | no |
| GO:0017076 | purine nucleotide binding | 22.2222 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 22.2222 | 4 | no |
| GO:0003954 | NADH dehydrogenase activity | 22.2222 | 4 | no |
| GO:0019001 | guanyl nucleotide binding | 20.6349 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 20.6349 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.6349 | 4 | no |
| GO:0003955 | NAD(P)H dehydrogenase (quinone) activity | 20.6349 | 5 | no |
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity | 20.6349 | 4 | no |
| GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | 20.6349 | 4 | no |
| GO:0050136 | NADH dehydrogenase (quinone) activity | 20.6349 | 5 | no |
| GO:0051537 | 2 iron, 2 sulfur cluster binding | 6.3492 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CISD1_HUMAN |
|---|---|---|---|---|
| GO:0022607 | cellular component assembly | 44.4444 | 4 | no |
| GO:0006996 | organelle organization | 34.9206 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 33.3333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 31.7460 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 28.5714 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 26.9841 | 5 | no |
| GO:0043933 | protein-containing complex organization | 26.9841 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 26.9841 | 5 | no |
| GO:0009060 | aerobic respiration | 26.9841 | 6 | no |
| GO:0015980 | energy derivation by oxidation of organic compounds | 26.9841 | 4 | no |
| GO:0022900 | electron transport chain | 26.9841 | 4 | no |
| GO:0022904 | respiratory electron transport chain | 26.9841 | 5 | no |
| GO:0045333 | cellular respiration | 26.9841 | 5 | no |
| GO:0019646 | aerobic electron transport chain | 25.3968 | 6 | no |
| GO:0048523 | negative regulation of cellular process | 23.8095 | 4 | no |
| GO:0010941 | regulation of cell death | 23.8095 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 23.8095 | 5 | no |
| GO:0061024 | membrane organization | 23.8095 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 22.2222 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 22.2222 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 22.2222 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.2222 | 6 | no |
| GO:0071702 | organic substance transport | 20.6349 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 20.6349 | 4 | no |
| GO:0009966 | regulation of signal transduction | 20.6349 | 4 | no |
| GO:0010646 | regulation of cell communication | 20.6349 | 4 | no |
| GO:0033108 | mitochondrial respiratory chain complex assembly | 20.6349 | 6 | no |
| GO:0009894 | regulation of catabolic process | 12.6984 | 4 | yes |
| GO:0031329 | regulation of cellular catabolic process | 11.1111 | 5 | yes |
| GO:0010506 | regulation of autophagy | 9.5238 | 6 | yes |
| GO:0043467 | regulation of generation of precursor metabolites and energy | 6.3492 | 5 | yes |
| GO:0043457 | regulation of cellular respiration | 4.7619 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in CISD1_HUMAN |
|---|---|---|---|---|
| DOID:574 | peripheral nervous system disease | 4.7619 | 3 | no |
| DOID:870 | neuropathy | 4.7619 | 4 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 3.1746 | 6 | no |
| DOID:440 | neuromuscular disease | 3.1746 | 5 | no |
| DOID:700 | mitochondrial metabolism disease | 3.1746 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CISD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5I_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5J_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACPM_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS5_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDH3G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDH3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ISCA1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA6_HUMAN | [view interactions] | High throughput | no | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| EXD2_HUMAN | [view interactions] | High throughput | no | yes |
| FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAVS_HUMAN | [view interactions] | High throughput | no | yes |
| MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD3_HUMAN | [view interactions] | High throughput | no | yes |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMES1_HUMAN | [view interactions] | High throughput | no | no |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPM1_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB2_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| TT30B_HUMAN | [view interactions] | High throughput | no | no |
| NR4A2_HUMAN | [view interactions] | High throughput | no | yes |
| TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNRPA_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| CISD2_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
| WIPI4_HUMAN | [view interactions] | High throughput | no | no |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| PDE2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM7_HUMAN | [view interactions] | High throughput | no | no |
| RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| ANX11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD7_HUMAN | [view interactions] | High throughput | no | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| TECR_HUMAN | [view interactions] | High throughput | no | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| TSPO_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPIN1_HUMAN | [view interactions] | Computational | no | no |
| CISD3_HUMAN | [view interactions] | Computational | no | yes |