TOM20_HUMAN
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore . Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in TOM20_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 31.1688 | 4 | no |
GO:0000166 | nucleotide binding | 29.8701 | 4 | no |
GO:0017076 | purine nucleotide binding | 28.5714 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 27.2727 | 4 | no |
GO:0043169 | cation binding | 25.9740 | 4 | no |
GO:0046872 | metal ion binding | 23.3766 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 22.0779 | 4 | no |
GO:0015399 | primary active transmembrane transporter activity | 5.1948 | 4 | yes |
GO:0030943 | mitochondrion targeting sequence binding | 2.5974 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in TOM20_HUMAN |
---|---|---|---|---|
GO:0006996 | organelle organization | 48.0519 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 40.2597 | 4 | no |
GO:0048522 | positive regulation of cellular process | 40.2597 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 40.2597 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 38.9610 | 4 | no |
GO:0048523 | negative regulation of cellular process | 37.6623 | 4 | no |
GO:0010646 | regulation of cell communication | 36.3636 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 33.7662 | 4 | no |
GO:0051128 | regulation of cellular component organization | 33.7662 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 32.4675 | 5 | no |
GO:0008104 | protein localization | 31.1688 | 4 | yes |
GO:0022607 | cellular component assembly | 31.1688 | 4 | no |
GO:0009966 | regulation of signal transduction | 29.8701 | 4 | no |
GO:0009894 | regulation of catabolic process | 28.5714 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 27.2727 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 27.2727 | 5 | no |
GO:0033043 | regulation of organelle organization | 27.2727 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 25.9740 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 25.9740 | 5 | no |
GO:0071702 | organic substance transport | 24.6753 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 24.6753 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 24.6753 | 6 | no |
GO:0007005 | mitochondrion organization | 23.3766 | 5 | yes |
GO:0010468 | regulation of gene expression | 23.3766 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 23.3766 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 23.3766 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 23.3766 | 5 | no |
GO:0071705 | nitrogen compound transport | 22.0779 | 4 | yes |
GO:0019220 | regulation of phosphate metabolic process | 22.0779 | 6 | no |
GO:0031399 | regulation of protein modification process | 22.0779 | 6 | no |
GO:0042981 | regulation of apoptotic process | 22.0779 | 5 | no |
GO:0043067 | regulation of programmed cell death | 22.0779 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 22.0779 | 5 | no |
GO:0061024 | membrane organization | 20.7792 | 4 | yes |
GO:0042325 | regulation of phosphorylation | 20.7792 | 7 | no |
GO:0043933 | protein-containing complex organization | 20.7792 | 4 | no |
GO:0051248 | negative regulation of protein metabolic process | 20.7792 | 6 | no |
GO:0033365 | protein localization to organelle | 19.4805 | 5 | yes |
GO:0007006 | mitochondrial membrane organization | 14.2857 | 5 | yes |
GO:0015031 | protein transport | 14.2857 | 4 | yes |
GO:0006839 | mitochondrial transport | 11.6883 | 4 | yes |
GO:0070585 | protein localization to mitochondrion | 11.6883 | 6 | yes |
GO:0072594 | establishment of protein localization to organelle | 10.3896 | 4 | yes |
GO:0006605 | protein targeting | 9.0909 | 4 | yes |
GO:0006886 | intracellular protein transport | 9.0909 | 4 | yes |
GO:0072657 | protein localization to membrane | 9.0909 | 4 | yes |
GO:0072655 | establishment of protein localization to mitochondrion | 6.4935 | 5 | yes |
GO:0090150 | establishment of protein localization to membrane | 6.4935 | 4 | yes |
GO:0170036 | import into the mitochondrion | 6.4935 | 4 | yes |
GO:0006626 | protein targeting to mitochondrion | 5.1948 | 5 | yes |
GO:0015931 | nucleobase-containing compound transport | 5.1948 | 5 | yes |
GO:0007008 | outer mitochondrial membrane organization | 2.5974 | 6 | yes |
GO:0016031 | tRNA import into mitochondrion | 2.5974 | 6 | yes |
GO:0030150 | protein import into mitochondrial matrix | 2.5974 | 5 | yes |
GO:0035927 | RNA import into mitochondrion | 2.5974 | 5 | yes |
GO:0044743 | protein transmembrane import into intracellular organelle | 2.5974 | 4 | yes |
GO:0045040 | protein insertion into mitochondrial outer membrane | 2.5974 | 5 | yes |
GO:0050657 | nucleic acid transport | 2.5974 | 6 | yes |
GO:0050658 | RNA transport | 2.5974 | 4 | yes |
GO:0051031 | tRNA transport | 2.5974 | 5 | yes |
GO:0090151 | establishment of protein localization to mitochondrial membrane | 2.5974 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
PINK1_HUMAN | [view interactions] | Low throughput | no | yes |
R144B_HUMAN | [view interactions] | Low throughput | no | yes |
BAX_HUMAN | [view interactions] | Low throughput | no | yes |
MID49_HUMAN | [view interactions] | Low throughput | no | yes |
BAG6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DYL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CALX_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MID51_HUMAN | [view interactions] | Low throughput | no | no |
UBP30_HUMAN | [view interactions] | Low throughput | no | yes |
TOM22_HUMAN | [view interactions] | Low throughput | no | yes |
TOM40_HUMAN | [view interactions] | Low throughput | no | yes |
BIRC2_HUMAN | [view interactions] | Low throughput | no | yes |
KPCE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FBX7_HUMAN | [view interactions] | Low throughput | no | yes |
TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
OTUD1_HUMAN | [view interactions] | Low throughput | no | yes |
DPOG1_HUMAN | [view interactions] | Low throughput | no | yes |
VDAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
OTC_HUMAN | [view interactions] | Low throughput | no | no |
UCP1_HUMAN | [view interactions] | Low throughput | no | no |
BCL2_HUMAN | [view interactions] | Low throughput | no | no |
SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
HCD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MLP3B_HUMAN | [view interactions] | Low throughput | no | yes |
TF65_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ALDH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
AIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CGL_HUMAN | [view interactions] | Low throughput | no | yes |
CE126_HUMAN | [view interactions] | High throughput | no | no |
PTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FEZ1_HUMAN | [view interactions] | High throughput | no | no |
HAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
APOA1_HUMAN | [view interactions] | High throughput | no | no |
PPHLN_HUMAN | [view interactions] | High throughput | no | yes |
CDC73_HUMAN | [view interactions] | High throughput | no | yes |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
CRBG3_HUMAN | [view interactions] | High throughput | no | no |
SCYL2_HUMAN | [view interactions] | High throughput | no | yes |
MTFR2_HUMAN | [view interactions] | High throughput | no | no |
C1TM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SAS6_HUMAN | [view interactions] | High throughput | no | no |
LARP4_HUMAN | [view interactions] | High throughput | no | yes |
ZCCHV_HUMAN | [view interactions] | High throughput | no | yes |
MAVS_HUMAN | [view interactions] | High throughput | no | yes |
PRSR1_HUMAN | [view interactions] | High throughput | no | yes |
TEX2_HUMAN | [view interactions] | High throughput | no | yes |
MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUP93_HUMAN | [view interactions] | High throughput | no | yes |
PLD6_HUMAN | [view interactions] | High throughput | no | yes |
MIGA1_HUMAN | [view interactions] | High throughput | no | yes |
EHBP1_HUMAN | [view interactions] | High throughput | no | yes |
TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
SMCR8_HUMAN | [view interactions] | High throughput | no | yes |
NU133_HUMAN | [view interactions] | High throughput | no | yes |
SMG7_HUMAN | [view interactions] | High throughput | no | no |
TM131_HUMAN | [view interactions] | High throughput | no | yes |
UBXN4_HUMAN | [view interactions] | High throughput | no | yes |
NU205_HUMAN | [view interactions] | High throughput | no | no |
AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MARC2_HUMAN | [view interactions] | High throughput | no | no |
SYAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CI072_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RMD2_HUMAN | [view interactions] | High throughput | no | yes |
VP13A_HUMAN | [view interactions] | High throughput | no | yes |
RMD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TTC1_HUMAN | [view interactions] | High throughput | no | yes |
CDCA3_HUMAN | [view interactions] | High throughput | no | no |
GPTC1_HUMAN | [view interactions] | High throughput | no | yes |
B2L13_HUMAN | [view interactions] | High throughput | no | no |
K1671_HUMAN | [view interactions] | High throughput | no | yes |
MFF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LSG1_HUMAN | [view interactions] | High throughput | no | yes |
GCP60_HUMAN | [view interactions] | High throughput | no | yes |
CA198_HUMAN | [view interactions] | High throughput | no | yes |
PEAK1_HUMAN | [view interactions] | High throughput | no | yes |
AGO3_HUMAN | [view interactions] | High throughput | no | yes |
WDR41_HUMAN | [view interactions] | High throughput | no | yes |
TNR6C_HUMAN | [view interactions] | High throughput | no | no |
CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
4ET_HUMAN | [view interactions] | High throughput | no | yes |
SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EXD2_HUMAN | [view interactions] | High throughput | no | yes |
MIC19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CISD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARMX3_HUMAN | [view interactions] | High throughput | no | no |
CDC23_HUMAN | [view interactions] | High throughput | no | yes |
AGO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SUFU_HUMAN | [view interactions] | High throughput | no | yes |
TNR6B_HUMAN | [view interactions] | High throughput | no | yes |
TRAK1_HUMAN | [view interactions] | High throughput | no | yes |
TDRKH_HUMAN | [view interactions] | High throughput | no | no |
AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOM70_HUMAN | [view interactions] | High throughput | no | yes |
AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
NUD19_HUMAN | [view interactions] | High throughput | no | no |
DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
DVL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TPP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
YKT6_HUMAN | [view interactions] | High throughput | no | yes |
CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
M3K7_HUMAN | [view interactions] | High throughput | no | yes |
PEX14_HUMAN | [view interactions] | High throughput | no | yes |
TACC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCO1_HUMAN | [view interactions] | High throughput | no | yes |
ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TACC2_HUMAN | [view interactions] | High throughput | no | yes |
SNP29_HUMAN | [view interactions] | High throughput | no | yes |
GLI3_HUMAN | [view interactions] | High throughput | no | yes |
ETFA_HUMAN | [view interactions] | High throughput | no | yes |
KAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATP5J_HUMAN | [view interactions] | High throughput | no | yes |
HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IF2B_HUMAN | [view interactions] | High throughput | no | yes |
APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ABCD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KAP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLPK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TTK_HUMAN | [view interactions] | High throughput | no | yes |
ATPG_HUMAN | [view interactions] | High throughput | no | yes |
PEX19_HUMAN | [view interactions] | High throughput | no | yes |
ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPO_HUMAN | [view interactions] | High throughput | no | yes |
PEX5_HUMAN | [view interactions] | High throughput | no | yes |
AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HXK2_HUMAN | [view interactions] | High throughput | no | yes |
NUP98_HUMAN | [view interactions] | High throughput | no | no |
NU107_HUMAN | [view interactions] | High throughput | no | no |
DYST_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GOGA3_HUMAN | [view interactions] | High throughput | no | yes |
NU160_HUMAN | [view interactions] | High throughput | no | no |
ABR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECH1_HUMAN | [view interactions] | High throughput | no | yes |
NDK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTFR1_HUMAN | [view interactions] | High throughput | no | yes |
TAB1_HUMAN | [view interactions] | High throughput | no | yes |
PCKGM_HUMAN | [view interactions] | High throughput | no | no |
MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TGO1_HUMAN | [view interactions] | High throughput | no | yes |
SNP47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FA83B_HUMAN | [view interactions] | High throughput | no | no |
ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATPF1_HUMAN | [view interactions] | High throughput | no | yes |
SE1L2_HUMAN | [view interactions] | High throughput | no | no |
VP13D_HUMAN | [view interactions] | High throughput | no | no |
IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
UBP40_HUMAN | [view interactions] | High throughput | no | yes |
ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SARM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MOV10_HUMAN | [view interactions] | High throughput | no | no |
NXF1_HUMAN | [view interactions] | High throughput | no | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FXRD1_HUMAN | [view interactions] | High throughput | no | no |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DTX1_HUMAN | [view interactions] | High throughput | no | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
MARH5_HUMAN | [view interactions] | High throughput | no | no |
RIGI_HUMAN | [view interactions] | High throughput | no | yes |
UFL1_HUMAN | [view interactions] | High throughput | no | yes |
DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
F107A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CUL2_HUMAN | [view interactions] | High throughput | no | yes |
FEM1B_HUMAN | [view interactions] | High throughput | no | yes |
SEC63_HUMAN | [view interactions] | High throughput | no | yes |
BPHL_HUMAN | [view interactions] | High throughput | no | no |
H2A2B_HUMAN | [view interactions] | High throughput | no | yes |
H2AY_HUMAN | [view interactions] | High throughput | no | yes |
H33_HUMAN | [view interactions] | High throughput | no | yes |
SP16H_HUMAN | [view interactions] | High throughput | no | yes |
UTP18_HUMAN | [view interactions] | High throughput | no | yes |
H2A2C_HUMAN | [view interactions] | High throughput | no | yes |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
CCNF_HUMAN | [view interactions] | High throughput | no | no |
TM192_HUMAN | [view interactions] | High throughput | no | yes |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYCN_HUMAN | [view interactions] | High throughput | no | no |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
RIT1_HUMAN | [view interactions] | High throughput | no | yes |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
S25A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SFXN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MRP2_HUMAN | [view interactions] | High throughput | no | no |
TI17B_HUMAN | [view interactions] | High throughput | no | no |
SRSF1_HUMAN | [view interactions] | High throughput | no | yes |
NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
OPTN_HUMAN | [view interactions] | High throughput | no | yes |
MK14_HUMAN | [view interactions] | High throughput | no | yes |
STING_HUMAN | [view interactions] | High throughput | no | yes |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
RFA4_HUMAN | [view interactions] | High throughput | no | yes |
MK06_HUMAN | [view interactions] | High throughput | no | yes |
NU155_HUMAN | [view interactions] | High throughput | no | yes |
NICA_HUMAN | [view interactions] | High throughput | no | yes |
PSB5_HUMAN | [view interactions] | High throughput | no | yes |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
ARP5_HUMAN | [view interactions] | High throughput | no | yes |
PML_HUMAN | [view interactions] | High throughput | no | yes |
OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
SYJ2B_HUMAN | [view interactions] | High throughput | no | no |
H15_HUMAN | [view interactions] | High throughput | no | no |
NFXL1_HUMAN | [view interactions] | High throughput | no | yes |
TOM7_HUMAN | [view interactions] | High throughput | no | no |
SYP2L_HUMAN | [view interactions] | High throughput | no | no |
PABP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FAF2_HUMAN | [view interactions] | High throughput | no | yes |
JUN_HUMAN | [view interactions] | High throughput | no | yes |