Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TOM20_HUMAN

Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore . Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases. [View more on UniProt]

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No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in TOM20_HUMAN
GO:0043168 anion binding 31.1688 4 no
GO:0000166 nucleotide binding 29.8701 4 no
GO:0017076 purine nucleotide binding 28.5714 5 no
GO:0032555 purine ribonucleotide binding 27.2727 4 no
GO:0043169 cation binding 25.9740 4 no
GO:0046872 metal ion binding 23.3766 5 no
GO:0035639 purine ribonucleoside triphosphate binding 22.0779 4 no
GO:0015399 primary active transmembrane transporter activity 5.1948 4 yes
GO:0030943 mitochondrion targeting sequence binding 2.5974 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TOM20_HUMAN
GO:0006996 organelle organization 48.0519 4 yes
GO:0080090 regulation of primary metabolic process 40.2597 4 no
GO:0048522 positive regulation of cellular process 40.2597 4 no
GO:0060255 regulation of macromolecule metabolic process 40.2597 4 no
GO:0031323 regulation of cellular metabolic process 38.9610 4 no
GO:0048523 negative regulation of cellular process 37.6623 4 no
GO:0010646 regulation of cell communication 36.3636 4 no
GO:0009893 positive regulation of metabolic process 33.7662 4 no
GO:0051128 regulation of cellular component organization 33.7662 4 no
GO:0051246 regulation of protein metabolic process 32.4675 5 no
GO:0008104 protein localization 31.1688 4 yes
GO:0022607 cellular component assembly 31.1688 4 no
GO:0009966 regulation of signal transduction 29.8701 4 no
GO:0009894 regulation of catabolic process 28.5714 4 no
GO:0009892 negative regulation of metabolic process 27.2727 4 no
GO:0010604 positive regulation of macromolecule metabolic process 27.2727 5 no
GO:0033043 regulation of organelle organization 27.2727 5 no
GO:0009889 regulation of biosynthetic process 25.9740 4 no
GO:0031325 positive regulation of cellular metabolic process 25.9740 5 no
GO:0071702 organic substance transport 24.6753 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 24.6753 5 no
GO:0051247 positive regulation of protein metabolic process 24.6753 6 no
GO:0007005 mitochondrion organization 23.3766 5 yes
GO:0010468 regulation of gene expression 23.3766 6 no
GO:0010556 regulation of macromolecule biosynthetic process 23.3766 5 no
GO:0031324 negative regulation of cellular metabolic process 23.3766 5 no
GO:0031326 regulation of cellular biosynthetic process 23.3766 5 no
GO:0071705 nitrogen compound transport 22.0779 4 yes
GO:0019220 regulation of phosphate metabolic process 22.0779 6 no
GO:0031399 regulation of protein modification process 22.0779 6 no
GO:0042981 regulation of apoptotic process 22.0779 5 no
GO:0043067 regulation of programmed cell death 22.0779 4 no
GO:0051174 regulation of phosphorus metabolic process 22.0779 5 no
GO:0061024 membrane organization 20.7792 4 yes
GO:0042325 regulation of phosphorylation 20.7792 7 no
GO:0043933 protein-containing complex organization 20.7792 4 no
GO:0051248 negative regulation of protein metabolic process 20.7792 6 no
GO:0033365 protein localization to organelle 19.4805 5 yes
GO:0007006 mitochondrial membrane organization 14.2857 5 yes
GO:0015031 protein transport 14.2857 4 yes
GO:0006839 mitochondrial transport 11.6883 4 yes
GO:0070585 protein localization to mitochondrion 11.6883 6 yes
GO:0072594 establishment of protein localization to organelle 10.3896 4 yes
GO:0006605 protein targeting 9.0909 4 yes
GO:0006886 intracellular protein transport 9.0909 4 yes
GO:0072657 protein localization to membrane 9.0909 4 yes
GO:0072655 establishment of protein localization to mitochondrion 6.4935 5 yes
GO:0090150 establishment of protein localization to membrane 6.4935 4 yes
GO:0170036 import into the mitochondrion 6.4935 4 yes
GO:0006626 protein targeting to mitochondrion 5.1948 5 yes
GO:0015931 nucleobase-containing compound transport 5.1948 5 yes
GO:0007008 outer mitochondrial membrane organization 2.5974 6 yes
GO:0016031 tRNA import into mitochondrion 2.5974 6 yes
GO:0030150 protein import into mitochondrial matrix 2.5974 5 yes
GO:0035927 RNA import into mitochondrion 2.5974 5 yes
GO:0044743 protein transmembrane import into intracellular organelle 2.5974 4 yes
GO:0045040 protein insertion into mitochondrial outer membrane 2.5974 5 yes
GO:0050657 nucleic acid transport 2.5974 6 yes
GO:0050658 RNA transport 2.5974 4 yes
GO:0051031 tRNA transport 2.5974 5 yes
GO:0090151 establishment of protein localization to mitochondrial membrane 2.5974 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PINK1_HUMAN [view interactions] Low throughput no yes
R144B_HUMAN [view interactions] Low throughput no yes
BAX_HUMAN [view interactions] Low throughput no yes
MID49_HUMAN [view interactions] Low throughput no yes
BAG6_HUMAN [view entry] [view interactions] Low throughput yes yes
DYL1_HUMAN [view entry] [view interactions] Low throughput yes no
CALX_HUMAN [view entry] [view interactions] Low throughput yes yes
MID51_HUMAN [view interactions] Low throughput no no
UBP30_HUMAN [view interactions] Low throughput no yes
TOM22_HUMAN [view interactions] Low throughput no yes
TOM40_HUMAN [view interactions] Low throughput no yes
BIRC2_HUMAN [view interactions] Low throughput no yes
KPCE_HUMAN [view entry] [view interactions] Low throughput yes yes
FBX7_HUMAN [view interactions] Low throughput no yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
OTUD1_HUMAN [view interactions] Low throughput no yes
DPOG1_HUMAN [view interactions] Low throughput no yes
VDAC1_HUMAN [view entry] [view interactions] Low throughput yes yes
OTC_HUMAN [view interactions] Low throughput no no
UCP1_HUMAN [view interactions] Low throughput no no
BCL2_HUMAN [view interactions] Low throughput no no
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
HCD2_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
MLP3B_HUMAN [view interactions] Low throughput no yes
TF65_HUMAN [view entry] [view interactions] Low throughput yes yes
ALDH2_HUMAN [view entry] [view interactions] Low throughput yes no
AIP_HUMAN [view entry] [view interactions] Low throughput yes yes
CGL_HUMAN [view interactions] Low throughput no yes
CE126_HUMAN [view interactions] High throughput no no
PTN_HUMAN [view entry] [view interactions] High throughput yes yes
FEZ1_HUMAN [view interactions] High throughput no no
HAP1_HUMAN [view entry] [view interactions] High throughput yes yes
APOA1_HUMAN [view interactions] High throughput no no
PPHLN_HUMAN [view interactions] High throughput no yes
CDC73_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
CRBG3_HUMAN [view interactions] High throughput no no
SCYL2_HUMAN [view interactions] High throughput no yes
MTFR2_HUMAN [view interactions] High throughput no no
C1TM_HUMAN [view entry] [view interactions] High throughput yes yes
SAS6_HUMAN [view interactions] High throughput no no
LARP4_HUMAN [view interactions] High throughput no yes
ZCCHV_HUMAN [view interactions] High throughput no yes
MAVS_HUMAN [view interactions] High throughput no yes
PRSR1_HUMAN [view interactions] High throughput no yes
TEX2_HUMAN [view interactions] High throughput no yes
MIRO2_HUMAN [view entry] [view interactions] High throughput yes yes
NUP93_HUMAN [view interactions] High throughput no yes
PLD6_HUMAN [view interactions] High throughput no yes
MIGA1_HUMAN [view interactions] High throughput no yes
EHBP1_HUMAN [view interactions] High throughput no yes
TNR6A_HUMAN [view interactions] High throughput no yes
SMCR8_HUMAN [view interactions] High throughput no yes
NU133_HUMAN [view interactions] High throughput no yes
SMG7_HUMAN [view interactions] High throughput no no
TM131_HUMAN [view interactions] High throughput no yes
UBXN4_HUMAN [view interactions] High throughput no yes
NU205_HUMAN [view interactions] High throughput no no
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
MARC2_HUMAN [view interactions] High throughput no no
SYAP1_HUMAN [view entry] [view interactions] High throughput yes yes
CI072_HUMAN [view entry] [view interactions] High throughput yes no
RMD2_HUMAN [view interactions] High throughput no yes
VP13A_HUMAN [view interactions] High throughput no yes
RMD3_HUMAN [view entry] [view interactions] High throughput yes yes
TTC1_HUMAN [view interactions] High throughput no yes
CDCA3_HUMAN [view interactions] High throughput no no
GPTC1_HUMAN [view interactions] High throughput no yes
B2L13_HUMAN [view interactions] High throughput no no
K1671_HUMAN [view interactions] High throughput no yes
MFF_HUMAN [view entry] [view interactions] High throughput yes yes
LSG1_HUMAN [view interactions] High throughput no yes
GCP60_HUMAN [view interactions] High throughput no yes
CA198_HUMAN [view interactions] High throughput no yes
PEAK1_HUMAN [view interactions] High throughput no yes
AGO3_HUMAN [view interactions] High throughput no yes
WDR41_HUMAN [view interactions] High throughput no yes
TNR6C_HUMAN [view interactions] High throughput no no
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
4ET_HUMAN [view interactions] High throughput no yes
SYIM_HUMAN [view entry] [view interactions] High throughput yes yes
EXD2_HUMAN [view interactions] High throughput no yes
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
CISD1_HUMAN [view entry] [view interactions] High throughput yes yes
ARMX3_HUMAN [view interactions] High throughput no no
CDC23_HUMAN [view interactions] High throughput no yes
AGO2_HUMAN [view entry] [view interactions] High throughput yes yes
SUFU_HUMAN [view interactions] High throughput no yes
TNR6B_HUMAN [view interactions] High throughput no yes
TRAK1_HUMAN [view interactions] High throughput no yes
TDRKH_HUMAN [view interactions] High throughput no no
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
TOM70_HUMAN [view interactions] High throughput no yes
AT5F1_HUMAN [view interactions] High throughput no yes
NUD19_HUMAN [view interactions] High throughput no no
DNM1L_HUMAN [view entry] [view interactions] High throughput yes yes
P3C2A_HUMAN [view interactions] High throughput no yes
DVL1_HUMAN [view entry] [view interactions] High throughput yes yes
TPP1_HUMAN [view entry] [view interactions] High throughput yes yes
YKT6_HUMAN [view interactions] High throughput no yes
CYB5B_HUMAN [view entry] [view interactions] High throughput yes yes
M3K7_HUMAN [view interactions] High throughput no yes
PEX14_HUMAN [view interactions] High throughput no yes
TACC1_HUMAN [view entry] [view interactions] High throughput yes yes
SCO1_HUMAN [view interactions] High throughput no yes
ATP5H_HUMAN [view interactions] High throughput no yes
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
TACC2_HUMAN [view interactions] High throughput no yes
SNP29_HUMAN [view interactions] High throughput no yes
GLI3_HUMAN [view interactions] High throughput no yes
ETFA_HUMAN [view interactions] High throughput no yes
KAP2_HUMAN [view entry] [view interactions] High throughput yes yes
PTN1_HUMAN [view entry] [view interactions] High throughput yes yes
ATP5J_HUMAN [view interactions] High throughput no yes
HXK1_HUMAN [view entry] [view interactions] High throughput yes yes
IF2B_HUMAN [view interactions] High throughput no yes
APC_HUMAN [view entry] [view interactions] High throughput yes no
ABCD3_HUMAN [view entry] [view interactions] High throughput yes yes
KAP3_HUMAN [view entry] [view interactions] High throughput yes yes
GLPK_HUMAN [view entry] [view interactions] High throughput yes no
TTK_HUMAN [view interactions] High throughput no yes
ATPG_HUMAN [view interactions] High throughput no yes
PEX19_HUMAN [view interactions] High throughput no yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
NSF_HUMAN [view entry] [view interactions] High throughput yes yes
ATPO_HUMAN [view interactions] High throughput no yes
PEX5_HUMAN [view interactions] High throughput no yes
AL3A2_HUMAN [view entry] [view interactions] High throughput yes yes
HXK2_HUMAN [view interactions] High throughput no yes
NUP98_HUMAN [view interactions] High throughput no no
NU107_HUMAN [view interactions] High throughput no no
DYST_HUMAN [view entry] [view interactions] High throughput yes yes
GOGA3_HUMAN [view interactions] High throughput no yes
NU160_HUMAN [view interactions] High throughput no no
ABR_HUMAN [view entry] [view interactions] High throughput yes yes
ECH1_HUMAN [view interactions] High throughput no yes
NDK3_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
TOM20_HUMAN [view entry] [view interactions] High throughput yes yes
MTFR1_HUMAN [view interactions] High throughput no yes
TAB1_HUMAN [view interactions] High throughput no yes
PCKGM_HUMAN [view interactions] High throughput no no
MIC60_HUMAN [view entry] [view interactions] High throughput yes yes
INF2_HUMAN [view entry] [view interactions] High throughput yes yes
TGO1_HUMAN [view interactions] High throughput no yes
SNP47_HUMAN [view entry] [view interactions] High throughput yes yes
FA83B_HUMAN [view interactions] High throughput no no
ACBD5_HUMAN [view entry] [view interactions] High throughput yes yes
ATPF1_HUMAN [view interactions] High throughput no yes
SE1L2_HUMAN [view interactions] High throughput no no
VP13D_HUMAN [view interactions] High throughput no no
IMP2L_HUMAN [view interactions] High throughput no yes
UBP40_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
SARM1_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
ABCE1_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
FXRD1_HUMAN [view interactions] High throughput no no
TIF1B_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
DTX1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
MARH5_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
F107A_HUMAN [view entry] [view interactions] High throughput yes no
CUL2_HUMAN [view interactions] High throughput no yes
FEM1B_HUMAN [view interactions] High throughput no yes
SEC63_HUMAN [view interactions] High throughput no yes
BPHL_HUMAN [view interactions] High throughput no no
H2A2B_HUMAN [view interactions] High throughput no yes
H2AY_HUMAN [view interactions] High throughput no yes
H33_HUMAN [view interactions] High throughput no yes
SP16H_HUMAN [view interactions] High throughput no yes
UTP18_HUMAN [view interactions] High throughput no yes
H2A2C_HUMAN [view interactions] High throughput no yes
BTF3_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
TM192_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
NB5R3_HUMAN [view interactions] High throughput no yes
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
MYCN_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
UBE2O_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
RIT1_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
S25A3_HUMAN [view entry] [view interactions] High throughput yes no
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB4_HUMAN [view entry] [view interactions] High throughput yes yes
SFXN3_HUMAN [view entry] [view interactions] High throughput yes yes
MRP2_HUMAN [view interactions] High throughput no no
TI17B_HUMAN [view interactions] High throughput no no
SRSF1_HUMAN [view interactions] High throughput no yes
NDUS4_HUMAN [view interactions] High throughput no yes
ADT2_HUMAN [view entry] [view interactions] High throughput yes yes
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
CUL4B_HUMAN [view interactions] High throughput no yes
OPTN_HUMAN [view interactions] High throughput no yes
MK14_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
RFA4_HUMAN [view interactions] High throughput no yes
MK06_HUMAN [view interactions] High throughput no yes
NU155_HUMAN [view interactions] High throughput no yes
NICA_HUMAN [view interactions] High throughput no yes
PSB5_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
NEDD1_HUMAN [view interactions] High throughput no yes
ARP5_HUMAN [view interactions] High throughput no yes
PML_HUMAN [view interactions] High throughput no yes
OCAD1_HUMAN [view interactions] High throughput no yes
SYJ2B_HUMAN [view interactions] High throughput no no
H15_HUMAN [view interactions] High throughput no no
NFXL1_HUMAN [view interactions] High throughput no yes
TOM7_HUMAN [view interactions] High throughput no no
SYP2L_HUMAN [view interactions] High throughput no no
PABP4_HUMAN [view entry] [view interactions] High throughput yes yes
FAF2_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes