Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TOM20_HUMAN

Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore . Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases. [View more on UniProt]

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No data found.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in TOM20_HUMAN
GO:0017076 purine nucleotide binding 31.0345 4 no
GO:0032555 purine ribonucleotide binding 31.0345 4 no
GO:0035639 purine ribonucleoside triphosphate binding 26.4368 4 no
GO:0046872 metal ion binding 20.6897 4 no
GO:0015399 primary active transmembrane transporter activity 5.7471 4 yes
GO:0005048 signal sequence binding 3.4483 4 yes
GO:0030943 mitochondrion targeting sequence binding 3.4483 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TOM20_HUMAN
GO:0006996 organelle organization 47.1264 4 no
GO:0071702 organic substance transport 39.0805 4 yes
GO:0071705 nitrogen compound transport 36.7816 4 yes
GO:0031323 regulation of cellular metabolic process 36.7816 4 no
GO:0008104 protein localization 35.6322 4 yes
GO:0048522 positive regulation of cellular process 35.6322 4 no
GO:0051171 regulation of nitrogen compound metabolic process 33.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0048523 negative regulation of cellular process 33.3333 4 no
GO:0051128 regulation of cellular component organization 29.8851 4 no
GO:0009893 positive regulation of metabolic process 29.8851 4 no
GO:0015031 protein transport 28.7356 4 yes
GO:0010646 regulation of cell communication 28.7356 4 no
GO:0022607 cellular component assembly 27.5862 4 no
GO:0007005 mitochondrion organization 26.4368 5 no
GO:0051246 regulation of protein metabolic process 26.4368 5 no
GO:0061024 membrane organization 25.2874 4 no
GO:0006886 intracellular protein transport 24.1379 4 yes
GO:0033043 regulation of organelle organization 24.1379 5 no
GO:0009966 regulation of signal transduction 24.1379 4 no
GO:0033365 protein localization to organelle 22.9885 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 22.9885 5 no
GO:0009894 regulation of catabolic process 21.8391 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 21.8391 5 no
GO:0010941 regulation of cell death 20.6897 4 no
GO:0031325 positive regulation of cellular metabolic process 20.6897 5 no
GO:0051247 positive regulation of protein metabolic process 20.6897 6 no
GO:0072594 establishment of protein localization to organelle 18.3908 4 yes
GO:0070585 protein localization to mitochondrion 14.9425 6 yes
GO:0072655 establishment of protein localization to mitochondrion 13.7931 5 yes
GO:0006839 mitochondrial transport 12.6437 4 yes
GO:0010243 response to organonitrogen compound 12.6437 4 yes
GO:0006605 protein targeting 11.4943 5 yes
GO:0014070 response to organic cyclic compound 9.1954 4 yes
GO:0006626 protein targeting to mitochondrion 6.8966 5 yes
GO:0015931 nucleobase-containing compound transport 5.7471 5 yes
GO:0044743 protein transmembrane import into intracellular organelle 5.7471 4 yes
GO:0065002 intracellular protein transmembrane transport 5.7471 4 yes
GO:0030150 protein import into mitochondrial matrix 4.5977 4 yes
GO:0016031 tRNA import into mitochondrion 2.2989 5 yes
GO:0035927 RNA import into mitochondrion 2.2989 4 yes
GO:0043200 response to amino acid 2.2989 4 yes
GO:0050657 nucleic acid transport 2.2989 6 yes
GO:0050658 RNA transport 2.2989 4 yes
GO:0051031 tRNA transport 2.2989 5 yes
GO:1905242 response to 3,3,5-triiodo-L-thyronine 2.2989 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in TOM20_HUMAN
DOID:574 peripheral nervous system disease 4.5977 3 no
DOID:870 neuropathy 4.5977 4 no
DOID:10595 Charcot-Marie-Tooth disease 3.4483 6 no
DOID:440 neuromuscular disease 3.4483 5 no
DOID:0050539 Charcot-Marie-Tooth disease type 2 2.2989 7 no
DOID:1289 neurodegenerative disease 2.2989 4 no
DOID:331 central nervous system disease 2.2989 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TOM22_HUMAN [view interactions] Low throughput no yes
UBP30_HUMAN [view interactions] Low throughput no yes
TOM40_HUMAN [view interactions] Low throughput no yes
BIRC2_HUMAN [view interactions] Low throughput no yes
KPCE_HUMAN [view entry] [view interactions] Low throughput yes yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
OTUD1_HUMAN [view interactions] Low throughput no yes
DPOG1_HUMAN [view interactions] Low throughput no yes
VDAC1_HUMAN [view entry] [view interactions] Low throughput yes yes
OTC_HUMAN [view interactions] Low throughput no no
UCP1_HUMAN [view interactions] Low throughput no no
BCL2_HUMAN [view interactions] Low throughput no no
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
HCD2_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
MLP3B_HUMAN [view interactions] Low throughput no yes
AIP_HUMAN [view entry] [view interactions] Low throughput yes yes
ALDH2_HUMAN [view entry] [view interactions] Low throughput yes no
CGL_HUMAN [view interactions] Low throughput no yes
PINK1_HUMAN [view interactions] Low throughput no yes
R144B_HUMAN [view interactions] Low throughput no yes
BAX_HUMAN [view interactions] Low throughput no yes
MID49_HUMAN [view interactions] Low throughput no yes
BAG6_HUMAN [view entry] [view interactions] Low throughput yes yes
DYL1_HUMAN [view entry] [view interactions] Low throughput yes no
CALX_HUMAN [view entry] [view interactions] Low throughput yes yes
MID51_HUMAN [view interactions] Low throughput no no
ACBD5_HUMAN [view entry] [view interactions] High throughput yes yes
FA83B_HUMAN [view interactions] High throughput no no
SNP47_HUMAN [view entry] [view interactions] High throughput yes yes
TGO1_HUMAN [view interactions] High throughput no yes
INF2_HUMAN [view entry] [view interactions] High throughput yes yes
MIC60_HUMAN [view entry] [view interactions] High throughput yes yes
PCKGM_HUMAN [view interactions] High throughput no no
TAB1_HUMAN [view interactions] High throughput no yes
MTFR1_HUMAN [view interactions] High throughput no yes
TOM20_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
NDK3_HUMAN [view entry] [view interactions] High throughput yes yes
ECH1_HUMAN [view interactions] High throughput no yes
ABR_HUMAN [view entry] [view interactions] High throughput yes yes
NU160_HUMAN [view interactions] High throughput no no
GOGA3_HUMAN [view interactions] High throughput no yes
DYST_HUMAN [view entry] [view interactions] High throughput yes yes
NU107_HUMAN [view interactions] High throughput no no
NUP98_HUMAN [view interactions] High throughput no no
HXK2_HUMAN [view interactions] High throughput no yes
AL3A2_HUMAN [view entry] [view interactions] High throughput yes yes
PEX5_HUMAN [view interactions] High throughput no yes
ATPO_HUMAN [view interactions] High throughput no yes
NSF_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
PEX19_HUMAN [view interactions] High throughput no yes
ATPG_HUMAN [view interactions] High throughput no yes
TTK_HUMAN [view interactions] High throughput no yes
GLPK_HUMAN [view entry] [view interactions] High throughput yes no
KAP3_HUMAN [view entry] [view interactions] High throughput yes yes
ABCD3_HUMAN [view entry] [view interactions] High throughput yes yes
APC_HUMAN [view entry] [view interactions] High throughput yes no
IF2B_HUMAN [view interactions] High throughput no yes
HXK1_HUMAN [view entry] [view interactions] High throughput yes yes
ATP5J_HUMAN [view interactions] High throughput no yes
PTN1_HUMAN [view interactions] High throughput no yes
KAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ETFA_HUMAN [view interactions] High throughput no yes
GLI3_HUMAN [view interactions] High throughput no yes
SNP29_HUMAN [view interactions] High throughput no yes
TACC2_HUMAN [view interactions] High throughput no yes
VAPB_HUMAN [view entry] [view interactions] High throughput yes yes
ATP5H_HUMAN [view interactions] High throughput no yes
SCO1_HUMAN [view interactions] High throughput no yes
TACC1_HUMAN [view entry] [view interactions] High throughput yes yes
PEX14_HUMAN [view interactions] High throughput no yes
M3K7_HUMAN [view interactions] High throughput no yes
CYB5B_HUMAN [view entry] [view interactions] High throughput yes yes
YKT6_HUMAN [view interactions] High throughput no yes
TPP1_HUMAN [view entry] [view interactions] High throughput yes yes
DVL1_HUMAN [view entry] [view interactions] High throughput yes yes
P3C2A_HUMAN [view interactions] High throughput no yes
DNM1L_HUMAN [view entry] [view interactions] High throughput yes yes
NUD19_HUMAN [view interactions] High throughput no no
AT5F1_HUMAN [view interactions] High throughput no yes
TOM70_HUMAN [view interactions] High throughput no yes
AFG32_HUMAN [view entry] [view interactions] High throughput yes yes
TDRKH_HUMAN [view interactions] High throughput no no
TRAK1_HUMAN [view interactions] High throughput no yes
TNR6B_HUMAN [view interactions] High throughput no yes
SUFU_HUMAN [view interactions] High throughput no yes
CDC23_HUMAN [view interactions] High throughput no yes
ARMX3_HUMAN [view interactions] High throughput no no
CISD1_HUMAN [view entry] [view interactions] High throughput yes yes
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
SYIM_HUMAN [view entry] [view interactions] High throughput yes yes
4ET_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
TNR6C_HUMAN [view interactions] High throughput no no
WDR41_HUMAN [view interactions] High throughput no yes
AGO3_HUMAN [view interactions] High throughput no yes
PEAK1_HUMAN [view interactions] High throughput no yes
CA198_HUMAN [view interactions] High throughput no yes
GCP60_HUMAN [view interactions] High throughput no yes
LSG1_HUMAN [view interactions] High throughput no yes
MFF_HUMAN [view entry] [view interactions] High throughput yes yes
K1671_HUMAN [view interactions] High throughput no yes
B2L13_HUMAN [view interactions] High throughput no no
GPTC1_HUMAN [view interactions] High throughput no yes
CDCA3_HUMAN [view interactions] High throughput no no
TTC1_HUMAN [view interactions] High throughput no yes
RMD3_HUMAN [view interactions] High throughput no yes
VP13A_HUMAN [view interactions] High throughput no yes
RMD2_HUMAN [view interactions] High throughput no yes
CI072_HUMAN [view interactions] High throughput no no
SYAP1_HUMAN [view entry] [view interactions] High throughput yes yes
MARC2_HUMAN [view interactions] High throughput no no
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
NU205_HUMAN [view interactions] High throughput no no
UBXN4_HUMAN [view interactions] High throughput no yes
TM131_HUMAN [view interactions] High throughput no yes
SMG7_HUMAN [view interactions] High throughput no no
NU133_HUMAN [view interactions] High throughput no yes
SMCR8_HUMAN [view interactions] High throughput no yes
TNR6A_HUMAN [view interactions] High throughput no yes
EHBP1_HUMAN [view interactions] High throughput no yes
MIGA1_HUMAN [view interactions] High throughput no yes
PLD6_HUMAN [view interactions] High throughput no yes
NUP93_HUMAN [view interactions] High throughput no yes
TEX2_HUMAN [view interactions] High throughput no yes
PRSR1_HUMAN [view interactions] High throughput no yes
ZCCHV_HUMAN [view interactions] High throughput no yes
LARP4_HUMAN [view interactions] High throughput no yes
C1TM_HUMAN [view entry] [view interactions] High throughput yes yes
MTFR2_HUMAN [view interactions] High throughput no no
SCYL2_HUMAN [view interactions] High throughput no yes
CRBG3_HUMAN [view interactions] High throughput no no
IMP2L_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
TRAF6_HUMAN [view interactions] High throughput no yes
SARM1_HUMAN [view interactions] High throughput no yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
ABCE1_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
FBX7_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
FXRD1_HUMAN [view interactions] High throughput no no
TIF1B_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
DTX1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
MARH5_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
F107A_HUMAN [view entry] [view interactions] High throughput yes no
CUL2_HUMAN [view interactions] High throughput no yes
FEM1B_HUMAN [view interactions] High throughput no yes
SEC63_HUMAN [view interactions] High throughput no yes
BPHL_HUMAN [view interactions] High throughput no no
H2A2B_HUMAN [view interactions] High throughput no yes
H2AY_HUMAN [view interactions] High throughput no yes
H33_HUMAN [view interactions] High throughput no yes
SP16H_HUMAN [view interactions] High throughput no yes
UTP18_HUMAN [view interactions] High throughput no yes
H2A2C_HUMAN [view interactions] High throughput no yes
BTF3_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
TM192_HUMAN [view interactions] High throughput no yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
NB5R3_HUMAN [view interactions] High throughput no yes
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
RIT1_HUMAN [view interactions] High throughput no yes
MPCP_HUMAN [view entry] [view interactions] High throughput yes no
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB4_HUMAN [view entry] [view interactions] High throughput yes yes
SFXN3_HUMAN [view entry] [view interactions] High throughput yes yes
MRP2_HUMAN [view interactions] High throughput no no
TI17B_HUMAN [view interactions] High throughput no no
SRSF1_HUMAN [view interactions] High throughput no yes
NDUS4_HUMAN [view interactions] High throughput no yes
ADT2_HUMAN [view entry] [view interactions] High throughput yes yes
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
CUL4B_HUMAN [view interactions] High throughput no yes
OPTN_HUMAN [view interactions] High throughput no yes
MK14_HUMAN [view interactions] High throughput no yes
MK06_HUMAN [view interactions] High throughput no yes
NU155_HUMAN [view interactions] High throughput no yes
NICA_HUMAN [view interactions] High throughput no yes
PSB5_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
NEDD1_HUMAN [view interactions] High throughput no yes
ARP5_HUMAN [view interactions] High throughput no yes
PML_HUMAN [view interactions] High throughput no yes
OCAD1_HUMAN [view interactions] High throughput no yes
SYJ2B_HUMAN [view entry] [view interactions] High throughput yes no
H15_HUMAN [view interactions] High throughput no no
NFXL1_HUMAN [view interactions] High throughput no yes
TOM7_HUMAN [view interactions] High throughput no no
SYP2L_HUMAN [view interactions] High throughput no no
PABP4_HUMAN [view entry] [view interactions] High throughput yes yes
FAF2_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
CE126_HUMAN [view interactions] High throughput no no
PTN_HUMAN [view entry] [view interactions] High throughput yes yes
FEZ1_HUMAN [view interactions] High throughput no no
HAP1_HUMAN [view entry] [view interactions] High throughput yes yes
APOA1_HUMAN [view interactions] High throughput no no
PPHLN_HUMAN [view interactions] High throughput no yes
CDC73_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
AGO2_HUMAN [view interactions] High throughput no yes
MIRO2_HUMAN [view entry] [view interactions] High throughput yes yes
MAVS_HUMAN [view interactions] High throughput no yes
SAS6_HUMAN [view interactions] High throughput no no
EXD2_HUMAN [view interactions] High throughput no yes
VP13D_HUMAN [view interactions] High throughput no no
SE1L2_HUMAN [view interactions] High throughput no no
ATPF1_HUMAN [view interactions] High throughput no yes
AT5G1_HUMAN [view interactions] Computational no no
TIM44_HUMAN [view interactions] Computational no yes
VDAC3_HUMAN [view entry] [view interactions] Computational yes yes
TM40L_HUMAN [view entry] [view interactions] Computational yes yes
PTH2_HUMAN [view interactions] Computational no yes
FIS1_HUMAN [view entry] [view interactions] Computational yes yes
TOM5_HUMAN [view interactions] Computational no yes
GRP75_HUMAN [view entry] [view interactions] Computational yes yes
IDE_HUMAN [view interactions] Computational no yes
CY1_HUMAN [view entry] [view interactions] Computational yes yes
SAM50_HUMAN [view entry] [view interactions] Computational yes yes
ATPA_HUMAN [view interactions] Computational no yes
BCS1_HUMAN [view interactions] Computational no yes
MIRO1_HUMAN [view entry] [view interactions] Computational yes yes
MFN1_HUMAN [view interactions] Computational no yes
ATPB_HUMAN [view interactions] Computational no yes
TI17A_HUMAN [view interactions] Computational no yes
MTX1_HUMAN [view entry] [view interactions] Computational yes yes
MAT2B_HUMAN [view interactions] Computational no yes
HS90A_HUMAN [view entry] [view interactions] Computational yes yes
MUL1_HUMAN [view interactions] Computational no no
MFN2_HUMAN [view entry] [view interactions] Computational yes yes
TOM6_HUMAN [view interactions] Computational no yes
ACON_HUMAN [view entry] [view interactions] Computational yes yes
TIM22_HUMAN [view interactions] Computational no no
CH60_HUMAN [view entry] [view interactions] Computational yes yes
CISY_HUMAN [view entry] [view interactions] Computational yes yes
APEX1_HUMAN [view interactions] Computational no yes
IDH3G_HUMAN [view entry] [view interactions] Computational yes yes
TIM50_HUMAN [view entry] [view interactions] Computational yes yes
TIM23_HUMAN [view interactions] Computational no yes
MIC13_HUMAN [view interactions] Computational no yes
ADT1_HUMAN [view entry] [view interactions] Computational yes yes
STAT3_HUMAN [view entry] [view interactions] Computational yes yes