SFXN3_HUMAN
Evidence for PS localization
Functions
Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed). Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SFXN3_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 29.4118 | 4 | no |
| GO:0043168 | anion binding | 29.4118 | 4 | no |
| GO:0043169 | cation binding | 29.4118 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.4510 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 27.4510 | 4 | no |
| GO:0019900 | kinase binding | 27.4510 | 4 | no |
| GO:0046872 | metal ion binding | 25.4902 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.5686 | 4 | no |
| GO:0019901 | protein kinase binding | 21.5686 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SFXN3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.7843 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 54.9020 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.9804 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.9804 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 45.0980 | 4 | no |
| GO:0009966 | regulation of signal transduction | 41.1765 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.2157 | 4 | no |
| GO:0051049 | regulation of transport | 39.2157 | 4 | no |
| GO:0006996 | organelle organization | 37.2549 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 35.2941 | 4 | no |
| GO:0008104 | protein localization | 35.2941 | 4 | no |
| GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 29.4118 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 29.4118 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 29.4118 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.4118 | 5 | no |
| GO:0023056 | positive regulation of signaling | 29.4118 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 29.4118 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 29.4118 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 27.4510 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 27.4510 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 27.4510 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.4902 | 5 | no |
| GO:0010468 | regulation of gene expression | 25.4902 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.4902 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.4902 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.4902 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 25.4902 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 25.4902 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.4902 | 4 | no |
| GO:0071702 | organic substance transport | 25.4902 | 4 | yes |
| GO:0032880 | regulation of protein localization | 25.4902 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.4902 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.4902 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.4902 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 25.4902 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.4902 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.5294 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.5294 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.5294 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.5294 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.5294 | 5 | no |
| GO:0071705 | nitrogen compound transport | 23.5294 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 23.5294 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.5294 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.5294 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.5294 | 6 | no |
| GO:0031399 | regulation of protein modification process | 23.5294 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 23.5294 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 21.5686 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 21.5686 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.5686 | 5 | no |
| GO:0061024 | membrane organization | 21.5686 | 4 | no |
| GO:0006839 | mitochondrial transport | 9.8039 | 4 | yes |
| GO:0006865 | amino acid transport | 7.8431 | 5 | yes |
| GO:0015695 | organic cation transport | 7.8431 | 5 | yes |
| GO:0015711 | organic anion transport | 7.8431 | 5 | yes |
| GO:0015849 | organic acid transport | 7.8431 | 5 | yes |
| GO:0046942 | carboxylic acid transport | 7.8431 | 6 | yes |
| GO:0170036 | import into the mitochondrion | 7.8431 | 4 | yes |
| GO:1905039 | carboxylic acid transmembrane transport | 7.8431 | 4 | yes |
| GO:0015804 | neutral amino acid transport | 5.8824 | 6 | yes |
| GO:0032329 | serine transport | 3.9216 | 5 | yes |
| GO:0140300 | serine import into mitochondrion | 3.9216 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| NFYA_HUMAN | [view interactions] | High throughput | no | yes |
| ATP7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB4B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XRCC3_HUMAN | [view interactions] | High throughput | no | no |
| LAMB3_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| PDCD1_HUMAN | [view interactions] | High throughput | no | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| S15A1_HUMAN | [view interactions] | High throughput | no | no |
| SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCN3B_HUMAN | [view interactions] | High throughput | no | no |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| TR16L_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADCK1_HUMAN | [view interactions] | High throughput | no | no |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRID2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIM26_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EBP_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP4_HUMAN | [view interactions] | High throughput | no | no |
| RETR3_HUMAN | [view interactions] | High throughput | no | yes |
| TMM51_HUMAN | [view interactions] | High throughput | no | yes |
| TMX2_HUMAN | [view interactions] | High throughput | no | yes |
| TLCD4_HUMAN | [view interactions] | High throughput | no | no |
| LERL1_HUMAN | [view interactions] | High throughput | no | no |
| TM14B_HUMAN | [view interactions] | High throughput | no | no |
| RUSF1_HUMAN | [view interactions] | High throughput | no | yes |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| DHB13_HUMAN | [view interactions] | High throughput | no | yes |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| FCERG_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLN3_HUMAN | [view interactions] | High throughput | no | no |
| CLN5_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| NRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZMYM2_HUMAN | [view interactions] | High throughput | no | yes |
| TRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| PJA1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| GLMP_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| EDEM2_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DUS7_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| ASXL1_HUMAN | [view interactions] | High throughput | no | no |
| KLRD1_HUMAN | [view interactions] | High throughput | no | no |
| CD80_HUMAN | [view interactions] | High throughput | no | no |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| TOIP2_HUMAN | [view interactions] | High throughput | no | no |
| ITB7_HUMAN | [view interactions] | High throughput | no | no |
| S22A4_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA8_HUMAN | [view interactions] | High throughput | no | no |
| LRC55_HUMAN | [view interactions] | High throughput | no | yes |
| HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSTM1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNE1_HUMAN | [view interactions] | High throughput | no | no |
| TM108_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLRB1_HUMAN | [view interactions] | High throughput | no | yes |
| CL12B_HUMAN | [view interactions] | High throughput | no | no |
| RAMP3_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| CSCL1_HUMAN | [view interactions] | High throughput | no | no |
| AL3B2_HUMAN | [view interactions] | High throughput | no | yes |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CML1_HUMAN | [view interactions] | High throughput | no | yes |
| T184A_HUMAN | [view interactions] | High throughput | no | no |
| PPBN_HUMAN | [view interactions] | High throughput | no | no |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPBI_HUMAN | [view interactions] | High throughput | no | no |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DRA_HUMAN | [view interactions] | High throughput | no | no |
| T150A_HUMAN | [view interactions] | High throughput | no | yes |
| LRN4L_HUMAN | [view interactions] | High throughput | no | yes |
| THTPA_HUMAN | [view interactions] | High throughput | no | yes |
| SPRY7_HUMAN | [view interactions] | High throughput | no | yes |
| FCG3B_HUMAN | [view interactions] | High throughput | no | no |
| ISLR_HUMAN | [view interactions] | High throughput | no | no |
| GPIX_HUMAN | [view interactions] | High throughput | no | no |
| CST9L_HUMAN | [view interactions] | High throughput | no | no |
| EFNA2_HUMAN | [view interactions] | High throughput | no | no |
| TNFL8_HUMAN | [view interactions] | High throughput | no | no |
| APJ_HUMAN | [view interactions] | High throughput | no | yes |
| GPBAR_HUMAN | [view interactions] | High throughput | no | no |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| NAAA_HUMAN | [view interactions] | High throughput | no | yes |
| PDE2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| LATS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK7_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRSF5_HUMAN | [view interactions] | High throughput | no | yes |
| SURF1_HUMAN | [view interactions] | High throughput | no | yes |
| MPV17_HUMAN | [view interactions] | High throughput | no | no |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLP2_HUMAN | [view interactions] | High throughput | no | yes |
| STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAM3C_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TI17A_HUMAN | [view interactions] | High throughput | no | yes |
| THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR8_HUMAN | [view interactions] | High throughput | no | yes |
| F120A_HUMAN | [view interactions] | High throughput | no | yes |
| CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIPC_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXO1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |