SFXN3_HUMAN
Evidence for PS localization
Functions
Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed). Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SFXN3_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 33.3333 | 4 | no |
| GO:0019901 | protein kinase binding | 28.5714 | 5 | no |
| GO:0017076 | purine nucleotide binding | 26.1905 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.1905 | 4 | no |
| GO:0046872 | metal ion binding | 26.1905 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.4286 | 4 | no |
| GO:0008324 | cation transmembrane transporter activity | 11.9048 | 4 | yes |
| GO:0008509 | anion transmembrane transporter activity | 11.9048 | 4 | yes |
| GO:0008514 | organic anion transmembrane transporter activity | 7.1429 | 5 | yes |
| GO:0015171 | amino acid transmembrane transporter activity | 7.1429 | 5 | yes |
| GO:0015175 | neutral amino acid transmembrane transporter activity | 7.1429 | 6 | yes |
| GO:0046943 | carboxylic acid transmembrane transporter activity | 7.1429 | 4 | yes |
| GO:0022889 | serine transmembrane transporter activity | 4.7619 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SFXN3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 61.9048 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 54.7619 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0006996 | organelle organization | 42.8571 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.8571 | 4 | no |
| GO:0009966 | regulation of signal transduction | 42.8571 | 4 | no |
| GO:0008104 | protein localization | 40.4762 | 4 | no |
| GO:0051049 | regulation of transport | 40.4762 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 38.0952 | 4 | no |
| GO:0022607 | cellular component assembly | 35.7143 | 4 | no |
| GO:0071702 | organic substance transport | 33.3333 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010941 | regulation of cell death | 33.3333 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 33.3333 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 33.3333 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 33.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0071705 | nitrogen compound transport | 30.9524 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 30.9524 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.9524 | 5 | no |
| GO:0033043 | regulation of organelle organization | 28.5714 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 28.5714 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.5714 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 28.5714 | 5 | no |
| GO:0015031 | protein transport | 26.1905 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.1905 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.1905 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.1905 | 5 | no |
| GO:0071310 | cellular response to organic substance | 26.1905 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.1905 | 5 | no |
| GO:0030030 | cell projection organization | 26.1905 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 26.1905 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.1905 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.1905 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 23.8095 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.8095 | 6 | no |
| GO:0032880 | regulation of protein localization | 23.8095 | 5 | no |
| GO:0036211 | protein modification process | 23.8095 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 23.8095 | 7 | no |
| GO:0043066 | negative regulation of apoptotic process | 23.8095 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 23.8095 | 6 | no |
| GO:0043412 | macromolecule modification | 23.8095 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.8095 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.8095 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.8095 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 23.8095 | 5 | no |
| GO:0060341 | regulation of cellular localization | 23.8095 | 4 | no |
| GO:0060548 | negative regulation of cell death | 23.8095 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.8095 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 23.8095 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 23.8095 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 23.8095 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 23.8095 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.8095 | 4 | no |
| GO:0043269 | regulation of ion transport | 23.8095 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 21.4286 | 7 | no |
| GO:0010243 | response to organonitrogen compound | 21.4286 | 4 | no |
| GO:0031399 | regulation of protein modification process | 21.4286 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.4286 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.4286 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 21.4286 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 21.4286 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.4286 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.4286 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 21.4286 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 21.4286 | 5 | no |
| GO:0051050 | positive regulation of transport | 21.4286 | 4 | no |
| GO:0006811 | ion transport | 16.6667 | 4 | yes |
| GO:0006820 | anion transport | 14.2857 | 5 | yes |
| GO:0006812 | cation transport | 11.9048 | 5 | yes |
| GO:0003333 | amino acid transmembrane transport | 9.5238 | 5 | yes |
| GO:0006865 | amino acid transport | 9.5238 | 5 | yes |
| GO:0015711 | organic anion transport | 9.5238 | 5 | yes |
| GO:0015849 | organic acid transport | 9.5238 | 5 | yes |
| GO:0046942 | carboxylic acid transport | 9.5238 | 6 | yes |
| GO:0098655 | cation transmembrane transport | 9.5238 | 4 | yes |
| GO:0098656 | anion transmembrane transport | 9.5238 | 4 | yes |
| GO:1905039 | carboxylic acid transmembrane transport | 9.5238 | 4 | yes |
| GO:0015804 | neutral amino acid transport | 7.1429 | 6 | yes |
| GO:0032329 | serine transport | 4.7619 | 6 | yes |
| GO:0140300 | serine import into mitochondrion | 4.7619 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SFXN3_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 7.1429 | 4 | no |
| DOID:331 | central nervous system disease | 7.1429 | 3 | no |
| DOID:12377 | spinal muscular atrophy | 4.7619 | 6 | no |
| DOID:231 | motor neuron disease | 4.7619 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CLN5_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| NRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZMYM2_HUMAN | [view interactions] | High throughput | no | yes |
| TRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| PJA1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| GLMP_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| EDEM2_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DUS7_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| INS_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| ASXL1_HUMAN | [view interactions] | High throughput | no | no |
| KLRD1_HUMAN | [view interactions] | High throughput | no | no |
| CD80_HUMAN | [view interactions] | High throughput | no | no |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| TOIP2_HUMAN | [view interactions] | High throughput | no | no |
| ITB7_HUMAN | [view interactions] | High throughput | no | no |
| S22A4_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA8_HUMAN | [view interactions] | High throughput | no | no |
| LRC55_HUMAN | [view interactions] | High throughput | no | yes |
| HUMMR_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSTM1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNE1_HUMAN | [view interactions] | High throughput | no | no |
| TM108_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLRB1_HUMAN | [view interactions] | High throughput | no | yes |
| CL12B_HUMAN | [view interactions] | High throughput | no | no |
| RAMP3_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| CSCL1_HUMAN | [view interactions] | High throughput | no | no |
| AL3B2_HUMAN | [view interactions] | High throughput | no | yes |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNK1_HUMAN | [view interactions] | High throughput | no | yes |
| CML1_HUMAN | [view interactions] | High throughput | no | yes |
| T184A_HUMAN | [view interactions] | High throughput | no | no |
| PPBN_HUMAN | [view interactions] | High throughput | no | no |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPBI_HUMAN | [view interactions] | High throughput | no | no |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DRA_HUMAN | [view interactions] | High throughput | no | no |
| T150A_HUMAN | [view interactions] | High throughput | no | yes |
| LRN4L_HUMAN | [view interactions] | High throughput | no | yes |
| THTPA_HUMAN | [view interactions] | High throughput | no | yes |
| SPRY7_HUMAN | [view interactions] | High throughput | no | yes |
| FCG3B_HUMAN | [view interactions] | High throughput | no | no |
| ISLR_HUMAN | [view interactions] | High throughput | no | no |
| GPIX_HUMAN | [view interactions] | High throughput | no | no |
| CST9L_HUMAN | [view interactions] | High throughput | no | no |
| EFNA2_HUMAN | [view interactions] | High throughput | no | no |
| TNFL8_HUMAN | [view interactions] | High throughput | no | no |
| APJ_HUMAN | [view interactions] | High throughput | no | yes |
| GPBAR_HUMAN | [view interactions] | High throughput | no | no |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| NAAA_HUMAN | [view interactions] | High throughput | no | yes |
| PDE2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRSF5_HUMAN | [view interactions] | High throughput | no | yes |
| SURF1_HUMAN | [view interactions] | High throughput | no | yes |
| MPV17_HUMAN | [view interactions] | High throughput | no | no |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLP2_HUMAN | [view interactions] | High throughput | no | yes |
| STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIM50_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAM3C_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TI17A_HUMAN | [view interactions] | High throughput | no | yes |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR8_HUMAN | [view interactions] | High throughput | no | yes |
| F120A_HUMAN | [view interactions] | High throughput | no | yes |
| CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO3_HUMAN | [view interactions] | High throughput | no | yes |
| TRIPC_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| NFYA_HUMAN | [view interactions] | High throughput | no | yes |
| ATP7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB4B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XRCC3_HUMAN | [view interactions] | High throughput | no | no |
| LAMB3_HUMAN | [view interactions] | High throughput | no | yes |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| PDCD1_HUMAN | [view interactions] | High throughput | no | yes |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| S15A1_HUMAN | [view interactions] | High throughput | no | no |
| SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCN3B_HUMAN | [view interactions] | High throughput | no | no |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| TR16L_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADCK1_HUMAN | [view interactions] | High throughput | no | no |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRID2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| EBP_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP4_HUMAN | [view interactions] | High throughput | no | no |
| RETR3_HUMAN | [view interactions] | High throughput | no | yes |
| TMM51_HUMAN | [view interactions] | High throughput | no | yes |
| TMX2_HUMAN | [view interactions] | High throughput | no | yes |
| TLCD4_HUMAN | [view interactions] | High throughput | no | no |
| LERL1_HUMAN | [view interactions] | High throughput | no | no |
| TM14B_HUMAN | [view interactions] | High throughput | no | no |
| RUSF1_HUMAN | [view interactions] | High throughput | no | yes |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| DHB13_HUMAN | [view interactions] | High throughput | no | yes |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| FCERG_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLN3_HUMAN | [view interactions] | High throughput | no | no |