NRG1_HUMAN
Evidence for PS localization
Functions
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed, PubMed). Binds to ERBB3 (PubMed). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NRG1_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 25.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
| GO:0043168 | anion binding | 25.0000 | 4 | no |
| GO:0043169 | cation binding | 25.0000 | 4 | no |
| GO:0046872 | metal ion binding | 25.0000 | 5 | no |
| GO:0019900 | kinase binding | 10.0000 | 4 | yes |
| GO:0019901 | protein kinase binding | 10.0000 | 5 | yes |
| GO:0030971 | receptor tyrosine kinase binding | 10.0000 | 4 | yes |
| GO:0043125 | ErbB-3 class receptor binding | 10.0000 | 4 | yes |
| GO:0048018 | receptor ligand activity | 10.0000 | 4 | yes |
| GO:1990782 | protein tyrosine kinase binding | 10.0000 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NRG1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 70.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | yes |
| GO:0043067 | regulation of programmed cell death | 40.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 35.0000 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 35.0000 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 35.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 35.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 35.0000 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 30.0000 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | yes |
| GO:0043066 | negative regulation of apoptotic process | 30.0000 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 30.0000 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 30.0000 | 4 | yes |
| GO:0051049 | regulation of transport | 30.0000 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 30.0000 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 30.0000 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | yes |
| GO:0030030 | cell projection organization | 30.0000 | 4 | no |
| GO:0036211 | protein modification process | 30.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 30.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 30.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | yes |
| GO:0010468 | regulation of gene expression | 25.0000 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | yes |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | yes |
| GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | yes |
| GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 25.0000 | 6 | yes |
| GO:2000026 | regulation of multicellular organismal development | 25.0000 | 4 | yes |
| GO:0006996 | organelle organization | 25.0000 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.0000 | 5 | no |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
| GO:0008104 | protein localization | 25.0000 | 4 | no |
| GO:0001558 | regulation of cell growth | 20.0000 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 20.0000 | 7 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 20.0000 | 8 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 20.0000 | 7 | yes |
| GO:0008284 | positive regulation of cell population proliferation | 20.0000 | 5 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.0000 | 6 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.0000 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 20.0000 | 6 | yes |
| GO:0030155 | regulation of cell adhesion | 20.0000 | 4 | yes |
| GO:0031401 | positive regulation of protein modification process | 20.0000 | 7 | yes |
| GO:0042325 | regulation of phosphorylation | 20.0000 | 7 | yes |
| GO:0042327 | positive regulation of phosphorylation | 20.0000 | 8 | yes |
| GO:0043408 | regulation of MAPK cascade | 20.0000 | 6 | yes |
| GO:0045595 | regulation of cell differentiation | 20.0000 | 4 | yes |
| GO:0045927 | positive regulation of growth | 20.0000 | 4 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.0000 | 7 | yes |
| GO:0048585 | negative regulation of response to stimulus | 20.0000 | 4 | yes |
| GO:0048638 | regulation of developmental growth | 20.0000 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 20.0000 | 4 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 20.0000 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 20.0000 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 20.0000 | 5 | yes |
| GO:0051338 | regulation of transferase activity | 20.0000 | 4 | yes |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | 20.0000 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 20.0000 | 6 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 15.0000 | 4 | yes |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 15.0000 | 5 | yes |
| GO:0007399 | nervous system development | 15.0000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 15.0000 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 15.0000 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 15.0000 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 15.0000 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 15.0000 | 4 | yes |
| GO:0030307 | positive regulation of cell growth | 15.0000 | 5 | yes |
| GO:0033674 | positive regulation of kinase activity | 15.0000 | 6 | yes |
| GO:0038127 | ERBB signaling pathway | 15.0000 | 6 | yes |
| GO:0038128 | ERBB2 signaling pathway | 15.0000 | 7 | yes |
| GO:0038130 | ERBB4 signaling pathway | 15.0000 | 7 | yes |
| GO:0038135 | ERBB2-ERBB4 signaling pathway | 15.0000 | 8 | yes |
| GO:0043410 | positive regulation of MAPK cascade | 15.0000 | 7 | yes |
| GO:0043549 | regulation of kinase activity | 15.0000 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 15.0000 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 15.0000 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 15.0000 | 5 | yes |
| GO:0045597 | positive regulation of cell differentiation | 15.0000 | 5 | yes |
| GO:0045859 | regulation of protein kinase activity | 15.0000 | 6 | yes |
| GO:0045860 | positive regulation of protein kinase activity | 15.0000 | 7 | yes |
| GO:0048639 | positive regulation of developmental growth | 15.0000 | 5 | yes |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 15.0000 | 8 | yes |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 15.0000 | 9 | yes |
| GO:0051347 | positive regulation of transferase activity | 15.0000 | 5 | yes |
| GO:0065003 | protein-containing complex assembly | 15.0000 | 5 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 10.0000 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 10.0000 | 6 | yes |
| GO:0030100 | regulation of endocytosis | 10.0000 | 5 | yes |
| GO:0030855 | epithelial cell differentiation | 10.0000 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 10.0000 | 5 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 10.0000 | 6 | yes |
| GO:0031334 | positive regulation of protein-containing complex assembly | 10.0000 | 6 | yes |
| GO:0038129 | ERBB3 signaling pathway | 10.0000 | 7 | yes |
| GO:0038133 | ERBB2-ERBB3 signaling pathway | 10.0000 | 8 | yes |
| GO:0038138 | ERBB4-ERBB4 signaling pathway | 10.0000 | 8 | yes |
| GO:0042060 | wound healing | 10.0000 | 4 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 10.0000 | 5 | yes |
| GO:0045445 | myoblast differentiation | 10.0000 | 4 | yes |
| GO:0045785 | positive regulation of cell adhesion | 10.0000 | 5 | yes |
| GO:0046620 | regulation of organ growth | 10.0000 | 4 | yes |
| GO:0046622 | positive regulation of organ growth | 10.0000 | 5 | yes |
| GO:0055021 | regulation of cardiac muscle tissue growth | 10.0000 | 6 | yes |
| GO:0055023 | positive regulation of cardiac muscle tissue growth | 10.0000 | 7 | yes |
| GO:0060043 | regulation of cardiac muscle cell proliferation | 10.0000 | 5 | yes |
| GO:0060045 | positive regulation of cardiac muscle cell proliferation | 10.0000 | 6 | yes |
| GO:0060420 | regulation of heart growth | 10.0000 | 5 | yes |
| GO:0060421 | positive regulation of heart growth | 10.0000 | 6 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 10.0000 | 4 | yes |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10.0000 | 8 | yes |
| GO:2001233 | regulation of apoptotic signaling pathway | 10.0000 | 5 | yes |
| GO:2001234 | negative regulation of apoptotic signaling pathway | 10.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| ERBB3_HUMAN | [view interactions] | Low throughput | no | yes |
| LIMK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALY_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ERBB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
| S10A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| LAP4B_HUMAN | [view interactions] | High throughput | no | yes |
| M4A4A_HUMAN | [view interactions] | High throughput | no | no |
| TMM54_HUMAN | [view interactions] | High throughput | no | no |
| MYPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD72_HUMAN | [view interactions] | High throughput | no | no |
| ASGR2_HUMAN | [view interactions] | High throughput | no | no |
| JAGN1_HUMAN | [view interactions] | High throughput | no | no |
| MBOA7_HUMAN | [view interactions] | High throughput | no | no |
| LSR_HUMAN | [view interactions] | High throughput | no | yes |
| PGAP1_HUMAN | [view interactions] | High throughput | no | no |
| K2013_HUMAN | [view interactions] | High throughput | no | yes |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| MAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TMTC3_HUMAN | [view interactions] | High throughput | no | yes |
| TMTC4_HUMAN | [view interactions] | High throughput | no | yes |
| PMGT2_HUMAN | [view interactions] | High throughput | no | yes |
| S38AA_HUMAN | [view interactions] | High throughput | no | yes |
| ATP7B_HUMAN | [view interactions] | High throughput | no | no |
| S35B2_HUMAN | [view interactions] | High throughput | no | no |
| NDUA3_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM39B_HUMAN | [view interactions] | High throughput | no | yes |
| DAAF5_HUMAN | [view interactions] | High throughput | no | no |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| RHBT3_HUMAN | [view interactions] | High throughput | no | no |
| CISD2_HUMAN | [view interactions] | High throughput | no | yes |
| POMT1_HUMAN | [view interactions] | High throughput | no | no |
| SPTC2_HUMAN | [view interactions] | High throughput | no | no |
| GDC_HUMAN | [view interactions] | High throughput | no | no |
| RDH11_HUMAN | [view interactions] | High throughput | no | no |
| MGAT1_HUMAN | [view interactions] | High throughput | no | yes |
| HMOX1_HUMAN | [view interactions] | High throughput | no | no |
| F234B_HUMAN | [view interactions] | High throughput | no | yes |
| EXTL3_HUMAN | [view interactions] | High throughput | no | yes |
| SCMC3_HUMAN | [view interactions] | High throughput | no | yes |
| NETO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGRL1_HUMAN | [view interactions] | High throughput | no | no |
| CNTP3_HUMAN | [view interactions] | High throughput | no | yes |
| DPB1_HUMAN | [view interactions] | High throughput | no | no |
| QCR8_HUMAN | [view interactions] | High throughput | no | yes |
| GLMN_HUMAN | [view interactions] | High throughput | no | no |
| DEGS1_HUMAN | [view interactions] | High throughput | no | no |
| CSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| ABCBA_HUMAN | [view interactions] | High throughput | no | yes |
| LARG2_HUMAN | [view interactions] | High throughput | no | yes |
| B3GL2_HUMAN | [view interactions] | High throughput | no | yes |
| TM181_HUMAN | [view interactions] | High throughput | no | yes |
| INT7_HUMAN | [view interactions] | High throughput | no | no |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| GLT11_HUMAN | [view interactions] | High throughput | no | yes |
| C1GLC_HUMAN | [view interactions] | High throughput | no | yes |
| S22AI_HUMAN | [view interactions] | High throughput | no | no |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| ABCA3_HUMAN | [view interactions] | High throughput | no | yes |
| TM164_HUMAN | [view interactions] | High throughput | no | yes |
| MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OPA3_HUMAN | [view interactions] | High throughput | no | yes |
| H6ST1_HUMAN | [view interactions] | High throughput | no | no |
| SFXN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM2D3_HUMAN | [view interactions] | High throughput | no | yes |
| DSE_HUMAN | [view interactions] | High throughput | no | yes |
| TM205_HUMAN | [view interactions] | High throughput | no | yes |
| GOLI_HUMAN | [view interactions] | High throughput | no | yes |
| PIGU_HUMAN | [view interactions] | High throughput | no | no |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B4GT7_HUMAN | [view interactions] | High throughput | no | yes |
| S35F6_HUMAN | [view interactions] | High throughput | no | yes |
| HLAC_HUMAN | [view interactions] | High throughput | no | no |
| CHSTA_HUMAN | [view interactions] | High throughput | no | yes |
| SCNNA_HUMAN | [view interactions] | High throughput | no | yes |
| ORNT1_HUMAN | [view interactions] | High throughput | no | yes |
| B3GA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GALT5_HUMAN | [view interactions] | High throughput | no | no |
| DRB1_HUMAN | [view interactions] | High throughput | no | no |
| SPIT1_HUMAN | [view interactions] | High throughput | no | yes |
| B3GN3_HUMAN | [view interactions] | High throughput | no | no |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLXA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SFXN2_HUMAN | [view interactions] | High throughput | no | no |
| GLOD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CGT_HUMAN | [view interactions] | High throughput | no | no |
| T131L_HUMAN | [view interactions] | High throughput | no | yes |
| GLT12_HUMAN | [view interactions] | High throughput | no | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEM6B_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |