Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NRG1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed, PubMed). Binds to ERBB3 (PubMed). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NRG1_HUMAN
GO:0017076 purine nucleotide binding 37.5000 4 no
GO:0032555 purine ribonucleotide binding 37.5000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 no
GO:0030554 adenyl nucleotide binding 27.5000 5 no
GO:0032559 adenyl ribonucleotide binding 27.5000 5 no
GO:0005524 ATP binding 27.5000 5 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 25.0000 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 25.0000 4 no
GO:0016301 kinase activity 25.0000 4 no
GO:0019900 kinase binding 17.5000 4 yes
GO:0019901 protein kinase binding 17.5000 5 yes
GO:1990782 protein tyrosine kinase binding 10.0000 6 yes
GO:0019209 kinase activator activity 7.5000 4 yes
GO:0019887 protein kinase regulator activity 7.5000 4 yes
GO:0030295 protein kinase activator activity 7.5000 5 yes
GO:0030971 receptor tyrosine kinase binding 7.5000 4 yes
GO:0005176 ErbB-2 class receptor binding 5.0000 4 yes
GO:0043125 ErbB-3 class receptor binding 5.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NRG1_HUMAN
GO:0048522 positive regulation of cellular process 85.0000 4 yes
GO:0010646 regulation of cell communication 65.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 62.5000 4 yes
GO:0009893 positive regulation of metabolic process 60.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 60.0000 4 yes
GO:0080090 regulation of primary metabolic process 60.0000 4 yes
GO:0009966 regulation of signal transduction 57.5000 4 yes
GO:0051246 regulation of protein metabolic process 57.5000 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 55.0000 5 yes
GO:0031323 regulation of cellular metabolic process 55.0000 4 yes
GO:0010647 positive regulation of cell communication 52.5000 5 yes
GO:0023056 positive regulation of signaling 52.5000 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 52.5000 5 yes
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 yes
GO:0048523 negative regulation of cellular process 50.0000 4 yes
GO:0051247 positive regulation of protein metabolic process 50.0000 6 yes
GO:0010468 regulation of gene expression 47.5000 5 yes
GO:0051128 regulation of cellular component organization 47.5000 4 yes
GO:0048584 positive regulation of response to stimulus 45.0000 4 yes
GO:0001932 regulation of protein phosphorylation 42.5000 7 yes
GO:0019220 regulation of phosphate metabolic process 42.5000 6 yes
GO:0031399 regulation of protein modification process 42.5000 6 yes
GO:0042325 regulation of phosphorylation 42.5000 7 yes
GO:0051174 regulation of phosphorus metabolic process 42.5000 5 yes
GO:1902531 regulation of intracellular signal transduction 42.5000 5 yes
GO:0001934 positive regulation of protein phosphorylation 40.0000 8 yes
GO:0009967 positive regulation of signal transduction 40.0000 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 40.0000 6 yes
GO:0031401 positive regulation of protein modification process 40.0000 7 yes
GO:0042327 positive regulation of phosphorylation 40.0000 8 yes
GO:0045937 positive regulation of phosphate metabolic process 40.0000 7 yes
GO:0051049 regulation of transport 40.0000 4 yes
GO:0010941 regulation of cell death 37.5000 4 yes
GO:0043085 positive regulation of catalytic activity 37.5000 4 yes
GO:0051130 positive regulation of cellular component organization 37.5000 5 yes
GO:1902533 positive regulation of intracellular signal transduction 37.5000 6 yes
GO:0060341 regulation of cellular localization 35.0000 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 32.5000 4 yes
GO:0009889 regulation of biosynthetic process 32.5000 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 32.5000 5 yes
GO:0031326 regulation of cellular biosynthetic process 32.5000 5 yes
GO:0042127 regulation of cell population proliferation 32.5000 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 30.0000 5 yes
GO:0008284 positive regulation of cell population proliferation 30.0000 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 30.0000 5 yes
GO:0010628 positive regulation of gene expression 30.0000 6 yes
GO:0043067 regulation of programmed cell death 30.0000 5 yes
GO:0045595 regulation of cell differentiation 30.0000 4 yes
GO:0006996 organelle organization 30.0000 4 no
GO:0071310 cellular response to organic substance 30.0000 4 no
GO:0036211 protein modification process 30.0000 4 no
GO:0043412 macromolecule modification 30.0000 4 no
GO:0042981 regulation of apoptotic process 27.5000 6 yes
GO:0043408 regulation of MAPK cascade 27.5000 6 yes
GO:0051338 regulation of transferase activity 27.5000 4 yes
GO:0060548 negative regulation of cell death 27.5000 5 yes
GO:0050804 modulation of chemical synaptic transmission 27.5000 5 no
GO:0099177 regulation of trans-synaptic signaling 27.5000 4 no
GO:0030030 cell projection organization 27.5000 4 no
GO:0032386 regulation of intracellular transport 27.5000 5 no
GO:0006355 regulation of DNA-templated transcription 25.0000 6 yes
GO:0009892 negative regulation of metabolic process 25.0000 4 yes
GO:0009894 regulation of catabolic process 25.0000 4 yes
GO:0022607 cellular component assembly 25.0000 4 yes
GO:0051252 regulation of RNA metabolic process 25.0000 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 25.0000 7 yes
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 yes
GO:0006796 phosphate-containing compound metabolic process 25.0000 4 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.0000 6 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 22.5000 5 yes
GO:0030155 regulation of cell adhesion 22.5000 4 yes
GO:0030334 regulation of cell migration 22.5000 5 yes
GO:0043069 negative regulation of programmed cell death 22.5000 6 yes
GO:0043410 positive regulation of MAPK cascade 22.5000 7 yes
GO:0043549 regulation of kinase activity 22.5000 5 yes
GO:0051240 positive regulation of multicellular organismal process 22.5000 4 yes
GO:0051347 positive regulation of transferase activity 22.5000 5 yes
GO:2000026 regulation of multicellular organismal development 22.5000 4 yes
GO:2000145 regulation of cell motility 22.5000 4 yes
GO:0002684 positive regulation of immune system process 22.5000 4 no
GO:0007010 cytoskeleton organization 22.5000 5 no
GO:0016310 phosphorylation 22.5000 5 no
GO:0051336 regulation of hydrolase activity 22.5000 4 no
GO:0032101 regulation of response to external stimulus 22.5000 4 no
GO:0080134 regulation of response to stress 22.5000 4 no
GO:0043066 negative regulation of apoptotic process 20.0000 7 yes
GO:0044087 regulation of cellular component biogenesis 20.0000 4 yes
GO:0045785 positive regulation of cell adhesion 20.0000 5 yes
GO:0045859 regulation of protein kinase activity 20.0000 6 yes
GO:0051094 positive regulation of developmental process 20.0000 4 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 20.0000 7 yes
GO:0000165 MAPK cascade 17.5000 4 yes
GO:0010001 glial cell differentiation 17.5000 4 yes
GO:0033674 positive regulation of kinase activity 17.5000 6 yes
GO:0038127 ERBB signaling pathway 17.5000 6 yes
GO:0048585 negative regulation of response to stimulus 17.5000 4 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 17.5000 8 yes
GO:0070374 positive regulation of ERK1 and ERK2 cascade 17.5000 8 yes
GO:0042176 regulation of protein catabolic process 15.0000 5 yes
GO:0043933 protein-containing complex organization 15.0000 4 yes
GO:0044089 positive regulation of cellular component biogenesis 15.0000 5 yes
GO:0045597 positive regulation of cell differentiation 15.0000 5 yes
GO:0045860 positive regulation of protein kinase activity 15.0000 7 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 15.0000 9 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 15.0000 5 yes
GO:0060627 regulation of vesicle-mediated transport 15.0000 4 yes
GO:0065003 protein-containing complex assembly 15.0000 5 yes
GO:0009895 negative regulation of catabolic process 12.5000 5 yes
GO:0010648 negative regulation of cell communication 12.5000 5 yes
GO:0023057 negative regulation of signaling 12.5000 4 yes
GO:0031324 negative regulation of cellular metabolic process 12.5000 5 yes
GO:0043254 regulation of protein-containing complex assembly 12.5000 5 yes
GO:0048638 regulation of developmental growth 12.5000 4 yes
GO:0048732 gland development 12.5000 4 yes
GO:0051248 negative regulation of protein metabolic process 12.5000 6 yes
GO:0001558 regulation of cell growth 10.0000 4 yes
GO:0009968 negative regulation of signal transduction 10.0000 5 yes
GO:0031334 positive regulation of protein-containing complex assembly 10.0000 6 yes
GO:0042177 negative regulation of protein catabolic process 10.0000 6 yes
GO:0045927 positive regulation of growth 10.0000 4 yes
GO:0051046 regulation of secretion 10.0000 5 yes
GO:0009890 negative regulation of biosynthetic process 7.5000 5 yes
GO:0014032 neural crest cell development 7.5000 5 yes
GO:0030100 regulation of endocytosis 7.5000 5 yes
GO:0030307 positive regulation of cell growth 7.5000 5 yes
GO:0030855 epithelial cell differentiation 7.5000 4 yes
GO:0031327 negative regulation of cellular biosynthetic process 7.5000 6 yes
GO:0034330 cell junction organization 7.5000 4 yes
GO:0042552 myelination 7.5000 4 yes
GO:0046578 regulation of Ras protein signal transduction 7.5000 7 yes
GO:0046579 positive regulation of Ras protein signal transduction 7.5000 8 yes
GO:0048639 positive regulation of developmental growth 7.5000 5 yes
GO:0048864 stem cell development 7.5000 4 yes
GO:0050808 synapse organization 7.5000 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 7.5000 6 yes
GO:0051057 positive regulation of small GTPase mediated signal transduction 7.5000 7 yes
GO:0051896 regulation of protein kinase B signaling 7.5000 6 yes
GO:0051897 positive regulation of protein kinase B signaling 7.5000 7 yes
GO:0002090 regulation of receptor internalization 5.0000 7 yes
GO:0007399 nervous system development 5.0000 4 yes
GO:0007416 synapse assembly 5.0000 6 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 5.0000 6 yes
GO:0010656 negative regulation of muscle cell apoptotic process 5.0000 8 yes
GO:0010660 regulation of muscle cell apoptotic process 5.0000 7 yes
GO:0010662 regulation of striated muscle cell apoptotic process 5.0000 8 yes
GO:0010664 negative regulation of striated muscle cell apoptotic process 5.0000 9 yes
GO:0010665 regulation of cardiac muscle cell apoptotic process 5.0000 9 yes
GO:0010667 negative regulation of cardiac muscle cell apoptotic process 5.0000 10 yes
GO:0032147 activation of protein kinase activity 5.0000 8 yes
GO:0034329 cell junction assembly 5.0000 5 yes
GO:0040013 negative regulation of locomotion 5.0000 4 yes
GO:0042060 wound healing 5.0000 4 yes
GO:0042692 muscle cell differentiation 5.0000 4 yes
GO:0045892 negative regulation of DNA-templated transcription 5.0000 7 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 5.0000 6 yes
GO:0046620 regulation of organ growth 5.0000 4 yes
GO:0046622 positive regulation of organ growth 5.0000 5 yes
GO:0048259 regulation of receptor-mediated endocytosis 5.0000 6 yes
GO:0048709 oligodendrocyte differentiation 5.0000 5 yes
GO:0050919 negative chemotaxis 5.0000 4 yes
GO:0051048 negative regulation of secretion 5.0000 5 yes
GO:0051051 negative regulation of transport 5.0000 4 yes
GO:0051146 striated muscle cell differentiation 5.0000 5 yes
GO:0051253 negative regulation of RNA metabolic process 5.0000 6 yes
GO:0055021 regulation of cardiac muscle tissue growth 5.0000 6 yes
GO:0055023 positive regulation of cardiac muscle tissue growth 5.0000 7 yes
GO:0060043 regulation of cardiac muscle cell proliferation 5.0000 5 yes
GO:0060045 positive regulation of cardiac muscle cell proliferation 5.0000 6 yes
GO:0060420 regulation of heart growth 5.0000 5 yes
GO:0060421 positive regulation of heart growth 5.0000 6 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 5.0000 4 yes
GO:0099527 postsynapse to nucleus signaling pathway 5.0000 4 yes
GO:1902679 negative regulation of RNA biosynthetic process 5.0000 7 yes
GO:1903507 negative regulation of nucleic acid-templated transcription 5.0000 8 yes
GO:2001233 regulation of apoptotic signaling pathway 5.0000 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in NRG1_HUMAN
DOID:0050686 organ system cancer 5.0000 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ERBB3_HUMAN [view interactions] Low throughput no yes
ERBB2_HUMAN [view entry] [view interactions] Low throughput yes no
ERBB4_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] Low throughput no no
LIMK1_HUMAN [view interactions] Low throughput no yes
CALY_HUMAN [view entry] [view interactions] Low throughput yes yes
T131L_HUMAN [view interactions] High throughput no yes
GLT12_HUMAN [view interactions] High throughput no yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
DAD1_HUMAN [view entry] [view interactions] High throughput yes yes
SEM6B_HUMAN [view interactions] High throughput no yes
RASN_HUMAN [view entry] [view interactions] High throughput yes no
UBP7_HUMAN [view interactions] High throughput no yes
H2B1H_HUMAN [view interactions] High throughput no yes
S10A4_HUMAN [view entry] [view interactions] High throughput yes no
CDC5L_HUMAN [view interactions] High throughput no yes
LAP4B_HUMAN [view interactions] High throughput no yes
M4A4A_HUMAN [view interactions] High throughput no no
TMM54_HUMAN [view interactions] High throughput no no
MYPR_HUMAN [view entry] [view interactions] High throughput yes yes
CD72_HUMAN [view interactions] High throughput no no
ASGR2_HUMAN [view interactions] High throughput no no
JAGN1_HUMAN [view interactions] High throughput no no
MBOA7_HUMAN [view interactions] High throughput no no
LSR_HUMAN [view interactions] High throughput no yes
PGAP1_HUMAN [view interactions] High throughput no no
K2013_HUMAN [view interactions] High throughput no yes
SRBP2_HUMAN [view interactions] High throughput no yes
MAN1_HUMAN [view interactions] High throughput no yes
TMTC3_HUMAN [view interactions] High throughput no yes
TMTC4_HUMAN [view interactions] High throughput no yes
PMGT2_HUMAN [view interactions] High throughput no yes
S38AA_HUMAN [view interactions] High throughput no yes
ATP7B_HUMAN [view interactions] High throughput no no
S35B2_HUMAN [view interactions] High throughput no no
NDUA3_HUMAN [view interactions] High throughput no yes
ZDH17_HUMAN [view interactions] High throughput no yes
TM39B_HUMAN [view interactions] High throughput no yes
DAAF5_HUMAN [view interactions] High throughput no no
B3GN2_HUMAN [view interactions] High throughput no yes
RHBT3_HUMAN [view interactions] High throughput no no
CISD2_HUMAN [view interactions] High throughput no yes
POMT1_HUMAN [view interactions] High throughput no no
SPTC2_HUMAN [view interactions] High throughput no no
GDC_HUMAN [view interactions] High throughput no no
RDH11_HUMAN [view interactions] High throughput no no
MGAT1_HUMAN [view interactions] High throughput no yes
HMOX1_HUMAN [view interactions] High throughput no no
F234B_HUMAN [view interactions] High throughput no yes
EXTL3_HUMAN [view interactions] High throughput no yes
SCMC3_HUMAN [view interactions] High throughput no yes
NETO2_HUMAN [view entry] [view interactions] High throughput yes yes
AGRL1_HUMAN [view entry] [view interactions] High throughput yes no
CNTP3_HUMAN [view interactions] High throughput no yes
DPB1_HUMAN [view interactions] High throughput no no
QCR8_HUMAN [view interactions] High throughput no yes
GLMN_HUMAN [view interactions] High throughput no no
DEGS1_HUMAN [view interactions] High throughput no no
CSCL2_HUMAN [view interactions] High throughput no yes
ABCBA_HUMAN [view interactions] High throughput no yes
LARG2_HUMAN [view interactions] High throughput no yes
B3GL2_HUMAN [view interactions] High throughput no yes
TM181_HUMAN [view interactions] High throughput no yes
INT7_HUMAN [view interactions] High throughput no no
MYO19_HUMAN [view interactions] High throughput no yes
GLT11_HUMAN [view interactions] High throughput no yes
C1GLC_HUMAN [view interactions] High throughput no yes
S22AI_HUMAN [view interactions] High throughput no no
NEK4_HUMAN [view interactions] High throughput no yes
ABCA3_HUMAN [view interactions] High throughput no yes
TM164_HUMAN [view interactions] High throughput no yes
MTCH1_HUMAN [view entry] [view interactions] High throughput yes yes
OPA3_HUMAN [view interactions] High throughput no yes
H6ST1_HUMAN [view interactions] High throughput no no
SFXN3_HUMAN [view entry] [view interactions] High throughput yes yes
TM2D3_HUMAN [view interactions] High throughput no yes
DSE_HUMAN [view interactions] High throughput no yes
TM205_HUMAN [view interactions] High throughput no yes
GOLI_HUMAN [view interactions] High throughput no yes
PIGU_HUMAN [view interactions] High throughput no no
LGR4_HUMAN [view interactions] High throughput no yes
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
B4GT7_HUMAN [view interactions] High throughput no yes
S35F6_HUMAN [view interactions] High throughput no yes
HLAC_HUMAN [view interactions] High throughput no no
CHSTA_HUMAN [view interactions] High throughput no yes
SCNNA_HUMAN [view interactions] High throughput no yes
ORNT1_HUMAN [view interactions] High throughput no yes
B3GA3_HUMAN [view entry] [view interactions] High throughput yes yes
GALT5_HUMAN [view interactions] High throughput no no
DRB1_HUMAN [view interactions] High throughput no no
SPIT1_HUMAN [view interactions] High throughput no yes
B3GN3_HUMAN [view interactions] High throughput no no
ADT1_HUMAN [view entry] [view interactions] High throughput yes yes
PLXA3_HUMAN [view entry] [view interactions] High throughput yes no
SFXN2_HUMAN [view interactions] High throughput no no
GLOD4_HUMAN [view entry] [view interactions] High throughput yes yes
CGT_HUMAN [view interactions] High throughput no no
ERBIN_HUMAN [view entry] [view interactions] Computational yes yes
RASH_HUMAN [view entry] [view interactions] Computational yes no
DOCK7_HUMAN [view entry] [view interactions] Computational yes no
NRG2_HUMAN [view interactions] Computational no yes
WWP1_HUMAN [view interactions] Computational no yes
KAPCA_HUMAN [view entry] [view interactions] Computational yes yes
PK3CA_HUMAN [view entry] [view interactions] Computational yes yes
BTC_HUMAN [view interactions] Computational no no
MP2K1_HUMAN [view entry] [view interactions] Computational yes yes
LRIG1_HUMAN [view interactions] Computational no yes
HBEGF_HUMAN [view interactions] Computational no no
JAK2_HUMAN [view entry] [view interactions] Computational yes yes
CDC37_HUMAN [view interactions] Computational no yes
EREG_HUMAN [view interactions] Computational no no
NRG4_HUMAN [view interactions] Computational no no
MK08_HUMAN [view interactions] Computational no yes
P85A_HUMAN [view interactions] Computational no yes
EGF_HUMAN [view interactions] Computational no no
NRG3_HUMAN [view interactions] Computational no no
NMDE3_HUMAN [view entry] [view interactions] Computational yes no
NMDE1_HUMAN [view entry] [view interactions] Computational yes yes
FYN_HUMAN [view entry] [view interactions] Computational yes no
GRB2_HUMAN [view entry] [view interactions] Computational yes yes
ESR2_HUMAN [view interactions] Computational no no
HS90A_HUMAN [view entry] [view interactions] Computational yes yes
MK03_HUMAN [view entry] [view interactions] Computational yes yes
STA5B_HUMAN [view interactions] Computational no yes
YES_HUMAN [view entry] [view interactions] Computational yes yes
DISC1_HUMAN [view entry] [view interactions] Computational yes no
GPC1_HUMAN [view entry] [view interactions] Computational yes no
RNF41_HUMAN [view interactions] Computational no yes
MK01_HUMAN [view entry] [view interactions] Computational yes yes
SHC1_HUMAN [view entry] [view interactions] Computational yes yes
ADA17_HUMAN [view interactions] Computational no yes
PK3CB_HUMAN [view interactions] Computational no yes
NMDE2_HUMAN [view entry] [view interactions] Computational yes no
STA5A_HUMAN [view interactions] Computational no no
PTN11_HUMAN [view entry] [view interactions] Computational yes yes
DTBP1_HUMAN [view entry] [view interactions] Computational yes yes
RASK_HUMAN [view entry] [view interactions] Computational yes no
PTN12_HUMAN [view interactions] Computational no yes