DAD1_HUMAN
Evidence for PS localization
Functions
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity . Required for the assembly of both SST3A- and SS3B-containing OST complexes. Loss of the DAD1 protein triggers apoptosis (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
No data found.
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DAD1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 60.8696 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 60.8696 | 4 | no |
| GO:0051049 | regulation of transport | 47.8261 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 47.8261 | 4 | no |
| GO:0010941 | regulation of cell death | 43.4783 | 4 | yes |
| GO:0010646 | regulation of cell communication | 43.4783 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.4783 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.1304 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 39.1304 | 5 | no |
| GO:0023056 | positive regulation of signaling | 39.1304 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 39.1304 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 39.1304 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 39.1304 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.1304 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.1304 | 4 | no |
| GO:0036211 | protein modification process | 34.7826 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 34.7826 | 6 | yes |
| GO:0043066 | negative regulation of apoptotic process | 34.7826 | 7 | yes |
| GO:0043067 | regulation of programmed cell death | 34.7826 | 5 | yes |
| GO:0043069 | negative regulation of programmed cell death | 34.7826 | 6 | yes |
| GO:0043412 | macromolecule modification | 34.7826 | 4 | yes |
| GO:0060548 | negative regulation of cell death | 34.7826 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 34.7826 | 4 | no |
| GO:0018193 | peptidyl-amino acid modification | 30.4348 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.4348 | 5 | no |
| GO:0031399 | regulation of protein modification process | 30.4348 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 30.4348 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.4348 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 30.4348 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.4348 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 30.4348 | 5 | no |
| GO:0010468 | regulation of gene expression | 30.4348 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.4348 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 30.4348 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 26.0870 | 7 | no |
| GO:0008104 | protein localization | 26.0870 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 26.0870 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 26.0870 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.0870 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 26.0870 | 7 | no |
| GO:0034330 | cell junction organization | 26.0870 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 26.0870 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.0870 | 5 | no |
| GO:0060341 | regulation of cellular localization | 26.0870 | 4 | no |
| GO:0071310 | cellular response to organic substance | 26.0870 | 4 | no |
| GO:0071702 | organic substance transport | 26.0870 | 4 | no |
| GO:0071705 | nitrogen compound transport | 26.0870 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 26.0870 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 26.0870 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.0870 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 26.0870 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.0870 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.0870 | 5 | no |
| GO:0033043 | regulation of organelle organization | 26.0870 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 26.0870 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.0870 | 5 | no |
| GO:0006915 | apoptotic process | 21.7391 | 4 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 21.7391 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.7391 | 6 | no |
| GO:0015031 | protein transport | 21.7391 | 4 | no |
| GO:0032880 | regulation of protein localization | 21.7391 | 5 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.7391 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.7391 | 7 | no |
| GO:0050808 | synapse organization | 21.7391 | 5 | no |
| GO:0051338 | regulation of transferase activity | 21.7391 | 4 | no |
| GO:0051347 | positive regulation of transferase activity | 21.7391 | 5 | no |
| GO:0071417 | cellular response to organonitrogen compound | 21.7391 | 4 | no |
| GO:1901214 | regulation of neuron death | 21.7391 | 5 | no |
| GO:1901699 | cellular response to nitrogen compound | 21.7391 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 21.7391 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.7391 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.7391 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.7391 | 6 | no |
| GO:0030100 | regulation of endocytosis | 21.7391 | 5 | no |
| GO:0043408 | regulation of MAPK cascade | 21.7391 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.7391 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.7391 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.7391 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.7391 | 5 | no |
| GO:0022607 | cellular component assembly | 21.7391 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.7391 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.7391 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 21.7391 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 21.7391 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.7391 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 21.7391 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 21.7391 | 5 | no |
| GO:0006486 | protein glycosylation | 17.3913 | 4 | yes |
| GO:0006487 | protein N-linked glycosylation | 17.3913 | 5 | yes |
| GO:0018196 | peptidyl-asparagine modification | 17.3913 | 6 | yes |
| GO:0018279 | protein N-linked glycosylation via asparagine | 17.3913 | 6 | yes |
| GO:0031667 | response to nutrient levels | 13.0435 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RPN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MCL1_HUMAN | [view interactions] | Low throughput | no | yes |
| TM258_HUMAN | [view interactions] | Low throughput | no | yes |
| STT3B_HUMAN | [view interactions] | Low throughput | no | yes |
| MLEC_HUMAN | [view interactions] | Low throughput | no | no |
| OST48_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAGT1_HUMAN | [view interactions] | Low throughput | no | yes |
| STT3A_HUMAN | [view interactions] | Low throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OST4_HUMAN | [view interactions] | Low throughput | no | no |
| OSTC_HUMAN | [view interactions] | Low throughput | no | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| PDCD1_HUMAN | [view interactions] | High throughput | no | yes |
| VIPR2_HUMAN | [view interactions] | High throughput | no | no |
| FSHR_HUMAN | [view interactions] | High throughput | no | no |
| SC5A8_HUMAN | [view interactions] | High throughput | no | no |
| CLC5A_HUMAN | [view interactions] | High throughput | no | no |
| SGCA_HUMAN | [view interactions] | High throughput | no | yes |
| LRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TF_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| EFNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHI1_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| ENTP2_HUMAN | [view interactions] | High throughput | no | yes |
| GPR35_HUMAN | [view interactions] | High throughput | no | no |
| EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLRT1_HUMAN | [view interactions] | High throughput | no | no |
| GPBAR_HUMAN | [view interactions] | High throughput | no | no |
| LRC32_HUMAN | [view interactions] | High throughput | no | no |
| CK001_HUMAN | [view interactions] | High throughput | no | no |
| ZACN_HUMAN | [view interactions] | High throughput | no | no |
| TM231_HUMAN | [view interactions] | High throughput | no | yes |
| TUSC3_HUMAN | [view interactions] | High throughput | no | yes |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| TYOBP_HUMAN | [view interactions] | High throughput | no | no |
| CCR6_HUMAN | [view interactions] | High throughput | no | no |
| P2RY2_HUMAN | [view interactions] | High throughput | no | no |
| F241A_HUMAN | [view interactions] | High throughput | no | yes |
| LRAD4_HUMAN | [view interactions] | High throughput | no | yes |
| I27RA_HUMAN | [view interactions] | High throughput | no | no |
| CD27_HUMAN | [view interactions] | High throughput | no | no |
| NPDC1_HUMAN | [view interactions] | High throughput | no | yes |
| TECTB_HUMAN | [view interactions] | High throughput | no | no |
| ICAM2_HUMAN | [view interactions] | High throughput | no | no |
| NRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMED5_HUMAN | [view interactions] | High throughput | no | yes |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| KTAP2_HUMAN | [view interactions] | High throughput | no | no |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E2AK3_HUMAN | [view interactions] | High throughput | no | yes |
| SMG7_HUMAN | [view interactions] | High throughput | no | no |
| TMM43_HUMAN | [view interactions] | High throughput | no | no |
| SRPRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KAT6A_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| NCPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYJ2B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TOM5_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DOPP1_HUMAN | [view interactions] | Computational | no | yes |
| TMEDA_HUMAN | [view interactions] | Computational | no | yes |
| SC61B_HUMAN | [view interactions] | Computational | no | yes |
| AG10A_HUMAN | [view interactions] | Computational | no | yes |
| ASTER_HUMAN | [view interactions] | Computational | no | yes |
| S61A1_HUMAN | [view interactions] | Computational | no | no |
| SSRD_HUMAN | [view interactions] | Computational | no | yes |
| SPCS3_HUMAN | [view interactions] | Computational | no | yes |
| SC61G_HUMAN | [view interactions] | Computational | no | yes |