DAD1_HUMAN
Evidence for PS localization
Functions
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity . Required for the assembly of both SST3A- and SS3B-containing OST complexes. Loss of the DAD1 protein triggers apoptosis (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DAD1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 34.6154 | 4 | no |
| GO:0000166 | nucleotide binding | 30.7692 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.9231 | 5 | no |
| GO:0043169 | cation binding | 26.9231 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 23.0769 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.0769 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DAD1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 57.6923 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 57.6923 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 46.1538 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.3077 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 38.4615 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 38.4615 | 4 | no |
| GO:0051049 | regulation of transport | 38.4615 | 4 | no |
| GO:0008104 | protein localization | 34.6154 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 34.6154 | 4 | no |
| GO:0010468 | regulation of gene expression | 34.6154 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.6154 | 5 | no |
| GO:0010646 | regulation of cell communication | 34.6154 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 34.6154 | 5 | no |
| GO:0023056 | positive regulation of signaling | 34.6154 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 34.6154 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 30.7692 | 5 | yes |
| GO:0043066 | negative regulation of apoptotic process | 30.7692 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 30.7692 | 4 | yes |
| GO:0043069 | negative regulation of programmed cell death | 30.7692 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 30.7692 | 4 | no |
| GO:0022607 | cellular component assembly | 30.7692 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.7692 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.7692 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.7692 | 5 | no |
| GO:0006915 | apoptotic process | 26.9231 | 4 | yes |
| GO:0036211 | protein modification process | 26.9231 | 4 | yes |
| GO:0043412 | macromolecule modification | 26.9231 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 26.9231 | 7 | no |
| GO:0009892 | negative regulation of metabolic process | 26.9231 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.9231 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 26.9231 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.9231 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.9231 | 5 | no |
| GO:0031399 | regulation of protein modification process | 26.9231 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 26.9231 | 4 | no |
| GO:0043933 | protein-containing complex organization | 26.9231 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.9231 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.9231 | 6 | no |
| GO:0060341 | regulation of cellular localization | 26.9231 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 26.9231 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.0769 | 7 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 23.0769 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.0769 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.0769 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.0769 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.0769 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.0769 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 23.0769 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.0769 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 23.0769 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.0769 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.0769 | 6 | no |
| GO:0065003 | protein-containing complex assembly | 23.0769 | 5 | no |
| GO:0071702 | organic substance transport | 23.0769 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.0769 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.0769 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.0769 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0032880 | regulation of protein localization | 23.0769 | 5 | no |
| GO:0050890 | cognition | 23.0769 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 23.0769 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 23.0769 | 4 | no |
| GO:0033043 | regulation of organelle organization | 23.0769 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.0769 | 5 | no |
| GO:0006486 | protein glycosylation | 15.3846 | 4 | yes |
| GO:0006487 | protein N-linked glycosylation | 15.3846 | 5 | yes |
| GO:0018279 | protein N-linked glycosylation via asparagine | 15.3846 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RPN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OST48_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OST4_HUMAN | [view interactions] | Low throughput | no | no |
| OSTC_HUMAN | [view interactions] | Low throughput | no | no |
| STT3A_HUMAN | [view interactions] | Low throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TM258_HUMAN | [view interactions] | Low throughput | no | yes |
| MLEC_HUMAN | [view interactions] | Low throughput | no | no |
| MAGT1_HUMAN | [view interactions] | Low throughput | no | yes |
| STT3B_HUMAN | [view interactions] | Low throughput | no | yes |
| MCL1_HUMAN | [view interactions] | Low throughput | no | yes |
| SC61G_HUMAN | [view interactions] | Low throughput | no | yes |
| SSRG_HUMAN | [view interactions] | Low throughput | no | yes |
| SSRD_HUMAN | [view interactions] | Low throughput | no | yes |
| SC61B_HUMAN | [view interactions] | Low throughput | no | yes |
| S61A1_HUMAN | [view interactions] | Low throughput | no | no |
| SSRA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SSRB_HUMAN | [view interactions] | Low throughput | no | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| PDCD1_HUMAN | [view interactions] | High throughput | no | yes |
| VIPR2_HUMAN | [view interactions] | High throughput | no | no |
| FSHR_HUMAN | [view interactions] | High throughput | no | no |
| SC5A8_HUMAN | [view interactions] | High throughput | no | no |
| CLC5A_HUMAN | [view interactions] | High throughput | no | no |
| SGCA_HUMAN | [view interactions] | High throughput | no | yes |
| LRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TF_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| ETS2_HUMAN | [view interactions] | High throughput | no | no |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| EFNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHI1_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| ENTP2_HUMAN | [view interactions] | High throughput | no | yes |
| GPR35_HUMAN | [view interactions] | High throughput | no | no |
| EAA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLRT1_HUMAN | [view interactions] | High throughput | no | no |
| GPBAR_HUMAN | [view interactions] | High throughput | no | no |
| LRC32_HUMAN | [view interactions] | High throughput | no | no |
| CFA68_HUMAN | [view interactions] | High throughput | no | no |
| ZACN_HUMAN | [view interactions] | High throughput | no | no |
| TM231_HUMAN | [view interactions] | High throughput | no | yes |
| TUSC3_HUMAN | [view interactions] | High throughput | no | yes |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| TYOBP_HUMAN | [view interactions] | High throughput | no | no |
| CCR6_HUMAN | [view interactions] | High throughput | no | no |
| P2RY2_HUMAN | [view interactions] | High throughput | no | no |
| F241A_HUMAN | [view interactions] | High throughput | no | yes |
| LRAD4_HUMAN | [view interactions] | High throughput | no | yes |
| I27RA_HUMAN | [view interactions] | High throughput | no | no |
| CD27_HUMAN | [view interactions] | High throughput | no | no |
| NPDC1_HUMAN | [view interactions] | High throughput | no | yes |
| TECTB_HUMAN | [view interactions] | High throughput | no | no |
| ICAM2_HUMAN | [view interactions] | High throughput | no | no |
| NRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMED5_HUMAN | [view interactions] | High throughput | no | yes |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| KTAP2_HUMAN | [view interactions] | High throughput | no | no |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E2AK3_HUMAN | [view interactions] | High throughput | no | yes |
| SMG7_HUMAN | [view interactions] | High throughput | no | no |
| TMM43_HUMAN | [view interactions] | High throughput | no | no |
| SRPRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KAT6A_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| NCPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYJ2B_HUMAN | [view interactions] | High throughput | no | no |
| TOM5_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA4_HUMAN | [view interactions] | High throughput | no | yes |