Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

EFNB2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

(Microbial infection) Acts as a receptor for Hendra virus and Nipah virus. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI003879 LIG_SH2_NCK_1 LIG 304 308 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in EFNB2_HUMAN
GO:0017076 purine nucleotide binding 48.0769 4 no
GO:0032555 purine ribonucleotide binding 48.0769 4 no
GO:0035639 purine ribonucleoside triphosphate binding 48.0769 4 no
GO:0019900 kinase binding 34.6154 4 no
GO:0019901 protein kinase binding 34.6154 5 no
GO:0005525 GTP binding 32.6923 5 no
GO:0019001 guanyl nucleotide binding 32.6923 5 no
GO:0032561 guanyl ribonucleotide binding 32.6923 5 no
GO:0003924 GTPase activity 30.7692 7 no
GO:0016462 pyrophosphatase activity 30.7692 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 30.7692 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 30.7692 6 no
GO:0046875 ephrin receptor binding 9.6154 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in EFNB2_HUMAN
GO:0048522 positive regulation of cellular process 67.3077 4 yes
GO:0048523 negative regulation of cellular process 55.7692 4 yes
GO:0051128 regulation of cellular component organization 55.7692 4 yes
GO:0051049 regulation of transport 50.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 48.0769 4 no
GO:0016192 vesicle-mediated transport 48.0769 4 no
GO:0022607 cellular component assembly 44.2308 4 yes
GO:0080090 regulation of primary metabolic process 44.2308 4 no
GO:0010646 regulation of cell communication 42.3077 4 no
GO:0051171 regulation of nitrogen compound metabolic process 42.3077 4 no
GO:0008104 protein localization 42.3077 4 no
GO:0071702 organic substance transport 42.3077 4 no
GO:0071705 nitrogen compound transport 40.3846 4 no
GO:0006996 organelle organization 40.3846 4 no
GO:0009966 regulation of signal transduction 38.4615 4 no
GO:0022603 regulation of anatomical structure morphogenesis 36.5385 4 yes
GO:0031344 regulation of cell projection organization 36.5385 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 36.5385 6 yes
GO:0009893 positive regulation of metabolic process 36.5385 4 no
GO:0010604 positive regulation of macromolecule metabolic process 36.5385 5 no
GO:1902531 regulation of intracellular signal transduction 36.5385 5 no
GO:0010941 regulation of cell death 34.6154 4 yes
GO:0071310 cellular response to organic substance 34.6154 4 yes
GO:0030030 cell projection organization 32.6923 4 yes
GO:0030155 regulation of cell adhesion 32.6923 4 yes
GO:0060627 regulation of vesicle-mediated transport 32.6923 4 yes
GO:0031323 regulation of cellular metabolic process 32.6923 4 no
GO:0048584 positive regulation of response to stimulus 32.6923 4 no
GO:0051130 positive regulation of cellular component organization 32.6923 5 no
GO:0051246 regulation of protein metabolic process 32.6923 5 no
GO:0015031 protein transport 32.6923 4 no
GO:0010468 regulation of gene expression 32.6923 5 no
GO:0042127 regulation of cell population proliferation 30.7692 4 yes
GO:0051094 positive regulation of developmental process 30.7692 4 yes
GO:0010647 positive regulation of cell communication 30.7692 5 no
GO:0023056 positive regulation of signaling 30.7692 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 30.7692 5 no
GO:0033043 regulation of organelle organization 30.7692 5 no
GO:0051050 positive regulation of transport 30.7692 4 no
GO:0008284 positive regulation of cell population proliferation 28.8462 5 yes
GO:0045595 regulation of cell differentiation 28.8462 4 yes
GO:0051129 negative regulation of cellular component organization 28.8462 5 yes
GO:0120036 plasma membrane bounded cell projection organization 28.8462 5 yes
GO:0009892 negative regulation of metabolic process 28.8462 4 no
GO:0007010 cytoskeleton organization 28.8462 5 no
GO:0042981 regulation of apoptotic process 28.8462 6 no
GO:0043067 regulation of programmed cell death 28.8462 5 no
GO:0002684 positive regulation of immune system process 26.9231 4 yes
GO:0045785 positive regulation of cell adhesion 26.9231 5 yes
GO:1901701 cellular response to oxygen-containing compound 26.9231 4 yes
GO:0009967 positive regulation of signal transduction 26.9231 5 no
GO:0010605 negative regulation of macromolecule metabolic process 26.9231 5 no
GO:0030334 regulation of cell migration 26.9231 5 no
GO:2000145 regulation of cell motility 26.9231 4 no
GO:0006886 intracellular protein transport 26.9231 4 no
GO:0032880 regulation of protein localization 26.9231 5 no
GO:0060341 regulation of cellular localization 26.9231 4 no
GO:0044087 regulation of cellular component biogenesis 26.9231 4 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 yes
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:0006897 endocytosis 25.0000 5 no
GO:0030100 regulation of endocytosis 23.0769 5 yes
GO:0045597 positive regulation of cell differentiation 23.0769 5 yes
GO:0006796 phosphate-containing compound metabolic process 23.0769 4 no
GO:0010243 response to organonitrogen compound 23.0769 4 no
GO:0019220 regulation of phosphate metabolic process 23.0769 6 no
GO:0030335 positive regulation of cell migration 23.0769 6 no
GO:0031399 regulation of protein modification process 23.0769 6 no
GO:0036211 protein modification process 23.0769 4 no
GO:0040017 positive regulation of locomotion 23.0769 4 no
GO:0042325 regulation of phosphorylation 23.0769 7 no
GO:0043412 macromolecule modification 23.0769 4 no
GO:0051174 regulation of phosphorus metabolic process 23.0769 5 no
GO:2000147 positive regulation of cell motility 23.0769 5 no
GO:0051493 regulation of cytoskeleton organization 23.0769 6 no
GO:0097435 supramolecular fiber organization 23.0769 4 no
GO:0032970 regulation of actin filament-based process 23.0769 4 no
GO:0010942 positive regulation of cell death 21.1538 5 yes
GO:0001932 regulation of protein phosphorylation 21.1538 7 no
GO:0010648 negative regulation of cell communication 21.1538 5 no
GO:0022604 regulation of cell morphogenesis 21.1538 5 no
GO:0023057 negative regulation of signaling 21.1538 4 no
GO:0031346 positive regulation of cell projection organization 21.1538 6 no
GO:2000026 regulation of multicellular organismal development 21.1538 4 no
GO:0009889 regulation of biosynthetic process 21.1538 4 no
GO:0032535 regulation of cellular component size 21.1538 4 no
GO:0032956 regulation of actin cytoskeleton organization 21.1538 5 no
GO:0044089 positive regulation of cellular component biogenesis 21.1538 5 no
GO:0060491 regulation of cell projection assembly 21.1538 5 no
GO:0007264 small GTPase mediated signal transduction 21.1538 4 no
GO:0002694 regulation of leukocyte activation 19.2308 4 yes
GO:0002696 positive regulation of leukocyte activation 19.2308 5 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 19.2308 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 19.2308 5 yes
GO:0010975 regulation of neuron projection development 19.2308 7 yes
GO:0031175 neuron projection development 19.2308 6 yes
GO:0034330 cell junction organization 19.2308 4 yes
GO:0050865 regulation of cell activation 19.2308 4 yes
GO:0050867 positive regulation of cell activation 19.2308 5 yes
GO:0022407 regulation of cell-cell adhesion 17.3077 5 yes
GO:0031345 negative regulation of cell projection organization 17.3077 6 yes
GO:0051249 regulation of lymphocyte activation 17.3077 5 yes
GO:0051251 positive regulation of lymphocyte activation 17.3077 6 yes
GO:1901214 regulation of neuron death 17.3077 5 yes
GO:0002009 morphogenesis of an epithelium 15.3846 4 yes
GO:0010977 negative regulation of neuron projection development 15.3846 7 yes
GO:0022409 positive regulation of cell-cell adhesion 15.3846 6 yes
GO:0032101 regulation of response to external stimulus 15.3846 4 yes
GO:0033993 response to lipid 15.3846 4 yes
GO:0045216 cell-cell junction organization 15.3846 5 yes
GO:0050863 regulation of T cell activation 15.3846 6 yes
GO:0050870 positive regulation of T cell activation 15.3846 7 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 15.3846 6 yes
GO:1903039 positive regulation of leukocyte cell-cell adhesion 15.3846 7 yes
GO:0008285 negative regulation of cell population proliferation 13.4615 5 yes
GO:0048013 ephrin receptor signaling pathway 13.4615 6 yes
GO:0048259 regulation of receptor-mediated endocytosis 13.4615 6 yes
GO:0071396 cellular response to lipid 13.4615 5 yes
GO:0050678 regulation of epithelial cell proliferation 11.5385 5 yes
GO:0060562 epithelial tube morphogenesis 11.5385 4 yes
GO:0001667 ameboidal-type cell migration 9.6154 4 yes
GO:0002237 response to molecule of bacterial origin 9.6154 4 yes
GO:0007411 axon guidance 9.6154 8 yes
GO:0032496 response to lipopolysaccharide 9.6154 4 yes
GO:0034332 adherens junction organization 9.6154 6 yes
GO:0050920 regulation of chemotaxis 9.6154 4 yes
GO:0071219 cellular response to molecule of bacterial origin 9.6154 4 yes
GO:0071222 cellular response to lipopolysaccharide 9.6154 5 yes
GO:0097485 neuron projection guidance 9.6154 7 yes
GO:1901216 positive regulation of neuron death 9.6154 6 yes
GO:0002090 regulation of receptor internalization 7.6923 7 yes
GO:0010631 epithelial cell migration 7.6923 5 yes
GO:0043542 endothelial cell migration 7.6923 6 yes
GO:0048514 blood vessel morphogenesis 7.6923 4 yes
GO:0050680 negative regulation of epithelial cell proliferation 5.7692 6 yes
GO:0072178 nephric duct morphogenesis 5.7692 5 yes
GO:0002042 cell migration involved in sprouting angiogenesis 3.8462 8 yes
GO:0010837 regulation of keratinocyte proliferation 3.8462 6 yes
GO:0010839 negative regulation of keratinocyte proliferation 3.8462 7 yes
GO:0043534 blood vessel endothelial cell migration 3.8462 7 yes
GO:0048845 venous blood vessel morphogenesis 3.8462 5 yes
GO:0051147 regulation of muscle cell differentiation 3.8462 5 yes
GO:0051149 positive regulation of muscle cell differentiation 3.8462 6 yes
GO:0051153 regulation of striated muscle cell differentiation 3.8462 6 yes
GO:0051155 positive regulation of striated muscle cell differentiation 3.8462 7 yes
GO:0099054 presynapse assembly 3.8462 5 yes
GO:0099172 presynapse organization 3.8462 4 yes
GO:1903847 regulation of aorta morphogenesis 3.8462 6 yes
GO:1903849 positive regulation of aorta morphogenesis 3.8462 6 yes
GO:1905207 regulation of cardiocyte differentiation 3.8462 5 yes
GO:1905209 positive regulation of cardiocyte differentiation 3.8462 5 yes
GO:1905651 regulation of artery morphogenesis 3.8462 5 yes
GO:1905653 positive regulation of artery morphogenesis 3.8462 5 yes
GO:2000725 regulation of cardiac muscle cell differentiation 3.8462 6 yes
GO:2000727 positive regulation of cardiac muscle cell differentiation 3.8462 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in EFNB2_HUMAN
DOID:0050700 cardiomyopathy 3.8462 4 no
DOID:0060036 intrinsic cardiomyopathy 3.8462 5 no
DOID:114 heart disease 3.8462 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NCK2_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
EPHA4_HUMAN [view entry] [view interactions] Low throughput yes yes
EFNB1_HUMAN [view interactions] Low throughput no yes
EPHB4_HUMAN [view interactions] Low throughput no yes
EPHB3_HUMAN [view interactions] Low throughput no yes
RELN_HUMAN [view interactions] Low throughput no no
DAB1_HUMAN [view interactions] Low throughput no yes
EPHB2_HUMAN [view entry] [view interactions] Low throughput yes yes
CXA1_HUMAN [view entry] [view interactions] Low throughput yes yes
PHAG1_HUMAN [view interactions] Low throughput no yes
EPHB1_HUMAN [view interactions] Low throughput no no
EPHA3_HUMAN [view interactions] Low throughput no yes
AQP1_HUMAN [view entry] [view interactions] Low throughput yes no
EFNB2_HUMAN [view entry] [view interactions] Low throughput yes yes
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
NGBR_HUMAN [view interactions] High throughput no no
DIP2B_HUMAN [view entry] [view interactions] High throughput yes yes
DPH1_HUMAN [view interactions] High throughput no yes
RADIL_HUMAN [view interactions] High throughput no no
P4K2B_HUMAN [view interactions] High throughput no yes
DEN6A_HUMAN [view interactions] High throughput no yes
PKN3_HUMAN [view interactions] High throughput no yes
TIGD5_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
EI2BB_HUMAN [view entry] [view interactions] High throughput yes yes
MAOX_HUMAN [view interactions] High throughput no yes
PK3CB_HUMAN [view interactions] High throughput no yes
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
SDC2_HUMAN [view interactions] High throughput no yes
TYK2_HUMAN [view interactions] High throughput no no
SDC3_HUMAN [view interactions] High throughput no yes
TSN3_HUMAN [view interactions] High throughput no yes
PHLP1_HUMAN [view interactions] High throughput no yes
P85B_HUMAN [view interactions] High throughput no yes
F1712_HUMAN [view interactions] High throughput no no
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A2_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
DYN2_HUMAN [view entry] [view interactions] High throughput yes yes
MYH6_HUMAN [view entry] [view interactions] High throughput yes no
DAB2_HUMAN [view interactions] High throughput no yes
PARD3_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
TM216_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
ANR46_HUMAN [view interactions] High throughput no yes
CAND2_HUMAN [view entry] [view interactions] High throughput yes no
EI2BD_HUMAN [view interactions] High throughput no yes
MA7D2_HUMAN [view interactions] High throughput no yes
EPHA5_HUMAN [view interactions] High throughput no no
SAAL1_HUMAN [view interactions] High throughput no yes
DIP2A_HUMAN [view interactions] High throughput no no
PKHH3_HUMAN [view interactions] High throughput no no
P121A_HUMAN [view interactions] High throughput no yes
MTMR5_HUMAN [view entry] [view interactions] High throughput yes no
RETST_HUMAN [view interactions] High throughput no yes
EFNMT_HUMAN [view interactions] High throughput no yes
P85A_HUMAN [view interactions] High throughput no yes
P55G_HUMAN [view interactions] High throughput no yes
UBE3C_HUMAN [view entry] [view interactions] High throughput yes yes
DYN3_HUMAN [view entry] [view interactions] High throughput yes no
USO1_HUMAN [view entry] [view interactions] High throughput yes yes
MA7D3_HUMAN [view interactions] High throughput no no
AT2B2_HUMAN [view entry] [view interactions] High throughput yes yes
MED16_HUMAN [view interactions] High throughput no yes
PKP2_HUMAN [view interactions] High throughput no yes
HPS3_HUMAN [view interactions] High throughput no yes
AAAS_HUMAN [view interactions] High throughput no yes
PKHG4_HUMAN [view interactions] High throughput no no
MTMR1_HUMAN [view interactions] High throughput no yes
F120A_HUMAN [view interactions] High throughput no yes
MRPP3_HUMAN [view interactions] High throughput no yes
NF1_HUMAN [view entry] [view interactions] High throughput yes no
LMBR1_HUMAN [view interactions] High throughput no yes
EI2BE_HUMAN [view interactions] High throughput no yes
DAD1_HUMAN [view entry] [view interactions] High throughput yes yes
RGS3_HUMAN [view interactions] High throughput no no
TEX2_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
UBQL1_HUMAN [view interactions] High throughput no yes
TM9S3_HUMAN [view interactions] High throughput no yes
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
S39AB_HUMAN [view interactions] High throughput no no
CD28_HUMAN [view interactions] High throughput no no
PLPL6_HUMAN [view entry] [view interactions] High throughput yes yes
RRFM_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOF_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND3_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
PZRN3_HUMAN [view interactions] High throughput no yes
RHDF2_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
B3GA1_HUMAN [view interactions] High throughput no yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
DIRA3_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
CXD3_HUMAN [view interactions] High throughput no no
LAMP1_HUMAN [view interactions] High throughput no yes
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
AFAD_HUMAN [view interactions] High throughput no yes
OCLN_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
SC61B_HUMAN [view interactions] High throughput no yes
STX4_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes