MTMR5_HUMAN
Evidence for PS localization
Functions
Acts as an adapter for the phosphatase MTMR2 to regulate MTMR2 catalytic activity and subcellular location (PubMed). May function as a guanine nucleotide exchange factor (GEF) activating RAB28 (PubMed). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed). Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MTMR5_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 45.0000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 45.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 45.0000 | 4 | no |
| GO:0003924 | GTPase activity | 35.0000 | 7 | no |
| GO:0005525 | GTP binding | 35.0000 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 35.0000 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 35.0000 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 35.0000 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 35.0000 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 35.0000 | 5 | no |
| GO:0019900 | kinase binding | 32.5000 | 4 | no |
| GO:0019901 | protein kinase binding | 32.5000 | 5 | no |
| GO:0030695 | GTPase regulator activity | 12.5000 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 7.5000 | 5 | yes |
| GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | 7.5000 | 4 | yes |
| GO:0016791 | phosphatase activity | 7.5000 | 5 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 7.5000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MTMR5_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 70.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 60.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 60.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.5000 | 4 | no |
| GO:0010646 | regulation of cell communication | 52.5000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.5000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 47.5000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 47.5000 | 4 | no |
| GO:0051049 | regulation of transport | 45.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 42.5000 | 4 | no |
| GO:0006996 | organelle organization | 40.0000 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 37.5000 | 4 | no |
| GO:0033043 | regulation of organelle organization | 37.5000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 37.5000 | 4 | no |
| GO:0008104 | protein localization | 37.5000 | 4 | no |
| GO:0007264 | small GTPase mediated signal transduction | 37.5000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 35.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.0000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 35.0000 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 35.0000 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 35.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 35.0000 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 35.0000 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.5000 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 32.5000 | 7 | no |
| GO:0044087 | regulation of cellular component biogenesis | 32.5000 | 4 | no |
| GO:0071702 | organic substance transport | 32.5000 | 4 | no |
| GO:0051050 | positive regulation of transport | 32.5000 | 4 | no |
| GO:0022607 | cellular component assembly | 32.5000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 32.5000 | 4 | no |
| GO:0007265 | Ras protein signal transduction | 32.5000 | 5 | no |
| GO:0010941 | regulation of cell death | 32.5000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 30.0000 | 5 | no |
| GO:0010468 | regulation of gene expression | 30.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.0000 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 30.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 30.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | no |
| GO:0030030 | cell projection organization | 30.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 30.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 30.0000 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 27.5000 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 27.5000 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 27.5000 | 7 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 27.5000 | 6 | no |
| GO:0031399 | regulation of protein modification process | 27.5000 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 27.5000 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 27.5000 | 7 | no |
| GO:0015031 | protein transport | 27.5000 | 4 | no |
| GO:0051726 | regulation of cell cycle | 27.5000 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 27.5000 | 5 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 27.5000 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 27.5000 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 27.5000 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 27.5000 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 27.5000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.5000 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 27.5000 | 6 | no |
| GO:0071310 | cellular response to organic substance | 27.5000 | 4 | no |
| GO:0032880 | regulation of protein localization | 27.5000 | 5 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | yes |
| GO:0043412 | macromolecule modification | 25.0000 | 4 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 25.0000 | 8 | no |
| GO:0031401 | positive regulation of protein modification process | 25.0000 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
| GO:0030334 | regulation of cell migration | 25.0000 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | no |
| GO:2000145 | regulation of cell motility | 25.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 22.5000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.5000 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.5000 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.5000 | 5 | no |
| GO:0060491 | regulation of cell projection assembly | 22.5000 | 5 | no |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 22.5000 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 22.5000 | 4 | no |
| GO:0043549 | regulation of kinase activity | 22.5000 | 5 | no |
| GO:0051338 | regulation of transferase activity | 22.5000 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 22.5000 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.5000 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 22.5000 | 4 | no |
| GO:0022604 | regulation of cell morphogenesis | 22.5000 | 5 | no |
| GO:0030335 | positive regulation of cell migration | 22.5000 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 22.5000 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 22.5000 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 22.5000 | 6 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 22.5000 | 5 | no |
| GO:0060548 | negative regulation of cell death | 22.5000 | 5 | no |
| GO:2000147 | positive regulation of cell motility | 22.5000 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 22.5000 | 5 | no |
| GO:0008284 | positive regulation of cell population proliferation | 22.5000 | 5 | no |
| GO:0043087 | regulation of GTPase activity | 12.5000 | 5 | yes |
| GO:0006470 | protein dephosphorylation | 7.5000 | 5 | yes |
| GO:0016311 | dephosphorylation | 7.5000 | 5 | yes |
| GO:0007286 | spermatid development | 5.0000 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MTMR5_HUMAN |
|---|---|---|---|---|
| DOID:10595 | Charcot-Marie-Tooth disease | 7.5000 | 6 | no |
| DOID:440 | neuromuscular disease | 7.5000 | 5 | no |
| DOID:574 | peripheral nervous system disease | 7.5000 | 3 | no |
| DOID:870 | neuropathy | 7.5000 | 4 | no |
| DOID:0050700 | cardiomyopathy | 5.0000 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 5.0000 | 5 | no |
| DOID:114 | heart disease | 5.0000 | 3 | no |
| DOID:2843 | long QT syndrome | 5.0000 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SUV91_HUMAN | [view interactions] | Low throughput | no | no |
| KMT2A_HUMAN | [view interactions] | Low throughput | no | yes |
| MTMR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| PMS1_HUMAN | [view interactions] | High throughput | no | no |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| CDN1A_HUMAN | [view interactions] | High throughput | no | no |
| EFNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGFR2_HUMAN | [view interactions] | High throughput | no | no |
| SKAP1_HUMAN | [view interactions] | High throughput | no | no |
| GFOD1_HUMAN | [view interactions] | High throughput | no | yes |
| RHEX_HUMAN | [view interactions] | High throughput | no | no |
| FBW1B_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CO1A2_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR1_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPAP3_HUMAN | [view interactions] | High throughput | no | yes |
| SP16H_HUMAN | [view interactions] | High throughput | no | yes |
| WDR55_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UQCC1_HUMAN | [view interactions] | High throughput | no | yes |
| UQCC2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFT27_HUMAN | [view interactions] | High throughput | no | yes |
| CT2NL_HUMAN | [view interactions] | High throughput | no | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFT52_HUMAN | [view interactions] | High throughput | no | no |
| RT16_HUMAN | [view interactions] | High throughput | no | yes |
| PTG3L_HUMAN | [view interactions] | High throughput | no | no |
| RAB6B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAVR2_HUMAN | [view interactions] | High throughput | no | no |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| MANS1_HUMAN | [view interactions] | High throughput | no | yes |
| HENMT_HUMAN | [view interactions] | High throughput | no | yes |
| PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC4C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH5_HUMAN | [view interactions] | High throughput | no | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| LYAM2_HUMAN | [view interactions] | High throughput | no | no |
| IN80B_HUMAN | [view interactions] | High throughput | no | no |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| DHE4_HUMAN | [view interactions] | High throughput | no | yes |
| ZNHI1_HUMAN | [view interactions] | High throughput | no | yes |
| TLE1_HUMAN | [view interactions] | High throughput | no | yes |
| SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| ACINU_HUMAN | [view interactions] | High throughput | no | yes |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| PSME1_HUMAN | [view interactions] | High throughput | no | yes |
| PNMA2_HUMAN | [view interactions] | High throughput | no | yes |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| IBP3_HUMAN | [view interactions] | High throughput | no | no |
| EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
| X3CL1_HUMAN | [view interactions] | High throughput | no | yes |
| BTNL9_HUMAN | [view interactions] | High throughput | no | no |
| PRPS2_HUMAN | [view interactions] | High throughput | no | no |
| TRI52_HUMAN | [view interactions] | High throughput | no | yes |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| CD6_HUMAN | [view interactions] | High throughput | no | no |
| LURA1_HUMAN | [view interactions] | High throughput | no | yes |
| CTG1B_HUMAN | [view interactions] | High throughput | no | no |
| PPM1M_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW5_HUMAN | [view interactions] | High throughput | no | no |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| SNX21_HUMAN | [view interactions] | High throughput | no | yes |
| SPRY7_HUMAN | [view interactions] | High throughput | no | yes |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| D2HDH_HUMAN | [view interactions] | High throughput | no | no |
| AL3B1_HUMAN | [view interactions] | High throughput | no | yes |
| KLH14_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B3_HUMAN | [view interactions] | High throughput | no | yes |
| CRBB3_HUMAN | [view interactions] | High throughput | no | no |
| CRBA4_HUMAN | [view interactions] | High throughput | no | no |
| ST1C4_HUMAN | [view interactions] | High throughput | no | no |
| TFPT_HUMAN | [view interactions] | High throughput | no | yes |
| B4GT2_HUMAN | [view interactions] | High throughput | no | no |
| DHDH_HUMAN | [view interactions] | High throughput | no | no |
| HDHD1_HUMAN | [view interactions] | High throughput | no | yes |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INAVA_HUMAN | [view interactions] | High throughput | no | yes |
| CIB2_HUMAN | [view interactions] | High throughput | no | yes |
| TRM61_HUMAN | [view interactions] | High throughput | no | no |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APBA3_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CND1_HUMAN | [view interactions] | High throughput | no | yes |
| RIF1_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| PDPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNF11_HUMAN | [view interactions] | High throughput | no | no |
| MTMRD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIR3_HUMAN | [view interactions] | High throughput | no | yes |
| NEK7_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAE2_HUMAN | [view interactions] | Computational | no | yes |
| GDIA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAE1_HUMAN | [view interactions] | Computational | no | yes |
| GDIB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB21_HUMAN | [view entry] [view interactions] | Computational | yes | yes |