SRC8_HUMAN
Contributes to the organization of the actin cytoskeleton and cell shape (PubMed). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones . Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density . Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed). Plays a role in focal adhesion assembly and turnover . In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed). Plays a role in receptor-mediated endocytosis via clathrin-coated pits . Required for stabilization of KCNH1 channels at the cell membrane (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI003882 | LIG_SH2_NCK_1 | LIG | 419 | 425 | - |
| ELMI003882 | LIG_SH2_NCK_1 | LIG | 419 | 425 | - |
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SRC8_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 32.4742 | 4 | no |
| GO:0003779 | actin binding | 30.4124 | 4 | no |
| GO:0000166 | nucleotide binding | 29.3814 | 4 | no |
| GO:0017076 | purine nucleotide binding | 29.3814 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 28.3505 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.8351 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 26.8041 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.7732 | 5 | no |
| GO:0005524 | ATP binding | 25.2577 | 5 | no |
| GO:0045296 | cadherin binding | 24.2268 | 4 | yes |
| GO:0003723 | RNA binding | 23.7113 | 4 | no |
| GO:0043169 | cation binding | 20.1031 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SRC8_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.8247 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.5155 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 48.9691 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 46.9072 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 46.9072 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.8144 | 4 | no |
| GO:0010646 | regulation of cell communication | 41.7526 | 4 | yes |
| GO:0006996 | organelle organization | 39.6907 | 4 | yes |
| GO:0022607 | cellular component assembly | 39.1753 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 38.6598 | 4 | no |
| GO:0009966 | regulation of signal transduction | 37.1134 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.1134 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 34.5361 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.5361 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 34.5361 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 34.5361 | 5 | no |
| GO:0010468 | regulation of gene expression | 34.0206 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.4742 | 5 | no |
| GO:0008104 | protein localization | 31.4433 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 29.3814 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 29.3814 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 26.8041 | 6 | no |
| GO:0051049 | regulation of transport | 26.2887 | 4 | no |
| GO:0007010 | cytoskeleton organization | 25.7732 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 25.7732 | 4 | no |
| GO:0043933 | protein-containing complex organization | 25.7732 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.7423 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 24.7423 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 24.7423 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.7423 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 24.2268 | 6 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.2268 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.2268 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.7113 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.7113 | 4 | no |
| GO:0030030 | cell projection organization | 23.1959 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 23.1959 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 23.1959 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 23.1959 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 22.6804 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.6804 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.6804 | 6 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.1649 | 6 | no |
| GO:0043412 | macromolecule modification | 22.1649 | 4 | no |
| GO:0036211 | protein modification process | 21.6495 | 4 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 21.1340 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 21.1340 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.1340 | 5 | no |
| GO:0071310 | cellular response to organic substance | 21.1340 | 4 | no |
| GO:0007015 | actin filament organization | 20.6186 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.6186 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.1031 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.1031 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 20.1031 | 5 | no |
| GO:0009894 | regulation of catabolic process | 19.5876 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 19.5876 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 19.5876 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 18.0412 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 18.0412 | 4 | yes |
| GO:0071702 | organic substance transport | 18.0412 | 4 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 17.5258 | 5 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 17.5258 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 17.5258 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 17.0103 | 4 | yes |
| GO:0110053 | regulation of actin filament organization | 17.0103 | 6 | yes |
| GO:0043066 | negative regulation of apoptotic process | 15.9794 | 6 | yes |
| GO:0043069 | negative regulation of programmed cell death | 15.9794 | 5 | yes |
| GO:0010638 | positive regulation of organelle organization | 14.9485 | 6 | yes |
| GO:0015031 | protein transport | 14.4330 | 4 | yes |
| GO:0032271 | regulation of protein polymerization | 14.4330 | 6 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 14.4330 | 5 | yes |
| GO:0032535 | regulation of cellular component size | 13.4021 | 4 | yes |
| GO:0034330 | cell junction organization | 13.4021 | 4 | yes |
| GO:0034329 | cell junction assembly | 11.3402 | 5 | yes |
| GO:0098657 | import into cell | 11.3402 | 4 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 10.8247 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 10.8247 | 5 | yes |
| GO:0031329 | regulation of cellular catabolic process | 10.3093 | 5 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 10.3093 | 7 | yes |
| GO:1902905 | positive regulation of supramolecular fiber organization | 10.3093 | 6 | yes |
| GO:0030833 | regulation of actin filament polymerization | 9.7938 | 7 | yes |
| GO:0010506 | regulation of autophagy | 9.2784 | 6 | yes |
| GO:0031334 | positive regulation of protein-containing complex assembly | 8.7629 | 6 | yes |
| GO:0044057 | regulation of system process | 8.7629 | 4 | yes |
| GO:0006886 | intracellular protein transport | 8.2474 | 4 | yes |
| GO:0001558 | regulation of cell growth | 7.7320 | 4 | yes |
| GO:0030031 | cell projection assembly | 7.7320 | 5 | yes |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 7.7320 | 4 | yes |
| GO:2001233 | regulation of apoptotic signaling pathway | 7.7320 | 5 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 7.2165 | 6 | yes |
| GO:0032273 | positive regulation of protein polymerization | 6.1856 | 7 | yes |
| GO:0048812 | neuron projection morphogenesis | 6.1856 | 5 | yes |
| GO:0048638 | regulation of developmental growth | 5.6701 | 4 | yes |
| GO:2001234 | negative regulation of apoptotic signaling pathway | 5.6701 | 6 | yes |
| GO:0010821 | regulation of mitochondrion organization | 5.1546 | 6 | yes |
| GO:2001236 | regulation of extrinsic apoptotic signaling pathway | 5.1546 | 6 | yes |
| GO:0006898 | receptor-mediated endocytosis | 4.6392 | 4 | yes |
| GO:0090257 | regulation of muscle system process | 4.6392 | 5 | yes |
| GO:0099173 | postsynapse organization | 4.6392 | 4 | yes |
| GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 4.6392 | 7 | yes |
| GO:0030516 | regulation of axon extension | 3.6082 | 5 | yes |
| GO:0061387 | regulation of extent of cell growth | 3.6082 | 5 | yes |
| GO:0097581 | lamellipodium organization | 3.6082 | 6 | yes |
| GO:0106027 | neuron projection organization | 3.6082 | 6 | yes |
| GO:0007044 | cell-substrate junction assembly | 3.0928 | 6 | yes |
| GO:0097061 | dendritic spine organization | 3.0928 | 5 | yes |
| GO:0150115 | cell-substrate junction organization | 3.0928 | 5 | yes |
| GO:0006937 | regulation of muscle contraction | 2.5773 | 6 | yes |
| GO:0030838 | positive regulation of actin filament polymerization | 2.5773 | 7 | yes |
| GO:0048041 | focal adhesion assembly | 2.5773 | 7 | yes |
| GO:0097191 | extrinsic apoptotic signaling pathway | 2.5773 | 4 | yes |
| GO:0043954 | cellular component maintenance | 2.0619 | 4 | yes |
| GO:0097062 | dendritic spine maintenance | 1.5464 | 5 | yes |
| GO:1903146 | regulation of autophagy of mitochondrion | 1.5464 | 7 | yes |
| GO:0006930 | substrate-dependent cell migration, cell extension | 1.0309 | 7 | yes |
| GO:0006940 | regulation of smooth muscle contraction | 1.0309 | 7 | yes |
| GO:0045933 | positive regulation of muscle contraction | 1.0309 | 5 | yes |
| GO:0045987 | positive regulation of smooth muscle contraction | 1.0309 | 6 | yes |
Disease
No data found.
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CBL_HUMAN | [view interactions] | Low throughput | no | yes |
| MARE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHG35_HUMAN | [view interactions] | Low throughput | no | yes |
| FAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FGD1_HUMAN | [view interactions] | Low throughput | no | no |
| WIPF1_HUMAN | [view interactions] | Low throughput | no | no |
| WASL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MTSS1_HUMAN | [view interactions] | Low throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HAKAI_HUMAN | [view interactions] | Low throughput | no | yes |
| ARP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CTND1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCNA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ASAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | Low throughput | no | yes |
| ARPC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARPC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WASP_HUMAN | [view interactions] | Low throughput | no | yes |
| NCK1_HUMAN | [view interactions] | Low throughput | no | yes |
| MMP2_HUMAN | [view interactions] | Low throughput | no | no |
| ABL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WASF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CCL2_HUMAN | [view interactions] | Low throughput | no | no |
| PKD1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WASH1_HUMAN | [view interactions] | Low throughput | no | yes |
| EXOC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RN125_HUMAN | [view interactions] | Low throughput | no | yes |
| PAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CBLC_HUMAN | [view interactions] | Low throughput | no | yes |
| SPR2A_HUMAN | [view interactions] | Low throughput | no | no |
| PDK2_HUMAN | [view interactions] | Low throughput | no | yes |
| PAXI_HUMAN | [view interactions] | Low throughput | no | yes |
| MYLK_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KSYK_HUMAN | [view interactions] | Low throughput | no | no |
| CASP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHAN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SDC3_HUMAN | [view interactions] | Low throughput | no | yes |
| ACTG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATM_HUMAN | [view interactions] | Low throughput | no | yes |
| KCNA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FER_HUMAN | [view interactions] | Low throughput | no | yes |
| CRUM2_HUMAN | [view interactions] | Low throughput | no | no |
| SIR1_HUMAN | [view interactions] | Low throughput | no | yes |
| EP300_HUMAN | [view interactions] | Low throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FBW1A_HUMAN | [view interactions] | Low throughput | no | yes |
| CD2AP_HUMAN | [view interactions] | Low throughput | no | no |
| SPD2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCF1_HUMAN | [view interactions] | Low throughput | no | no |
| TRI15_HUMAN | [view interactions] | Low throughput | no | no |
| CASL_HUMAN | [view interactions] | Low throughput | no | yes |
| AURKA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| YES_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KEAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| AHNK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKAP9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| R113A_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAF1_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TXNIP_HUMAN | [view interactions] | High throughput | no | no |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| DUS28_HUMAN | [view interactions] | High throughput | no | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| BICD1_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHDF2_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| BRSK2_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| KCNQ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| PCDH7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| FOXO1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| MT21E_HUMAN | [view interactions] | High throughput | no | no |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDX42_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIL4_HUMAN | [view interactions] | High throughput | no | yes |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| PP1RA_HUMAN | [view interactions] | High throughput | no | yes |
| SND1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
| RFA4_HUMAN | [view interactions] | High throughput | no | yes |
| AMRP_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| NUFP2_HUMAN | [view interactions] | High throughput | no | no |
| SNUT1_HUMAN | [view interactions] | High throughput | no | yes |
| TYY1_HUMAN | [view interactions] | High throughput | no | yes |
| TOP1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM25_HUMAN | [view interactions] | High throughput | no | yes |
| RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX2L_HUMAN | [view interactions] | High throughput | no | no |
| TOX4_HUMAN | [view interactions] | High throughput | no | yes |
| IF5A1_HUMAN | [view interactions] | High throughput | no | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| WDR82_HUMAN | [view interactions] | High throughput | no | no |
| DHE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAF2_HUMAN | [view interactions] | High throughput | no | no |
| PR40A_HUMAN | [view interactions] | High throughput | no | no |
| RS19_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MECP2_HUMAN | [view interactions] | High throughput | no | yes |
| KC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MMTA2_HUMAN | [view interactions] | High throughput | no | yes |
| MFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| DCA13_HUMAN | [view interactions] | High throughput | no | yes |
| PRP4B_HUMAN | [view interactions] | High throughput | no | yes |
| FIP1_HUMAN | [view interactions] | High throughput | no | yes |
| CBX4_HUMAN | [view interactions] | High throughput | no | yes |
| DDX56_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FA76B_HUMAN | [view interactions] | High throughput | no | no |
| RCL1_HUMAN | [view interactions] | High throughput | no | no |
| RB15B_HUMAN | [view interactions] | High throughput | no | yes |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| AMOT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCNT2_HUMAN | [view interactions] | High throughput | no | yes |
| FA98A_HUMAN | [view interactions] | High throughput | no | no |
| SF3B2_HUMAN | [view interactions] | High throughput | no | yes |
| NUSAP_HUMAN | [view interactions] | High throughput | no | no |
| PR38A_HUMAN | [view interactions] | High throughput | no | no |
| LYAR_HUMAN | [view interactions] | High throughput | no | no |
| ELOA1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| POP1_HUMAN | [view interactions] | High throughput | no | no |
| RRP1B_HUMAN | [view interactions] | High throughput | no | yes |
| CAH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HXA5_HUMAN | [view interactions] | High throughput | no | no |
| SNIP1_HUMAN | [view interactions] | High throughput | no | no |
| TMA16_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3H_HUMAN | [view interactions] | High throughput | no | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M4K5_HUMAN | [view interactions] | High throughput | no | no |
| MA2C1_HUMAN | [view interactions] | High throughput | no | no |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| SH24A_HUMAN | [view interactions] | High throughput | no | no |
| HEMH_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR54_HUMAN | [view interactions] | High throughput | no | yes |
| NPHP4_HUMAN | [view interactions] | High throughput | no | yes |
| MAP2_HUMAN | [view interactions] | High throughput | no | yes |
| ATF2_HUMAN | [view interactions] | High throughput | no | yes |
| KS6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| SIR6_HUMAN | [view interactions] | High throughput | no | yes |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIFC3_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCBP2_HUMAN | [view interactions] | High throughput | no | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| STRP1_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FOCAD_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AIF1L_HUMAN | [view interactions] | High throughput | no | yes |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| CYTSB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBN2_HUMAN | [view interactions] | High throughput | no | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LUZP1_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIRA_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEXN_HUMAN | [view interactions] | High throughput | no | yes |
| MLH1_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPN90_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NOP9_HUMAN | [view interactions] | High throughput | no | no |
| RAI14_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CT2NL_HUMAN | [view interactions] | High throughput | no | yes |
| NDE1_HUMAN | [view interactions] | High throughput | no | yes |
| WRP73_HUMAN | [view interactions] | High throughput | no | no |
| STRN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRF2_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CABIN_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| NEB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASF1A_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNO10_HUMAN | [view interactions] | High throughput | no | yes |
| DLG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H1X_HUMAN | [view interactions] | High throughput | no | yes |
| K1671_HUMAN | [view interactions] | High throughput | no | yes |
| ARP5L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFHD1_HUMAN | [view interactions] | High throughput | no | no |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEAD1_HUMAN | [view interactions] | High throughput | no | no |
| ITPI2_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEAK1_HUMAN | [view interactions] | High throughput | no | yes |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| CTTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VMP1_HUMAN | [view interactions] | High throughput | no | yes |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNOT3_HUMAN | [view interactions] | High throughput | no | yes |
| PAX7_HUMAN | [view interactions] | High throughput | no | no |
| CYTSA_HUMAN | [view interactions] | High throughput | no | yes |
| MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG3_HUMAN | [view interactions] | High throughput | no | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNOT1_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA2_HUMAN | [view interactions] | High throughput | no | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA4_HUMAN | [view interactions] | High throughput | no | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| ARC1B_HUMAN | [view interactions] | High throughput | no | no |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| LIN7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| ARPC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTMR5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| TRI31_HUMAN | [view interactions] | High throughput | no | no |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LOXL2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNT1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| KDM4C_HUMAN | [view interactions] | High throughput | no | no |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RHG24_HUMAN | [view interactions] | High throughput | no | yes |
| RSPH1_HUMAN | [view interactions] | High throughput | no | no |
| MP2K3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TINF2_HUMAN | [view interactions] | High throughput | no | no |
| GCSP_HUMAN | [view interactions] | High throughput | no | yes |
| ACD_HUMAN | [view interactions] | High throughput | no | no |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| SMC5_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| RHG17_HUMAN | [view interactions] | High throughput | no | no |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| 3BP2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| RL9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| SF01_HUMAN | [view interactions] | High throughput | no | yes |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MBP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| YTHD1_HUMAN | [view interactions] | High throughput | no | no |
| SDHF2_HUMAN | [view interactions] | High throughput | no | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| SART3_HUMAN | [view interactions] | High throughput | no | yes |
| PRP6_HUMAN | [view interactions] | High throughput | no | yes |
| THY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SF3B4_HUMAN | [view interactions] | High throughput | no | yes |
| UPAR_HUMAN | [view interactions] | High throughput | no | yes |
| RBM15_HUMAN | [view interactions] | High throughput | no | yes |
| UBL4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL37_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUCB2_HUMAN | [view interactions] | High throughput | no | no |
| RL23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YTHD3_HUMAN | [view interactions] | High throughput | no | no |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CPSF7_HUMAN | [view interactions] | High throughput | no | yes |
| ACPH_HUMAN | [view interactions] | High throughput | no | yes |
| NONO_HUMAN | [view interactions] | High throughput | no | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZC11A_HUMAN | [view interactions] | High throughput | no | yes |
| GARS_HUMAN | [view interactions] | High throughput | no | yes |
| ZC11B_HUMAN | [view interactions] | High throughput | no | no |
| IDE_HUMAN | [view interactions] | High throughput | no | yes |
| MAOX_HUMAN | [view interactions] | High throughput | no | yes |
| RADI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYC_HUMAN | [view interactions] | High throughput | no | no |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| LA_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERF3A_HUMAN | [view interactions] | High throughput | no | yes |
| ERF3B_HUMAN | [view interactions] | High throughput | no | yes |
| SYSC_HUMAN | [view interactions] | High throughput | no | yes |
| SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UGDH_HUMAN | [view interactions] | High throughput | no | no |
| CSN7A_HUMAN | [view interactions] | High throughput | no | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| CTND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| GNA13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| URP2_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| ABL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| PUR2_HUMAN | [view interactions] | High throughput | no | yes |
| PUR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTBP1_HUMAN | [view interactions] | High throughput | no | no |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPCE_HUMAN | [view interactions] | High throughput | no | yes |
| ARNT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBP2_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| ACLY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |